Our research in the CRUK CI focusses on cancer genomics, primarily the statistical analysis of microarray and second-generation sequencing technologies to study e.g. gDNA, expression, methylation, microRNAs and transcription factor binding. We have a particular emphasis on analysis of data from Illumina platforms. With Rebecca Fitzgerald we have recently begun a CRUK-funded International Cancer Genome Consortium project to sequence 500 matched oesophageal adenocarcinoma-normal pairs. A second theme is the development of statistical and stochastic methods arising in evolutionary approaches to cancer.
