Dr Jane Fleming moved into research from a clinical background in nursing, mainly with older people, through epidemiology training and a PhD on falls and their consequences in older old age. She has since co-ordinated the Cambridge City over-75s Cohort (CC75C) Study, supporting postgraduate students, visiting researchers and external collaborators working on a wide range of ageing-related and neuropathological research projects. A rare resource combining almost three decades of epidemiological data collection and a brain donation programme, CC75C is the longest-running of several population-based studies of ageing run from the Life-course and Ageing group in Cambridge Public Health.
Jane’s own programme of research, using mixed methods approaches to inform policy and practice affecting older people, has a focus on the growing numbers of ‘older old’ people and common challenges so many face in their later years – falls, osteoporosis, incontinence, social isolation, physical frailty, cognitive impairment and dementia. Particular interests include very old people’s care needs, preferences and transitions towards the end of life; the role that exercise, social and physical activity can play in postponing frailty, maximising independence and quality of life; policy implications and impacts on older people and their carers, both family and staff working across care settings. She also works part-time as a fall and fracture prevention clinical nurse specialist in Addenbrooke’s Hospital.
Publications
Death and the oldest old: Attitudes and preferences for end-of-life care – Qualitative research within a population-based cohort study Jane Fleming, Morag Farquhar, CC75C study collaboration, Carol Brayne, Stephen Barclay PLOS ONE 2016 April 5,DOI: 10.1371/journal.pone.0150686
- Featured in: BuzzFeed and The Conversation
- Ranked in top10% most cited PLOS ONE 2016 papers (56 citations by July 2021)
Peter T. Nelson, Carol Brayne, Margaret E. Flanagan, Erin L. Abner, Sonal Agrawal, Johannes Attems, Rudolph J. Castellani, Maria M. Corrada, Matthew D. Cykowski, Jing Di, Dennis W. Dickson,
Brittany N. Dugger, John F. Ervin, Jane Fleming, Jonathan Graff‑Radford, Lea T. Grinberg, Suvi R. K. Hokkanen, Sally Hunter, Alifiya Kapasi, Claudia H. Kawas, Hannah A. D. Keage, C. Dirk Keene, Mia Kero, David S. Knopman, Naomi Kouri, Gabor G. Kovacs, Sydney A. Labuzan, Eric B. Larson, Caitlin S. Latimer, Renata E. P. Leite, Billie J. Matchett, Fiona E. Matthews, Richard Merrick, Thomas J. Montine, Melissa E. Murray, Liisa Myllykangas, Sukriti Nag, Ruth S. Nelson, Janna H. Neltner, Aivi T. Nguyen, Ronald C. Petersen, Tuomo Polvikoski, R. Ross Reichard, Roberta D. Rodriguez, Claudia K. Suemoto, Shih‑Hsiu J. Wang, Stephen B. Wharton, Lon White, Julie A. Schneider
Acta Neuropathologica, 2022: 144(1), 27-44. doi:10.1007/s00401-022-02444-1
Kenneth E S Poole, Daniel D G Chappell, Emma Clark, Jane Fleming, Lee Shepstone, Thomas D Turmezei, Adam P Wagner, Karen Willoughby, Stephen K Kaptoge
BMJ Open 2022;12:e050343. doi: 10.1136/bmjopen-2021-050343
Zoe Paskins, Laurna Bullock, Fay Crawford-Manning, Elizabeth Cottrell, Jane Fleming, Sarah Leyland, John James Edwards, Emma Clark, Simon Thomas, Stephen Robert Chapman, Sarah Ryan, J E Lefroy, Christopher J Gidlow, C Iglesias, Joanne Protheroe, Robert Horne, Terence W O'Neill, Christian Mallen, Clare Jinks
BMJ Open, 2021, doi:10.1136/bmjopen-2021-048811
Laurna Bullock, Fay Crawford-Manning, Elizabeth Cottrell, Jane Fleming, Sarah Leyland, John Edwards, Emma M Clark, Simon Thomas, Stephen Chapman, Christopher Gidlow, Cynthia P Iglesias, Joanne Protheroe, Robert Horne, Terence W O’Neill, Christian Mallen, Clare Jinks, Zoe Paskins
Archives of Osteoporosis, 2021 Mar 24;16(1):58. doi: 10.1007/s11657-021-00913-w.
Frailty and neuropathology in relation to dementia status: the Cambridge City over-75s Cohort study.
Wallace, L., Hunter, S., Theou, O., Fleming, J., Rockwood, K., & Brayne, C.
International Psychogeriatrics, 2021, 1-9. doi:10.1017/S1041610220003932
S Hunter, SRK Hokkanen, HAD Keage, J Fleming, T Minett, T Polvikoski, K Allinson, C Brayne on behalf of the Cambridge City over-75s Cohort collaboration.
J Alzheimers Dis 75, 337-350 (2020).
When frail older people relocate in very old age who makes the decision?
Fiona Scheibl, Morag Farquhar, Jackie Buck, Stephen Barclay, Carol Brayne and Jane Fleming on behalf of the Cambridge City over-75s Cohort (CC75C) study collaboration
Innovation in Aging Volume 3, Issue 4, August 2019, igz030, DOI: 10.1093/geroni/igz030
Longitudinal analysis of the impact of loneliness on cognitive function over a 20-year follow-up
Hanyuying Wang, Caroline Lee, Sally Hunter, Jane Fleming, Carol Brayne and The CC75C study collaboration
Aging and Mental Health e-pub 20 Aug 2019, DOI: 10.1080/13607863.2019.1655704
Suvi R. K. Hokkanen, Mia Kero, Karri Kaivola, Sally Hunter, Hannah A. D. Keage, Anna Kiviharju, Anna Raunio, Pentti J. Tienari, Anders Paetau, Fiona E. Matthews, Jane Fleming, Caroline Graff, Tuomo M. Polvikoski, Liisa Myllykangas and Carol Brayne on behalf of the EClipSE collaboration Brain Pathol e-pub 3 Aug 2019, DOI:10.1111/bpa.12773
The experience of transitions in care in very old age: implications for general practice
Fiona Scheibl, Jane Fleming, Jackie Buck, Stephen Barclay, Carol Brayne and Morag Farquhar on behalf of the Cambridge City over-75s Cohort (CC75C) study collaboration
Family Practice e-pub June 2019, DOI: 10.1093/fampra/cmz014
Anne-Marie Burn, Frances Bunn, Jane Fleming, David Turner, Chris Fox, Alexandra Malyon, Carol Brayne
BMJ Open 2019;9(6):e026927.
Hanyuying Wang, Emily Zhao, Jane Fleming, Tom Dening, Kay-Tee Khaw, Carol Brayne & The CC75C Study Collaboration
BMJ Open 2019;9:e024645
Mortality risk of loneliness in the oldest old over a 10-year follow-up
Hanyuying Wang, Yue Leng, Emily Zhao, Jane Fleming, Carol Brayne & The CC75C Study Collaboration
Aging & Mental Health, e-pub 17 Nov 2018. DOI: 10.1080/13607863.2018.1510897
Anne-Marie Burn, Jane Fleming, Carol Brayne, Chris Fox, Frances Bunn
BMJ Open 2018;8:e020521. DOI: 10.1136/bmjopen-2017-020521
Fleming J, Calloway R, Perrels A, Barclay S, Farquhar M, Brayne C on behalf of the CC75C study collaboration
BMC Geriatrics 2017 17/222 DOI: 10.1186/s12877-017-0605-2
Policy briefing: Key findings and policy implications
Kay Deckers, Sebastian Köhler, Martin van Boxtel, Frans Verhey, the CC75C study collaboration, Carol Brayne, Jane Fleming
Aging and Mental Health e-pub: 2 February 2017, DOI: 10.1080/13607863.2017.1280767
Daniel H.J. Davis, Graciela Muniz Terrera, Hannah A.D. Keage, Blossom C.M. Stephan, Jane Fleming, Paul G. Ince, Fiona E. Matthews, Colm Cunningham, E. Wesley Ely, Alasdair M.J. MacLullich, Carol Brayne, on behalf of the EClipSE Collaborative Members
JAMA Psychiatry e-pub: 18 January 2017, DOI: 10.1001/jamapsychiatry.2016.3423
Using ambulance service PCRs to understand 999 call-outs to older people with dementia.
Buswell M, Lumbard P, Fleming J, Ayres D, Brayne C, Goodman C.
Journal of Paramedic Practice 2016; 8(5):246-251.
Steven Martin*, Jane Fleming, Sarah Cullum, Tom Dening, Greta Rait, Chris Fox, Cornelius Katona, Carol Brayne and Louise Lafortune
BMC Geriatrics 2015, 15:110, DOI: 10.1186/s12877-015-0100-6
Does dementia matter? Is dementia an important factor in 999 call-outs to older people?
Buswell M, Amado S, Goodman C, William J, Fleming J, Lumbard P, et al.
Emergency Medicine Journal 2015 Jun 1;32(6):e14-e15.
Marina Buswell, Jane Fleming, Philip Lumbard, Larissa S Prothero, Sarah Amador, Claire Goodman
Eur J Emerg Med 2015 Apr;22(2):147-8. DOI: 10.1097/MEJ.0000000000000237 [E-pub: 2015 Jan 2]
Marina Buswell, Philip Lumbard, Larissa Prothero, Caroline Lee, Steven Martin, Jane Fleming, Claire Goodman
Emerg Med J Published Online First: 2 December 2014, DOI: 10.1136/emermed-2014-203941
Rachael E Docking, Jane Fleming, Carol Brayne, Jun Zhao, Gary J Macfarlane, Gareth T Jones and the Cambridge City over-75s Cohort (CC75C) study collaboration
European Journal of Pain Published online: 28 JUL 2014, DOI: 10.1002/ejp.568
Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: a meta-analysis. Wu Y-T, Lee H-Y, Norton S, Fleming J, Matthews F, Brayne C
Int J Ger Psych 29(12):1212–1220, December 2014 (e-pub: 22 MAY 2014, DOI: 10.1002/gps.4148)
Pain reporting in older adults: the influence of cognitive impairment
Rachael E Docking, Jane Fleming, Carol Brayne, Jun Zhao, Gary J Macfarlane, Gareth T Jones and the Cambridge City over-75s Cohort (CC75C) study collaboration
British Journal of Pain 2014 8:3 (e-pub 10 Apr 2014) http://bjp.sagepub.com/content/8/3/119.full
J Perales, TD Cosco, BCM Stephan, J Fleming, S Martin, JM Haro, C Brayne
BMC Geriatrics 2014 14:18, DOI: 10.1186/1471-2318-14-18
Place of death and end-of-life transitions experienced by very old people with differing cognitive status: retrospective analysis of a prospective population-based cohort aged 85 and over
Anouk J. Perrels, Jane Fleming, Jun Zhao, Stephen Barclay, Morag Farquhar, Hilde M. Buiting, Carol Brayne and the Cambridge City over-75s Cohort (CC75C) study collaboration
Palliative Medicine, 2014 Mar 3;28(3):220-233 (e-pub ahead of print Dec 2013)
Prevalence studies of dementia in mainland China, Hong Kong and Taiwan: a meta-analysis.
Wu Y-T, Lee H-Y, Norton S, Chen C-F, Chen H-X, He C-L, Fleming J, Matthews F, Brayne C
PLOS One 2013 Jun 11;8(6):e66252. DOI: 10.1371/journal.pone.0066252.
Neuropathological correlates of falling in the CC75C population-based sample of the older old
Richardson K, Hunter S, Dening T, Xuereb JH, Matthews FE, Brayne C, Fleming J and the Cambridge City over-75s Cohort (CC75C) study neuropathology collaboration
Current Alzheimer Research 2012 Jul;9(6):697-708 [e-pub ahead of print 2 Apr 2012]
Epidemiology of back pain in older adults: Prevalence and risk factors for back pain onset
Rachael E Docking, Jane Fleming, Carol Brayne, Jun Zhao, Gary J Macfarlane, Gareth T Jones and the Cambridge City over-75s Cohort (CC75C) study collaboration
Rheumatology 2011 Sep;50(9):1645-53 [E-published 23 May 2011] doi:10.1093/rheumatology/ker175
Place of death for the 'oldest old': > or =85-year-olds in the CC75C population-based cohort.
Fleming J, Zhao J, Farquhar M, Brayne C, Barclay S and the Cambridge City over-75s Cohort (CC75C) study collaboration
British Journal of General Practice 2010 (April); 60(573): e171-179, DOI: 10.3399/bjgp10X483959.
The “oldest old” in the last year of life: population-based findings from CC75C study participants aged at least 85 at death Zhao J, Barclay S, Farquhar M, Kinmonth AL, Brayne C, Fleming J and the Cambridge City over-75s Cohort (CC75C) study collaboration
Journal of the American Geriatrics Society 2010 Jan;58(1) 1-11
Featured in:
GeriPal (Geriatrics and Palliative Care blog): https://geripal.org/last-year-of-life-in-oldest-old/ and
The Conversation: http://theconversation.com/heres-what-people-in-their-90s-really-think-about-death-58053
Brayne C, Richardson K, Matthews FE, Fleming J, Hunter S, Xuereb JH, Paykel E, Mukaetova-Ladinska EB, Huppert FA, O’Sullivan A, Dening T, and the Cambridge City over-75s Cohort (CC75C) study neuropathology collaboration. Journal of Alzheimer Disease 2009 Aug;18(3) 645-658
Inability to get up after falling, subsequent time on floor, and summoning help: prospective cohort study in people over 90.
Jane Fleming, Carol Brayne and the Cambridge City over-75s Cohort (CC75C) study collaboration
BMJ 2008;337:a2227.
Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study.
Jane Fleming, Fiona E Matthews, Carol Brayne and the Cambridge City over-75s Cohort (CC75C) study collaboration
BMC Geriatrics 2008, 8:6.
Cohort profile: the Cambridge City over-75s Cohort (CC75C).
Fleming J, Zhao E, O'Connor DW, Pollitt PA, Brayne C and the CC75C study.
International Journal of Epidemiology 2007 Feb;36(1):40-6.
