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Petra Klepac

My research focuses on several topics:
1) Integrating epidemiological and demographic processes into a unified framework to understand the role of demography as an important epidemiological driver.
2) Incorporating economic constraints into epidemiological models to investigate the combined economic and epidemic dynamics of vaccination.
3) Drawing on game theory and theory of self-enforcing international agreements to identify the levels of international cooperation necessary to reach optimal and more uniform regional vaccination coverage.
http://www.petraklepac.com

Publications from Elements

Journal articles

2013

  • Klepac, P., Metcalf, CJE., McLean, A. and Hampson, K., 2013. Towards the endgame and beyond: complexities and challenges for the elimination of infectious diseases Philosophical Transactions of the Royal Society, v. 368
    Doi: http://doi.org/10.1098/rstb.2012.0137
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  • Metcalf, CJE., Cohen, C., Lessler, J., McAnerney, JM., Ntshoe, GM., Puren, A., Klepac, P., Tatem, A., Grenfell, BT. and Bjørnstad, ON., 2013. Implications of spatially heterogeneous vaccination coverage for the risk of congenital rubella syndrome in South Africa. J R Soc Interface, v. 10
    Doi: http://doi.org/10.1098/rsif.2012.0756
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  • Henderson, DA. and Klepac, P., 2013. Lessons from the eradication of smallpox: an interview with D. A. Henderson Philosophical Transactions of the Royal Society: Biological Sciences, v. 368
    Doi: http://doi.org/10.1098/rstb.2013.0113
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  • Henderson, DA. and Klepac, P., 2013. Lessons from the eradication of smallpox: an interview with D. A. Henderson Philosophical transactions of the Royal Society of London. Series B, Biological sciences, v. 368
    Doi: http://doi.org/10.1098/rstb.2013.0113
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    2012

  • Metcalf, CJE., Lessler, J., Klepac, P., Morice, A., Grenfell, BT. and Bjørnstad, ON., 2012. Structured models of infectious disease: Inference with discrete data Theoretical Population Biology, v. 82
    Doi: http://doi.org/10.1016/j.tpb.2011.12.001
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  • Metcalf, CJE., Lessler, J., Klepac, P., Cutts, F. and Grenfell, BT., 2012. Impact of birth rate, seasonality and transmission rate on minimum levels of coverage needed for rubella vaccination. Epidemiol Infect, v. 140
    Doi: http://doi.org/10.1017/S0950268812000131
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  • Klepac, P., Bjørnstad, ON., Metcalf, CJE. and Grenfell, BT., 2012. Optimizing reactive responses to outbreaks of immunizing infections: balancing case management and vaccination. PLoS One, v. 7
    Doi: http://doi.org/10.1371/journal.pone.0041428
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  • Metcalf, CJE., Lessler, J., Klepac, P., Morice, A., Grenfell, BT. and Bjørnstad, ON., 2012. Structured models of infectious disease: inference with discrete data. Theor Popul Biol, v. 82
    Doi: http://doi.org/10.1016/j.tpb.2011.12.001
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    2011

  • Klepac, P. and Caswell, H., 2011. The stage-structured epidemic: Linking disease and demography with a multi-state matrix approach model Theoretical Ecology, v. 4
    Doi: http://doi.org/10.1007/s12080-010-0079-8
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  • Metcalf, CJE., Bjørnstad, ON., Ferrari, MJ., Klepac, P., Bharti, N., Lopez-Gatell, H. and Grenfell, BT., 2011. The epidemiology of rubella in Mexico: Seasonality, stochasticity and regional variation Epidemiology and Infection, v. 139
    Doi: http://doi.org/10.1017/S0950268810002165
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  • Klepac, P., Laxminarayan, R. and Grenfell, BT., 2011. Synthesizing epidemiological and economic optima for control of immunizing infections. Proc Natl Acad Sci U S A, v. 108
    Doi: http://doi.org/10.1073/pnas.1101694108
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  • Metcalf, CJE., Bjørnstad, ON., Ferrari, MJ., Klepac, P., Bharti, N., Lopez-Gatell, H. and Grenfell, BT., 2011. The epidemiology of rubella in Mexico: seasonality, stochasticity and regional variation. Epidemiol Infect, v. 139
    Doi: http://doi.org/10.1017/S0950268810002165
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  • Metcalf, CJE., Klepac, P., Ferrari, M., Grais, RF., Djibo, A. and Grenfell, BT., 2011. Modelling the first dose of measles vaccination: the role of maternal immunity, demographic factors, and delivery systems. Epidemiol Infect, v. 139
    Doi: http://doi.org/10.1017/S0950268810001329
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    2009

  • Klepac, P., Pomeroy, LW., Bjørnstad, ON., Kuiken, T., Osterhaus, ADME. and Rijks, JM., 2009. Stage-structured transmission of phocine distemper virus in the Dutch 2002 outbreak. Proc Biol Sci, v. 276
    Doi: http://doi.org/10.1098/rspb.2009.0175
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    2007

  • Klepac, P., Neubert, MG. and van den Driessche, P., 2007. Dispersal delays, predator-prey stability, and the paradox of enrichment. Theor Popul Biol, v. 71
    Doi: http://doi.org/10.1016/j.tpb.2007.02.002
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    2006

  • Rapatski, B., Klepac, P., Dueck, S., Liu, M. and Weiss, LI., 2006. Mathematical epidemiology of HIV/AIDS in Cuba during the period 1986-2000 Mathematical Biosciences and Engineering, v. 3
    Doi: http://doi.org/10.3934/mbe.2006.3.545
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    2002

  • Neubert, MG., Klepac, P. and van den Driessche, P., 2002. Stabilizing dispersal delays in predator-prey metapopulation models. Theor Popul Biol, v. 61
    Doi: http://doi.org/10.1006/tpbi.2002.1578
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    Books

    2012 (No publication date)

  • Klepac, P., Metcalf, CJ. and Hampson, K., 2012 (No publication date). Towards the endgame and beyond: complexities and challenges for the elimination of infectious diseases

    • Contact

    Cambridge Public Health
    Department of Engineering
    Trumpington Street
    Cambridge, CB2 1PZ

    Email: cph-contact@eng.cam.ac.uk

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