skip to content

Cambridge Public Health

 

Working on the neuropathology of ageing with the Cambridge City Over-75s Cohort and MRC-CFAS groups.

Publications from Elements

Journal articles

2023

  • Nelson, PT., Lee, EB., Cykowski, MD., Alafuzoff, I., Arfanakis, K., Attems, J., Brayne, C., Corrada, MM., Dugger, BN., Flanagan, ME., Ghetti, B., Grinberg, LT., Grossman, M., Grothe, MJ., Halliday, GM., Hasegawa, M., Hokkanen, SRK., Hunter, S., Jellinger, K., Kawas, CH., Keene, CD., Kouri, N., Kovacs, GG., Leverenz, JB., Latimer, CS., Mackenzie, IR., Mao, Q., McAleese, KE., Merrick, R., Montine, TJ., Murray, ME., Myllykangas, L., Nag, S., Neltner, JH., Newell, KL., Rissman, RA., Saito, Y., Sajjadi, SA., Schwetye, KE., Teich, AF., Thal, DR., Tomé, SO., Troncoso, JC., Wang, S-HJ., White, CL., Wisniewski, T., Yang, H-S., Schneider, JA., Dickson, DW. and Neumann, M., 2023. LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathol, v. 145
    Doi: http://doi.org/10.1007/s00401-022-02524-2
  • Nichols, E., Merrick, R., Hay, SI., Himali, D., Himali, JJ., Hunter, S., Keage, HAD., Latimer, CS., Scott, MR., Steinmetz, JD., Walker, JM., Wharton, SB., Wiedner, CD., Crane, PK., Keene, CD., Launer, LJ., Matthews, FE., Schneider, J., Seshadri, S., White, L., Brayne, C. and Vos, T., 2023. The prevalence, correlation, and co-occurrence of neuropathology in old age: harmonisation of 12 measures across six community-based autopsy studies of dementia. Lancet Healthy Longev, v. 4
    Doi: http://doi.org/10.1016/S2666-7568(23)00019-3
  • 2022

  • Nelson, PT., Brayne, C., Flanagan, ME., Abner, EL., Agrawal, S., Attems, J., Castellani, RJ., Corrada, MM., Cykowski, MD., Di, J., Dickson, DW., Dugger, BN., Ervin, JF., Fleming, J., Graff-Radford, J., Grinberg, LT., Hokkanen, SRK., Hunter, S., Kapasi, A., Kawas, CH., Keage, HAD., Keene, CD., Kero, M., Knopman, DS., Kouri, N., Kovacs, GG., Labuzan, SA., Larson, EB., Latimer, CS., Leite, REP., Matchett, BJ., Matthews, FE., Merrick, R., Montine, TJ., Murray, ME., Myllykangas, L., Nag, S., Nelson, RS., Neltner, JH., Nguyen, AT., Petersen, RC., Polvikoski, T., Reichard, RR., Rodriguez, RD., Suemoto, CK., Wang, S-HJ., Wharton, SB., White, L. and Schneider, JA., 2022. Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. Acta Neuropathol, v. 144
    Doi: http://doi.org/10.1007/s00401-022-02444-1
  • 2021

  • Wallace, L., Hunter, S., Theou, O., Fleming, J., Rockwood, K. and Brayne, C., 2021. Frailty and neuropathology in relation to dementia status: the Cambridge City over-75s Cohort study. Int Psychogeriatr,
    Doi: http://doi.org/10.1017/S1041610220003932
  • Hunter, S. and Brayne, C., 2021. Amyloid in the ageing brain: New frameworks and perspectives Aging Brain, v. 1
    Doi: http://doi.org/10.1016/j.nbas.2021.100008
  • 2020

  • Wang, H., Lee, C., Hunter, S., Fleming, J., Brayne, C. and CC75C Study Collaboration, , 2020. Longitudinal analysis of the impact of loneliness on cognitive function over a 20-year follow-up. Aging Ment Health, v. 24
    Doi: http://doi.org/10.1080/13607863.2019.1655704
  • Hokkanen, SRK., Kero, M., Kaivola, K., Hunter, S., Keage, HAD., Kiviharju, A., Raunio, A., Tienari, PJ., Paetau, A., Matthews, FE., Fleming, J., Graff, C., Polvikoski, TM., Myllykangas, L., Brayne, C. and EClipSE Collaboration, , 2020. Putative risk alleles for LATE-NC with hippocampal sclerosis in population-representative autopsy cohorts. Brain Pathol, v. 30
    Doi: http://doi.org/10.1111/bpa.12773
  • Hunter, S., Hokkanen, SRK., Keage, HAD., Fleming, J., Minett, T., Polvikoski, T., Allinson, K. and Brayne, C., 2020. TDP-43 Related Neuropathologies and Phosphorylation State: Associations with Age and Clinical Dementia in the Cambridge City over-75s Cohort Journal of Alzheimer's Disease,
    Doi: http://doi.org/10.3233/jad-191093
  • 2019 (Accepted for publication)

  • Nelson, P., Dickson, D., Trokanowski, J., Jack, CJ., Boyle, P., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., Chui, H., Coyle-Gilchrist, I., Fardo, D., Flanagan, M., Halliday, G., Hokkanen, S., Hunter, S., Jicha, G., Katsumata, Y., Kawas, C., Keene, C., Kovacs, G., Kukull, W., Levey, A., Makkinejad, N., Montine, T., Murayama, S., Murray, M., Nag, S., Rissman, R., Seeley, W., Sperling, R., White, C., Yu, L. and Schneider, J., 2019 (Accepted for publication). Limbic-predominant Age-related TDP-43 Encephalopathy (LATE): Consensus Working Group Report Brain,
    Doi: http://doi.org/10.1093/brain/awz099
  • 2019

  • Nelson, PT., Dickson, DW., Trojanowski, JQ., Jack, CR., Boyle, PA., Arfanakis, K., Rademakers, R., Alafuzoff, I., Attems, J., Brayne, C., Coyle-Gilchrist, ITS., Fardo, DW., Flanagan, ME., Halliday, G., Hunter, S., Jicha, GA., Katsumata, Y., Kawas, CH., Keene, CD., Kovacs, GG., Kukull, WA., Levey, AI., Makkinejad, N., Montine, TJ., Murray, ME., Nag, S., Seeley, WW., Sperling, RA., White, CL. and Schneider, JA., 2019. Reply: LATE to the PART-y. Brain, v. 142
    Doi: http://doi.org/10.1093/brain/awz226
  • 2019. Erratum. Brain, v. 142
    Doi: http://doi.org/10.1093/brain/awz163
  • 2018 (Accepted for publication)

  • Hunter, S., Smailagic, N. and Brayne, CEG., 2018 (Accepted for publication). Aβ and the dementia syndrome: simple versus complex perspectives. European Journal of Clinical Investigation,
  • 2018

  • Nascimento, C., Di Lorenzo Alho, AT., Bazan Conceição Amaral, C., Leite, REP., Nitrini, R., Jacob-Filho, W., Pasqualucci, CA., Hokkanen, SRK., Hunter, S., Keage, H., Kovacs, GG., Grinberg, LT. and Suemoto, CK., 2018. Prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis. Neuropathol Appl Neurobiol, v. 44
    Doi: http://doi.org/10.1111/nan.12430
  • Smailagic, N., Hunter, S., Lafortune, L. and Brayne, CEG., 2018. Do CSF biomarkers and FDG PET imaging show sufficient clinical utility for diagnosis of dementia subtypes? BMJ: British Medical Journal, v. 361
    Doi: http://doi.org/10.1136/bmj.k2438
  • 2017 (Accepted for publication)

  • Hunter, SE. and Brayne, C., 2017 (Accepted for publication). Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease Molecular Psychiatry,
    Doi: 10.1038/mp.2017.218
  • Hunter, SE., Smailagic, N. and Brayne, C., 2017 (Accepted for publication). Dementia research: populations, progress, problems and predictions Journal of Alzheimer's Disease,
  • Hokkanen, SRK., Hunter, S., Polvikoski, TM., Keage, HAD., Minett, T., Matthews, FE. and Brayne, C., 2017 (Accepted for publication). Hippocampal sclerosis, hippocampal neuron loss patterns and Tdp-43 in the aged population Brain Pathology,
    Doi: http://doi.org/10.1111/bpa.12556
  • 2017

  • Fleming, J., Brayne, C., Calloway, R., Perrels, A., Farquhar, M., Barclay, S. and CC75C Cambridge City over-75s Cohort, , 2017. Dying comfortably in very old age with or without dementia in different care settings – a representative "older old" population study BMC Geriatrics, v. 17
    Doi: http://doi.org/10.1186/s12877-017-0605-2
  • Hunter, S. and Brayne, C., 2017. Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research? J Negat Results Biomed, v. 16
    Doi: 10.1186/s12952-017-0066-3
  • Hunter, S. and Brayne, C., 2017. Erratum to: Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research? J Negat Results Biomed, v. 16
    Doi: http://doi.org/10.1186/s12952-017-0073-4
  • 2016

  • Hunter, S., Martin, S. and Brayne, C., 2016. The APP Proteolytic System and Its Interactions with Dynamic Networks in Alzheimer's Disease. Methods Mol Biol, v. 1303
    Doi: 10.1007/978-1-4939-2627-5_3
  • Fleming, J., Farquhar, M., Brayne, C. and Barclay, S., 2016. Death and the Oldest Old: Attitudes and Preferences for End-of-Life Care - Qualitative Research within a Population-Based Cohort Study PLOS ONE, v. 11
    Doi: http://doi.org/10.1371/journal.pone.0150686
  • Le Couteur, DG., Hunter, S. and Brayne, C., 2016. Solanezumab and the amyloid hypothesis for Alzheimer's disease. BMJ, v. 355
  • 2015

  • Hunter, S., Minett, T., Polvikoski, T., Mukaetova-Ladinska, E., Brayne, C. and Cambridge City over-75s Cohort Collaboration, , 2015. Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles. Alzheimers Res Ther, v. 7
    Doi: 10.1186/s13195-015-0141-2
  • 2014

  • Hunter, S. and Brayne, C., 2014. Integrating the molecular and the population approaches to dementia research to help guide the future development of appropriate therapeutics. Biochem Pharmacol, v. 88
    Doi: http://doi.org/10.1016/j.bcp.2013.12.015
  • Hunter, S. and Brayne, C., 2014. Integrating the molecular and the population approaches to dementia research to help guide the future development of appropriate therapeutics Biochemical Pharmacology, v. 88
    Doi: http://doi.org/10.1016/j.bcp.2013.12.015
  • Keage, HAD., Hunter, S., Matthews, FE., Ince, PG., Hodges, J., Hokkanen, S., Highley, JR., Dening, T. and Brayne, C., 2014. TDP-43 in the Population: Prevalence and Associations with Dementia and Age. J Alzheimers Dis,
    Doi: http://doi.org/10.3233/JAD-132351
  • D'Alton, S., Hunter, S., Whitehouse, P., Brayne, C. and George, D., 2014. Adapting to dementia in society: a challenge for our lifetimes and a charge for public health. J Alzheimers Dis, v. 42
    Doi: http://doi.org/10.3233/JAD-140213
  • Keage, HAD., Hunter, S., Matthews, FE., Ince, PG., Hodges, J., Hokkanen, SRK., Highley, JR., Dening, T. and Brayne, C., 2014. TDP-43 pathology in the population: prevalence and associations with dementia and age. J Alzheimers Dis, v. 42
    Doi: http://doi.org/10.3233/JAD-132351
  • 2013

  • Hunter, S., Arendt, T. and Brayne, C., 2013. The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD. Mol Neurobiol, v. 48
    Doi: http://doi.org/10.1007/s12035-013-8445-3
  • Hunter, S., Arendt, T. and Brayne, C., 2013. The senescence hypothesis of disease progression in alzheimer disease: An Integrated matrix of disease pathways for FAD and SAD Molecular Neurobiology, v. 48
    Doi: http://doi.org/10.1007/s12035-013-8445-3
  • 2012

  • Hunter, S. and Brayne, C., 2012. Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems Alzheimer's Research and Therapy, v. 4
    Doi: 10.1186/alzrt108
  • Stephan, BCM., Hunter, S., Harris, D., Llewellyn, DJ., Siervo, M., Matthews, FE. and Brayne, C., 2012. The neuropathological profile of mild cognitive impairment (MCI): A systematic review Molecular Psychiatry, v. 17
    Doi: http://doi.org/10.1038/mp.2011.147
  • Stephan, BCM., Matthews, FE., Hunter, S., Savva, GM., Bond, J., McKeith, IG., Ince, P., Brayne, C. and Medical Research Council Cognitive Function and Ageing Study (MRC CFAS), , 2012. Neuropathological profile of mild cognitive impairment from a population perspective. Alzheimer Dis Assoc Disord, v. 26
    Doi: http://doi.org/10.1097/WAD.0b013e31822fc24d
  • Stephan, BCM., Hunter, S., Harris, D., Llewellyn, DJ., Siervo, M., Matthews, FE. and Brayne, C., 2012. The neuropathological profile of mild cognitive impairment (MCI): a systematic review. Mol Psychiatry, v. 17
    Doi: 10.1038/mp.2011.147
  • Stephan, BCM., Matthews, FE., Ma, B., Muniz, G., Hunter, S., Davis, D., McKeith, IG., Foster, G., Ince, PG. and Brayne, C., 2012. Alzheimer and vascular neuropathological changes associated with different cognitive States in a non-demented sample. J Alzheimers Dis, v. 29
    Doi: http://doi.org/10.3233/JAD-2011-110518
  • Richardson, K., Hunter, S., Dening, T., Xuereb, JH., Matthews, FE., Brayne, C., Fleming, J. and Cambridge City over-75s Cohort (CC75C) Study Neuropathology Collaboration, , 2012. Neuropathological correlates of falling in the CC75C population-based sample of the older old. Current Alzheimer Research, v. 9
    Doi: 10.2174/156720512801322636
  • 2011

  • Stephan, BCM., Matthews, FE., Hunter, S., Savva, GM., Bond, J., McKeith, IG., Ince, P. and Brayne, C., 2011. Neuropathological profile of mild cognitive impairment from a population perspective Alzheimer Disease & Associated Disorders,
  • 2010

  • Hunter, S., Friedland, RP. and Brayne, C., 2010. Time for a change in the research paradigm for Alzheimer's disease: the value of a chaotic matrix modeling approach. CNS Neurosci Ther, v. 16
    Doi: http://doi.org/10.1111/j.1755-5949.2009.00117.x
  • 2009

  • Brayne, C., Richardson, K., Matthews, FE., Fleming, J., Hunter, S., Xuereb, JH., Paykel, E., Mukaetova-Ladinska, EB., Huppert, FA., O'Sullivan, A., Dening, T. and Cambridge City Over-75s Cohort Cc75c Study Neuropathology Collaboration, , 2009. Neuropathological correlates of dementia in over-80-year-old brain donors from the population-based Cambridge city over-75s cohort (CC75C) study. J Alzheimers Dis, v. 18
    Doi: 10.3233/JAD-2009-1182
  • Book chapters

    2014

  • Hunter, S. and Brayne, C., 2014. Integrating data for modeling biological complexity
    Doi: http://doi.org/10.1007/978-3-642-30574-0_52