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Cambridge Public Health

 

Genetic and environmental factors are implicated in the aetiology of breast cancer. Genetic susceptibility is mediated by rare highly penetrant mutations and variants with more modest effects on risk. Mutations in the BRCA1 and BRCA2 genes confer high risks of breast and ovarian cancer. Genetic models have been devised to calculate the probability of carrying mutations in these genes and of subsequently developing cancer. My research currently involves risk modelling of breast cancer, and constructing genomic profiles for breast cancer using data from recent genome wide association studies.

Publications from Elements

Journal articles

2021 (Accepted for publication)

  • Antoniou, A., Yang, X., Cunningham, A., Tischkowitz, M., Easton, DF. and Pharoah, P., 2021 (Accepted for publication). A Comprehensive Epithelial Tubo-Ovarian Cancer Risk Prediction Model Incorporating Genetic and Epidemiological Risk Factors Journal of Medical Genetics,
  • Easton, D., 2021 (Accepted for publication). Pathology of tumors associated with pathogenic germline variants in nine breast cancer susceptibility genes JAMA Oncology,
  • 2021

  • Ho, W-K., Tai, M-C., Dennis, J., Shu, X., Li, J., Ho, PJ., Millwood, IY., Lin, K., Jee, Y-H., Lee, S-H., Mavaddat, N., Bolla, MK., Wang, Q., Michailidou, K., Long, J., Wijaya, EA., Hassan, T., Rahmat, K., Tan, VKM., Tan, BKT., Tan, SM., Tan, EY., Lim, SH., Gao, Y-T., Zheng, Y., Kang, D., Choi, J-Y., Han, W., Lee, H-B., Kubo, M., Okada, Y., Namba, S., BioBank Japan Project, , Park, SK., Kim, S-W., Shen, C-Y., Wu, P-E., Park, B., Muir, KR., Lophatananon, A., Wu, AH., Tseng, C-C., Matsuo, K., Ito, H., Kwong, A., Chan, TL., John, EM., Kurian, AW., Iwasaki, M., Yamaji, T., Kweon, S-S., Aronson, KJ., Murphy, RA., Koh, W-P., Khor, C-C., Yuan, J-M., Dorajoo, R., Walters, RG., Chen, Z., Li, L., Lv, J., Jung, K-J., Kraft, P., Pharoah, PDB., Dunning, AM., Simard, J., Shu, X-O., Yip, C-H., Taib, NAM., Antoniou, AC., Zheng, W., Hartman, M., Easton, DF. and Teo, S-H., 2021. Polygenic risk scores for prediction of breast cancer risk in Asian populations Genetics in Medicine,
    Doi: http://doi.org/10.1016/j.gim.2021.11.008
  • 2020 (Accepted for publication)

  • Mavaddat, N., Antoniou, AC., Mooij, TM., Hooning, MJ., Heemskerk-Gerritsen, BA., GENEPSO, , Noguès, C., Gauthier-Villars, M., Caron, O., Gesta, P., Pujol, P., Lortholary, A., EMBRACE, , Barrowdale, D., Frost, D., Evans, DG., Izatt, L., Adlard, J., Eeles, R., Brewer, C., Tischkowitz, M., Henderson, A., Cook, J., Eccles, D., HEBON, , van Engelen, K., Mourits, MJE., Ausems, MGEM., Koppert, LB., Hopper, JL., John, EM., Chung, WK., Andrulis, IL., Daly, MB., Buys, SS., kConFab Investigators, , Benitez, J., Caldes, T., Jakubowska, A., Simard, J., Singer, CF., Tan, Y., Olah, E., Navratilova, M., Foretova, L., Gerdes, A-M., Roos-Blom, M-J., Van Leeuwen, FE., Arver, B., Olsson, H., Schmutzler, RK., Engel, C., Kast, K., Phillips, K-A., Terry, MB., Milne, RL., Goldgar, DE., Rookus, MA., Andrieu, N., Easton, DF., IBCCS, , kConFab, and BCFR, , 2020 (Accepted for publication). Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers. Breast Cancer Research, v. 22
    Doi: http://doi.org/10.1186/s13058-020-1247-4
  • Easton, D., 2020 (Accepted for publication). Combined associations of a polygenic risk score and classical risk factors with breast cancer risk Journal of the National Cancer Institute,
  • Antoniou, A., Barnes, D., Easton, D. and Mavaddat, N., 2020 (Accepted for publication). Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants Genetics in Medicine,
  • Mavaddat, N., Antoniou, AC. and Easton, DF., 2020 (Accepted for publication). Prospective Evaluation of a Breast Cancer Risk Model Integrating Classical Risk Factors and Polygenic Risk in 15 Cohorts from Six Countries International Journal of Epidemiology,
  • Easton, D., 2020 (Accepted for publication). Breast cancer risk genes: association analysis in more than 113,000 women New England Journal of Medicine,
    Doi: http://doi.org/10.1056/NEJMoa1913948
  • 2020

  • Mavaddat, N., Antoniou, AC., Mooij, TM., Hooning, MJ., Heemskerk-Gerritsen, BA., GENEPSO, , Noguès, C., Gauthier-Villars, M., Caron, O., Gesta, P., Pujol, P., Lortholary, A., EMBRACE, , Barrowdale, D., Frost, D., Evans, DG., Izatt, L., Adlard, J., Eeles, R., Brewer, C., Tischkowitz, M., Henderson, A., Cook, J., Eccles, D., HEBON, , van Engelen, K., Mourits, MJE., Ausems, MGEM., Koppert, LB., Hopper, JL., John, EM., Chung, WK., Andrulis, IL., Daly, MB., Buys, SS., kConFab Investigators, , Benitez, J., Caldes, T., Jakubowska, A., Simard, J., Singer, CF., Tan, Y., Olah, E., Navratilova, M., Foretova, L., Gerdes, A-M., Roos-Blom, M-J., Van Leeuwen, FE., Arver, B., Olsson, H., Schmutzler, RK., Engel, C., Kast, K., Phillips, K-A., Terry, MB., Milne, RL., Goldgar, DE., Rookus, MA., Andrieu, N., Easton, DF. and IBCCS, kConFab and BCFR, , 2020. Correction to: Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers. Breast Cancer Res, v. 22
    Doi: http://doi.org/10.1186/s13058-020-01259-w
  • Eriksson, M., Czene, K., Strand, F., Zackrisson, S., Lindholm, P., Lång, K., Förnvik, D., Sartor, H., Mavaddat, N., Easton, D. and Hall, P., 2020. Identification of Women at High Risk of Breast Cancer Who Need Supplemental Screening. Radiology, v. 297
    Doi: http://doi.org/10.1148/radiol.2020201620
  • Kramer, I., Hooning, MJ., Mavaddat, N., Hauptmann, M., Keeman, R., Steyerberg, EW., Giardiello, D., Antoniou, AC., Pharoah, PDP., Canisius, S., Abu-Ful, Z., Andrulis, IL., Anton-Culver, H., Aronson, KJ., Augustinsson, A., Becher, H., Beckmann, MW., Behrens, S., Benitez, J., Bermisheva, M., Bogdanova, NV., Bojesen, SE., Bolla, MK., Bonanni, B., Brauch, H., Bremer, M., Brucker, SY., Burwinkel, B., Castelao, JE., Chan, TL., Chang-Claude, J., Chanock, SJ., Chenevix-Trench, G., Choi, J-Y., Clarke, CL., NBCS Collaborators, , Collée, JM., Couch, FJ., Cox, A., Cross, SS., Czene, K., Daly, MB., Devilee, P., Dörk, T., Dos-Santos-Silva, I., Dunning, AM., Dwek, M., Eccles, DM., Evans, DG., Fasching, PA., Flyger, H., Gago-Dominguez, M., García-Closas, M., García-Sáenz, JA., Giles, GG., Goldgar, DE., González-Neira, A., Haiman, CA., Håkansson, N., Hamann, U., Hartman, M., Heemskerk-Gerritsen, BAM., Hollestelle, A., Hopper, JL., Hou, M-F., Howell, A., ABCTB Investigators, , kConFab Investigators, , Ito, H., Jakimovska, M., Jakubowska, A., Janni, W., John, EM., Jung, A., Kang, D., Kets, CM., Khusnutdinova, E., Ko, Y-D., Kristensen, VN., Kurian, AW., Kwong, A., Lambrechts, D., Le Marchand, L., Li, J., Lindblom, A., Lubiński, J., Mannermaa, A., Manoochehri, M., Margolin, S., Matsuo, K., Mavroudis, D., Meindl, A., Milne, RL., Mulligan, AM., Muranen, TA., Neuhausen, SL., Nevanlinna, H., Newman, WG., Olshan, AF., Olson, JE., Olsson, H., Park-Simon, T-W., Peto, J., Petridis, C., Plaseska-Karanfilska, D., Presneau, N., Pylkäs, K., Radice, P., Rennert, G., Romero, A., Roylance, R., Saloustros, E., Sawyer, EJ., Schmutzler, RK., Schwentner, L., Scott, C., See, M-H., Shah, M., Shen, C-Y., Shu, X-O., Siesling, S., Slager, S., Sohn, C., Southey, MC., Spinelli, JJ., Stone, J., Tapper, WJ., Tengström, M., Teo, SH., Terry, MB., Tollenaar, RAEM., Tomlinson, I., Troester, MA., Vachon, CM., van Ongeval, C., van Veen, EM., Winqvist, R., Wolk, A., Zheng, W., Ziogas, A., Easton, DF., Hall, P. and Schmidt, MK., 2020. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk. Am J Hum Genet, v. 107
    Doi: http://doi.org/10.1016/j.ajhg.2020.09.001
  • Ho, W-K., Tan, M-M., Mavaddat, N., Tai, M-C., Mariapun, S., Li, J., Ho, P-J., Dennis, J., Tyrer, JP., Bolla, MK., Michailidou, K., Wang, Q., Kang, D., Choi, J-Y., Jamaris, S., Shu, X-O., Yoon, S-Y., Park, SK., Kim, S-W., Shen, C-Y., Yu, J-C., Tan, EY., Chan, PMY., Muir, K., Lophatananon, A., Wu, AH., Stram, DO., Matsuo, K., Ito, H., Chan, CW., Ngeow, J., Yong, WS., Lim, SH., Lim, GH., Kwong, A., Chan, TL., Tan, SM., Seah, J., John, EM., Kurian, AW., Koh, W-P., Khor, CC., Iwasaki, M., Yamaji, T., Tan, KMV., Tan, KTB., Spinelli, JJ., Aronson, KJ., Hasan, SN., Rahmat, K., Vijayananthan, A., Sim, X., Pharoah, PDP., Zheng, W., Dunning, AM., Simard, J., van Dam, RM., Yip, C-H., Taib, NAM., Hartman, M., Easton, DF., Teo, S-H. and Antoniou, AC., 2020. European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nat Commun, v. 11
    Doi: http://doi.org/10.1038/s41467-020-17680-w
  • Lee, A., Yang, X., Tyrer, J., Gentry-Maharaj, A., Ryan, A., Mavaddat, N., Cunningham, AP., Carver, T., Archer, S., Leslie, G., Kalsi, J., Gaba, F., Manchanda, R., Gayther, SA., Ramus, SJ., Walter, FM., Tischkowitz, M., Jacobs, I., Menon, U., Easton, DF., Pharoah, PPD. and Antoniou, AC., 2020. A Comprehensive Epithelial Tubo-Ovarian Cancer Risk Prediction Model Incorporating Genetic and Epidemiological Risk Factors
    Doi: 10.1101/2020.12.04.20244046
  • 2019

  • Antoniou, A., Anton-Culver, H., Borowsky, A., Broeders, M., Brooks, J., Chiarelli, A., Chiquette, J., Cuzick, J., Delaloge, S., Devilee, P., Dorval, M., Easton, D., Eisen, A., Eklund, M., Eloy, L., Esserman, L., Garcia-Closas, M., Goldgar, D., Hall, P., Knoppers, BM., Kraft, P., La Croix, A., Madalensky, L., Mavaddat, N., Mittman, N., Nabi, H., Olopade, O., Pashayan, N., Schmidt, M., Shieh, Y., Simard, J., Stover-Fiscallini, A., Tice, JA., Van't Veer, L., Wenger, N., Wolfson, M., Yau, C. and Ziv, E., 2019. A response to "Personalised medicine and population health: breast and ovarian cancer". Hum Genet, v. 138
    Doi: http://doi.org/10.1007/s00439-019-01984-z
  • Lee, A., Mavaddat, N., Wilcox, AN., Cunningham, AP., Carver, T., Hartley, S., de Villiers, CB., Izquierdo, A., Simard, J., Schmidt, MK., Walter, FM., Chatterjee, N., Garcia-Closas, M., Tischkowitz, M., Pharoah, P., Easton, DF. and Antoniou, AC., 2019. Correction: BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors. Genet Med, v. 21
    Doi: http://doi.org/10.1038/s41436-019-0459-4
  • 2018 (Accepted for publication)

  • Antoniou, A., Lee, A., Mavaddat, N., Easton, D. and Cunningham, A., 2018 (Accepted for publication). BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and non-genetic risk factors Genetics in Medicine,
  • Easton, DF., 2018 (Accepted for publication). Polygenic risk scores for prediction of breast cancer and breast cancer subtypes American Journal of Human Genetics, v. 104
    Doi: http://doi.org/10.1016/j.ajhg.2018.11.002
  • 2017 (Accepted for publication)

  • rudolph, A. and easton, DF., 2017 (Accepted for publication). Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium International Journal of Epidemiology,
  • 2017

  • Kuchenbaecker, KB., McGuffog, L., Barrowdale, D., Lee, A., Soucy, P., Dennis, J., Domchek, SM., Robson, M., Spurdle, AB., Ramus, SJ., Mavaddat, N., Terry, MB., Neuhausen, SL., Schmutzler, RK., Simard, J., Pharoah, PDP., Offit, K., Couch, FJ., Chenevix-Trench, G., Easton, DF. and Antoniou, AC., 2017. Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers Journal of the National Cancer Institute, v. 109
    Doi: http://doi.org/10.1093/jnci/djw302
  • Mavaddat, N., Michailidou, K., Kraft, P., Garcia-Closas, M., Simard, J., Easton, DF. and Consortium, BCA., 2017. An Improved Polygenic Risk Score for Risk Prediction in Breast Cancer GENETIC EPIDEMIOLOGY, v. 41
  • 2016

  • Muranen, TA., Mavaddat, N., Khan, S., Fagerholm, R., Pelttari, L., Lee, A., Aittomäki, K., Blomqvist, C., Easton, DF. and Nevanlinna, H., 2016. Polygenic risk score is associated with increased disease risk in 52 Finnish breast cancer families Breast Cancer Research and Treatment, v. 158
    Doi: http://doi.org/10.1007/s10549-016-3897-6
  • Adab, P., Mavaddat, N., Lee, C., Foroughi, M. and Lilford, RJ., 2016. Post-sanctions era in Iran: opportunity for science and publication. Lancet, v. 388
    Doi: http://doi.org/10.1016/S0140-6736(16)30897-2
  • 2015

  • Mavaddat, N., Pharoah, PDP., Michailidou, K., Tyrer, J., Brook, MN., Bolla, MK., Wang, Q., Dennis, J., Dunning, AM., Shah, M., Luben, R., Brown, J., Bojesen, SE., Nordestgaard, BG., Nielsen, SF., Flyger, H., Czene, K., Darabi, H., Eriksson, M., Peto, J., Dos-Santos-Silva, I., Dudbridge, F., Johnson, N., Schmidt, MK., Broeks, A., Verhoef, S., Rutgers, EJ., Swerdlow, A., Ashworth, A., Orr, N., Schoemaker, MJ., Figueroa, J., Chanock, SJ., Brinton, L., Lissowska, J., Couch, FJ., Olson, JE., Vachon, C., Pankratz, VS., Lambrechts, D., Wildiers, H., Van Ongeval, C., van Limbergen, E., Kristensen, V., Grenaker Alnæs, G., Nord, S., Borresen-Dale, A-L., Nevanlinna, H., Muranen, TA., Aittomäki, K., Blomqvist, C., Chang-Claude, J., Rudolph, A., Seibold, P., Flesch-Janys, D., Fasching, PA., Haeberle, L., Ekici, AB., Beckmann, MW., Burwinkel, B., Marme, F., Schneeweiss, A., Sohn, C., Trentham-Dietz, A., Newcomb, P., Titus, L., Egan, KM., Hunter, DJ., Lindstrom, S., Tamimi, RM., Kraft, P., Rahman, N., Turnbull, C., Renwick, A., Seal, S., Li, J., Liu, J., Humphreys, K., Benitez, J., Pilar Zamora, M., Arias Perez, JI., Menéndez, P., Jakubowska, A., Lubinski, J., Jaworska-Bieniek, K., Durda, K., Bogdanova, NV., Antonenkova, NN., Dörk, T., Anton-Culver, H., Neuhausen, SL., Ziogas, A., Bernstein, L., Devilee, P., Tollenaar, RAEM., Seynaeve, C., van Asperen, CJ., Cox, A., Cross, SS., Reed, MWR., Khusnutdinova, E., Bermisheva, M., Prokofyeva, D., Takhirova, Z., Meindl, A., Schmutzler, RK., Sutter, C., Yang, R., Schürmann, P., Bremer, M., Christiansen, H., Park-Simon, T-W., Hillemanns, P., Guénel, P., Truong, T., Menegaux, F., Sanchez, M., Radice, P., Peterlongo, P., Manoukian, S., Pensotti, V., Hopper, JL., Tsimiklis, H., Apicella, C., Southey, MC., Brauch, H., Brüning, T., Ko, Y-D., Sigurdson, AJ., Doody, MM., Hamann, U., Torres, D., Ulmer, H-U., Försti, A., Sawyer, EJ., Tomlinson, I., Kerin, MJ., Miller, N., Andrulis, IL., Knight, JA., Glendon, G., Marie Mulligan, A., Chenevix-Trench, G., Balleine, R., Giles, GG., Milne, RL., McLean, C., Lindblom, A., Margolin, S., Haiman, CA., Henderson, BE., Schumacher, F., Le Marchand, L., Eilber, U., Wang-Gohrke, S., Hooning, MJ., Hollestelle, A., van den Ouweland, AMW., Koppert, LB., Carpenter, J., Clarke, C., Scott, R., Mannermaa, A., Kataja, V., Kosma, V-M., Hartikainen, JM., Brenner, H., Arndt, V., Stegmaier, C., Karina Dieffenbach, A., Winqvist, R., Pylkäs, K., Jukkola-Vuorinen, A., Grip, M., Offit, K., Vijai, J., Robson, M., Rau-Murthy, R., Dwek, M., Swann, R., Annie Perkins, K., Goldberg, MS., Labrèche, F., Dumont, M., Eccles, DM., Tapper, WJ., Rafiq, S., John, EM., Whittemore, AS., Slager, S., Yannoukakos, D., Toland, AE., Yao, S., Zheng, W., Halverson, SL., González-Neira, A., Pita, G., Rosario Alonso, M., Álvarez, N., Herrero, D., Tessier, DC., Vincent, D., Bacot, F., Luccarini, C., Baynes, C., Ahmed, S., Maranian, M., Healey, CS., Simard, J., Hall, P., Easton, DF. and Garcia-Closas, M., 2015. Prediction of breast cancer risk based on profiling with common genetic variants. J Natl Cancer Inst, v. 107
    Doi: http://doi.org/10.1093/jnci/djv036
  • 2014

  • Lee, AJ., Cunningham, AP., Kuchenbaecker, KB., Mavaddat, N., Easton, DF., Antoniou, AC., Consortium of Investigators of Modifiers of BRCA1/2, and Breast Cancer Association Consortium, , 2014. BOADICEA breast cancer risk prediction model: updates to cancer incidences, tumour pathology and web interface. Br J Cancer, v. 110
    Doi: http://doi.org/10.1038/bjc.2013.730
  • 2013

  • Fischer, C., Kuchenbäcker, K., Engel, C., Zachariae, S., Rhiem, K., Meindl, A., Rahner, N., Dikow, N., Plendl, H., Debatin, I., Grimm, T., Gadzicki, D., Flöttmann, R., Horvath, J., Schröck, E., Stock, F., Schäfer, D., Schwaab, I., Kartsonaki, C., Mavaddat, N., Schlegelberger, B., Antoniou, AC., Schmutzler, R. and German Consortium for Hereditary Breast and Ovarian Cancer, , 2013. Evaluating the performance of the breast cancer genetic risk models BOADICEA, IBIS, BRCAPRO and Claus for predicting BRCA1/2 mutation carrier probabilities: a study based on 7352 families from the German Hereditary Breast and Ovarian Cancer Consortium. J Med Genet, v. 50
    Doi: http://doi.org/10.1136/jmedgenet-2012-101415
  • Mavaddat, N., Peock, S., Frost, D., Ellis, S., Platte, R., Fineberg, E., Evans, DG., Izatt, L., Eeles, RA., Adlard, J., Davidson, R., Eccles, D., Cole, T., Cook, J., Brewer, C., Tischkowitz, M., Douglas, F., Hodgson, S., Walker, L., Porteous, ME., Morrison, PJ., Side, LE., Kennedy, MJ., Houghton, C., Donaldson, A., Rogers, MT., Dorkins, H., Miedzybrodzka, Z., Gregory, H., Eason, J., Barwell, J., McCann, E., Murray, A., Antoniou, AC., Easton, DF. and EMBRACE, , 2013. Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE. J Natl Cancer Inst, v. 105
    Doi: http://doi.org/10.1093/jnci/djt095
  • Fischer, C., Kuchenbäcker, K., Engel, C., Zachariae, S., Rhiem, K., Meindl, A., Rahner, N., Dikow, N., Plendl, H., Debatin, I., Grimm, T., Gadzicki, D., Flöttmann, R., Horvath, J., Schröck, E., Stock, F., Schäfer, D., Schwaab, I., Kartsonaki, C., Mavaddat, N., Schlegelberger, B., Antoniou, AC. and Schmutzler, R., 2013. Evaluating the performance of the breast cancer genetic risk models BOADICEA, IBIS, BRCAPRO and Claus for predicting BRCA1/2 mutation carrier probabilities: A study based on 7352 families from the German hereditary breast and ovarian cancer consortium Journal of Medical Genetics, v. 50
    Doi: http://doi.org/10.1136/jmedgenet-2012-10141
  • 2012

  • Mavaddat, N., Barrowdale, D., Andrulis, IL., Domchek, SM., Eccles, D., Nevanlinna, H., Ramus, SJ., Spurdle, A., Robson, M., Sherman, M., Mulligan, AM., Couch, FJ., Engel, C., McGuffog, L., Healey, S., Sinilnikova, OM., Southey, MC., Terry, MB., Goldgar, D., O'Malley, F., John, EM., Janavicius, R., Tihomirova, L., Hansen, TVO., Nielsen, FC., Osorio, A., Stavropoulou, A., Benítez, J., Manoukian, S., Peissel, B., Barile, M., Volorio, S., Pasini, B., Dolcetti, R., Putignano, AL., Ottini, L., Radice, P., Hamann, U., Rashid, MU., Hogervorst, FB., Kriege, M., Van Der Luijt, RB., Peock, S., Frost, D., Evans, DG., Brewer, C., Walker, L., Rogers, MT., Side, LE., Houghton, C., Weaver, JE., Godwin, AK., Schmutzler, RK., Wappenschmidt, B., Meindl, A., Kast, K., Arnold, N., Niederacher, D., Sutter, C., Deissler, H., Gadzicki, D., Preisler-Adams, S., Varon-Mateeva, R., Schönbuchner, I., Gevensleben, H., Stoppa-Lyonnet, D., Belotti, M., Barjhoux, L., Isaacs, C., Peshkin, BN., Caldes, T., De Al Hoya, M., Cañadas, C., Heikkinen, T., Heikkilä, P., Aittomäki, K., Blanco, I., Lazaro, C., Brunet, J., Agnarsson, BA., Arason, A., Barkardottir, RB., Dumont, M., Simard, J., Montagna, M., Agata, S., D'Andrea, E., Yan, M., Fox, S., Rebbeck, TR., Rubinstein, W., Tung, N., Garber, JE., Wang, X., Fredericksen, Z., Pankratz, VS., Lindor, NM., Szabo, C., Offit, K. and Sakr, R., 2012. Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: Results from the consortium of investigators of modifiers of BRCA1/2 (CIMBA) Cancer Epidemiology Biomarkers and Prevention, v. 21
    Doi: http://doi.org/10.1158/1055-9965.EPI-11-0775
  • Mavaddat, N., Barrowdale, D., Andrulis, IL., Domchek, SM., Eccles, D., Nevanlinna, H., Ramus, SJ., Spurdle, A., Robson, M., Sherman, M., Mulligan, AM., Couch, FJ., Engel, C., McGuffog, L., Healey, S., Sinilnikova, OM., Southey, MC., Terry, MB., Goldgar, D., O'Malley, F., John, EM., Janavicius, R., Tihomirova, L., Hansen, TVO., Nielsen, FC., Osorio, A., Stavropoulou, A., Benítez, J., Manoukian, S., Peissel, B., Barile, M., Volorio, S., Pasini, B., Dolcetti, R., Putignano, AL., Ottini, L., Radice, P., Hamann, U., Rashid, MU., Hogervorst, FB., Kriege, M., van der Luijt, RB., HEBON, , Peock, S., Frost, D., Evans, DG., Brewer, C., Walker, L., Rogers, MT., Side, LE., Houghton, C., EMBRACE, , Weaver, J., Godwin, AK., Schmutzler, RK., Wappenschmidt, B., Meindl, A., Kast, K., Arnold, N., Niederacher, D., Sutter, C., Deissler, H., Gadzicki, D., Preisler-Adams, S., Varon-Mateeva, R., Schönbuchner, I., Gevensleben, H., Stoppa-Lyonnet, D., Belotti, M., Barjhoux, L., GEMO Study Collaborators, , Isaacs, C., Peshkin, BN., Caldes, T., de la Hoya, M., Cañadas, C., Heikkinen, T., Heikkilä, P., Aittomäki, K., Blanco, I., Lazaro, C., Brunet, J., Agnarsson, BA., Arason, A., Barkardottir, RB., Dumont, M., Simard, J., Montagna, M., Agata, S., D'Andrea, E., Yan, M., Fox, S., kConFab Investigators, , Rebbeck, TR., Rubinstein, W., Tung, N., Garber, JE., Wang, X., Fredericksen, Z., Pankratz, VS., Lindor, NM., Szabo, C., Offit, K., Sakr, R., Gaudet, MM., Singer, CF., Tea, M-K., Rappaport, C., Mai, PL., Greene, MH., Sokolenko, A., Imyanitov, E., Toland, AE., Senter, L., Sweet, K., Thomassen, M., Gerdes, A-M., Kruse, T., Caligo, M., Aretini, P., Rantala, J., von Wachenfeld, A., Henriksson, K., SWE-BRCA Collaborators, , Steele, L., Neuhausen, SL., Nussbaum, R., Beattie, M., Odunsi, K., Sucheston, L., Gayther, SA., Nathanson, K., Gross, J., Walsh, C., Karlan, B., Chenevix-Trench, G., Easton, DF., Antoniou, AC. and Consortium of Investigators of Modifiers of BRCA1/2, , 2012. Pathology of breast and ovarian cancers among BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Cancer Epidemiol Biomarkers Prev, v. 21
    Doi: http://doi.org/10.1158/1055-9965.EPI-11-0775
  • 2010

  • Mavaddat, N., Pharoah, PD., Blows, F., Driver, KE., Provenzano, E., Thompson, D., Macinnis, RJ., Shah, M., SEARCH Team, , Easton, DF. and Antoniou, AC., 2010. Familial relative risks for breast cancer by pathological subtype: a population-based cohort study. Breast Cancer Res, v. 12
    Doi: http://doi.org/10.1186/bcr2476
  • Mavaddat, N., Rebbeck, TR., Lakhani, SR., Easton, DF. and Antoniou, AC., 2010. Incorporating tumour pathology information into breast cancer risk prediction algorithms. Breast Cancer Res, v. 12
    Doi: http://doi.org/10.1186/bcr2576
  • Mavaddat, N., Antoniou, AC., Easton, DF. and Garcia-Closas, M., 2010. Genetic susceptibility to breast cancer. Mol Oncol, v. 4
    Doi: http://doi.org/10.1016/j.molonc.2010.04.011
  • 2009

  • Mavaddat, N., Dunning, AM., Ponder, BAJ., Easton, DF. and Pharoah, PD., 2009. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. Cancer Epidemiol Biomarkers Prev, v. 18
    Doi: http://doi.org/10.1158/1055-9965.EPI-08-0704
  • 2006

  • Pozo, D., Valés-Gómez, M., Mavaddat, N., Williamson, SC., Chisholm, SE. and Reyburn, H., 2006. CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase. J Immunol, v. 176
    Doi: http://doi.org/10.4049/jimmunol.176.4.2397
  • 2005

  • Huetz, P., Mavaddat, N. and Mavri, J., 2005. Reaction between ellagic acid and an ultimate carcinogen. J Chem Inf Model, v. 45
    Doi: http://doi.org/10.1021/ci050163c
  • Rizzitelli, A., Vremec, D., Villadangos, JA., Mavaddat, N., Wright, MD. and Shortman, K., 2005. Switching from a restricted to an effective CD4 T cell response by activating CD8+ murine dendritic cells with a Toll-like receptor 9 ligand. Eur J Immunol, v. 35
    Doi: http://doi.org/10.1002/eji.200526231
  • 2003

  • Love, CA., Harlos, K., Mavaddat, N., Davis, SJ., Stuart, DI., Jones, EY. and Esnouf, RM., 2003. The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D. Nat Struct Biol, v. 10
    Doi: http://doi.org/10.1038/nsb977
  • 2002

  • Mavaddat, N., 2002. Time of death: The true story of the search for death's stopwatch TLS-TIMES LIT SUPPL,
  • Mavaddat, N., 2002. When the body clocks stop TLS - The Times Literary Supplement,
  • 2001

  • Vandenabeele, S., Hochrein, H., Mavaddat, N., Winkel, K. and Shortman, K., 2001. Human thymus contains 2 distinct dendritic cell populations. Blood, v. 97
    Doi: http://doi.org/10.1182/blood.v97.6.1733
  • 2000

  • Mavaddat, N., Mason, DW., Atkinson, PD., Evans, EJ., Gilbert, RJ., Stuart, DI., Fennelly, JA., Barclay, AN., Davis, SJ. and Brown, MH., 2000. Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity. J Biol Chem, v. 275
    Doi: http://doi.org/10.1074/jbc.M004117200
  • Mavaddat, N., 2000. Virus - The co-discoverer of HIV tracks its rampage and charts the future TLS-TIMES LIT SUPPL,
  • Mavaddat, N., 2000. A fly for the prosecution - How insect evidence helps solve crimes TLS-TIMES LIT SUPPL,
  • 1998

  • Vandenabeele, S., Mavaddat, N., Winkel, K., Liu, YJ. and Shortman, K., 1998. Two populations of mature dendritic cells can be isolated from human thymus J LEUKOCYTE BIOL,
  • 1997

  • Crowley, MP., Reich, Z., Mavaddat, N., Altman, JD. and Chien, Y., 1997. The recognition of the nonclassical major histocompatibility complex (MHC) class I molecule, T10, by the gammadelta T cell, G8. J Exp Med, v. 185
    Doi: http://doi.org/10.1084/jem.185.7.1223
  • 1994

  • Schild, H., Mavaddat, N., Litzenberger, C., Ehrich, EW., Davis, MM., Bluestone, JA., Matis, L., Draper, RK. and Chien, YH., 1994. The nature of major histocompatibility complex recognition by gamma delta T cells. Cell, v. 76
    Doi: http://doi.org/10.1016/0092-8674(94)90170-8
  • 1993

  • Mavaddat, N., Robinson, BW., Rose, AH., Manning, LS. and Garlepp, MJ., 1993. An analysis of the relationship between gamma delta T cell receptor V gene usage and non-major histocompatibility complex-restricted cytotoxicity. Immunol Cell Biol, v. 71 ( Pt 1)
    Doi: http://doi.org/10.1038/icb.1993.3
  • 1992

  • Garlepp, MJ., Rose, AH., Bowman, RV., Mavaddat, N., Dench, J., Holt, BJ., Baron-Hay, M., Holt, PG. and Robinson, BW., 1992. A clonal analysis of lung T cells derived by bronchoalveolar lavage of healthy individuals. Immunology, v. 77
  • Conference proceedings

    2020

  • Ho, W-K., Mavaddat, N., Tai, M-C., Koh, W-P., Taib, NAM., Hartman, M., Easton, DF., Teo, S-H. and Antoniou, AC., 2020. Evaluation of breast cancer polygenic risk score built on data from women of European decent in predicting breast cancer risk in Asian women GENETIC EPIDEMIOLOGY, v. 44
  • 2019

  • Kramer, I., Hooning, MJ., Mavaddat, N., Canisius, S., Keeman, R., van den Broek, AJ., Steyerberg, E., Hauptmann, M., Pharoah, PD., Easton, DF., Hall, P. and Schmidt, MK., 2019. Abstract P1-09-04: Association between a breast cancer polygenic risk score and contralateral breast cancer risk Cancer Research, v. 79
    Doi: 10.1158/1538-7445.sabcs18-p1-09-04
  • 2018

  • Middha, P., Mavaddat, N., Milne, RL., Simard, J., Schmidt, MK., Kraft, P., Pharoah, PDP., Easton, DF., Garcia-Closas, M., Chang-Claude, J. and Consortium, BCA., 2018. Combined association of a polygenic risk score with 313 genetic variants and established environmental risk factors in relation to breast cancer risk GENETIC EPIDEMIOLOGY, v. 42
  • 2013

  • Mavaddat, N., Pharoah, P., Hall, P., Easton, D. and Garcia-Closas, M., 2013. Genetic risk stratification for breast cancer based on a polygenic risk score and family history. CANCER RESEARCH, v. 73
    Doi: http://doi.org/10.1158/1538-7445.AM2013-2567
  • 2009

  • Mavaddat, N., Antoniou, AC. and Easton, DF., 2009. Incorporating tumour pathological characteristics into genetic risk algorithms ANNALS OF HUMAN GENETICS, v. 73