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Cambridge Public Health

 

My research interests include risk prediction using longitudinal and survival data, meta-analysis, cost-effectiveness analyses for public health interventions and novel designs for early phase trials.
I have worked on the joint modelling of growth and rupture rates in patients with abdominal aortic aneurysm (AAA) and have used the models to predict future risk of rupture for various AAA size categories. Through the synthesis of estimates from a large individual patient data meta-analysis we have been able to recommend cost-effective surveillance intervals for the NHS AAA Screening Programme.
I currently work on statistical methods in the development and assessment of cardiovascular risk scores and their predictive utility and am chief statistician in reviewing proposals submitted to the EPIC-CVD project. I am particularly interested in the comparison of traditional risk scores with dynamic (time-updated) predictions using repeatedly measured risk factors.

Publications from Elements

Journal articles

2020 (Accepted for publication)

  • Sweeting, M., Marshall, J., Glover, M., Nasim, A. and Bown, MJ., 2020 (Accepted for publication). Evaluating the cost-effectiveness of changes to the surveillance intervals in the UK abdominal aortic aneurysm screening programme Value in Health,
  • 2019 (Accepted for publication)

  • Paige, E., Clement, M., Lareyre, F., Sweeting, M., Raffort, J., Grenier, C., Finigan, A., Harrison, J., Peters, J., Sun, B., Butterworth, A., Harrison, S., Danesh, J., Freitag, D., Paul, DS. and Mallat, Z., 2019 (Accepted for publication). Interleukin-6 Receptor Signalling and Abdominal Aortic Aneurysm Growth Rates Circulation Genomic and Precision Medicine,
  • 2019

  • Chung, RK., Wood, AM. and Sweeting, MJ., 2019. Biases incurred from nonrandom repeat testing of haemoglobin levels in blood donors: Selective testing and its implications. Biom J, v. 61
    Doi: http://doi.org/10.1002/bimj.201700268
  • Adlam, D., Olson, TM., Combaret, N., Kovacic, JC., Iismaa, SE., Al-Hussaini, A., O'Byrne, MM., Bouajila, S., Georges, A., Mishra, K., Braund, PS., d'Escamard, V., Huang, S., Margaritis, M., Nelson, CP., de Andrade, M., Kadian-Dodov, D., Welch, CA., Mazurkiewicz, S., Jeunemaitre, X., DISCO Consortium, , Wong, CMY., Giannoulatou, E., Sweeting, M., Muller, D., Wood, A., McGrath-Cadell, L., Fatkin, D., Dunwoodie, SL., Harvey, R., Holloway, C., Empana, J-P., Jouven, X., CARDIoGRAMPlusC4D Study Group, , Olin, JW., Gulati, R., Tweet, MS., Hayes, SN., Samani, NJ., Graham, RM., Motreff, P. and Bouatia-Naji, N., 2019. Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol, v. 73
    Doi: http://doi.org/10.1016/j.jacc.2018.09.085
  • Gregson, J., Kaptoge, S., Bolton, T., Pennells, L., Willeit, P., Burgess, S., Bell, S., Sweeting, M., Rimm, EB., Kabrhel, C., Zöller, B., Assmann, G., Gudnason, V., Folsom, AR., Arndt, V., Fletcher, A., Norman, PE., Nordestgaard, BG., Kitamura, A., Mahmoodi, BK., Whincup, PH., Knuiman, M., Salomaa, V., Meisinger, C., Koenig, W., Kavousi, M., Völzke, H., Cooper, JA., Ninomiya, T., Casiglia, E., Rodriguez, B., Ben-Shlomo, Y., Després, J-P., Simons, L., Barrett-Connor, E., Björkelund, C., Notdurfter, M., Kromhout, D., Price, J., Sutherland, SE., Sundström, J., Kauhanen, J., Gallacher, J., Beulens, JWJ., Dankner, R., Cooper, C., Giampaoli, S., Deen, JF., Gómez de la Cámara, A., Kuller, LH., Rosengren, A., Svensson, PJ., Nagel, D., Crespo, CJ., Brenner, H., Albertorio-Diaz, JR., Atkins, R., Brunner, EJ., Shipley, M., Njølstad, I., Lawlor, DA., van der Schouw, YT., Selmer, RM., Trevisan, M., Verschuren, WMM., Greenland, P., Wassertheil-Smoller, S., Lowe, GDO., Wood, AM., Butterworth, AS., Thompson, SG., Danesh, J., Di Angelantonio, E., Meade, T. and Emerging Risk Factors Collaboration, , 2019. Cardiovascular Risk Factors Associated With Venous Thromboembolism. JAMA Cardiol,
    Doi: http://doi.org/10.1001/jamacardio.2018.4537
  • 2018 (Accepted for publication)

  • Wood, AM., Stevens, D., Barrett, J., Paige, E., Keogh, R., Sweeting, M., Nazareth, I. and Petersen, I., 2018 (Accepted for publication). Landmark models for optimizing the use of repeated measurements of risk factors in electronic health records to predict future disease risk American Journal of Epidemiology,
    Doi: http://doi.org/10.1093/aje/kwy018
  • Oliver-Williams, CT., Sweeting, M., Jacomelli, J., Summers, L., Stevenson, A., Lees, T. and Earnshaw, J., 2018 (Accepted for publication). Safety of men with small and medium abdominal aortic aneurysms under surveillance in the National Health Service screening programme Circulation,
  • Sweeting, MJ., Powell, JT., Ulug, P., Thompson, MM. and Hinchliffe, RJ., 2018 (Accepted for publication). Re-intervention after repair of ruptured abdominal aortic aneurysm: a report from the IMPROVE randomised trial European Journal of Vascular and Endovascular Surgery,
  • Butterworth, AS., Danesh, J., Wood, A. and Sweeting, M., 2018 (Accepted for publication). Alcohol intake in relation to fatal and non-fatal incident coronary heart disease and stroke in the EPIC-CVD study. British Medical Journal, v. 361
    Doi: http://doi.org/10.1136/bmj.k934
  • Sweeting, MJ., Li, J., Parrott, S., Farmer, A., Ross, J., Dack, C., Pal, K., Yardley, L., Barnard, M., Hudda, M., Alkhaldi, G. and Murray, E., 2018 (Accepted for publication). Cost-effectiveness of facilitated access to a self-management website (HeLP-Diabetes) compared to usual care for patients with Type 2 Diabetes: a randomised-control trial Journal of Medical Internet Research, v. 20
    Doi: http://doi.org/10.2196/jmir.9256
  • Grootes, I., Barrett, JK., Ulug, P., Rohlffs, F., Laukontaus, S., Tulamo, R., Venermo, M., Greenhalgh, R. and Sweeting, MJ., 2018 (Accepted for publication). Predicting risk of rupture and rupture-preventing re-interventions utilising repeated measures on aneurysm sac diameter following endovascular abdominal aortic aneurysm repair British Journal of Surgery, v. 105
    Doi: http://doi.org/10.1002/bjs.10964
  • Chung, RK., Wood, AM. and Sweeting, MJ., 2018 (Accepted for publication). Biases incurred from non-random repeat testing of haemoglobin levels in blood donors Biometrical Journal,
    Doi: http://doi.org/10.1002/bimj.201700268
  • Pennells, L., Kaptoge, S., Wood, A., Sweeting, M., Zhao, X., White, I., Burgess, S., Willeit, P., Bolton, T., Moons, KGM., Thompson, SG., Danesh, J. and Di Angelantonio, E., 2018 (Accepted for publication). Equalisation of four cardiovascular risk algorithms after systematic re-calibration: individual-participant meta-analysis of 86 prospective studies European Heart Journal,
  • 2018

  • Inouye, M., Abraham, G., Nelson, CP., Wood, AM., Sweeting, MJ., Dudbridge, F., Lai, FY., Kaptoge, S., Brozynska, M., Wang, T., Ye, S., Webb, TR., Rutter, MK., Tzoulaki, I., Patel, RS., Loos, RJF., Keavney, B., Hemingway, H., Thompson, J., Watkins, H., Deloukas, P., Di Angelantonio, E., Butterworth, AS., Danesh, J., Samani, NJ. and UK Biobank CardioMetabolic Consortium CHD Working Group, , 2018. Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention. J Am Coll Cardiol, v. 72
    Doi: http://doi.org/10.1016/j.jacc.2018.07.079
  • Patel, R., Powell, JT., Sweeting, MJ., Epstein, DM., Barrett, JK. and Greenhalgh, RM., 2018. The UK EndoVascular Aneurysm Repair (EVAR) randomised controlled trials: long-term follow-up and cost-effectiveness analysis. Health Technology Assessment, v. 22
    Doi: http://doi.org/10.3310/hta22050
  • Ulug, P., Hinchliffe, RJ., Sweeting, MJ., Gomes, M., Thompson, MT., Thompson, SG., Grieve, RJ., Ashleigh, R., Greenhalgh, RM. and Powell, JT., 2018. Strategy of endovascular versus open repair for patients with clinical diagnosis of ruptured abdominal aortic aneurysm: the IMPROVE RCT. Health Technol Assess, v. 22
    Doi: http://doi.org/10.3310/hta22310
  • Sweeting, MJ., Oliver-Williams, C. and Thompson, S., 2018. Lessons learned about prevalence and growth rates of abdominal aortic aneurysms from a 25-year ultrasound population screening programme British Journal of Surgery, v. 105
    Doi: http://doi.org/10.1002/bjs.10715
  • Sweeting, MJ., Masconi, KL., Jones, E., Ulug, P., Glover, MJ., Michaels, JA., Bown, MJ., Powell, JT. and Thompson, SG., 2018. Analysis of clinical benefit, harms, and cost-effectiveness of screening women for abdominal aortic aneurysm. Lancet, v. 392
    Doi: http://doi.org/10.1016/S0140-6736(18)31222-4
  • 2017 (Accepted for publication)

  • Sweeting, MJ., Ulug, P., Sweeting, MJ., Gomes, M., Hinchliffe, RJ., Thompson, MM., Thompson, SG., Grieve, R. and Greenhalgh, RM., 2017 (Accepted for publication). Comparative clinical effectiveness and cost effectiveness of endovascular strategy vs open repair for ruptured abdominal aortic aneurysm: three year results of the IMPROVE randomised trial BMJ, v. 359
    Doi: http://doi.org/10.1136/bmj.j4859
  • Ulug, P., Sweeting, MJ., von Allmen, RS., Thompson, SG., Powell, JT. and SWAN collaborators, , 2017 (Accepted for publication). Morphological suitability for endovascular repair, non-intervention rates, and operative mortality in women and men assessed for intact abdominal aortic aneurysm repair: systematic reviews with meta-analysis The Lancet,
    Doi: http://doi.org/10.1016/S0140-6736(17)30639-6
  • Glover, MJ., Jones, E., Masconi, K., Sweeting, M., Thompson, S., SWAN Collaborative Group, and Thompson, SG., 2017 (Accepted for publication). Discrete event simulation for decision modelling in health care: lessons from abdominal aortic aneurysm screening Medical Decision Making,
  • Thompson, SG., Bown, MJ., Glover, MJ., Jones, E., Masconi, K., Michaels, JA., Powell, JT., Ulug, P. and Sweeting, MJ., 2017 (Accepted for publication). Screening women for abdominal aortic aneurysm: a modelling study and health economic evaluation Health Technology Assessment,
  • Sweeting, MJ., Ulug, P., Roy, J., Hultgren, R., Indrakusuma, R., Balm, R., Thompson, MM., Hinchliffe, RJ., Thompson, SG., Powell, JT. and Ruptured Aneurysm Collaborators, , 2017 (Accepted for publication). Value of risk scores in the decision to palliate patients with ruptured abdominal aortic aneurysm British Journal of Surgery,
  • Sweeting, MJ., 2017 (Accepted for publication). Development, evaluation (including randomised controlled trial and economic evaluation) and implementation of a web-based self-management programme for people with type 2 diabetes (HeLP-Diabetes) Health Technology Assessment,
  • Sweeting, MJ., Ulug, P., Hinchliffe, RJ., Gomes, M., Thompson, MM., Thompson, SG., Grieve, RJ., Ashleigh, R., Greenlaugh, RM. and Powell, JT., 2017 (Accepted for publication). The immediate management of the patient with rupture: open versus endovascular repair (IMPROVE) randomised controlled trial for abdominal aortic aneurysm: clinical and health economic evaluation Health Technology Assessment,
  • Nelson, CP., Goel, A., Butterworth, AS., Kanoni, S., Webb, TR., Marouli, E., Zeng, L., Ntalla, I., Lai, FY., Hopewell, JC., Giannakopoulou, O., Jiang, T., Hamby, SE., Di Angelantonio, E., Assimes, TL., Bottinger, EP., Chambers, JC., Clarke, R., Palmer, CNA., Cubbon, RM., Ellinor, P., Ermel, R., Evangelou, E., Franks, PW., Grace, C., Gu, D., Hingorani, AD., Howson, JMM., Ingelsson, E., Kastrati, A., Kessler, T., Kyriakou, T., Lehtimäki, T., Lu, X., Lu, Y., März, W., McPherson, R., Metspalu, A., Pujades-Rodriguez, M., Ruusalepp, A., Schadt, EE., Schmidt, AF., Sweeting, MJ., Zalloua, PA., AlGhalayini, K., Keavney, BD., Kooner, JS., Loos, RJF., Patel, RS., Rutter, MK., Tomaszewski, M., Tzoulaki, I., Zeggini, E., Erdmann, J., Dedoussis, G., Björkegren, JLM., EPIC-CVD Consortium, , CARDIoGRAMplusC4D, , UK Biobank CardioMetabolic Consortium CHD working group, , Schunkert, H., Farrall, M., Danesh, J., Samani, NJ., Watkins, H. and Deloukas, P., 2017 (Accepted for publication). Association analyses based on false discovery rate implicate new loci for coronary artery disease Nature Genetics,
    Doi: http://doi.org/10.1038/ng.3913
  • Sidloff, DA., Saratzis, A., Sweeting, MJ., Michaels, J., Powell, JT., Thompson, SG. and Bown, MJ., 2017 (Accepted for publication). Sex differences in mortality after abdominal aortic aneurysm repair in the UK British Journal of Surgery, v. 104
    Doi: http://doi.org/10.1002/bjs.10600
  • Sweeting, MJ., Patel, R., Powell, JT., Greenhalgh, RM. and EVAR Trial Investigators, , 2017 (Accepted for publication). Endovascular Repair of Abdominal Aortic Aneurysm in Patients Physically Ineligible for Open Repair: Very Long-term Follow-up in the EVAR-2 Randomized Controlled Trial. Ann Surg, v. 266
    Doi: http://doi.org/10.1097/SLA.0000000000002392
  • 2017

  • Powell, JT., Ulug, P., Sweeting, MJ., von Allmen, RS. and Thompson, SG., 2017. Abdominal aortic aneurysms in women – Authors' reply The Lancet, v. 390
    Doi: http://doi.org/10.1016/S0140-6736(17)32421-2
  • Rossi, SH., Hsu, R., Blick, C., Goh, V., Nathan, P., Nicol, D., Fleming, S., Sweeting, M., Wilson, ECF. and Stewart, GD., 2017. Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography British Journal of Surgery, v. 104
    Doi: http://doi.org/10.1002/bjs.10523
  • Sweeting, MJ., 2017. Using predictions from a joint model for longitudinal and survival data to inform the optimal time of intervention in an abdominal aortic aneurysm screening programme Biometrical Journal,
    Doi: http://doi.org/10.1002/bimj.201600222
  • Paige, E., Barrett, J., Pennells, L., Sweeting, M., Willeit, P., Di Angelantonio, E., Gudnason, V., Nordestgaard, BG., Psaty, BM., Goldbourt, U., Best, LG., Assmann, G., Salonen, JT., Nietert, PJ., Verschuren, WM., Brunner, EJ., Kronmal, RA., Salomaa, V., Bakker, SJ., Dagenais, GR., Sato, S., Jansson, J-H., Willeit, J., Onat, A., de la Cámara, AG., Roussel, R., Völzke, H., Dankner, R., Tipping, RW., Meade, TW., Donfrancesco, C., Kuller, LH., Peters, A., Gallacher, J., Kromhout, D., Iso, H., Knuiman, M., Casiglia, E., Kavousi, M., Palmieri, L., Sundström, J., Davis, BR., Njølstad, I., Couper, D., Danesh, J., Thompson, SG. and Wood, A., 2017. Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis American Journal of Epidemiology,
    Doi: http://doi.org/10.1093/aje/kwx149
  • Wheeler, GM., Sweeting, MJ., Mander, AP., Lee, SM. and Cheung, YKK., 2017. Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration. Stat Med, v. 36
    Doi: http://doi.org/10.1002/sim.6912
  • Staley, JR., Jones, E., Kaptoge, S., Butterworth, AS., Sweeting, MJ., Wood, AM. and Howson, JMM., 2017. A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design European Journal of Human Genetics, v. 25
    Doi: http://doi.org/10.1038/ejhg.2017.78
  • Butterworth, AS., 2017. Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis European Heart Journal,
    Doi: http://doi.org/10.1093/eurheartj/ehx448
  • Sweeting, MJ., 2017. Web-based self-management support for people with type 2 diabetes (HeLP-Diabetes): randomised controlled trial in English primary care BMJ Open, v. 7
    Doi: http://doi.org/10.1136/bmjopen-2017-016009
  • Tom, BDM., Thompson, SG., Duffy, SW., Sweeting, MJ. and Ohlssen, DI., 2017. Richard Nixon, 1972-2016 Obituary JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, v. 180
    Doi: http://doi.org/10.1111/rssa.12286
  • Powell, JT., Sweeting, MJ., Ulug, P., Blankensteijn, JD., Lederle, FA., Becquemin, J-P., Greenhalgh, RM. and EVAR-1, DREAM, OVER and ACE Trialists, , 2017. Meta-analysis of individual-patient data from EVAR-1, DREAM, OVER and ACE trials comparing outcomes of endovascular or open repair for abdominal aortic aneurysm over 5 years. Br J Surg, v. 104
    Doi: http://doi.org/10.1002/bjs.10430
  • Wheeler, GM., Sweeting, MJ. and Mander, AP., 2017. Toxicity-dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials Statistics in Medicine,
    Doi: http://doi.org/10.1002/sim.7280
  • 2016 (Accepted for publication)

  • Law, M., Sweeting, MJ., Donaldson, GC. and Wedzicha, JA., 2016 (Accepted for publication). Misspecification of at-risk periods and distributional assumptions in estimating COPD exacerbation rates: The resultant bias in treatment effect estimation Pharmaceutical Statistics,
    Doi: http://doi.org/10.1002/pst.1798
  • 2016

  • Peters, SA., van der Schouw, YT., Wood, AM., Sweeting, MJ., Moons, KG., Weiderpass, E., Arriola, L., Benetou, V., Boeing, H., Bonnet, F., Butt, ST., Clavel-Chapelon, F., Drake, I., Gavrila, D., Key, TJ., Klinaki, E., Krogh, V., Kühn, T., Lassale, C., Masala, G., Matullo, G., Merritt, M., Molina-Portillo, E., Moreno-Iribas, C., Nøst, TH., Olsen, A., Onland-Moret, NC., Overvad, K., Panico, S., Redondo, ML., Tjønneland, A., Trichopoulou, A., Tumino, R., Turzanski-Fortner, R., Tzoulaki, I., Wennberg, P., Winkvist, A., Thompson, SG., Di Angelantonio, E., Riboli, E., Wareham, NJ., Danesh, J. and Butterworth, AS., 2016. Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study European Journal of Preventive Cardiology, v. 23
    Doi: http://doi.org/10.1177/2047487316658571
  • Ulug, P., Powell, JT., Sweeting, MJ., Bown, MJ., Thompson, SG. and SWAN Collaborative Group, , 2016. Meta-analysis of the current prevalence of screen-detected abdominal aortic aneurysm in women. Br J Surg, v. 103
    Doi: http://doi.org/10.1002/bjs.10225
  • Wheeler, GM., Sweeting, MJ. and Mander, AP., 2016. AplusB: A Web Application for Investigating A + B Designs for Phase I Cancer Clinical Trials. PLoS One, v. 11
    Doi: http://doi.org/10.1371/journal.pone.0159026
  • Sweeting, MJ., Barrett, JK., Thompson, SG. and Wood, AM., 2016. The use of repeated blood pressure measures for cardiovascular risk prediction: a comparison of statistical models in the ARIC study. Stat Med,
    Doi: http://doi.org/10.1002/sim.7144
  • Patel, R., Sweeting, MJ., Powell, JT., Greenhalgh, RM. and EVAR trial investigators, , 2016. Endovascular versus open repair of abdominal aortic aneurysm in 15-years' follow-up of the UK endovascular aneurysm repair trial 1 (EVAR trial 1): a randomised controlled trial The Lancet, v. 388
    Doi: http://doi.org/10.1016/S0140-6736(16)31135-7
  • Natriuretic Peptides Studies Collaboration, , Willeit, P., Kaptoge, S., Welsh, P., Butterworth, A., Chowdhury, R., Spackman, S., Pennells, L., Gao, P., Burgess, S., Freitag, D., Sweeting, M., Wood, A., Cook, N., Judd, S., Trompet, S., Nambi, V., Olsen, M., Everett, B., Kee, F., Ärnlöv, J., Salomaa, V., Levy, D., Kauhanen, J., Laukkanen, J., Kavousi, M., Ninomiya, T., Casas, J-P., Daniels, L., Lind, L., Kistorp, C., Rosenberg, J., Mueller, T., Rubattu, S., Panagiotakos, D., Franco, O., de Lemos, J., Luchner, A., Kizer, J., Kiechl, S., Salonen, J., Goya Wannamethee, S., de Boer, R., Nordestgaard, B., Andersson, J., Jørgensen, T., Melander, O., Ballantyne, C., DeFilippi, C., Ridker, P., Cushman, M., Rosamond, W., Thompson, S., Gudnason, V., Sattar, N., Danesh, J. and Di Angelantonio, E., 2016. Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. Lancet Diabetes Endocrinol, v. 4
    Doi: http://doi.org/10.1016/S2213-8587(16)30196-6
  • 2015

  • IMPROVE Trial Investigators, , 2015. The effect of aortic morphology on peri-operative mortality of ruptured abdominal aortic aneurysm. Eur Heart J, v. 36
    Doi: http://doi.org/10.1093/eurheartj/ehu521
  • Brill, SE., Law, M., El-Emir, E., Allinson, JP., James, P., Maddox, V., Donaldson, GC., McHugh, TD., Cookson, WO., Moffatt, MF., Nazareth, I., Hurst, JR., Calverley, PMA., Sweeting, MJ. and Wedzicha, JA., 2015. Effects of different antibiotic classes on airway bacteria in stable COPD using culture and molecular techniques: a randomised controlled trial. Thorax, v. 70
    Doi: http://doi.org/10.1136/thoraxjnl-2015-207194
  • Powell, JT. and Sweeting, MJ., 2015. Retrospective Studies. Eur J Vasc Endovasc Surg, v. 50
    Doi: http://doi.org/10.1016/j.ejvs.2015.07.005
  • Murray, E., Dack, C., Barnard, M., Farmer, A., Li, J., Michie, S., Pal, K., Parrott, S., Ross, J., Sweeting, M., Wood, B. and Yardley, L., 2015. HeLP-Diabetes: randomised controlled trial protocol. BMC Health Serv Res, v. 15
    Doi: http://doi.org/10.1186/s12913-015-1246-9
  • Crawford, MJ., Sanatinia, R., Barrett, B., Byford, S., Dean, M., Green, J., Jones, R., Leurent, B., Sweeting, MJ., Touquet, R., Greene, L., Tyrer, P., Ward, H. and Lingford-Hughes, A., 2015. The clinical and cost-effectiveness of brief advice for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial. Sex Transm Infect, v. 91
    Doi: http://doi.org/10.1136/sextrans-2014-051561
  • Mander, AP. and Sweeting, MJ., 2015. A product of independent beta probabilities dose escalation design for dual-agent phase I trials. Stat Med, v. 34
    Doi: http://doi.org/10.1002/sim.6434
  • Nolan, T., Dack, C., Pal, K., Ross, J., Stevenson, FA., Peacock, R., Pearson, M., Spiegelhalter, D., Sweeting, M. and Murray, E., 2015. Patient reactions to a web-based cardiovascular risk calculator in type 2 diabetes: a qualitative study in primary care. Br J Gen Pract, v. 65
    Doi: http://doi.org/10.3399/bjgp15X683953
  • Interleukin 1 Genetics Consortium, , 2015. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol, v. 3
    Doi: http://doi.org/10.1016/S2213-8587(15)00034-0
  • IMPROVE Trial Investigators, , 2015. Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: one-year outcomes from the IMPROVE randomized trial. Eur Heart J, v. 36
    Doi: http://doi.org/10.1093/eurheartj/ehv125
  • Sweeting, MJ., Ulug, P., Powell, JT., Desgranges, P., Balm, R. and Ruptured Aneurysm Trialists, , 2015. Ruptured Aneurysm Trials: The Importance of Longer-term Outcomes and Meta-analysis for 1-year Mortality. Eur J Vasc Endovasc Surg, v. 50
    Doi: http://doi.org/10.1016/j.ejvs.2015.04.015
  • Jones, E., Sweeting, MJ., Sharp, SJ., Thompson, SG. and EPIC-InterAct Consortium, , 2015. A method making fewer assumptions gave the most reliable estimates of exposure-outcome associations in stratified case-cohort studies. J Clin Epidemiol, v. 68
    Doi: http://doi.org/10.1016/j.jclinepi.2015.04.007
  • Sweeting, MJ., Balm, R., Desgranges, P., Ulug, P., Powell, JT. and Ruptured Aneurysm Trialists, , 2015. Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm. Br J Surg, v. 102
    Doi: http://doi.org/10.1002/bjs.9852
  • 2014

  • IMPROVE Trial Investigators, , Powell, JT., Sweeting, MJ., Thompson, MM., Ashleigh, R., Bell, R., Gomes, M., Greenhalgh, RM., Grieve, R., Heatley, F., Hinchliffe, RJ., Thompson, SG. and Ulug, P., 2014. Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes from IMPROVE randomised trial. BMJ, v. 348
    Doi: http://doi.org/10.1136/bmj.f7661
  • IMPROVE trial investigators, , Powell, JT., Hinchliffe, RJ., Thompson, MM., Sweeting, MJ., Ashleigh, R., Bell, R., Gomes, M., Greenhalgh, RM., Grieve, RJ., Heatley, F., Thompson, SG. and Ulug, P., 2014. Observations from the IMPROVE trial concerning the clinical care of patients with ruptured abdominal aortic aneurysm. Br J Surg, v. 101
    Doi: http://doi.org/10.1002/bjs.9410
  • IMPROVE Trial Investigators, , 2014. An endovascular strategy for suspected ruptured abdominal aortic aneurysm brings earlier home discharge but not early survival or cost benefits. Eur J Vasc Endovasc Surg, v. 47
    Doi: http://doi.org/10.1016/j.ejvs.2013.12.017
  • Crawford, MJ., Sanatinia, R., Barrett, B., Byford, S., Dean, M., Green, J., Jones, R., Leurent, B., Lingford-Hughes, A., Sweeting, M., Touquet, R., Tyrer, P. and Ward, H., 2014. The clinical effectiveness and cost-effectiveness of brief intervention for excessive alcohol consumption among people attending sexual health clinics: a randomised controlled trial (SHEAR). Health Technol Assess, v. 18
    Doi: http://doi.org/10.3310/hta18300
  • Turner, EL., Sweeting, MJ., Lindfield, RJ. and Deangelis, D., 2014. Incidence estimation using a single cross-sectional age-specific prevalence survey with differential mortality. Stat Med, v. 33
    Doi: http://doi.org/10.1002/sim.5942
  • Glover, MJ., Kim, LG., Sweeting, MJ., Thompson, SG. and Buxton, MJ., 2014. Cost-effectiveness of the National Health Service Abdominal Aortic Aneurysm Screening Programme in England. Br J Surg, v. 101
    Doi: http://doi.org/10.1002/bjs.9528
  • 2013

  • Sweeting, M., Mander, A. and Sabin, T., 2013. Bcrm: Bayesian continual reassessment method designs for phase I dose-finding trials Journal of Statistical Software, v. 54
    Doi: http://doi.org/10.18637/jss.v054.i13
  • Bown, MJ., Sweeting, MJ., Brown, LC., Powell, JT. and Thompson, SG., 2013. Surveillance intervals for small abdominal aortic aneurysms: A meta-analysis JAMA, v. 309
    Doi: http://doi.org/10.1001/jama.2013.950
  • Harrington, JA., Wheeler, GM., Sweeting, MJ., Mander, AP. and Jodrell, DI., 2013. Adaptive designs for dual-agent phase I dose-escalation studies NATURE REVIEWS CLINICAL ONCOLOGY, v. 10
    Doi: http://doi.org/10.1038/nrclinonc.2013.35
  • Thompson, SG., Brown, LC., Sweeting, MJ., Bown, MJ., Kim, LG., Glover, MJ., Buxton, MJ. and Powell, JT., 2013. Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness. Health Technol Assess, v. 17
    Doi: http://doi.org/10.3310/hta17410
  • Lunn, D., Barrett, J., Sweeting, M. and Thompson, S., 2013. Fully Bayesian hierarchical modelling in two stages, with application to meta-analysis. J R Stat Soc Ser C Appl Stat, v. 62
    Doi: http://doi.org/10.1111/rssc.12007
  • Dumville, JC., Hinchliffe, RJ., Cullum, N., Game, F., Stubbs, N., Sweeting, M. and Peinemann, F., 2013. Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus. Cochrane Database Syst Rev,
    Doi: http://doi.org/10.1002/14651858.CD010318.pub2
  • 2012

  • Mander, AP., Wason, JMS., Sweeting, MJ. and Thompson, SG., 2012. Admissible two-stage designs for phase II cancer clinical trials that incorporate the expected sample size under the alternative hypothesis PHARMACEUTICAL STATISTICS, v. 11
    Doi: http://doi.org/10.1002/pst.501
  • Turner, RM., Lloyd-Jones, M., Anumba, DOC., Smith, GCS., Spiegelhalter, DJ., Squires, H., Stevens, JW., Sweeting, MJ., Urbaniak, SJ., Webster, R. and Thompson, SG., 2012. Routine antenatal anti-D prophylaxis in women who are Rh(D) negative: Meta-analyses adjusted for differences in study design and quality PLoS ONE, v. 7
  • Sweeting, MJ., Thompson, SG., Brown, LC., Powell, JT. and RESCAN collaborators, , 2012. Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms. Br J Surg, v. 99
    Doi: http://doi.org/10.1002/bjs.8707
  • Sweeting, MJ. and Mander, AP., 2012. Escalation strategies for combination therapy Phase I trials. Pharm Stat, v. 11
    Doi: http://doi.org/10.1002/pst.1497
  • Sanatinia, R., Barrett, B., Byford, S., Dean, M., Green, J., Jones, R., Leurent, B., Lingford-Hughes, A., Sweeting, M., Touquet, R., Tyrer, P., Ward, H. and Crawford, MJ., 2012. Brief intervention for alcohol misuse in people attending sexual health clinics: study protocol for a randomized controlled trial. Trials, v. 13
    Doi: http://doi.org/10.1186/1745-6215-13-149
  • Sweeting, MJ. and Thompson, SG., 2012. Making predictions from complex longitudinal data, with application to planning monitoring intervals in a national screening programme. J R Stat Soc Ser A Stat Soc, v. 175
    Doi: http://doi.org/10.1111/j.1467-985X.2011.01005.x
  • 2011

  • Powell, JT., Sweeting, MJ., Brown, LC., Gotensparre, SM., Fowkes, FG. and Thompson, SG., 2011. Systematic review and meta-analysis of growth rates of small abdominal aortic aneurysms BRITISH JOURNAL OF SURGERY, v. 98
    Doi: http://doi.org/10.1002/bjs.7465
  • Powell, JT., Gotensparre, SM., Sweeting, MJ., Brown, LC., Fowkes, FGR. and Thompson, SG., 2011. Rupture Rates of Small Abdominal Aortic Aneurysms: A Systematic Review of the Literature EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, v. 41
    Doi: http://doi.org/10.1016/j.ejvs.2010.09.005
  • Working Group on Estimation of HIV Prevalence in Europe, , 2011. HIV in hiding: methods and data requirements for the estimation of the number of people living with undiagnosed HIV. AIDS, v. 25
    Doi: http://doi.org/10.1097/QAD.0b013e3283467087
  • Sweeting, MJ. and Thompson, SG., 2011. Joint modelling of longitudinal and time-to-event data with application to predicting abdominal aortic aneurysm growth and rupture BIOMETRICAL JOURNAL, v. 53
    Doi: http://doi.org/10.1002/bimj.201100052
  • 2010

  • IMPROVE Trial Management Committee, , 2010. Getting research in the NHS started. Lancet, v. 375
    Doi: http://doi.org/10.1016/S0140-6736(10)60952-X
  • Sweeting, MJ., Farewell, VT. and De Angelis, D., 2010. Multi-state Markov models for disease progression in the presence of informative examination times: an application to hepatitis C. Stat Med, v. 29
    Doi: http://doi.org/10.1002/sim.3812
  • Sweeting, MJ., Thompson, SG., Brown, LC., Greenhalgh, RM. and Powell, JT., 2010. Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms JOURNAL OF VASCULAR SURGERY, v. 52
    Doi: http://doi.org/10.1016/j.jvs.2010.02.264
  • Sweeting, MJ., De Angelis, D., Parry, J. and Suligoi, B., 2010. Estimating the distribution of the window period for recent HIV infections: A comparison of statistical methods STATISTICS IN MEDICINE, v. 29
    Doi: http://doi.org/10.1002/sim.3941
  • 2009

  • Sweeting, MJ., Hope, VD., Hickman, M., Parry, JV., Ncube, F., Ramsay, ME. and De Angelis, D., 2009. Hepatitis C infection among injecting drug users in England and Wales (1992-2006): there and back again? Am J Epidemiol, v. 170
    Doi: http://doi.org/10.1093/aje/kwp141
  • Grishchenko, M., Grieve, RD., Sweeting, MJ., De Angelis, D., Thomson, BJ., Ryder, SD., Irving, WL. and Trent HCV Study Group, , 2009. Cost-effectiveness of pegylated interferon and ribavirin for patients with chronic hepatitis C treated in routine clinical practice. Int J Technol Assess Health Care, v. 25
    Doi: http://doi.org/10.1017/S0266462309090229
  • De Angelis, D., Sweeting, M., Ades, A., Hickman, M., Hope, V. and Ramsay, M., 2009. An evidence synthesis approach to estimating Hepatitis C prevalence in England and Wales. Stat Methods Med Res, v. 18
    Doi: http://doi.org/10.1177/0962280208094691
  • Sweeting, MJ., De Angelis, D., Ades, AE. and Hickman, M., 2009. Estimating the prevalence of ex-injecting drug use in the population STATISTICAL METHODS IN MEDICAL RESEARCH, v. 18
    Doi: http://doi.org/10.1177/0962280208094704
  • 2008

  • Sutton, AJ., Edmunds, WJ., Sweeting, MJ. and Gill, ON., 2008. The cost-effectiveness of screening and treatment for hepatitis C in prisons in England and Wales: a cost-utility analysis. J Viral Hepat, v. 15
    Doi: http://doi.org/10.1111/j.1365-2893.2008.01008.x
  • Sweeting, MJ., De Angelis, D., Hickman, M. and Ades, AE., 2008. Estimating hepatitis C prevalence in England and Wales by synthesizing evidence from multiple data sources. Assessing data conflict and model fit. Biostatistics, v. 9
    Doi: http://doi.org/10.1093/biostatistics/kxn004
  • Thomson, BJ., Kwong, G., Ratib, S., Sweeting, M., Ryder, SD., De Angelis, D., Grieve, R., Irving, WL. and Trent HCV Study Group, , 2008. Response rates to combination therapy for chronic HCV infection in a clinical setting and derivation of probability tables for individual patient management. J Viral Hepat, v. 15
    Doi: http://doi.org/10.1111/j.1365-2893.2007.00941.x
  • Hickman, M., De Angelis, D., Sweeting, M. and Ades, T., 2008. Estimating how many people are infected with hepatitis C virus in England and Wales: An evidence synthesis approach JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, v. 62
  • Copas, A., Seaman, S., Raab, G., Jewell, CP., Presanis, A., Sweeting, M., Bird, SM., Calleja, N., Farrington, CP., Greenland, S., Kalogeropoulos, K., Papaspiliopoulos, O., Katki, HA., Raftery, AE. and Alkema, L., 2008. Discussion on the paper by Goubar, Ades, De Angelis, McGarrigle, Mercer, Tookey, Fenton and Gill JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, v. 171
  • 2007

  • Sweeting, MJ., De Angelis, D., Brant, LJ., Harris, HE., Mann, AG. and Ramsay, ME., 2007. The burden of hepatitis C in England. J Viral Hepat, v. 14
    Doi: http://doi.org/10.1111/j.1365-2893.2007.00851.x
  • 2006

  • Sweeting, M., Sutton, A. and Lambert, P., 2006. Erratum: What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data (Statistics in Medicine (2004) vol. 23 (1351-1375)) Statistics in Medicine, v. 25
    Doi: http://doi.org/10.1002/sim.2536
  • Grieve, R., Roberts, J., Wright, M., Sweeting, M., DeAngelis, D., Rosenberg, W., Bassendine, M., Main, J. and Thomas, H., 2006. Cost effectiveness of interferon alpha or peginterferon alpha with ribavirin for histologically mild chronic hepatitis C. Gut, v. 55
    Doi: http://doi.org/10.1136/gut.2005.064774
  • Bongartz, T., Sutton, AJ., Sweeting, MJ., Buchan, I., Matteson, EL. and Montori, V., 2006. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA, v. 295
    Doi: http://doi.org/10.1001/jama.295.19.2275
  • Bongartz, T., Matteson, EL., Montori, VM., Sutton, AJ., Sweeting, M. and Buchan, I., 2006. In reply [5] JAMA, v. 296
  • Sweeting, MJ., De Angelis, D., Neal, KR., Ramsay, ME., Irving, WL., Wright, M., Brant, L. and Harris, HE., 2006. Estimated progression rates in three United Kingdom hepatitis C cohorts differed according to method of recruitment JOURNAL OF CLINICAL EPIDEMIOLOGY, v. 59
    Doi: http://doi.org/10.1016/j.jclinepi.2005.06.008
  • 2005

  • Sweeting, MJ., De Angelis, D. and Aalen, OO., 2005. Bayesian back-calculation using a multi-state model with application to HIV. Stat Med, v. 24
    Doi: http://doi.org/10.1002/sim.2432
  • Anderson, HR., Atkinson, RW., Peacock, JL., Sweeting, MJ. and Marston, L., 2005. Ambient particulate matter and health effects: publication bias in studies of short-term associations. Epidemiology, v. 16
    Doi: http://doi.org/10.1097/01.ede.0000152528.22746.0f
  • 2004

  • Sweeting, MJ., Sutton, AJ. and Lambert, PC., 2004. What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data STATISTICS IN MEDICINE, v. 23
    Doi: http://doi.org/10.1002/sim.1761
  • 2002

  • Sutton, AJ., Cooper, NJ., Lambert, PC., Jones, DR., Abrams, KR. and Sweeting, MJ., 2002. Meta-analysis of rare and adverse event data. Expert Rev Pharmacoecon Outcomes Res, v. 2
    Doi: http://doi.org/10.1586/14737167.2.4.367
  • Book chapters

    2017 (Published online)

  • Barrett, JK., Sweeting, MJ. and Wood, AM., 2017 (Published online). Dynamic risk prediction for cardiovascular disease: An illustration using the ARIC Study
    Doi: http://doi.org/10.1016/bs.host.2017.05.004
  • Conference proceedings

    2017

  • Wheeler, G., Sweeting, MJ. and Mander, AP., 2017. A model-free Bayesian adaptive design for combination therapy dose-finding trials with censored time-to-toxicity data TRIALS, v. 18
  • 2016

  • Toghill, BJ., Saratzis, A., Harrison, SC., Verissimo, AR., Samani, NJ., Thompson, JR., Sayers, R., Sweeting, MJ. and Bown, MJ., 2016. The role of DNA methylation in the pathology of abdominal aortic aneurysms BRITISH JOURNAL OF SURGERY, v. 103
  • Earnshaw, J., Williams, CO., Lees, T., Jacomelli, J., Summers, LJ., Stevenson, A., Sweeting, M. and Thompson, S., 2016. First Million Men Screened in the NHS Abdominal Aortic Aneurysm Screening Programme in England JOURNAL OF VASCULAR SURGERY, v. 63
    Doi: http://doi.org/10.1016/j.jvs.2016.03.219
  • 2015

  • Staley, J., Jones, E., Kaptoge, S., Sweeting, M., Wood, A. and Howson, J., 2015. A Comparison of Cox and Logistic Regression for Use in Genome-Wide Association Studies HUMAN HEREDITY, v. 79
  • Wheeler, G., Sweeting, M. and Mander, A., 2015. A toxicity-dependent feasibility bound for the escalation with overdose control approach in phase I cancer trials TRIALS, v. 16
    Doi: http://doi.org/10.1186/1745-6215-16-S2-P233
  • 2005

  • Bongartz, T., Sutton, AJ., Sweeting, MJ., Buchnan, I., Matteson, EL. and Montori, V., 2005. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies - A metaanalysis of rare harmful effects in randomized controlled trials. ARTHRITIS AND RHEUMATISM, v. 52