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Cambridge Public Health

 

I am a postdoctoral scientist who is passionate about science public policy and the importance of research in informing the public about managing infectious disease. My research has applied molecular virology to a range of important pathogens causing chronic infection and disease in both humans and animals, with particular emphasis on the role of RNA structures in the virus lifecycle and transmission.
In 2014 I applied my skillset to public health as part of the West Africa Ebola virus emergency response, where I performed diagnostic tests by multiplex qRT-PCR and gained insight into aspects of science public policy. I would be keen to discuss opportunities to apply my scientific knowledge and research skills to better public health or scientific policy.

Publications from Elements

Journal articles

2023 (Accepted for publication)

  • Stewart, H., Lu, Y., O’Keefe, S., Valpadashi, A., Cruz-Zaragoza, LD., Michel, HA., Nguyen, SK., Carnell, GW., Lukhovitskaya, N., Milligan, R., Adewusi, Y., Jungreis, I., Lulla, V., Matthews, DA., High, S., Rehling, P., Emmott, E., Heeney, JL., Davidson, AD., Edgar, JR., Smith, GL. and Firth, AE., 2023 (Accepted for publication). The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity iScience,
    Doi: http://doi.org/10.1016/j.isci.2023.108080
  • Stewart, H., Johansen, KH., McGovern, N., Palmulli, R., Carnell, GW., Heeney, JL., Okkenhaug, K., Firth, AE., Peden, AA. and Edgar, JR., 2023 (Accepted for publication). Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release EMBO Reports,
    Doi: 10.15252/embr.202357224
  • Vishwanath, S., 2023 (Accepted for publication). A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses Nature Biomedical Engineering,
  • 2023

  • Ali, YM., Carnell, GW., Fumagalli, S., Mercurio, D., Seminara, S., Lynch, NJ., Khatri, P., Arachchilage, CH., Mascheroni, L., Kaminski, C., George, CL., Stewart, H., Yabuki, M., Demopulos, G., Heeney, JL. and Schwaeble, W., 2023. Inhibition of the lectin pathway of complement activation reduces Acute Respiratory Distress Syndrome severity in a mouse model of SARS-CoV-2 infection. J Infect Dis,
    Doi: http://doi.org/10.1093/infdis/jiad462
  • 2022

  • Scherer, KM., Mascheroni, L., Carnell, GW., Wunderlich, LCS., Makarchuk, S., Brockhoff, M., Mela, I., Fernandez-Villegas, A., Barysevich, M., Stewart, H., Suau Sans, M., George, CL., Lamb, JR., Kaminski-Schierle, GS., Heeney, JL. and Kaminski, CF., 2022. SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress. Sci Adv, v. 8
    Doi: http://doi.org/10.1126/sciadv.abl4895
  • Khan, YA., Loughran, G., Steckelberg, A-L., Brown, K., Kiniry, SJ., Stewart, H., Baranov, PV., Kieft, JS., Firth, AE. and Atkins, JF., 2022. Evaluating ribosomal frameshifting in CCR5 mRNA decoding. Nature, v. 604
    Doi: http://doi.org/10.1038/s41586-022-04627-y
  • Parker, MD., Stewart, H., Shehata, OM., Lindsey, BB., Shah, DR., Hsu, S., Keeley, AJ., Partridge, DG., Leary, S., Cope, A., State, A., Johnson, K., Ali, N., Raghei, R., Heffer, J., Smith, N., Zhang, P., Gallis, M., Louka, SF., Hornsby, HR., Alamri, H., Whiteley, M., Foulkes, BH., Christou, S., Wolverson, P., Pohare, M., Hansford, SE., Green, LR., Evans, C., Raza, M., Wang, D., Firth, AE., Edgar, JR., Gaudieri, S., Mallal, S., COVID-19 Genomics UK (COG-UK) consortium, , Collins, MO., Peden, AA. and de Silva, TI., 2022. Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections. Commun Biol, v. 5
    Doi: http://doi.org/10.1038/s42003-022-03565-9
  • 2021 (Accepted for publication)

  • Scherer, K., Mascheroni, L., Carnell, G., Wunderlich, L., Makarchuk, S., Brockhoff, M., Mela, I., Fernandez-Villegas, A., Barysevich, M., Stewart, H., Sans, MS., George, C., Lamb, J., Kaminski-Schierle, G., Heeney, J. and Kaminski, C., 2021 (Accepted for publication). SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress Science Advances, v. 8
    Doi: http://doi.org/10.1126/sciadv.abl4895
  • 2019

  • Lattimer, J., Stewart, H., Locker, N., Tuplin, A., Stonehouse, NJ. and Harris, M., 2019. Structure-function analysis of the equine hepacivirus 5' untranslated region highlights the conservation of translational mechanisms across the hepaciviruses. J Gen Virol, v. 100
    Doi: http://doi.org/10.1099/jgv.0.001316
  • 2018 (Accepted for publication)

  • Firth, AE., Stewart, H., Brown, K., Dinan, A., Irigoyen, N. and Snijder, E., 2018 (Accepted for publication). The transcriptional and translational landscape of equine torovirus Journal of Virology,
  • Firth, AE., Stewart, H., Olspert, A. and Butt, B., 2018 (Accepted for publication). Propensity of a picornavirus polymerase to slip on potyvirus-derived transcriptional slippage sites Journal of General Virology,
  • 2018

  • Stewart, H., Brown, K., Dinan, A., Irigoyen, N., Snijder, E. and Firth, A., 2018. The transcriptional and translational landscape of equine torovirus
    Doi: http://doi.org/10.1101/296996
  • Yin, C., Goonawardane, N., Stewart, H. and Harris, M., 2018. A role for domain I of the hepatitis C virus NS5A protein in virus assembly. PLoS Pathog, v. 14
    Doi: http://doi.org/10.1371/journal.ppat.1006834
  • 2016

  • Stewart, H., Bingham, RJ., White, SJ., Dykeman, EC., Zothner, C., Tuplin, AK., Stockley, PG., Twarock, R. and Harris, M., 2016. Identification of novel RNA secondary structures within the hepatitis C virus genome reveals a cooperative involvement in genome packaging. Sci Rep, v. 6
    Doi: http://doi.org/10.1038/srep22952
  • Mankouri, J., Walter, C., Stewart, H., Bentham, M., Park, WS., Heo, WD., Fukuda, M., Griffin, S. and Harris, M., 2016. Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion. J Virol, v. 90
    Doi: http://doi.org/10.1128/JVI.00826-16
  • 2015

  • Stewart, H., Bartlett, C., Ross-Thriepland, D., Shaw, J., Griffin, S. and Harris, M., 2015. A novel method for the measurement of hepatitis C virus infectious titres using the IncuCyte ZOOM and its application to antiviral screening. J Virol Methods, v. 218
    Doi: http://doi.org/10.1016/j.jviromet.2015.03.009
  • 2013

  • Stewart, H., Jarrett, O., Hosie, MJ. and Willett, BJ., 2013. Complete genome sequences of two feline leukemia virus subgroup B isolates with novel recombination sites. Genome Announc, v. 1
    Doi: http://doi.org/10.1128/genomeA.00036-12
  • Stewart, H., Walter, C., Jones, D., Lyons, S., Simmonds, P. and Harris, M., 2013. The non-primate hepacivirus 5' untranslated region possesses internal ribosomal entry site activity. J Gen Virol, v. 94
    Doi: http://doi.org/10.1099/vir.0.055764-0
  • 2012

  • Stewart, H., Adema, KW., McMonagle, EL., Hosie, MJ. and Willett, BJ., 2012. Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus. Retrovirology, v. 9
    Doi: http://doi.org/10.1186/1742-4690-9-48
  • 2011

  • Stewart, H., Jarrett, O., Hosie, MJ. and Willett, BJ., 2011. Are endogenous feline leukemia viruses really endogenous? Vet Immunol Immunopathol, v. 143
    Doi: http://doi.org/10.1016/j.vetimm.2011.06.011
  • 2010

  • Miyazawa, T., Yoshikawa, R., Golder, M., Okada, M., Stewart, H. and Palmarini, M., 2010. Isolation of an infectious endogenous retrovirus in a proportion of live attenuated vaccines for pets. J Virol, v. 84
    Doi: http://doi.org/10.1128/JVI.02715-09