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Cambridge Public Health

 

Mark Holmes leads a research group whose current focus of research follows their discovery of a new livestock-associated MRSA harboring a mecA homologue (now named mecC). The new MRSA was discovered during an epidemiological project milking.pnglooking at the transmission of S. aureus in dairy cows by one of our PhD students, Laura Garcia Alvarez. The original isolate was whole genome sequenced and analysed in collaboration with the Wellcome Trust Sanger Institute by Matt Holden and colleagues. We subsequently obtained funding from Defra and the MRC to investigate the discovery further. We are now undertaking studies to establish the prevalence and diversity of the new MRSA using whole genome sequencing and other techniques. In collaboration with Prof Alexander Tomasz’s lab at Rockefeller University we have recently published the results of a study into the function of the PBP2a produced by the mecC gene.
http://www.vet.cam.ac.uk/directory/mah1@cam.ac.uk

Publications from Elements

Journal articles

2024

  • Coll, F., Gouliouris, T., Blane, B., Yeats, CA., Raven, KE., Ludden, C., Khokhar, FA., Wilson, HJ., Roberts, LW., Harrison, EM., Horner, CS., Le, TH., Nguyen, TH., Nguyen, VT., Brown, NM., Holmes, MA., Parkhill, J., Estee Török, M. and Peacock, SJ., 2024. Antibiotic resistance determination using Enterococcus faecium whole-genome sequences: a diagnostic accuracy study using genotypic and phenotypic data. Lancet Microbe, v. 5
    Doi: http://doi.org/10.1016/S2666-5247(23)00297-5
  • Bartlett, H., Zanella, M., Kaori, B., Sabei, L., Araujo, MS., de Paula, TM., Zanella, AJ., Holmes, MA., Wood, JLN. and Balmford, A., 2024. Trade-offs in the externalities of pig production are not inevitable. Nat Food, v. 5
    Doi: 10.1038/s43016-024-00921-2
  • Cole, J., Mughal, AN., Eltholth, M., Thomas, A. and Holmes, M., 2024. Transdisciplinary approaches to addressing factors that influence antimicrobial use in dairy cattle: A scoping review. Heliyon, v. 10
    Doi: http://doi.org/10.1016/j.heliyon.2024.e25550
  • Coll, F., Gouliouris, T., Blane, E., Yeats, C., Raven, K., Ludden, C., Khokhar, F., Wilson, H., Roberts, L., Harrison, E., Horner, C., Le Thi, H., Nguyen Thi, H., Trung, NV., Nguyen, VK., Brown, NM., Holmes, MA., Parkhill, J., Török, E. and Peacock, S., 2024. Antibiotic resistance determination using Enterococcus faecium whole-genome sequences: a diagnostic accuracy study using genotypic and phenotypic data The Lancet Microbe, v. 5
    Doi: http://doi.org/10.1016/S2666-5247(23)00297-5
  • 2023 (Accepted for publication)

  • Ba, X., Matuszewska, M., Kalmar, L., Fan, J., Zou, G., Corander, D., Raisen, C., Li, S., Li, L., Weinert, L., Tucker, A., Grant, A., Zhou, R. and Holmes, M., 2023 (Accepted for publication). High-throughput mutagenesis reveals a role for antimicrobial resistance- and virulence-associated mobile genetic elements in Staphylococcus aureus host adaptation Microbiology Spectrum,
    Doi: 10.1128/spectrum.04213-22
  • Bartlett, H., Balmford, A., Wood, J. and Holmes, M., 2023 (Accepted for publication). Identifying ways of producing pigs more sustainably - tradeoffs and co-benefits in land and antimicrobial use Scientific Reports,
  • Matuszewska, M., Dabrowska, A., Murray, G., Kett, S., Vick, A., Banister, S., Pantoja Munoz, L., Cunningham, P., Welch, J., Holmes, M. and Weinert, L., 2023 (Accepted for publication). Absence of Staphylococcus aureus in wild populations of fish supports a spillover hypothesis Microbiology Spectrum,
  • Holmes, M. and Ba, X., 2023 (Accepted for publication). Global emergence of a new hypervirulent carbapenem-resistant Escherichia coli ST410 clone Nature Communications,
  • Balmford, A., Bartlett, H., Zanella, M., Kaori, B., Sabei, L., Araujo, MS., de Paula, TM., Zanella, AJ., Holmes, MA. and Wood, JLN., 2023 (Accepted for publication). Trade-offs in the externalities of pig production are not inevitable Nature Food,
    Doi: 10.1038/s43016-024-00921-2
  • 2023

  • Bartlett, H., Balmford, A., Holmes, MA. and Wood, JLN., 2023. Advancing the quantitative characterization of farm animal welfare. Proc Biol Sci, v. 290
    Doi: http://doi.org/10.1098/rspb.2023.0120
  • Sajeev, S., Hamza, M., Rajan, V., Vijayan, A., Sivaraman, GK., Shome, BR. and Holmes, MA., 2023. Resistance profiles and genotyping of extended-spectrum beta-lactamase (ESBL) -producing and non-ESBL-producing E. coli and Klebsiella from retail market fishes. Infect Genet Evol, v. 112
    Doi: http://doi.org/10.1016/j.meegid.2023.105446
  • Phillips, H., Franklin, C., Brearley, J., Holmes, M. and Genain, M-A., 2023. Natural ballistic gelatine ultrasound phantoms are suitable to be used for student education and can be produced cheaply and effectively. Vet Radiol Ultrasound, v. 64
    Doi: http://doi.org/10.1111/vru.13235
  • Doughty, EL., Liu, H., Moran, RA., Hua, X., Ba, X., Guo, F., Chen, X., Zhang, L., Holmes, M., van Schaik, W., McNally, A. and Yu, Y., 2023. Endemicity and diversification of carbapenem-resistant Acinetobacter baumannii in an intensive care unit. Lancet Reg Health West Pac, v. 37
    Doi: 10.1016/j.lanwpc.2023.100780
  • Tams, KW., Larsen, I., Hansen, JE., Spiegelhauer, H., Strøm-Hansen, AD., Rasmussen, S., Ingham, AC., Kalmar, L., Kean, IRL., Angen, Ø., Holmes, MA., Pedersen, K., Jelsbak, L., Folkesson, A., Larsen, AR. and Strube, ML., 2023. The effects of antibiotic use on the dynamics of the microbiome and resistome in pigs. Anim Microbiome, v. 5
    Doi: 10.1186/s42523-023-00258-4
  • Zhou, Z., Shuai, X., Lin, Z., Yu, X., Ba, X., Holmes, MA., Xiao, Y., Gu, B. and Chen, H., 2023. Association between particulate matter (PM)2·5 air pollution and clinical antibiotic resistance: a global analysis. Lancet Planet Health, v. 7
    Doi: http://doi.org/10.1016/S2542-5196(23)00135-3
  • Ba, X., Raisen, CL., Restif, O., Cavaco, LM., Vingsbo Lundberg, C., Lee, JYH., Howden, BP., Bartels, MD., Strommenger, B., Harrison, EM., Larsen, AR., Holmes, MA. and Larsen, J., 2023. Cryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages. Nat Commun, v. 14
    Doi: http://doi.org/10.1038/s41467-023-42245-y
  • van Tonder, AJ., McCullagh, F., McKeand, H., Thaw, S., Bellis, K., Raisen, C., Lay, L., Aggarwal, D., Holmes, M., Parkhill, J., Harrison, EM., Kucharski, A. and Conlan, A., 2023. Colonization and transmission of Staphylococcus aureus in schools: a citizen science project. Microb Genom, v. 9
    Doi: http://doi.org/10.1099/mgen.0.000993
  • 2022

  • Kalmar, L., Gupta, S., Kean, IRL., Ba, X., Hadjirin, N., Lay, EM., de Vries, SPW., Bateman, M., Bartlet, H., Hernandez-Garcia, J., Tucker, AW., Restif, O., Stevens, MP., Wood, JLN., Maskell, DJ., Grant, AJ. and Holmes, MA., 2022. HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities. PLoS Genet, v. 18
    Doi: http://doi.org/10.1371/journal.pgen.1009776
  • Zhou, Z., Shuai, X., Lin, Z., Meng, L., Ba, X., Holmes, MA. and Chen, H., 2022. Short-term inhalation exposure evaluations of airborne antibiotic resistance genes in environments. J Environ Sci (China), v. 122
    Doi: http://doi.org/10.1016/j.jes.2021.10.002
  • Eltholth, M., Govindaraj, G., Das, B., Shanabhoga, MB., Swamy, HM., Thomas, A., Cole, J., Shome, BR., Holmes, MA. and Moran, D., 2022. Factors Influencing Antibiotic Prescribing Behavior and Understanding of Antimicrobial Resistance Among Veterinarians in Assam, India. Front Vet Sci, v. 9
    Doi: http://doi.org/10.3389/fvets.2022.864813
  • Sajeev, S., Hamza, M., Sivaraman, GK., Ghatak, S., Ojha, R., Mendem, SK., Murugesan, D., Raisen, C., Shome, BR. and Holmes, MA., 2022. Genomic insights of beta-lactamase producing Klebsiella quasipneumoniae subsp. similipneumoniae belonging to sequence type 1699 from retail market fish, India. Arch Microbiol, v. 204
    Doi: http://doi.org/10.1007/s00203-022-03071-w
  • Khokhar, F., Pickard, D., Dyson, Z., Iqbal, J., Pragasam, A., John, JJ., Veeraraghavan, B., Qamar, F., Dougan, G., MacQueen, H., Rigas, S., Holmes, M. and Mutreja, A., 2022. Multiplex PCR assay to detect high risk lineages of Salmonella Typhi and Paratyphi A. PLoS One, v. 17
    Doi: http://doi.org/10.1371/journal.pone.0267805
  • Ba, X., Raisen, CL., Zhou, Z-C., Harrison, EM., Peacock, SJ. and Holmes, MA., 2022. Simultaneously screening for methicillin-resistant Staphylococcus aureus and its susceptibility to potentiated penicillins. J Med Microbiol, v. 71
    Doi: http://doi.org/10.1099/jmm.0.001562
  • Chen, Y., Sun, L., Ba, X., Jiang, S., Zhuang, H., Zhu, F., Wang, H., Lan, P., Shi, Q., Wang, Z., Chen, Y., Shi, K., Ji, S., Jiang, Y., Holmes, MA. and Yu, Y., 2022. Epidemiology, evolution and cryptic susceptibility of methicillin-resistant Staphylococcus aureus in China: a whole-genome-based survey. Clin Microbiol Infect, v. 28
    Doi: http://doi.org/10.1016/j.cmi.2021.05.024
  • Bartlett, H., Holmes, MA., Petrovan, SO., Williams, DR., Wood, JLN. and Balmford, A., 2022. Understanding the relative risks of zoonosis emergence under contrasting approaches to meeting livestock product demand. R Soc Open Sci, v. 9
    Doi: http://doi.org/10.1098/rsos.211573
  • Alves, L., de Novais, FJ., da Silva, AN., Araujo, MS., Bernardino, T., Osowski, GV., Zanella, R., Lee Settles, M., Holmes, MA., Fukumasu, H., Ruiz, VLDA. and Zanella, AJ., 2022. Vaginal Microbiota Diversity in Response to Lipopolysaccharide in Gilts Housed Under Three Housing Systems. Front Genet, v. 13
    Doi: http://doi.org/10.3389/fgene.2022.836962
  • Muneeb, KH., Sudha, S., Sivaraman, GK., Ojha, R., Mendem, SK., Murugesan, D., Raisen, CL., Shome, B. and Holmes, M., 2022. Whole-genome sequence analysis of Staphylococcus aureus from retail fish acknowledged the incidence of highly virulent ST672-MRSA-IVa/t1309, an emerging Indian clone, in Assam, India. Environ Microbiol Rep, v. 14
    Doi: http://doi.org/10.1111/1758-2229.13024
  • Yebra, G., Harling-Lee, JD., Lycett, S., Aarestrup, FM., Larsen, G., Cavaco, LM., Seo, KS., Abraham, S., Norris, JM., Schmidt, T., Ehlers, MM., Sordelli, DO., Buzzola, FR., Gebreyes, WA., Gonçalves, JL., Dos Santos, MV., Zakaria, Z., Rall, VLM., Keane, OM., Niedziela, DA., Paterson, GK., Holmes, MA., Freeman, TC. and Fitzgerald, JR., 2022. Multiclonal human origin and global expansion of an endemic bacterial pathogen of livestock. Proc Natl Acad Sci U S A, v. 119
    Doi: http://doi.org/10.1073/pnas.2211217119
  • Huber, C., Wolf, SA., Ziebuhr, W., Holmes, MA., Assmann, J., Lübke-Becker, A., Thürmer, A., Semmler, T., Brombach, J., Bethe, A., Bischoff, M., Wieler, LH., Epping, L. and Walther, B., 2022. How to survive pig farming: Mechanism of SCCmec element deletion and metabolic stress adaptation in livestock-associated MRSA. Front Microbiol, v. 13
    Doi: http://doi.org/10.3389/fmicb.2022.969961
  • Larsen, J., Raisen, CL., Ba, X., Sadgrove, NJ., Padilla-González, GF., Simmonds, MSJ., Loncaric, I., Kerschner, H., Apfalter, P., Hartl, R., Deplano, A., Vandendriessche, S., Černá Bolfíková, B., Hulva, P., Arendrup, MC., Hare, RK., Barnadas, C., Stegger, M., Sieber, RN., Skov, RL., Petersen, A., Angen, Ø., Rasmussen, SL., Espinosa-Gongora, C., Aarestrup, FM., Lindholm, LJ., Nykäsenoja, SM., Laurent, F., Becker, K., Walther, B., Kehrenberg, C., Cuny, C., Layer, F., Werner, G., Witte, W., Stamm, I., Moroni, P., Jørgensen, HJ., de Lencastre, H., Cercenado, E., García-Garrote, F., Börjesson, S., Hæggman, S., Perreten, V., Teale, CJ., Waller, AS., Pichon, B., Curran, MD., Ellington, MJ., Welch, JJ., Peacock, SJ., Seilly, DJ., Morgan, FJE., Parkhill, J., Hadjirin, NF., Lindsay, JA., Holden, MTG., Edwards, GF., Foster, G., Paterson, GK., Didelot, X., Holmes, MA., Harrison, EM. and Larsen, AR., 2022. Emergence of methicillin resistance predates the clinical use of antibiotics. Nature, v. 602
    Doi: http://doi.org/10.1038/s41586-021-04265-w
  • 2021 (Accepted for publication)

  • Holmes, M., 2021 (Accepted for publication). Genomic analysis of Staphylococcus aureus of the lineage CC130, including mecC-carrying MRSA and MSSA isolates recovered of animal, human and environmental origins Frontiers in Microbiology,
  • 2021

  • Sivaraman, GK., Muneeb, KH., Sudha, S., Shome, B., Holmes, M. and Cole, J., 2021. Fish-borne methicillin resistant Staphylococcus haemolyticus carrying atypical staphylococcal cassette chromosome mec (SCCmec) elements Gene Reports, v. 22
    Doi: http://doi.org/10.1016/j.genrep.2020.100982
  • Cui, C., Ba, X. and Holmes, MA., 2021. Prevalence and characterization of mecC MRSA in bovine bulk tank milk in Great Britain, 2017–18 JAC-Antimicrobial Resistance, v. 3
    Doi: http://doi.org/10.1093/jacamr/dlaa125
  • Sivaraman, GK., Muneeb, KH., Sudha, S., Shome, B., Cole, J. and Holmes, M., 2021. Prevalence of virulent and biofilm forming ST88-IV-t2526 methicillin-resistant Staphylococcus aureus clones circulating in local retail fish markets in Assam, India Food Control, v. 127
    Doi: http://doi.org/10.1016/j.foodcont.2021.108098
  • Crestani, C., Forde, T., Lycett, S., Holmes, M., Fasth, C., Persson-Waller, K. and Zadoks, R., 2021. The fall and rise of group B <i>Streptococcus</i> in dairy cattle: reintroduction due to human-to-cattle host jumps?
    Doi: 10.1101/2021.04.21.440740
  • Anderson, T., Beever, L., Hall, J., Moores, A., Llanos, C., Adams, R., Meakin, L., Coppola, M., Bowlt-Blacklock, K., Holmes, MA. and Barnes, D., 2021. Outcome following surgery to treat septic peritonitis in 95 cats in the United Kingdom. J Small Anim Pract, v. 62
    Doi: http://doi.org/10.1111/jsap.13346
  • Crisci, MA., Chen, L-X., Devoto, AE., Borges, AL., Bordin, N., Sachdeva, R., Tett, A., Sharrar, AM., Segata, N., Debenedetti, F., Bailey, M., Burt, R., Wood, RM., Rowden, LJ., Corsini, PM., van Winden, S., Holmes, MA., Lei, S., Banfield, JF. and Santini, JM., 2021. Closely related Lak megaphages replicate in the microbiomes of diverse animals. iScience, v. 24
    Doi: http://doi.org/10.1016/j.isci.2021.102875
  • Zou, G., Matuszewska, M., Jia, M., Zhou, J., Ba, X., Duan, J., Zhang, C., Zhao, J., Tao, M., Fan, J., Zhang, X., Jin, W., Cui, T., Zeng, X., Jia, M., Qian, X., Huang, C., Zhuo, W., Yao, Z., Zhang, L., Li, S., Li, L., Huang, Q., Wu, B., Chen, H., Tucker, A., Grant, A., Holmes, M. and Zhou, R., 2021. A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations
    Doi: http://doi.org/10.1101/2021.08.02.454852
  • Kalmar, L., Gupta, S., Kean, I., Ba, X., Hadjirin, N., Lay, E., de Vries, SPW., Bateman, M., Bartlett, H., Hernandez-Garcia, J., Tucker, A., Restiff, O., Stevens, M., Wood, J., Maskell, D., Grant, A. and Holmes, M., 2021. HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities
    Doi: http://doi.org/10.1101/2021.08.16.456459
  • Muneeb, KH., Sudha, S., Sivaraman, GK., Shome, B., Cole, J. and Holmes, M., 2021. Virulence and intermediate resistance to high-end antibiotic (teicoplanin) among coagulase-negative staphylococci sourced from retail market fish. Arch Microbiol, v. 203
    Doi: http://doi.org/10.1007/s00203-021-02558-2
  • Crestani, C., Forde, TL., Lycett, SJ., Holmes, MA., Fasth, C., Persson-Waller, K. and Zadoks, RN., 2021. The fall and rise of group B Streptococcus in dairy cattle: reintroduction due to human-to-cattle host jumps? Microb Genom, v. 7
    Doi: http://doi.org/10.1099/mgen.0.000648
  • Zou, G., Matuszewska, M., Jia, M., Zhou, J., Ba, X., Duan, J., Zhang, C., Zhao, J., Tao, M., Fan, J., Zhang, X., Jin, W., Cui, T., Zeng, X., Jia, M., Qian, X., Huang, C., Zhuo, W., Yao, Z., Zhang, L., Li, S., Li, L., Huang, Q., Wu, B., Chen, H., Tucker, AW., Grant, AJ., Holmes, MA. and Zhou, R., 2021. A Survey of Chinese Pig Farms and Human Healthcare Isolates Reveals Separate Human and Animal Methicillin-Resistant Staphylococcus aureus Populations. Adv Sci (Weinh),
    Doi: http://doi.org/10.1002/advs.202103388
  • 2020 (Accepted for publication)

  • Holmes, M., Ba, X., Parkhill, J., Raisen, C., Hadjirin, N., Lay, E. and Restif, O., 2020 (Accepted for publication). Mechanisms of Beta-lactam resistance of Streptococcus uberis isolated from bovine mastitis cases Veterinary Microbiology,
  • 2020

  • Hoekstra, J., Zomer, AL., Rutten, VPMG., Benedictus, L., Stegeman, A., Spaninks, MP., Bennedsgaard, TW., Biggs, A., De Vliegher, S., Mateo, DH., Huber-Schlenstedt, R., Katholm, J., Kovács, P., Krömker, V., Lequeux, G., Moroni, P., Pinho, L., Smulski, S., Supré, K., Swinkels, JM., Holmes, MA., Lam, TJGM. and Koop, G., 2020. Genomic analysis of European bovine Staphylococcus aureus from clinical versus subclinical mastitis. Sci Rep, v. 10
    Doi: http://doi.org/10.1038/s41598-020-75179-2
  • Sivaraman, GK., Sudha, S., Muneeb, KH., Shome, B., Holmes, M. and Cole, J., 2020. Molecular assessment of antimicrobial resistance and virulence in multi drug resistant ESBL-producing Escherichia coli and Klebsiella pneumoniae from food fishes, Assam, India. Microb Pathog, v. 149
    Doi: http://doi.org/10.1016/j.micpath.2020.104581
  • Kepiro, IE., Marzuoli, I., Hammond, K., Ba, X., Lewis, H., Shaw, M., Gunnoo, SB., De Santis, E., Łapińska, U., Pagliara, S., Holmes, MA., Lorenz, CD., Hoogenboom, BW., Fraternali, F. and Ryadnov, MG., 2020. Engineering Chirally Blind Protein Pseudocapsids into Antibacterial Persisters. ACS Nano, v. 14
    Doi: http://doi.org/10.1021/acsnano.9b06814
  • Monforte Monteiro, SR., Rossmeisl, JH., Russell, J., Holmes, MA., Wessmann, A., Morris, J., Dobson, JM. and Vanhaesebrouck, AE., 2020. Effect of radiotherapy on freedom from seizures in dogs with brain tumors. J Vet Intern Med, v. 34
    Doi: http://doi.org/10.1111/jvim.15695
  • Egyir, B., Hadjirin, NF., Gupta, S., Owusu, F., Agbodzi, B., Adogla-Bessa, T., Addo, KK., Stegger, M., Larsen, AR. and Holmes, MA., 2020. Whole-genome sequence profiling of antibiotic-resistant Staphylococcus aureus isolates from livestock and farm attendants in Ghana. J Glob Antimicrob Resist, v. 22
    Doi: http://doi.org/10.1016/j.jgar.2020.03.029
  • Gómez, P., Aspiroz, C., Hadjirin, NF., Benito, D., Zarazaga, M., Torres, C. and Holmes, MA., 2020. Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin Susceptible Staphylococcus aureus of Lineage ST398 in a Live Pig Transporter. Pathogens, v. 9
    Doi: http://doi.org/10.3390/pathogens9050401
  • 2019 (Accepted for publication)

  • Peacock, S., Harrison, E., Blane, E., Holmes, M., Parkhill, J., Wagner, J. and Kronbichler, A., 2019 (Accepted for publication). The Composition and Functional Protein Subsystems of the Human Nasal Microbiome in Granulomatosis with Polyangiitis: A Pilot Study. Microbiome,
    Doi: http://doi.org/10.1186/s40168-019-0753-z
  • Ba, X., Kalmar, L., Hadjirin, N., Kerschner, H., Apfalter, P., Morgan, F., Paterson, G., Girvan, S., Zhou, R., Harrison, EM. and Holmes, MA., 2019 (Accepted for publication). Truncation of GdpP mediates β-lactam resistance in clinical isolates of Staphylococcus aureus Journal of Antimicrobial Chemotherapy,
  • Weinert, L., 2019 (Accepted for publication). The evolutionary genomics of host specificity in Staphylococcus aureus Trends in Microbiology,
  • Holmes, M., MacFadyen, A., Leroy, S., Harrison, E., Parkhill, J. and Paterson, G., 2019 (Accepted for publication). Staphylococcus pseudoxylosus sp. nov., isolated from bovine mastitis International Journal of Systematic and Evolutionary Microbiology, v. 69
    Doi: http://doi.org/10.1099/ijsem.0.003416
  • Peacock, S., Harrison, E., Coll, F., Blane, E., Bellis, K., Holmes, M., Parkhill, J. and Ba, X., 2019 (Accepted for publication). Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus Nature Microbiology,
  • 2019

  • Kronbichler, A., Blane, B., Holmes, MA., Wagner, J., Parkhill, J., Peacock, SJ., Jayne, DRW. and Harrison, EM., 2019. Nasal carriage of Staphylococcus pseudintermedius in patients with granulomatosis with polyangiitis. Rheumatology (Oxford), v. 58
    Doi: http://doi.org/10.1093/rheumatology/key317
  • MacFadyen, AC., Drigo, I., Harrison, EM., Parkhill, J., Holmes, MA. and Paterson, GK., 2019. Staphylococcus caeli sp. nov., isolated from air sampling in an industrial rabbit holding. International Journal of Systematic and Evolutionary Microbiology, v. 69
    Doi: http://doi.org/10.1099/ijsem.0.003098
  • Barkham, T., Zadoks, RN., Azmai, MNA., Baker, S., Bich, VTN., Chalker, V., Chau, ML., Dance, D., Deepak, RN., van Doorn, HR., Gutierrez, RA., Holmes, MA., Huong, LNP., Koh, TH., Martins, E., Mehershahi, K., Newton, P., Ng, LC., Phuoc, NN., Sangwichian, O., Sawatwong, P., Surin, U., Tan, TY., Tang, WY., Thuy, NV., Turner, P., Vongsouvath, M., Zhang, D., Whistler, T. and Chen, SL., 2019. One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia. PLoS Negl Trop Dis, v. 13
    Doi: http://doi.org/10.1371/journal.pntd.0007421
  • Seni, J., Mshana, SE., Msigwa, F., Iddi, S., Mazigo, H., Parkhill, J., Holmes, MA. and Paterson, GK., 2019. Draft genome sequence of a multidrug-resistant caprine isolate of Staphylococcus cohnii subsp. urealyticus from Tanzania encoding ermB, tet(K), dfrG, fusF and fosD. J Glob Antimicrob Resist, v. 18
    Doi: http://doi.org/10.1016/j.jgar.2019.07.006
  • Ludden, C., Moradigaravand, D., Jamrozy, D., Gouliouris, T., Blane, B., Naydenova, P., Hernandez-Garcia, J., Wood, P., Hadjirin, N., Radakovic, M., Crawley, C., Brown, NM., Holmes, M., Parkhill, J. and Peacock, SJ., 2019. A One Health study of the genetic relatedness of Klebsiella pneumoniae and their mobile elements in the East of England. Clin Infect Dis,
    Doi: http://doi.org/10.1093/cid/ciz174
  • MacFadyen, AC., Harrison, EM., Drigo, I., Parkhill, J., Holmes, MA. and Paterson, GK., 2019. A mecC allotype, mecC3, in the CoNS Staphylococcus caeli, encoded within a variant SCCmecC. J Antimicrob Chemother, v. 74
    Doi: http://doi.org/10.1093/jac/dky502
  • Loncaric, I., Kübber-Heiss, A., Posautz, A., Ruppitsch, W., Lepuschitz, S., Schauer, B., Feßler, AT., Krametter-Frötscher, R., Harrison, EM., Holmes, MA., Künzel, F., Szostak, MP., Hauschild, T., Desvars-Larrive, A., Misic, D., Rosengarten, R., Walzer, C., Slickers, P., Monecke, S., Ehricht, R., Schwarz, S. and Spergser, J., 2019. Characterization of mecC gene-carrying coagulase-negative Staphylococcus spp. isolated from various animals. Vet Microbiol, v. 230
    Doi: http://doi.org/10.1016/j.vetmic.2019.02.014
  • 2018 (Accepted for publication)

  • Harrison, EM. and Holmes, M., 2018 (Accepted for publication). Identification of a Staphylococcal Complement Inhibitor with broad host specificity in equid S. aureus strains Journal of Biological Chemistry,
  • Grant, AJ., Maskell, D. and Holmes, M., 2018 (Accepted for publication). Phylogenetic analyses and antimicrobial resistance profiles of Campylobacter spp. from diarrhoeal patients and chickens in Botswana PLoS ONE,
  • Peacock, SJ., Moradigaravand, D., Parkhill, J., Torok, ME., Gouliouris, T. and Ludden, C., 2018 (Accepted for publication). Genomic survey of Clostridium difficile reservoirs in the East of England implicates environmental contamination of wastewater treatment plants by clinical lineages Eurosurveillance,
  • Peacock, SJ., Raven, K., Gouliourus, T., Blane, B., Holmes, M. and Parkhill, J., 2018 (Accepted for publication). One Health genomic surveillance of Escherichia coli demonstrates distinct lineages and mobile genetic elements in isolates from humans versus livestock mBio,
  • Peacock, SJ., Harrison, EM., Parkhill, J., Weinert, L. and Holmes, M., 2018 (Accepted for publication). Gene exchange drives the ecological success of a multi-host bacterial pathogen Nature Ecology and Evolution,
  • Raven, KE., Gouliouris, T., Holmes, MA., Parkhill, J., Peacock, S. and Brown, N., 2018 (Accepted for publication). Genomic surveillance of Enterococcus faecium reveals limited sharing of strains and resistance genes between livestock and humans mBio,
  • 2018

  • Kriegeskorte, A., Idelevich, EA., Schlattmann, A., Layer, F., Strommenger, B., Denis, O., Paterson, GK., Holmes, MA., Werner, G. and Becker, K., 2018. Comparison of Different Phenotypic Approaches To Screen and Detect mecC-Harboring Methicillin-Resistant Staphylococcus aureus. J Clin Microbiol, v. 56
    Doi: http://doi.org/10.1128/JCM.00826-17
  • de Vries, SPW., Hadjirin, NF., Lay, EM., Zadoks, RN., Peacock, SJ., Parkhill, J., Grant, AJ., McDougall, S. and Holmes, MA., 2018. Streptococcus bovimastitidis sp. nov., isolated from a dairy cow with mastitis. Int J Syst Evol Microbiol, v. 68
    Doi: http://doi.org/10.1099/ijsem.0.002321
  • Knight, G., Lambert, H., Feil, E., Holmes, M. and Lindsay, J., 2018. The importance of cross-disciplinary research to combat antimicrobial resistance: introducing a new pop-up journal, X-AMR. J Med Microbiol, v. 67
    Doi: http://doi.org/10.1099/mic.0.000684
  • Holmes, A., Holmes, M., Gottlieb, T., Price, LB. and Sundsfjord, A., 2018. End non-essential use of antimicrobials in livestock. BMJ, v. 360
    Doi: http://doi.org/10.1136/bmj.k259
  • de Jong, NWM., Vrieling, M., Garcia, BL., Koop, G., Brettmann, M., Aerts, PC., Ruyken, M., van Strijp, JAG., Holmes, M., Harrison, EM., Geisbrecht, BV. and Rooijakkers, SHM., 2018. Identification of a staphylococcal complement inhibitor with broad host specificity in equid Staphylococcus aureus strains. J Biol Chem, v. 293
    Doi: http://doi.org/10.1074/jbc.RA117.000599
  • Xu, Z., Misra, R., Jamrozy, D., Paterson, GK., Cutler, RR., Holmes, MA., Gharbia, S. and Mkrtchyan, HV., 2018. Whole Genome Sequence and Comparative Genomics Analysis of Multi-drug Resistant Environmental Staphylococcus epidermidis ST59. G3 (Bethesda), v. 8
    Doi: http://doi.org/10.1534/g3.118.200314
  • Parry-Hanson Kunadu, A., Holmes, M., Miller, EL. and Grant, AJ., 2018. Microbiological quality and antimicrobial resistance characterization of Salmonella spp. in fresh milk value chains in Ghana. Int J Food Microbiol, v. 277
    Doi: http://doi.org/10.1016/j.ijfoodmicro.2018.04.025
  • Busche, T., Hillion, M., Van Loi, V., Berg, D., Walther, B., Semmler, T., Strommenger, B., Witte, W., Cuny, C., Mellmann, A., Holmes, MA., Kalinowski, J., Adrian, L., Bernhardt, J. and Antelmann, H., 2018. Comparative Secretome Analyses of Human and Zoonotic Staphylococcus aureus Isolates CC8, CC22, and CC398. Mol Cell Proteomics, v. 17
    Doi: http://doi.org/10.1074/mcp.RA118.001036
  • MacFadyen, AC., Harrison, EM., Ellington, MJ., Parkhill, J., Holmes, MA. and Paterson, GK., 2018. A highly conserved mecC-encoding SCCmec type XI in a bovine isolate of methicillin-resistant Staphylococcus xylosus. J Antimicrob Chemother, v. 73
    Doi: http://doi.org/10.1093/jac/dky333
  • 2017

  • Allcock, S., Young, EH., Holmes, M., Gurdasani, D., Dougan, G., Sandhu, MS., Solomon, L. and Török, ME., 2017. Antimicrobial resistance in human populations: challenges and opportunities. Glob Health Epidemiol Genom, v. 2
    Doi: http://doi.org/10.1017/gheg.2017.4
  • Kolenda, C., Dupieux, C., Decousser, J-W., Larsen, AR., Pichon, B., Holmes, M., Bès, M., Teale, C., Dickson, E., Hill, R., Skov, R., Kearns, A. and Laurent, F., 2017. Comparison of Automated Antimicrobial Susceptibility Testing Systems To Detect mecC-Positive Methicillin-Resistant Staphylococcus aureus. J Clin Microbiol, v. 55
    Doi: http://doi.org/10.1128/JCM.01150-17
  • Dean, R., Brennan, M., Ewers, R., Hudson, C., Daly, JM., Baillie, S., Eisler, MC., Place, EJ., Brearley, J., Holmes, M., Handel, I., Shaw, D., McLauchlan, G., McBrearty, A., Cripps, P., Jones, P., Smith, R. and Verheyen, K., 2017. The challenge of teaching undergraduates evidence-based veterinary medicine. Vet Rec, v. 181
    Doi: http://doi.org/10.1136/vr.j3441
  • Dupieux, C., Kolenda, C., Larsen, AR., Pichon, B., Holmes, M., Bes, M., Teale, C., Dickson, E., Hill, R., Skov, R., Kearns, A. and Laurent, F., 2017. Variable performance of four commercial chromogenic media for detection of methicillin-resistant Staphylococcus aureus isolates harbouring mecC. Int J Antimicrob Agents, v. 50
    Doi: http://doi.org/10.1016/j.ijantimicag.2017.03.008
  • Dupieux, C., Bouchiat, C., Larsen, AR., Pichon, B., Holmes, M., Teale, C., Edwards, G., Hill, R., Decousser, J-W., Trouillet-Assant, S., Petersen, A., Skov, R., Kearns, A. and Laurent, F., 2017. Detection of mecC-Positive Staphylococcus aureus: What To Expect from Immunological Tests Targeting PBP2a? J Clin Microbiol, v. 55
    Doi: http://doi.org/10.1128/JCM.00068-17
  • Rose, L., Rose, J., Gosling, S. and Holmes, M., 2017. Efficacy of a Probiotic-Prebiotic Supplement on Incidence of Diarrhea in a Dog Shelter: A Randomized, Double-Blind, Placebo-Controlled Trial. J Vet Intern Med, v. 31
    Doi: http://doi.org/10.1111/jvim.14666
  • Allcock, S., Young, EH., Holmes, M., Gurdasani, D., Dougan, G., Sandhu, MS., Solomon, L. and Török, ME., 2017. Erratum: Antimicrobial resistance in human populations: challenges and opportunities - ERRATUM. Glob Health Epidemiol Genom, v. 2
    Doi: http://doi.org/10.1017/gheg.2017.12
  • Koop, G., Vrieling, M., Storisteanu, DML., Lok, LSC., Monie, T., van Wigcheren, G., Raisen, C., Ba, X., Gleadall, N., Hadjirin, N., Timmerman, AJ., Wagenaar, JA., Klunder, HM., Fitzgerald, JR., Zadoks, R., Paterson, GK., Torres, C., Waller, AS., Loeffler, A., Loncaric, I., Hoet, AE., Bergström, K., De Martino, L., Pomba, C., de Lencastre, H., Ben Slama, K., Gharsa, H., Richardson, EJ., Chilvers, ER., de Haas, C., van Kessel, K., van Strijp, JAG., Harrison, EM. and Holmes, MA., 2017. Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus. Sci Rep, v. 7
    Doi: http://doi.org/10.1038/srep40660
  • Hernandez, J., Wang, J., Restif, O., Mather, A., Holmes, M., Weinert, L., Wileman, Y., Maskell, D. and Tucker, A., 2017. Patterns of antimicrobial resistance in Streptococcus suis isolates from pigs with or without streptococcal disease in England between 2009 and 2014 Veterinary Microbiology, v. 207
    Doi: http://doi.org/10.1016/j.vetmic.2017.06.002
  • Bateman, MD., de Vries, SPW., Gupta, S., Guardabassi, L., Cavaco, LM., Grant, AJ. and Holmes, MA., 2017. Genome and Plasmid Sequences of Escherichia coli KV7, an Extended-Spectrum β-Lactamase Isolate Derived from Feces of a Healthy Pig. Genome Announc, v. 5
    Doi: http://doi.org/10.1128/genomeA.00595-17
  • 2016 (Accepted for publication)

  • Seni, J., Mshana, SE., Msigwa, F., Matee, M., Mazigo, H., Parkhill, J., Holmes, MA. and Paterson, GK., 2016 (Accepted for publication). Draft genome sequence of a multiresistant bovine isolate of Staphylococcus lentus from Tanzania Genome Announcements, v. 4
    Doi: http://doi.org/10.1128/genomeA.01345-16
  • Bodey, AL., Almond, CJ. and Holmes, MA., 2016 (Accepted for publication). Double-blinded randomised placebo-controlled clinical trial of individualised homeopathic treatment of hyperthyroid cats Veterinary Record,
    Doi: http://doi.org/10.1136/vr.104007
  • 2016

  • McLennan, KM., Rebelo, CJB., Corke, MJ., Holmes, MA., Leach, MC. and Constantino-Casas, F., 2016. Development of a facial expression scale using footrot and mastitis as models of pain in sheep Applied Animal Behaviour Science, v. 176
    Doi: http://doi.org/10.1016/j.applanim.2016.01.007
  • Holmes, MA., Harrison, EM., Fisher, EA., Graham, EM., Parkhill, J., Foster, G. and Paterson, GK., 2016. Genomic Analysis of Companion Rabbit Staphylococcus aureus. PLoS One, v. 11
    Doi: http://doi.org/10.1371/journal.pone.0151458
  • McLennan, KM., Rebelo, CJB., Corke, MJ., Holmes, MA., Leach, MC. and Constantino- Casas, F., 2016. Corrigendum to "Development of a facial expression scale using footrot and mastitis as models of pain in sheep" [Appl. Anim. Behav. Sci. 176C (2016) 19-26] Applied Animal Behaviour Science, v. 179
    Doi: http://doi.org/10.1016/j.applanim.2016.03.005
  • Mather, AE., Lawson, B., de Pinna, E., Wigley, P., Parkhill, J., Thomson, NR., Page, AJ., Holmes, MA. and Paterson, GK., 2016. Genomic Analysis of Salmonella enterica Serovar Typhimurium from Wild Passerines in England and Wales. Appl Environ Microbiol, v. 82
    Doi: http://doi.org/10.1128/AEM.01660-16
  • Barker, DA., Foale, RD., Holmes, MA. and Demetriou, JL., 2016. Survey of UK-based veterinary surgeons' opinions on the use of surgery and chemotherapy in the treatment of canine high-grade mast cell tumour, splenic haemangiosarcoma and appendicular osteosarcoma. Vet Rec, v. 179
    Doi: http://doi.org/10.1136/vr.103479
  • Harrison, EM., Ludden, C., Brodrick, HJ., Blane, B., Brennan, G., Morris, D., Coll, F., Reuter, S., Brown, NM., Holmes, MA., O'Connell, B., Parkhill, J., Török, ME., Cormican, M. and Peacock, SJ., 2016. Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks. Genome Med, v. 8
    Doi: http://doi.org/10.1186/s13073-016-0353-5
  • Harrison, EM., Gleadall, NS., Ba, X., Danesh, J., Peacock, SJ. and Holmes, M., 2016. Validation of self-administered nasal swabs and postage for the isolation of $\textit{Staphylococcus aureus}$ Journal of Medical Microbiology, v. 65
    Doi: http://doi.org/10.1099/jmm.0.000381
  • Harrison, EM., Ba, X., Blane, B., Ellington, MJ., Loeffler, A., Hill, RLR., Holmes, MA. and Peacock, SJ., 2016. PBP2a substitutions linked to ceftaroline resistance in MRSA isolates from the UK. J Antimicrob Chemother, v. 71
    Doi: http://doi.org/10.1093/jac/dkv317
  • Murray, GGR., Wang, F., Harrison, EM., Paterson, GK., Mather, AE., Harris, SR., Holmes, MA., Rambaut, A. and Welch, JJ., 2016. The effect of genetic structure on molecular dating and tests for temporal signal. Methods Ecol Evol, v. 7
    Doi: http://doi.org/10.1111/2041-210X.12466
  • Semmler, T., Harrison, EM., Lübke-Becker, A., Ulrich, RG., Wieler, LH., Guenther, S., Stamm, I., Hanssen, A-M., Holmes, MA., Vincze, S. and Walther, B., 2016. A Look into the Melting Pot: The mecC-Harboring Region Is a Recombination Hot Spot in Staphylococcus stepanovicii. PLoS One, v. 11
    Doi: http://doi.org/10.1371/journal.pone.0147150
  • Salgüero, R., Herrtage, M., Holmes, M., Mannion, P. and Ladlow, J., 2016. COMPARISON BETWEEN COMPUTED TOMOGRAPHIC CHARACTERISTICS OF THE MIDDLE EAR IN NONBRACHYCEPHALIC AND BRACHYCEPHALIC DOGS WITH OBSTRUCTIVE AIRWAY SYNDROME. Vet Radiol Ultrasound, v. 57
    Doi: http://doi.org/10.1111/vru.12337
  • 2015

  • De Sousa, R., Sutcliffe, M., Rousset, N., Holmes, M. and Langley-Hobbs, SJ., 2015. Treatment of cranial cruciate ligament rupture in the feline stifle. Biomechanical comparison of a standard fabella-tibial suture and lateral sutures placed between quasi-isometric points. Vet Comp Orthop Traumatol, v. 28
    Doi: http://doi.org/10.3415/VCOT-14-05-0078
  • McCarthy, AJ., Harrison, EM., Stanczak-Mrozek, K., Leggett, B., Waller, A., Holmes, MA., Lloyd, DH., Lindsay, JA. and Loeffler, A., 2015. Genomic insights into the rapid emergence and evolution of MDR in Staphylococcus pseudintermedius. J Antimicrob Chemother, v. 70
    Doi: http://doi.org/10.1093/jac/dku496
  • Ives, EJ., Doyle, L., Holmes, M., Williams, TL. and Vanhaesebrouck, AE., 2015. Association between the findings on magnetic resonance imaging screening for syringomyelia in asymptomatic Cavalier King Charles spaniels and observation of clinical signs consistent with syringomyelia in later life. Vet J, v. 203
    Doi: http://doi.org/10.1016/j.tvjl.2014.11.010
  • Salgüero, R., Johnson, V., Williams, D., Hartley, C., Holmes, M., Dennis, R. and Herrtage, M., 2015. CT dimensions, volumes and densities of normal canine eyes. Vet Rec, v. 176
    Doi: http://doi.org/10.1136/vr.102940
  • Espinosa-Gongora, C., Harrison, EM., Moodley, A., Guardabassi, L. and Holmes, MA., 2015. MRSA carrying mecC in captive mara. J Antimicrob Chemother, v. 70
    Doi: http://doi.org/10.1093/jac/dkv024
  • Kerschner, H., Harrison, EM., Hartl, R., Holmes, MA. and Apfalter, P., 2015. First report of mecC MRSA in human samples from Austria: molecular characteristics and clinical data. New Microbes New Infect, v. 3
    Doi: http://doi.org/10.1016/j.nmni.2014.11.001
  • Paterson, GK., Harrison, EM., Murray, GGR., Welch, JJ., Warland, JH., Holden, MTG., Morgan, FJE., Ba, X., Koop, G., Harris, SR., Maskell, DJ., Peacock, SJ., Herrtage, ME., Parkhill, J. and Holmes, MA., 2015. Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission. Nat Commun, v. 6
    Doi: http://doi.org/10.1038/ncomms7560
  • Hadjirin, NF., Lay, EM., Paterson, GK., Harrison, EM., Peacock, SJ., Parkhill, J., Zadoks, RN. and Holmes, MA., 2015. Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015. Euro Surveill, v. 20
    Doi: http://doi.org/10.2807/1560-7917.es2015.20.24.21156
  • Hahn, C., Harrison, EM., Parkhill, J., Holmes, MA. and Paterson, GK., 2015. Draft Genome Sequence of the Streptococcus pneumoniae Avery Strain A66. Genome Announc, v. 3
    Doi: http://doi.org/10.1128/genomeA.00697-15
  • Larsen, AR., Petersen, A., Holmes, M., Kearns, A., Hill, R., Edwards, G., Teale, C. and Skov, R., 2015. Utility of a newly developed Mueller-Hinton E agar for the detection of MRSA carrying the novel mecA homologue mecC. J Antimicrob Chemother, v. 70
    Doi: http://doi.org/10.1093/jac/dku512
  • Aiken, MJ., Hughes, TK., Abercromby, RH., Holmes, MA. and Anderson, AA., 2015. Prospective, Randomized Comparison of the Effect of Two Antimicrobial Regimes on Surgical Site Infection Rate in Dogs Undergoing Orthopedic Implant Surgery. Vet Surg, v. 44
    Doi: http://doi.org/10.1111/vsu.12327
  • Ba, X., Harrison, EM., Lovering, AL., Gleadall, N., Zadoks, R., Parkhill, J., Peacock, SJ., Holden, MTG., Paterson, GK. and Holmes, MA., 2015. Old Drugs To Treat Resistant Bugs: Methicillin-Resistant Staphylococcus aureus Isolates with mecC Are Susceptible to a Combination of Penicillin and Clavulanic Acid. Antimicrob Agents Chemother, v. 59
    Doi: http://doi.org/10.1128/AAC.01469-15
  • Hadjirin, NF., Lay, EM., Paterson, GK., Harrison, EM., Peacock, SJ., Parkhill, J., Zadoks, RN. and Holmes, MA., 2015. Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015 Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin, v. 20
  • Riggs, J., Jennings, JLF., Friend, EJ., Halfacree, Z., Nelissen, P., Holmes, MA. and Demetriou, JL., 2015. Outcome of full-thickness skin grafts used to close skin defects involving the distal aspects of the limbs in cats and dogs: 52 cases (2005-2012). J Am Vet Med Assoc, v. 247
    Doi: http://doi.org/10.2460/javma.247.9.1042
  • 2014

  • Paterson, GK., Morgan, FJE., Harrison, EM., Cartwright, EJP., Török, ME., Zadoks, RN., Parkhill, J., Peacock, SJ. and Holmes, MA., 2014. Prevalence and characterization of human mecC methicillin-resistant Staphylococcus aureus isolates in England. J Antimicrob Chemother, v. 69
    Doi: http://doi.org/10.1093/jac/dkt462
  • Concepción Porrero, M., Harrison, EM., Fernández-Garayzábal, JF., Paterson, GK., Díez-Guerrier, A., Holmes, MA. and Domínguez, L., 2014. Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water: a potential role for water in the environmental dissemination. Environ Microbiol Rep, v. 6
    Doi: http://doi.org/10.1111/1758-2229.12191
  • Harrison, EM., Paterson, GK., Holden, MTG., Ba, X., Rolo, J., Morgan, FJE., Pichon, B., Kearns, A., Zadoks, RN., Peacock, SJ., Parkhill, J. and Holmes, MA., 2014. A novel hybrid SCCmec-mecC region in Staphylococcus sciuri. J Antimicrob Chemother, v. 69
    Doi: http://doi.org/10.1093/jac/dkt452
  • Paterson, GK., Harrison, EM. and Holmes, MA., 2014. The emergence of mecC methicillin-resistant Staphylococcus aureus. Trends Microbiol, v. 22
    Doi: http://doi.org/10.1016/j.tim.2013.11.003
  • De Sousa, RJR., Knudsen, CS., Holmes, MA. and Langley-Hobbs, SJ., 2014. Quasi-isometric points for the technique of lateral suture placement in the feline stifle joint. Vet Surg, v. 43
    Doi: http://doi.org/10.1111/j.1532-950X.2014.12090.x
  • Paterson, GK., Harrison, EM. and Holmes, MA., 2014. The emergence of mecC methicillin-resistant Staphylococcus aureus Trends in Microbiology, v. 22
    Doi: http://doi.org/10.1016/j.tim.2013.11.003
  • Little, CJL., Ferasin, L., Ferasin, H. and Holmes, MA., 2014. Purring in cats during auscultation: how common is it, and can we stop it? J Small Anim Pract, v. 55
    Doi: http://doi.org/10.1111/jsap.12159
  • Hadjirin, NF., Harrison, EM., Holmes, MA. and Paterson, GK., 2014. Conjugative transfer frequencies of mef(A)-containing Tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types. Lett Appl Microbiol, v. 58
    Doi: http://doi.org/10.1111/lam.12213
  • Christiansen, MT., Kaas, RS., Chaudhuri, RR., Holmes, MA., Hasman, H. and Aarestrup, FM., 2014. Genome-wide high-throughput screening to investigate essential genes involved in methicillin-resistant Staphylococcus aureus Sequence Type 398 survival. PLoS One, v. 9
    Doi: http://doi.org/10.1371/journal.pone.0089018
  • De Sousa, RJR., Knudsen, CS., Holmes, MA. and Langley-Hobbs, SJ., 2014. Quasi-Isometric Points for the Technique of Lateral Suture Placement in the Feline Stifle Joint Veterinary Surgery, v. 43
    Doi: http://doi.org/10.1111/j.1532-950X.2014.12090.x
  • Harrison, EM., Weinert, LA., Holden, MTG., Welch, JJ., Wilson, K., Morgan, FJE., Harris, SR., Loeffler, A., Boag, AK., Peacock, SJ., Paterson, GK., Waller, AS., Parkhill, J. and Holmes, MA., 2014. A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals. mBio, v. 5
    Doi: http://doi.org/10.1128/mBio.00985-13
  • Paterson, GK., Morgan, FJE., Harrison, EM., Peacock, SJ., Parkhill, J., Zadoks, RN. and Holmes, MA., 2014. Prevalence and properties of mecC methicillin-resistant Staphylococcus aureus (MRSA) in bovine bulk tank milk in Great Britain. J Antimicrob Chemother, v. 69
    Doi: http://doi.org/10.1093/jac/dkt417
  • Gómez Selgas, A., Bexfield, N., Scase, TJ., Holmes, MA. and Watson, P., 2014. Total serum bilirubin as a negative prognostic factor in idiopathic canine chronic hepatitis. J Vet Diagn Invest, v. 26
    Doi: http://doi.org/10.1177/1040638713520602
  • Prenafeta, A., Sitjà, M., Holmes, MA. and Paterson, GK., 2014. Short communication: biofilm production characterization of mecA and mecC methicillin-resistant Staphylococcus aureus isolated from bovine milk in Great Britain. J Dairy Sci, v. 97
    Doi: http://doi.org/10.3168/jds.2014-7986
  • Skov, R., Larsen, AR., Kearns, A., Holmes, M., Teale, C., Edwards, G. and Hill, R., 2014. Phenotypic detection of mecC-MRSA: cefoxitin is more reliable than oxacillin Journal of Antimicrobial Chemotherapy, v. 69
    Doi: 10.1093/jac/dkt341
  • Hadjirin, NF., Harrison, EM., Holmes, MA. and Paterson, GK., 2014. Conjugative transfer frequencies of mef(A)-containing tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types Letters in Applied Microbiology, v. 58
    Doi: http://doi.org/10.1111/lam.12213
  • Ba, X., Harrison, EM., Edwards, GF., Holden, MTG., Larsen, AR., Petersen, A., Skov, RL., Peacock, SJ., Parkhill, J., Paterson, GK. and Holmes, MA., 2014. Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene. J Antimicrob Chemother, v. 69
    Doi: http://doi.org/10.1093/jac/dkt418
  • Prenafeta, A., Sitjà, M., Holmes, MA. and Paterson, GK., 2014. Short communication: Biofilm production characterization of mecA and mecC methicillin-resistant Staphylococcus aureus isolated from bovine milk in Great Britain Journal of Dairy Science, v. 97
    Doi: http://doi.org/10.3168/jds.2014-7986
  • 2013

  • Freeman, PM., Holmes, MA., Jeffery, ND. and Granger, N., 2013. Time requirement and effect on owners of home-based management of dogs with severe chronic spinal cord injury Journal of Veterinary Behavior: Clinical Applications and Research, v. 8
    Doi: http://doi.org/10.1016/j.jveb.2013.06.001
  • Harrison, EM., Paterson, GK., Holden, MTG., Morgan, FJE., Larsen, AR., Petersen, A., Leroy, S., De Vliegher, S., Perreten, V., Fox, LK., Lam, TJGM., Sampimon, OC., Zadoks, RN., Peacock, SJ., Parkhill, J. and Holmes, MA., 2013. A Staphylococcus xylosus isolate with a new mecC allotype. Antimicrob Agents Chemother, v. 57
    Doi: http://doi.org/10.1128/AAC.01882-12
  • Rousset, N., Holmes, MA., Caine, A., Dobson, J. and Herrtage, ME., 2013. Clinical and low-field mri characteristics of injection site sarcoma in 19 cats Veterinary Radiology and Ultrasound, v. 54
    Doi: http://doi.org/10.1111/vru.12067
  • Harrison, EM., Paterson, GK., Holden, MTG., Larsen, J., Stegger, M., Larsen, AR., Petersen, A., Skov, RL., Christensen, JM., Bak Zeuthen, A., Heltberg, O., Harris, SR., Zadoks, RN., Parkhill, J., Peacock, SJ. and Holmes, MA., 2013. Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC EMBO Molecular Medicine, v. 5
    Doi: http://doi.org/10.1002/emmm.201202413
  • Cartwright, EJP., Paterson, GK., Raven, KE., Harrison, EM., Gouliouris, T., Kearns, A., Pichon, B., Edwards, G., Skov, RL., Larsen, AR., Holmes, MA., Parkhill, J., Peacock, SJ. and Török, ME., 2013. Use of Vitek 2 antimicrobial susceptibility profile to identify mecC in methicillin-resistant Staphylococcus aureus. J Clin Microbiol, v. 51
    Doi: http://doi.org/10.1128/JCM.00847-13
  • Becker, K., Larsen, AR., Skov, RL., Paterson, GK., Holmes, MA., Sabat, AJ., Friedrich, AW., Koc̈k, R., Peters, G. and Kriegeskorte, A., 2013. Evaluation of a modular multiplex-PCR methicillin-resistant staphylococcus aureus detection assay adapted for mecC detection Journal of Clinical Microbiology, v. 51
    Doi: http://doi.org/10.1128/JCM.00075-13
  • Rousset, N., Holmes, MA., Caine, A., Dobson, J. and Herrtage, ME., 2013. Clinical and low-field MRI characteristics of injection site sarcoma in 19 cats. Vet Radiol Ultrasound, v. 54
    Doi: http://doi.org/10.1111/vru.12067
  • Freeman, PM., Holmes, MA., Jeffery, ND. and Granger, N., 2013. Time requirement and effect on owners of home-based management of dogs with severe chronic spinal cord injury Journal of Veterinary Behavior: Clinical Applications and Research,
  • Paterson, GK., Harrison, EM., Craven, EF., Petersen, A., Larsen, AR., Ellington, MJ., Török, ME., Peacock, SJ., Parkhill, J., Zadoks, RN. and Holmes, MA., 2013. Incidence and characterisation of methicillin-resistant Staphylococcus aureus (MRSA) from nasal colonisation in participants attending a cattle veterinary conference in the UK. PLoS One, v. 8
    Doi: http://doi.org/10.1371/journal.pone.0068463
  • Hall, JL., Holmes, MA. and Baines, SJ., 2013. Prevalence and antimicrobial resistance of canine urinary tract pathogens. Vet Rec, v. 173
    Doi: http://doi.org/10.1136/vr.101482
  • 2012

  • Pichon, B., Hill, R., Laurent, F., Larsen, AR., Skov, RL., Holmes, MA., Edwards, GF., Teale, C. and Kearns, AM., 2012. Development of a real-time quadruplex PCR assay for simultaneous detection of nuc, Panton-Valentine leucocidin (PVL), mecA and homologue mecALGA251 J Antimicrob Chemother,
    Doi: http://doi.org/10.1093/jac/dks221
  • Kim, C., Milheiriço, C., Gardete, S., Holmes, MA., Holden, MTG., De Lencastre, H. and Tomasz, A., 2012. Properties of a novel PBP2A protein homolog from staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype Journal of Biological Chemistry, v. 287
    Doi: http://doi.org/10.1074/jbc.M112.395962
  • Paterson, GK., Larsen, J., Harrison, EM., Larsen, AR., Morgan, FJ., Peacock, SJ., Parkhill, J., Zadoks, RN. and Holmes, MA., 2012. First detection of livestock-associated meticillin-resistant Staphylococcus Aureus CC398 in bulk tank milk in the United Kingdom, January to July 2012 Eurosurveillance, v. 17
  • Holmes, MA., 2012. Systematic reviews in small animal veterinary medicine: what are they and why do we need them? J Small Anim Pract, v. 53
    Doi: http://doi.org/10.1111/j.1748-5827.2011.01194.x
  • Stegger, M., Andersen, PS., Kearns, A., Pichon, B., Holmes, MA., Edwards, G., Laurent, F., Teale, C., Skov, R. and Larsen, AR., 2012. Rapid detection, differentiation and typing of methicillin-resistant Staphylococcus aureus harbouring either mecA or the new mecA homologue mecA(LGA251). Clin Microbiol Infect, v. 18
    Doi: http://doi.org/10.1111/j.1469-0691.2011.03715.x
  • Paterson, GK., Larsen, AR., Robb, A., Edwards, GE., Pennycott, TW., Foster, G., Mot, D., Hermans, K., Baert, K., Peacock, SJ., Parkhill, J., Zadoks, RN. and Holmes, MA., 2012. The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species. J Antimicrob Chemother, v. 67
    Doi: http://doi.org/10.1093/jac/dks329
  • 2011 (No publication date)

  • Constantino Casas, F., Constantino-Casas, F., Belshaw, Z., Dobson, JM., Holmes, MA., Dunning, MD. and Brearley, MJ., 2011 (No publication date). COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy Veterinary and Comparative Oncology,
    Doi: http://doi.org/10.1111/j.1476-5829.2010.00243.x
  • 2011

  • Belshaw, Z., Constantio-Casas, F., Brearley, MJ., Dunning, MD., Holmes, MA. and Dobson, JM., 2011. COX-2 expression and outcome in canine nasal carcinomas treated with hypofractionated radiotherapy. Vet Comp Oncol, v. 9
    Doi: http://doi.org/10.1111/j.1476-5829.2010.00243.x
  • García-Álvarez, L., Holden, MTG., Lindsay, H., Webb, CR., Brown, DFJ., Curran, MD., Walpole, E., Brooks, K., Pickard, DJ., Teale, C., Parkhill, J., Bentley, SD., Edwards, GF., Girvan, EK., Kearns, AM., Pichon, B., Hill, RLR., Larsen, AR., Skov, RL., Peacock, SJ., Maskell, DJ. and Holmes, MA., 2011. Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. Lancet Infect Dis, v. 11
    Doi: 10.1016/S1473-3099(11)70126-8
  • Holmes, MA. and Zadoks, RN., 2011. Methicillin Resistant S. aureus in Human and Bovine Mastitis Journal of Mammary Gland Biology and Neoplasia,
  • García Álvarez, L., Webb, CR. and Holmes, MA., 2011. A novel field-based approach to validate the use of network models for disease spread between dairy herds. Epidemiol Infect, v. 139
    Doi: http://doi.org/10.1017/S0950268811000070
  • Holmes, MA., 2011. MRSA found in dairy cows and people in Europe Cattle Practice, v. 19
  • 2010

  • Holmes, M. and Jeffcott, L., 2010. Equitation science, rider effects, saddle and back problems in horses: can technology provide the answer? Vet J, v. 184
    Doi: http://doi.org/10.1016/j.tvjl.2009.07.036
  • Lucianez, A., Holmes, MA. and Tucker, AW., 2010. Relationships between Processing Delay and Microbial Load of Broiler Neck Skin Samples J FOOD PROTECT, v. 73
  • Tatton, B., Holmes, M. and Jeffrey, N., 2010. Author Response Journal of Small Animal Practice, v. 51
    Doi: http://doi.org/10.1111/j.1748-5827.2010.00920.x
  • 2009

  • Tatton, B., Jeffery, N. and Holmes, M., 2009. Predicting recovery of urination control in cats after sacrocaudal injury: a prospective study. J Small Anim Pract, v. 50
    Doi: http://doi.org/10.1111/j.1748-5827.2009.00770.x
  • Holmes, M., 2009. Practice-based clinical research: An introduction In Practice, v. 31
    Doi: http://doi.org/10.1136/inpract.31.10.520
  • Holmes, MA., 2009. Philosophical foundations of evidence-based medicine for veterinary clinicians. J Am Vet Med Assoc, v. 235
    Doi: http://doi.org/10.2460/javma.235.9.1035
  • Carruthers, H., Rusbridge, C., Dubé, M-P., Holmes, M. and Jeffery, N., 2009. Association between cervical and intracranial dimensions and syringomyelia in the cavalier King Charles spaniel. J Small Anim Pract, v. 50
    Doi: http://doi.org/10.1111/j.1748-5827.2009.00768.x
  • 2007

  • Holmes, M., 2007. Practice-based research [7] Veterinary Record, v. 160
    Doi: http://doi.org/10.1136/vr.160.3.100-b
  • Holmes, MA., 2007. Evaluation of the evidence. Vet Clin North Am Small Anim Pract, v. 37
    Doi: http://doi.org/10.1016/j.cvsm.2007.01.004
  • Holmes, MA., 2007. Does dantrolene sodium prevent recurrent exertional rhabdomyolysis in horses? EQUINE VET EDUC, v. 19
    Doi: http://doi.org/10.2746/095777307X180934
  • Holmes, MA. and Ramey, DW., 2007. An introduction to evidence-based veterinary medicine VET CLIN N AM-EQUINE, v. 23
    Doi: http://doi.org/10.1016/j.cveq.2007.03.001
  • Holmes, MA., 2007. Evidence for best veterinary practice: Clinical veterinary research J VET INTERN MED, v. 21
  • Rusbridge, C., Carruthers, H., Dubé, M-P., Holmes, M. and Jeffery, ND., 2007. Syringomyelia in cavalier King Charles spaniels: the relationship between syrinx dimensions and pain. J Small Anim Pract, v. 48
    Doi: http://doi.org/10.1111/j.1748-5827.2007.00344.x
  • Cockcroft, PD. and Holmes, MA., 2007. An introduction to practice-based veterinary clinical research IRISH VET J, v. 60
  • Holmes, M., 2007. 'Not guilty' but not necessarily 'innocent': a clinician's guide to negative trial results in the veterinary literature. J Small Anim Pract, v. 48
    Doi: http://doi.org/10.1111/j.1748-5827.2006.00328.x
  • 2006

  • Holmes, MA., Townsend, HGG., Kohler, AK., Hussey, S., Breathnach, C., Barnett, C., Holland, R. and Lunn, DP., 2006. Immune responses to commercial equine vaccines against equine herpesvirus-1, equine influenza virus, eastern equine encephalomyelitis, and tetanus. Vet Immunol Immunopathol, v. 111
    Doi: http://doi.org/10.1016/j.vetimm.2006.01.010
  • Wood, J., Holmes, M., Mumford, J. and Maskell, D., 2006. Practitioners' views. Vet Rec, v. 159
    Doi: 10.1136/vr.159.15.500-a
  • Holmes, M., 2006. Practice-based clinical research. Vet Rec, v. 158
    Doi: http://doi.org/10.1136/vr.158.5.176
  • 2005

  • Holmes, MA., Cockcroft, PD., Booth, CE. and Heath, MF., 2005. Controlled clinical trial of the effect of a homoeopathic nosode on the somatic cell counts in the milk of clinically normal dairy cows. Vet Rec, v. 156
    Doi: http://doi.org/10.1136/vr.156.18.565
  • 2004

  • Cockcroft, P. and Holmes, M., 2004. Evidence-based veterinary medicine: 2. Identifying information needs and finding the evidence In Practice, v. 26
    Doi: http://doi.org/10.1136/inpract.26.2.96
  • Rossdale, PD., Holmes, MA., Jeffcott, LB., Marr, CM. and May, SA., 2004. Home of rest for horses clinical evidence literary award Equine Veterinary Journal, v. 36
  • Holmes, M. and Cockcroft, P., 2004. Evidence-based veterinary medicine 1. Why is it important and what skills are needed? In Practice, v. 26
    Doi: http://doi.org/10.1136/inpract.26.1.28
  • Holmes, M. and Cockcroft, P., 2004. Evidence-based veterinary medicine 3. Appraising the evidence In Practice, v. 26
    Doi: http://doi.org/10.1136/inpract.26.3.154
  • 2003

  • Ware, S., Harwood, D., Love, S., Boswood, A., Holmes, M., Scott, A., Lewis, K., MacDonald, D. and Reid, I., 2003. 'Tour de Vets' [4] Veterinary Record, v. 153
  • Rossdale, PD., Jeffcott, LB. and Holmes, MA., 2003. Clinical evidence: an avenue to evidence-based medicine EQUINE VET J, v. 35
  • 2000

  • Sheoran, AS., Timoney, JF., Holmes, MA., Karzenski, SS. and Crisman, MV., 2000. Immunoglobulin isotypes in sera and nasal mucosal secretions and their neonatal transfer and distribution in horses AM J VET RES, v. 61
  • Aggarwal, N. and Holmes, MA., 2000. Production and characterisation of two monoclonal antibodies recognising equine IgG Fc receptors. Vet Immunol Immunopathol, v. 73
    Doi: http://doi.org/10.1016/s0165-2427(99)00153-1
  • 1999

  • Aggarwal, N. and Holmes, MA., 1999. Characterisation of equine T helper cells: demonstration of Th1- and Th2-like cells in long-term equine T-cell cultures. Res Vet Sci, v. 66
    Doi: http://doi.org/10.1053/rvsc.1998.0256
  • Jeffcott, LB., Holmes, MA. and Townsend, HG., 1999. Validity of saddle pressure measurements using force-sensing array technology--preliminary studies. Vet J, v. 158
    Doi: http://doi.org/10.1053/tvjl.1998.0334
  • 1998

  • Sheoran, AS., Lunn, DP. and Holmes, MA., 1998. Monoclonal antibodies to subclass-specific antigenic determinants on equine immunoglobulin gamma chains and their characterization. Vet Immunol Immunopathol, v. 62
    Doi: http://doi.org/10.1016/s0165-2427(97)00162-1
  • Scholes, SFE., Holliman, A., May, PDF. and Holmes, MA., 1998. A syndrome of anaemia, immunodeficiency and peripheral ganglionopathy in Fell pony foals VET REC, v. 142
  • Lunn, DP., Holmes, MA., Antczak, DF., Agerwal, N., Baker, J., Bendali-Ahcene, S., Blanchard-Channell, M., Byrne, KM., Cannizzo, K., Davis, W., Hamilton, MJ., Hannant, D., Kondo, T., Kydd, JH., Monier, MC., Moore, PF., O'Neil, T., Schram, BR., Sheoran, A., Stott, JL., Sugiura, T. and Vagnoni, KE., 1998. Report of the Second Equine Leucocyte Antigen Workshop, Squaw Valley, California, July 1995 VET IMMUNOL IMMUNOP, v. 62
  • Wagner, B., Overesch, G., Sheoran, AS., Holmes, MA., Richards, C., Leibold, W. and Radbruch, A., 1998. Organization of the equine immunoglobulin heavy chain constant region genes; III. Alignment of c mu, c gamma, c epsilon and c alpha genes IMMUNOBIOLOGY, v. 199
  • 1997

  • Proudman, CJ., Holmes, MA., Sheoran, AS., Edwards, SER. and Trees, AJ., 1997. Immunoepidemiology of the equine tapeworm Anoplocephala perfoliata: Age-intensity profile and age-dependency of antibody subtype responses PARASITOLOGY, v. 114
  • Prescott, JF., Nicholson, VM., Patterson, MC., Meleiro, MCZ., deAraujo, AC., Yager, JA. and Holmes, MA., 1997. Use of Rhodococcus equi virulence-associated protein for immunization of foals against R-equi pneumonia AM J VET RES, v. 58
  • Byrne, KM., Davis, WC., Holmes, MA., Brassfield, AL. and McGuire, TC., 1997. Cytokine RNA expression in an equine CD4+ subset differentiated by expression of a novel 46-kDa surface protein VET IMMUNOL IMMUNOP, v. 56
  • Wagner, B., Brandt, K., Sheoran, A., Holmes, MA., Deegen, E. and Leibold, W., 1997. Immunoglobulin isotypes in the vitreous of horses with and without recurrent uveitis. DEUT TIERARZTL WOCH, v. 104
  • Sheoran, AS., Sponseller, BT., Holmes, MA. and Timoney, JF., 1997. Serum and mucosal antibody isotype responses to M-like protein (SeM) of Streptococcus equi in convalescent and vaccinated horses VET IMMUNOL IMMUNOP, v. 59
  • Prescott, J., Holmes, M., Yager, J. and Takal, S., 1997. An overview of the havemeyer foundation workshop on 'Rhodococcus equi and neonatal immunology of the foal' Veterinary Microbiology, v. 56
    Doi: http://doi.org/10.1016/S0378-1135(97)00084-9
  • 1996

  • Holmes, MA. and Nicholls, PK., 1996. Computer-aided veterinary learning at the University of Cambridge. Vet Rec, v. 138
    Doi: http://doi.org/10.1136/vr.138.9.199
  • Sheoran, AS. and Holmes, MA., 1996. Separation of equine IgG subclasses (IgGa, IgGb and IgG(T)) using their differential binding characteristics for staphylococcal protein A and streptococcal protein G. Vet Immunol Immunopathol, v. 55
    Doi: http://doi.org/10.1016/s0165-2427(96)05618-8
  • Lunn, DP., Holmes, MA. and Antczak, DF., 1996. Summary Report of the Second Equine Leucocyte Antigen Workshop VET IMMUNOL IMMUNOP, v. 54
  • 1995

  • Lunn, DP., McClure, JT., Schobert, CS. and Holmes, MA., 1995. Abnormal patterns of equine leucocyte differentiation antigen expression in severe combined immunodeficiency foals suggests the phenotype of normal equine natural killer cells. Immunology, v. 84
  • Holmes, M., 1995. The greatest thing since the invention of printing! J Small Anim Pract, v. 36
    Doi: http://doi.org/10.1111/j.1748-5827.1995.tb02781.x
  • Lunn, DP., Holmes, MA., Schram, B. and Duffus, WPH., 1995. Monoclonal antibodies specific for equine IgG sub-isotypes including an antibody which recognizes B lymphocytes Veterinary Immunology and Immunopathology, v. 47
    Doi: http://doi.org/10.1016/0165-2427(95)97067-J
  • JOHNSTON, GM., TAYLOR, PM., HOLMES, MA. and WOOD, JLN., 1995. CONFIDENTIAL INQUIRY OF PERIOPERATIVE EQUINE FATALITIES (CEPEF-1) - PRELIMINARY-RESULTS EQUINE VET J, v. 27
  • 1994

  • Holmes, MA. and Lunn, DP., 1994. Variation of MHC II expression on canine lymphocytes with age. Tissue Antigens, v. 43
    Doi: http://doi.org/10.1111/j.1399-0039.1994.tb02319.x
  • PILSWORTH, RC., SHEPHERD, MC., HERINCKX, BMB. and HOLMES, MA., 1994. FRACTURE OF THE WING OF THE ILIUM, ADJACENT TO THE SACROILIAC JOINT, IN THOROUGHBRED RACEHORSES EQUINE VET J, v. 26
  • Cobbold, S., Holmes, M. and Willett, B., 1994. The immunology of companion animals: reagents and therapeutic strategies with potential veterinary and human clinical applications. Immunol Today, v. 15
    Doi: http://doi.org/10.1016/0167-5699(94)90171-6
  • 1993

  • HOLMES, MA., 1993. Advances in equine immunology Equine Veterinary Education, v. 5
    Doi: http://doi.org/10.1111/j.2042-3292.1993.tb00978.x
  • Lunn, DP., Holmes, MA. and Duffus, WP., 1993. Equine T-lymphocyte MHC II expression: variation with age and subset. Vet Immunol Immunopathol, v. 35
    Doi: http://doi.org/10.1016/0165-2427(93)90036-4
  • HOLMES, MA., 1993. AN IMPORTANT MILESTONE IN EQUINE IMMUNOLOGY - EQUINE INTERLEUKIN-2 EQUINE VET J, v. 25
  • HOLMES, MA., 1993. CALF PNEUMONIA IRISH VET J, v. 46
  • PILSWORTH, RC., HOLMES, MA. and SHEPHERD, M., 1993. AN IMPROVED METHOD FOR THE SCINTIGRAPHIC DETECTION OF ACUTE BONE DAMAGE TO THE EQUINE PELVIS BY PROBE POINT COUNTING VET REC, v. 133
  • 1992

  • O'Brien, MA., Holmes, MA. and Duffus, WPH., 1992. In vitro production of specific antibody by equine peripheral blood mononuclear cells using tetanus toxoid as a recall antigen Research in Veterinary Science, v. 53
    Doi: http://doi.org/10.1016/0034-5288(92)90108-E
  • O'Brien, MA., Holmes, MA. and Duffus, WP., 1992. In vitro production of specific antibody by equine peripheral blood mononuclear cells using tetanus toxoid as a recall antigen. Res Vet Sci, v. 53
    Doi: http://doi.org/10.1016/0034-5288(92)90108-e
  • 1991

  • Lunn, DP., Holmes, MA. and Duffus, WP., 1991. Three monoclonal antibodies identifying antigens on all equine T lymphocytes, and two mutually exclusive T-lymphocyte subsets. Immunology, v. 74
  • Holmes, MA. and Lunn, DP., 1991. A study of bovine and equine immunoglobulin levels in pony foals fed bovine colostrum. Equine Vet J, v. 23
    Doi: http://doi.org/10.1111/j.2042-3306.1991.tb02734.x
  • O'Brien, MA., Holmes, MA., Lunn, DP. and Duffus, WPH., 1991. Evidence for MHC class‐l restricted cytotoxicity in the one‐way, primary mixed lymphocyte reaction Equine Veterinary Journal, v. 23
    Doi: http://doi.org/10.1111/j.2042-3306.1991.tb04754.x
  • HOLMES, MA., 1991. THE EPIDEMIOLOGY AND POSSIBLE MHC LINKAGE OF CULICOIDES HYPERSENSITIVITY EQUINE VET J, v. 23
  • Lunn, DP., Holmes, MA., Gibson, J., Field, HJ., Kydd, JH. and Duffus, WPH., 1991. Haematological changes and equine lymphocyte subpopulation kinetics during primary infection and attempted re‐infection of specific pathogen free foals with EHV‐1 Equine Veterinary Journal, v. 23
    Doi: http://doi.org/10.1111/j.2042-3306.1991.tb04755.x
  • HOLMES, M., 1991. Equine immunology into the '90s Equine Veterinary Journal, v. 23
    Doi: http://doi.org/10.1111/j.2042-3306.1991.tb04748.x
  • 1990

  • Holmes, M., 1990. Culicoides hypersensitivity. Equine Vet J, v. 22
    Doi: http://doi.org/10.1111/j.2042-3306.1990.tb04257.x
  • 1989

  • Holmes, MA., Duffus, WP. and Gorman, NT., 1989. Natural cytotoxicity in the dog: description of two new allogeneic tumour targets. Vet Immunol Immunopathol, v. 23
    Doi: http://doi.org/10.1016/0165-2427(89)90118-9
  • Gerring, EL., Holmes, MA., Rossdale, PD. and Wade, JF., 1989. WELCOME TO EVE! Equine Veterinary Education, v. 1
    Doi: http://doi.org/10.1111/j.2042-3292.1989.tb01325.x
  • Gerring, EL., Holmes, MA., Rossdale, PD. and Wade, JF., 1989. Editorial Equine Veterinary Education, v. 1
    Doi: http://doi.org/10.1111/j.2042-3292.1989.tb01344.x
  • Datasets

    2022 (No publication date)

  • Kalmar, L., Gupta, S., Kean, I., Ba, X., Hadjirin, N., Lay, E., de Vries, S., Bateman, M., Bartlett, H., Hernandez-Garcia, J., Tucker, A., Restiff, O., Stevens, M., Wood, J., Maskell, D., Grant, A. and Holmes, M., 2022 (No publication date). Final Hi-C metagenomics assemblies from faecal samples on high- and low-antibiotics usage farms
  • Theses / dissertations

    2022 (No publication date)

  • Achi, C., 2022 (No publication date). Genomic diversity and antimicrobial resistance in Salmonella isolates recovered from diverse sources in Nigeria
  • 2022

  • Matuszewska, M., 2022. Genomic insights into the host range and interspecies transmission dynamics of Staphylococcus aureus
  • Book chapters

    2015

  • Holmes, MA., 2015. Practice-Based Clinical Research
  • Books

    2008

  • Holmes, MA. and Cockcroft, PD., 2008. Handbook of Veterinary Clinical Research
  • 2003

  • Holmes, MA. and Cockcroft, PD., 2003. Handbook of Evidence-based Veterinary Medicine
  • Conference proceedings

    1997

  • Wagner, B., Overesch, G., Sheoran, A., Holmes, MA., Richards, C., Leibold, W. and Radbruch, A., 1997. Organization of the equine immunoglobulin heavy chain constant region genes Immunobiology, v. 197
  • 1994

  • KYDD, J., ANTCZAK, DF., ALLEN, WR., BARBIS, D., BUTCHER, G., DAVIS, W., DUFFUS, WPH., EDINGTON, N., GRUNIG, G., HOLMES, MA., LUNN, DP., MCCULLOCH, J., OBRIEN, A., PERRYMAN, LE., TAVERNOR, A., WILLIAMSON, S. and ZHANG, C., 1994. REPORT OF THE FIRST INTERNATIONAL WORKSHOP ON EQUINE LEUKOCYTE ANTIGENS, CAMBRIDGE, UK, JULY 1991 VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 42
  • LUNN, DP., HOLMES, MA. and DUFFUS, WPH., 1994. POLYMORPHIC EXPRESSION OF AN EQUINE T-LYMPHOCYTE AND NEUTROPHIL SUBSET MARKER VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, v. 42