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Cambridge Public Health

 

My research interests lie in how computational approaches can be used to understand the relationship between protein sequence, protein structure and biological function and disease. My research has focused on many aspects of computational structural bioinformatics, including both the development of new algorithms and the application of these techniques to predict the effect genetic sequence variations have on the structure, dynamics, folding and function of proteins and their involvement in the onset and proliferation of disease. I am currently applying these aprroaches to strain variation in the Influenza virus and other infectious diseases.

Publications from Elements

Journal articles

2019 (Accepted for publication)

  • Linster, M., Schrauwen, EJA., van der Vliet, S., Burke, DF., Lexmond, P., Bestebroer, TM., Smith, DJ., Herfst, S., Koel, BF. and Fouchier, RAM., 2019 (Accepted for publication). The molecular basis for antigenic drift of human A/H2N2 influenza viruses Journal of Virology,
    Doi: http://doi.org/10.1128/jvi.01907-18
  • 2019

  • Gao, J., Couzens, L., Burke, DF., Wan, H., Wilson, P., Memoli, MJ., Xu, X., Harvey, R., Wrammert, J., Ahmed, R., Taubenberger, JK., Smith, DJ., Fouchier, RAM. and Eichelberger, MC., 2019. Antigenic Drift of the Influenza A(H1N1)pdm09 Virus Neuraminidase Results in Reduced Effectiveness of A/California/7/2009 (H1N1pdm09)-Specific Antibodies. MBio, v. 10
    Doi: http://doi.org/10.1128/mBio.00307-19
  • Koel, BF., Burke, DF., van der Vliet, S., Bestebroer, TM., Rimmelzwaan, GF., Osterhaus, ADME., Smith, DJ. and Fouchier, RAM., 2019. Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virus Journal of General Virology,
    Doi: http://doi.org/10.1099/jgv.0.001263
  • 2018 (Accepted for publication)

  • Burke, DF., 2018 (Accepted for publication). Antigenic characterization of highly pathogenic avian influenza A(H5N1) viruses with chicken and ferret antisera reveals clade-dependent variation in hemagglutination inhibition profiles Emerging Microbes and Infections,
    Doi: http://doi.org/10.1038/s41426-018-0100-7
  • 2018

  • Santos, JJS., Abente, EJ., Obadan, AO., Thompson, AJ., Ferreri, L., Geiger, G., Gonzalez-Reiche, AS., Lewis, NS., Burke, DF., Rajão, DS., Paulson, JC., Vincent, AL. and Perez, DR., 2018. Plasticity of amino acid residue 145 near the receptor binding site of H3 swine influenza A viruses and its impact on receptor binding and antibody recognition. J Virol,
    Doi: http://doi.org/10.1128/JVI.01413-18
  • 2017 (Accepted for publication)

  • Burke, DF., 2017 (Accepted for publication). Characterization of influenza A(H1N1)pdm09 viruses isolated from Nepalese and Indian outbreak patients in early 2015 Influenza and other Respiratory Viruses,
    Doi: http://doi.org/10.1111/irv.12469
  • 2017

  • Zhang, Y., Aevermann, BD., Anderson, TK., Burke, DF., Dauphin, G., Gu, Z., He, S., Kumar, S., Larsen, CN., Lee, AJ., Li, X., Macken, C., Mahaffey, C., Pickett, BE., Reardon, B., Smith, T., Stewart, L., Suloway, C., Sun, G., Tong, L., Vincent, AL., Walters, B., Zaremba, S., Zhao, H., Zhou, L., Zmasek, C., Klem, EB. and Scheuermann, RH., 2017. Influenza Research Database: An integrated bioinformatics resource for influenza virus research Nucleic Acids Research, v. 45
    Doi: http://doi.org/10.1093/nar/gkw857
  • 2016

  • Schrauwen, EJA., Richard, M., Burke, DF., Rimmelzwaan, GF., Herfst, S. and Fouchier, RAM., 2016. Amino Acid Substitutions That Affect Receptor Binding and Stability of the Hemagglutinin of Influenza A/H7N9 Virus. J Virol, v. 90
    Doi: http://doi.org/10.1128/JVI.03052-15
  • Lewis, NS., Russell, CA., Langat, P., Anderson, TK., Berger, K., Bielejec, F., Burke, DF., Dudas, G., Fonville, JM., Fouchier, RA., Kellam, P., Koel, BF., Lemey, P., Nguyen, T., Nuansrichy, B., Peiris, JM., Saito, T., Simon, G., Skepner, E., Takemae, N., ESNIP3 consortium, , Webby, RJ., Van Reeth, K., Brookes, SM., Larsen, L., Watson, SJ., Brown, IH. and Vincent, AL., 2016. The global antigenic diversity of swine influenza A viruses. Elife, v. 5
    Doi: http://doi.org/10.7554/eLife.12217
  • Li, C., Hatta, M., Burke, DF., Ping, J., Zhang, Y., Ozawa, M., Taft, AS., Das, SC., Hanson, AP., Song, J., Imai, M., Wilker, PR., Watanabe, T., Watanabe, S., Ito, M., Iwatsuki-Horimoto, K., Russell, CA., James, SL., Skepner, E., Maher, EA., Neumann, G., Klimov, AI., Kelso, A., McCauley, J., Wang, D., Shu, Y., Odagiri, T., Tashiro, M., Xu, X., Wentworth, DE., Katz, JM., Cox, NJ., Smith, DJ. and Kawaoka, Y., 2016. Selection of antigenically advanced variants of seasonal influenza viruses. Nat Microbiol, v. 1
    Doi: http://doi.org/10.1038/nmicrobiol.2016.58
  • 2015

  • Koel, BF., Mögling, R., Chutinimitkul, S., Fraaij, PL., Burke, DF., van der Vliet, S., de Wit, E., Bestebroer, TM., Rimmelzwaan, GF., Osterhaus, ADME., Smith, DJ., Fouchier, RAM. and de Graaf, M., 2015. Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses. J Virol, v. 89
    Doi: http://doi.org/10.1128/JVI.02962-14
  • 2014

  • Koel, BF., van der Vliet, S., Burke, DF., Bestebroer, TM., Bharoto, EE., Yasa, IWW., Herliana, I., Laksono, BM., Xu, K., Skepner, E., Russell, CA., Rimmelzwaan, GF., Perez, DR., Osterhaus, ADME., Smith, DJ., Prajitno, TY. and Fouchier, RAM., 2014. Antigenic variation of clade 2.1 H5N1 virus is determined by a few amino acid substitutions immediately adjacent to the receptor binding site. mBio, v. 5
    Doi: http://doi.org/10.1128/mBio.01070-14
  • Watanabe, T., Zhong, G., Russell, CA., Nakajima, N., Hatta, M., Hanson, A., McBride, R., Burke, DF., Takahashi, K., Fukuyama, S., Tomita, Y., Maher, EA., Watanabe, S., Imai, M., Neumann, G., Hasegawa, H., Paulson, JC., Smith, DJ. and Kawaoka, Y., 2014. Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential. Cell Host Microbe, v. 15
    Doi: http://doi.org/10.1016/j.chom.2014.05.006
  • Yang, S., Thackray, AM., Hopkins, L., Monie, TP., Burke, DF. and Bujdoso, R., 2014. Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP. Biomed Res Int, v. 2014
    Doi: http://doi.org/10.1155/2014/372491
  • Koel, BF., van der Vliet, S., Burke, DF., Bestebroer, TM., Bharoto, EE., Yasa, IW., Herliana, I., Laksono, BM., Xu, K., Skepner, E., Russell, CA., Rimmelzwaan, GF., Perez, DR., Osterhaus, AD., Smith, DJ., Prajitno, TY. and Fouchier, RA., 2014. Correction for Koel et al., Antigenic Variation of Clade 2.1 H5N1 Virus Is Determined by a Few Amino Acid Substitutions Immediately Adjacent to the Receptor Binding Site. MBio, v. 5
    Doi: http://doi.org/10.1128/mBio.01645-14
  • Burke, DF. and Smith, DJ., 2014. A recommended numbering scheme for influenza A HA subtypes. PLoS One, v. 9
    Doi: http://doi.org/10.1371/journal.pone.0112302
  • Ke, C., Lu, J., Wu, J., Guan, D., Zou, L., Song, T., Yi, L., Zeng, X., Liang, L., Ni, H., Kang, M., Zhang, X., Zhong, H., He, J., Lin, J., Smith, D., Burke, D., Fouchier, RAM., Koopmans, M. and Zhang, Y., 2014. Circulation of reassortant influenza A(H7N9) viruses in poultry and humans, Guangdong Province, China, 2013. Emerg Infect Dis, v. 20
    Doi: http://doi.org/10.3201/eid2012.140765
  • Burke, DF. and Smith, DJ., 2014. A recommended numbering scheme for influenza a ha subtypes PLoS ONE, v. 9
    Doi: http://doi.org/10.1371/journal.pone
  • Lewis, NS., Anderson, TK., Kitikoon, P., Skepner, E., Burke, DF. and Vincent, AL., 2014. Substitutions near the hemagglutinin receptor-binding site determine the antigenic evolution of influenza A H3N2 viruses in U.S. swine. J Virol, v. 88
    Doi: http://doi.org/10.1128/JVI.03805-13
  • 2013

  • Richard, M., Schrauwen, EJA., de Graaf, M., Bestebroer, TM., Spronken, MIJ., van Boheemen, S., de Meulder, D., Lexmond, P., Linster, M., Herfst, S., Smith, DJ., van den Brand, JM., Burke, DF., Kuiken, T., Rimmelzwaan, GF., Osterhaus, ADME. and Fouchier, RAM., 2013. Limited airborne transmission of H7N9 influenza A virus between ferrets. Nature, v. 501
    Doi: http://doi.org/10.1038/nature12476
  • Fonville, JM., Burke, DF., Lewis, NS., Katzelnick, LC. and Russell, CA., 2013. Quantifying the Fitness Advantage of Polymerase Substitutions in Influenza A/H7N9 Viruses during Adaptation to Humans PLoS ONE, v. 8
    Doi: http://doi.org/10.1371/journal.pone.0076047
  • Koel, BF., Burke, DF., Bestebroer, TM., van der Vliet, S., Zondag, GCM., Vervaet, G., Skepner, E., Lewis, NS., Spronken, MIJ., Russell, CA., Eropkin, MY., Hurt, AC., Barr, IG., de Jong, JC., Rimmelzwaan, GF., Osterhaus, ADME., Fouchier, RAM. and Smith, DJ., 2013. Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution. Science, v. 342
    Doi: http://doi.org/10.1126/science.1244730
  • 2012

  • Wilks, S., de Graaf, M., Smith, DJ. and Burke, DF., 2012. A review of influenza haemagglutinin receptor binding as it relates to pandemic properties. Vaccine, v. 30
    Doi: http://doi.org/10.1016/j.vaccine.2012.02.076
  • Russell, CA., Fonville, JM., Brown, AE., Burke, DF., Smith, DL., James, SL., Herfst, S., van Boheemen, S., Linster, M., Schrauwen, EJ., Katzelnick, L., Mosterín, A., Kuiken, T., Maher, E., Neumann, G., Osterhaus, AD., Kawaoka, Y., Fouchier, RA. and Smith, DJ., 2012. The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host. Science, v. 336
    Doi: http://doi.org/10.1126/science.1222526
  • Herfst, S., Schrauwen, EJA., Linster, M., Chutinimitkul, S., De Wit, E., Munster, VJ., Sorrell, EM., Bestebroer, TM., Burke, DF., Smith, DJ., Rimmelzwaan, GF., Osterhaus, ADME. and Fouchier, RAM., 2012. Airborne transmission of influenza A/H5N1 virus between ferrets Science, v. 336
    Doi: http://doi.org/10.1126/science.1213362
  • 2011

  • Lewis, NS., Daly, JM., Russell, CA., Horton, DL., Skepner, E., Bryant, NA., Burke, DF., Rash, AS., Wood, JLN., Chambers, TM., Fouchier, RAM., Mumford, JA., Elton, DM. and Smith, DJ., 2011. Antigenic and genetic evolution of equine influenza A (H3N8) virus from 1968 to 2007. J Virol, v. 85
    Doi: http://doi.org/10.1128/JVI.05319-11
  • Sandbulte, MR., Westgeest, KB., Gao, J., Xu, X., Klimov, AI., Russell, CA., Burke, DF., Smith, DJ., Fouchier, RAM. and Eichelberger, MC., 2011. Discordant antigenic drift of neuraminidase and hemagglutinin in H1N1 and H3N2 influenza viruses Proceedings of the National Academy of Sciences of the United States of America, v. 108
    Doi: http://doi.org/10.1073/pnas.1113801108
  • 2010

  • Chutinimitkul, S., Herfst, S., Steel, J., Lowen, AC., Ye, J., van Riel, D., Schrauwen, EJA., Bestebroer, TM., Koel, B., Burke, DF., Sutherland-Cash, KH., Whittleston, CS., Russell, CA., Wales, DJ., Smith, DJ., Jonges, M., Meijer, A., Koopmans, M., Rimmelzwaan, GF., Kuiken, T., Osterhaus, ADME., García-Sastre, A., Perez, DR. and Fouchier, RAM., 2010. Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding. J Virol, v. 84
    Doi: http://doi.org/10.1128/JVI.01136-10
  • 2009

  • Garten, RJ., Davis, CT., Russell, CA., Shu, B., Lindstrom, S., Balish, A., Sessions, WM., Xu, X., Skepner, E., Deyde, V., Okomo-Adhiambo, M., Gubareva, L., Barnes, J., Smith, CB., Emery, SL., Hillman, MJ., Rivailler, P., Smagala, J., de Graaf, M., Burke, DF., Fouchier, RA., Pappas, C., Alpuche-Aranda, CM., Lopez-Gatell, H., Olivera, H., Lopez, I., Myers, CA., Faix, D., Blair, PJ., Yu, C., Keene, KM., Dotson, PD., Boxrud, D., Sambol, AR., Abid, SH., St George, K., Bannerman, T., Moore, AL., Stringer, DJ., Blevins, P., Demmler-Harrison, GJ., Ginsberg, M., Kriner, P., Waterman, S., Smole, S., Guevara, HF., Belongia, EA., Clark, PA., Beatrice, ST., Donis, R., Katz, J., Finelli, L., Bridges, CB., Shaw, M., Jernigan, DB., Uyeki, TM., Smith, DJ., Klimov, AI. and Cox, NJ., 2009. Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans. Science,
  • 2008

  • Jones, NG., Nietlispach, D., Sharma, R., Burke, DF., Eyres, I., Mues, M., Mott, HR. and Carrington, M., 2008. Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein. J Biol Chem, v. 283
    Doi: http://doi.org/10.1074/jbc.M706207200
  • Fitzmaurice, TJ., Burke, DF., Hopkins, L., Yang, S., Yu, S., Sy, MS., Thackray, AM. and Bujdoso, R., 2008. The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2 Biochemical Journal, v. 409
    Doi: http://doi.org/10.1042/BJ20071122
  • Furnham, N., De Bakker, PIW., Gore, S., Burke, DF. and Blundell, TL., 2008. Comparative modelling by restraint-based conformational sampling BMC Structural Biology, v. 8
    Doi: http://doi.org/10.1186/1472-6807-8-7
  • 2007

  • Smith, RE., Lovell, SC., Burke, DF., Montalvao, RW. and Blundell, TL., 2007. Andante: reducing side-chain rotamer search space during comparative modeling using environment-specific substitution probabilities. Bioinformatics, v. 23
    Doi: http://doi.org/10.1093/bioinformatics/btm073
  • Worth, CL., Burke, DF. and Blundell, TL., 2007. Estimating the effects of single nucleotide polymorphisms on protein structure: how good are we at identifying likely disease associated mutations Proceedings of ??Molecular Interactions-Bringing Chemistry to Life,
  • Burke, DF., Worth, CL., Priego, E-M., Cheng, T., Smink, LJ., Todd, JA. and Blundell, TL., 2007. Genome bioinformatic analysis of nonsynonymous SNPs. BMC Bioinformatics, v. 8
    Doi: http://doi.org/10.1186/1471-2105-8-301
  • Porollo, A. and Meller, J., 2007. Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. BMC Bioinformatics, v. 8
    Doi: http://doi.org/10.1186/1471-2105-8-316
  • Worth, CL., Bickerton, GRJ., Schreyer, A., Forman, JR., Cheng, TMK., Lee, S., Gong, S., Burke, DF. and Blundell, TL., 2007. A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease. J Bioinform Comput Biol, v. 5
    Doi: http://doi.org/10.1142/s0219720007003120
  • 2006

  • Blundell, TL., Sibanda, BL., Montalvão, RW., Brewerton, S., Chelliah, V., Worth, CL., Harmer, NJ., Davies, O. and Burke, D., 2006. Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery. Philos Trans R Soc Lond B Biol Sci, v. 361
    Doi: http://doi.org/10.1098/rstb.2005.1800
  • 2005

  • Bujdoso, R., Burke, DF. and Thackray, AM., 2005. Structural differences between allelic variants of the ovine prion protein revealed by molecular dynamics simulations. Proteins, v. 61
    Doi: http://doi.org/10.1002/prot.20755
  • Gore, SP., Burke, DF. and Blundell, TL., 2005. PROVAT – a versatile tool for Voronoi tessellation analysis of protein structures and complexes BMC Bioinformatics, v. 6
    Doi: 10.1186/1471-2105-6-s3-p12
  • Gore, SP., Burke, DF. and Blundell, TL., 2005. PROVAT: a tool for Voronoi tessellation analysis of protein structures and complexes. Bioinformatics, v. 21
    Doi: http://doi.org/10.1093/bioinformatics/bti523
  • Gore, SP., Burke, DF. and Blundell, TL., 2005. PROVAT: a tool for Voronoi tessellation analysis of protein structures and complexes. Bioinform., v. 21
    Doi: http://doi.org/10.1093/bioinformatics/bti523
  • 2003

  • de Bakker, PIW., DePristo, MA., Burke, DF. and Blundell, TL., 2003. Ab initio construction of polypeptide fragments: Accuracy of loop decoy discrimination by an all-atom statistical potential and the AMBER force field with the Generalized Born solvation model. Proteins, v. 51
    Doi: http://doi.org/10.1002/prot.10235
  • Evans, PC., Smith, TS., Lai, M-J., Williams, MG., Burke, DF., Heyninck, K., Kreike, MM., Beyaert, R., Blundell, TL. and Kilshaw, PJ., 2003. A novel type of deubiquitinating enzyme. J Biol Chem, v. 278
    Doi: http://doi.org/10.1074/jbc.M301863200
  • 2001

  • Nagendra, HG., Harrington, AE., Harmer, NJ., Pellegrini, L., Blundell, TL. and Burke, DF., 2001. Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution. FEBS Lett, v. 501
    Doi: http://doi.org/10.1016/s0014-5793(01)02603-5
  • de Bakker, PI., Bateman, A., Burke, DF., Miguel, RN., Mizuguchi, K., Shi, J., Shirai, H. and Blundell, TL., 2001. HOMSTRAD: adding sequence information to structure-based alignments of homologous protein families. Bioinformatics, v. 17
    Doi: http://doi.org/10.1093/bioinformatics/17.8.748
  • Burke, DF. and Deane, CM., 2001. Improved protein loop prediction from sequence alone. Protein Eng, v. 14
    Doi: http://doi.org/10.1093/protein/14.7.473
  • Williams, MG., Shirai, H., Shi, J., Nagendra, HG., Mueller, J., Mizuguchi, K., Miguel, RN., Lovell, SC., Innis, CA., Deane, CM., Chen, L., Campillo, N., Burke, DF., Blundell, TL. and de Bakker, PI., 2001. Sequence-structure homology recognition by iterative alignment refinement and comparative modeling. Proteins, v. Suppl 5
    Doi: http://doi.org/10.1002/prot.1169
  • 2000

  • Pellegrini, L., Burke, DF., von Delft, F., Mulloy, B. and Blundell, TL., 2000. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature, v. 407
    Doi: http://doi.org/10.1038/35039551
  • Burke, DF., Deane, CM. and Blundell, TL., 2000. Browsing the SLoop database of structurally classified loops connecting elements of protein secondary structure. Bioinformatics, v. 16
    Doi: http://doi.org/10.1093/bioinformatics/16.6.513
  • Blundell, TL., Burke, DF., Chirgadze, D., Dhanaraj, V., Hyvönen, M., Innis, CA., Parisini, E., Pellegrini, L., Sayed, M. and Sibanda, BL., 2000. Protein-protein interactions in receptor activation and intracellular signalling. Biol Chem, v. 381
    Doi: http://doi.org/10.1515/BC.2000.117
  • 1999

  • Burke, DF., Deane, CM., Nagarajaram, HA., Campillo, N., Martin-Martinez, M., Mendes, J., Molina, F., Perry, J., Reddy, BV., Soares, CM., Steward, RE., Williams, M., Carrondo, MA., Blundell, TL. and Mizuguchi, K., 1999. An iterative structure-assisted approach to sequence alignment and comparative modeling. Proteins, v. Suppl 3
    Doi: http://doi.org/10.1002/(sici)1097-0134(1999)37:3+<55::aid-prot8>3.3.co;2-2
  • Burke, DF., Deane, CM., Nagarajaram, HA., Campillo, N., Martin-Martinez, M., Mendes, J., Molina, F., Perry, J., Reddy, BVB., Soares, CM., Steward, RE., Williams, M., Carrondo, MA., Blundell, TL. and Mizuguchi, K., 1999. An iterative structure-assisted approach to sequence alignment and comparative modeling Proteins: Structure, Function, and Genetics, v. 37
    Doi: 10.1002/(sici)1097-0134(1999)37:3+&lt;55::aid-prot8&gt;3.0.co;2-b
  • 1998

  • Burke, D., Wilkes, D., Blundell, TL. and Malcolm, S., 1998. Fibroblast growth factor receptors: lessons from the genes. Trends Biochem Sci, v. 23
    Doi: http://doi.org/10.1016/s0968-0004(97)01170-5
  • Pellegrini, L., Commander, P., Mulloy, B., Martin-Martinez, M., Blundell, TL. and Burke, DF., 1998. The role of heparin in the complex formation between fibroblast growth factor 2 and its high affinity receptor: comparative modelling and biochemical studies. Biochem Soc Trans, v. 26
    Doi: http://doi.org/10.1042/bst0260545
  • Sowdhamini, R., Burke, DF., Deane, C., Huang, JF., Mizuguchi, K., Nagarajaram, HA., Overington, JP., Srinivasan, N., Steward, RE. and Blundell, TL., 1998. Protein three-dimensional structural databases: domains, structurally aligned homologues and superfamilies. Acta Crystallogr D Biol Crystallogr, v. 54
    Doi: http://doi.org/10.1107/s0907444998007148
  • Sowdhamini, R., Burke, DF., Huang, JF., Mizuguchi, K., Nagarajaram, HA., Srinivasan, N., Steward, RE. and Blundell, TL., 1998. CAMPASS: a database of structurally aligned protein superfamilies. Structure, v. 6
    Doi: http://doi.org/10.1016/s0969-2126(98)00110-5
  • 1997

  • Burke, DF., Laughton, CA. and Neidle, S., 1997. Homology modelling of the enzyme P450 17 alpha-hydroxylase/17,20-lyase--a target for prostate cancer chemotherapy--from the crystal structure of P450BM-3. Anticancer Drug Des, v. 12
  • 1995

  • Burke, DF., Laughton, CA., Snook, CF., Neidle, S., Potter, GA. and Jarman, M., 1995. Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase Bioorganic &amp; Medicinal Chemistry Letters, v. 5
    Doi: 10.1016/0960-894x(95)00178-v
  • Books

    2014 (No publication date)

  • I. S Blagbrough, , Malcolm M Campbell, and Royal Society of Chemistry (Great Britain), , 2014 (No publication date). Medicinal Chemistry Into The Millennium
  • Conference proceedings

    2002

  • Pellegrini, L., Burke, DF. and Blundell, TL., 2002. Activation mechanism of fibroblast growth factor receptor tyrosine kinase revealed by crystal structure of fibroblast growth factor receptor ectodomain bound to fibroblast growth factor and heparin. INSULIN & RELATED PROTEINS - STRUCTURE TO FUNCTION AND PHARMACOLOGY,
  • Book chapters

    2001

  • Burke, DF., 2001. Genomics, Protein Superfamilies and Drug Discovery. “Medicinal Chemistry Into the Millennium