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Cambridge Public Health

 

My research interests lie in host-pathogen interactions and the molecular basis of virulence. My research is broad-ranging and multidisciplinary, from understanding the roles of individual bacterial proteins in virulence, studying the within-host population dynamics of bacterial pathogens and understanding the host response to infection. My research focuses on bacterial pathogens of veterinary and clinical significance, including; enteropathogenic Escherichia coli (EPEC), Campylobacter jejuni and Salmonella enterica. I aim to use integrated approaches where advanced molecular, genomic, proteomic and microscopy techniques, in combination with mathematical and statistical models, enable me to tease out heterogeneous events in infection.

Publications from Elements

Journal articles

2024 (Accepted for publication)

  • Grant, A., 2024 (Accepted for publication). Identification of Campylobacter jejuni and Campylobacter coli genes contributing to oxidative stress response using TraDIS analysis BMC Microbiology,
  • Grant, A., Fahmy, L., Generalovic, T., Ali, Y., Seilly, D., Sivanesan, K., Kalmar, L., Pipan, M. and Christie, G., 2024 (Accepted for publication). A novel family of defensin-like peptides from Hermetia illucens with antibacterial properties BMC Microbiology,
  • 2023 (Accepted for publication)

  • Ba, X., Matuszewska, M., Kalmar, L., Fan, J., Zou, G., Corander, D., Raisen, C., Li, S., Li, L., Weinert, L., Tucker, A., Grant, A., Zhou, R. and Holmes, M., 2023 (Accepted for publication). High-throughput mutagenesis reveals a role for antimicrobial resistance- and virulence-associated mobile genetic elements in Staphylococcus aureus host adaptation Microbiology Spectrum,
    Doi: 10.1128/spectrum.04213-22
  • Stoakes, E., Turner, K., Baker, D., Suau Sans, M., Yasir, M., Kalmar, L., Costigan, R., Lott, M. and Grant, A., 2023 (Accepted for publication). Application of TraDIS to define the core essential genome of Campylobacter jejuni and Campylobacter coli BMC Microbiology,
    Doi: 10.1186/s12866-023-02835-8
  • Grant, A., 2023 (Accepted for publication). An attacin antimicrobial peptide, Hill_BB_C10074, from Hermetia illucens with anti-Pseudomonas aeruginosa activity BMC Microbiology,
  • 2023

  • Vogt, SL., Serapio-Palacios, A., Woodward, SE., Santos, AS., de Vries, SPW., Daigneault, MC., Brandmeier, LV., Grant, AJ., Maskell, DJ., Allen-Vercoe, E. and Finlay, BB., 2023. Enterohemorrhagic Escherichia coli responds to gut microbiota metabolites by altering metabolism and activating stress responses. Gut Microbes, v. 15
    Doi: http://doi.org/10.1080/19490976.2023.2190303
  • 2022 (Accepted for publication)

  • Costigan, R., Stoakes, E., Floto, A., Parkhill, J. and Grant, A., 2022 (Accepted for publication). Development and validation of a CRISPR interference system for gene regulation in Campylobacter jejuni BMC Microbiology,
    Doi: 10.1186/s12866-022-02645-4
  • Grant, A., Smith, A., Corona-Torres, R., Hewitt, R. and Stevens, M., 2022 (Accepted for publication). Modification of avian pathogenic Escherichia coli χ7122 lipopolysaccharide increases accessibility to glycoconjugate antigens Microbial Cell Factories,
  • 2022

  • Terra, VS., Mauri, M., Sannasiddappa, TH., Smith, AA., Stevens, MP., Grant, AJ., Wren, BW., Cuccui, J. and Glycoengineering of Veterinary Vaccines consortium (GoVV), , 2022. PglB function and glycosylation efficiency is temperature dependent when the pgl locus is integrated in the Escherichia coli chromosome. Microb Cell Fact, v. 21
    Doi: http://doi.org/10.1186/s12934-021-01728-7
  • de Oliveira Martins, L., Bloomfield, S., Stoakes, E., Grant, AJ., Page, AJ. and Mather, AE., 2022. Tatajuba: exploring the distribution of homopolymer tracts. NAR Genom Bioinform, v. 4
    Doi: http://doi.org/10.1093/nargab/lqac003
  • Kalmar, L., Gupta, S., Kean, IRL., Ba, X., Hadjirin, N., Lay, EM., de Vries, SPW., Bateman, M., Bartlet, H., Hernandez-Garcia, J., Tucker, AW., Restif, O., Stevens, MP., Wood, JLN., Maskell, DJ., Grant, AJ. and Holmes, MA., 2022. HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities. PLoS Genet, v. 18
    Doi: http://doi.org/10.1371/journal.pgen.1009776
  • Stoakes, E., Savva, GM., Coates, R., Tejera, N., Poolman, MG., Grant, AJ., Wain, J. and Singh, D., 2022. Substrate Utilisation and Energy Metabolism in Non-Growing Campylobacter jejuni M1cam. Microorganisms, v. 10
    Doi: http://doi.org/10.3390/microorganisms10071355
  • 2021 (Accepted for publication)

  • Karttunen, J., Stewart, S., Kalmar, L., Grant, A., Karet, F. and Williams, T., 2021 (Accepted for publication). Size-exclusion chromatography separation reveals that vesicu-lar and non-vesicular small RNA profiles differ in cell free urine International Journal of Molecular Sciences,
  • Grant, A., Mauri, M., Sannasiddappa, T., Vohra, P., Corona-Torres, R., Smith, A., Chintoan-Uta, C., Bremner, A., Terra, V., Abouelhadid, S., Stevens, M., Cuccui, J. and Wren, B., 2021 (Accepted for publication). Multivalent poultry vaccine development using Protein Glycan Coupling Technology Microbial Cell Factories,
    Doi: http://doi.org/10.1186/s12934-021-01682-4
  • Berry, S., Rust, S., Caceres, C., Irving, L., Bartholdson Scott, J., Tabor, D., Dougan, G., Christie, G., Warrener, P., Minter, R. and Grant, A., 2021 (Accepted for publication). Phenotypic whole-cell screening identifies a protective carbohydrate epitope on Klebsiella pneumoniae mAbs,
  • 2021

  • Kalmar, L., Gupta, S., Kean, I., Ba, X., Hadjirin, N., Lay, E., de Vries, SPW., Bateman, M., Bartlett, H., Hernandez-Garcia, J., Tucker, A., Restiff, O., Stevens, M., Wood, J., Maskell, D., Grant, A. and Holmes, M., 2021. HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities
    Doi: http://doi.org/10.1101/2021.08.16.456459
  • Zou, G., Matuszewska, M., Jia, M., Zhou, J., Ba, X., Duan, J., Zhang, C., Zhao, J., Tao, M., Fan, J., Zhang, X., Jin, W., Cui, T., Zeng, X., Jia, M., Qian, X., Huang, C., Zhuo, W., Yao, Z., Zhang, L., Li, S., Li, L., Huang, Q., Wu, B., Chen, H., Tucker, A., Grant, A., Holmes, M. and Zhou, R., 2021. A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations
    Doi: http://doi.org/10.1101/2021.08.02.454852
  • Zou, G., Matuszewska, M., Jia, M., Zhou, J., Ba, X., Duan, J., Zhang, C., Zhao, J., Tao, M., Fan, J., Zhang, X., Jin, W., Cui, T., Zeng, X., Jia, M., Qian, X., Huang, C., Zhuo, W., Yao, Z., Zhang, L., Li, S., Li, L., Huang, Q., Wu, B., Chen, H., Tucker, AW., Grant, AJ., Holmes, MA. and Zhou, R., 2021. A Survey of Chinese Pig Farms and Human Healthcare Isolates Reveals Separate Human and Animal Methicillin-Resistant Staphylococcus aureus Populations. Adv Sci (Weinh),
    Doi: http://doi.org/10.1002/advs.202103388
  • 2020 (Accepted for publication)

  • Mastroeni, P., Grant, A., Kanvatirth, P. and Blacklaws, B., 2020 (Accepted for publication). The dual role of splenic mononuclear and polymorphonuclear cells in the outcome of ciprofloxacin treatment of Salmonella enterica infections Journal of Antimicrobial Chemotherapy,
  • Vlazaki, M., Rossi, O., Price, DJ., McLean, C., Grant, AJ., Mastroeni, P. and Restif, O., 2020 (Accepted for publication). A data-based mathematical modelling study to quantify the effects of ciprofloxacin and ampicillin on the within-host dynamics of Salmonella enterica during treatment and relapse Journal of the Royal Society Interface,
  • Leulmi Pichot, S., Cowburn, R., Grant, A., Dieny, B. and Joisten, H., 2020 (Accepted for publication). Magneto-mechanically actuated microstructures to efficiently prevent bacterial biofilm formation Scientific Reports,
  • 2018 (Accepted for publication)

  • Grant, AJ., Maskell, D. and Holmes, M., 2018 (Accepted for publication). Phylogenetic analyses and antimicrobial resistance profiles of Campylobacter spp. from diarrhoeal patients and chickens in Botswana PLoS ONE,
  • 2018

  • de Vries, SPW., Hadjirin, NF., Lay, EM., Zadoks, RN., Peacock, SJ., Parkhill, J., Grant, AJ., McDougall, S. and Holmes, MA., 2018. Streptococcus bovimastitidis sp. nov., isolated from a dairy cow with mastitis. Int J Syst Evol Microbiol, v. 68
    Doi: http://doi.org/10.1099/ijsem.0.002321
  • Parry-Hanson Kunadu, A., Holmes, M., Miller, EL. and Grant, AJ., 2018. Microbiological quality and antimicrobial resistance characterization of Salmonella spp. in fresh milk value chains in Ghana. Int J Food Microbiol, v. 277
    Doi: http://doi.org/10.1016/j.ijfoodmicro.2018.04.025
  • 2017

  • Yahara, K., Méric, G., Taylor, AJ., de Vries, SPW., Murray, S., Pascoe, B., Mageiros, L., Torralbo, A., Vidal, A., Ridley, A., Komukai, S., Wimalarathna, H., Cody, AJ., Colles, FM., McCarthy, N., Harris, D., Bray, JE., Jolley, KA., Maiden, MCJ., Bentley, SD., Parkhill, J., Bayliss, CD., Grant, A., Maskell, D., Didelot, X., Kelly, DJ. and Sheppard, SK., 2017. Genome-wide association of functional traits linked with Campylobacter jejuni survival from farm to fork. Environmental Microbiology, v. 19
    Doi: http://doi.org/10.1111/1462-2920.13628
  • Scanlan, E., Yu, L., Maskell, D., Choudhary, J. and Grant, A., 2017. A quantitative proteomic screen of the $\textit{Campylobacter jejuni}$ flagellar-dependent secretome Journal of Proteomics, v. 152
    Doi: http://doi.org/10.1016/j.jprot.2016.11.009
  • Rossi, O., Grant, AJ. and Mastroeni, P., 2017. Effect of in vivo neutralisation of Tumor Necrosis Factor alpha on the efficacy of antibiotic treatment in systemic Salmonella enterica infections. Pathogens and Disease, v. 75
    Doi: http://doi.org/10.1093/femspd/ftx002
  • Esson, D., Gupta, S., Bailey, D., Wigley, P., Wedley, A., Mather, AE., Méric, G., Mastroeni, P., Sheppard, SK., Thomson, NR., Parkhill, J., Maskell, DJ., Christie, G. and Grant, AJ., 2017. Identification and initial characterisation of a protein involved in $\textit{Campylobacter jejuni}$ cell shape Microbial Pathogenesis, v. 104
    Doi: http://doi.org/10.1016/j.micpath.2017.01.042
  • de Vries, SPW., Linn, A., Macleod, K., MacCallum, A., Hardy, SP., Douce, G., Watson, E., Dagleish, MP., Thompson, H., Stevenson, A., Kennedy, D., Baig, A., Coward, C., Maskell, DJ., Smith, DGE., Grant, AJ. and Everest, P., 2017. Analysis of Campylobacter jejuni infection in the gnotobiotic piglet and genome-wide identification of bacterial factors required for infection Scientific Reports, v. 7
    Doi: http://doi.org/10.1038/srep44283
  • Vries, SPWD., Gupta, S., Baig, A., Wright, E., Wedley, A., Jensen, AN., Lora, LL., Humphrey, S., Skovgård, H., Macleod, K., Pont, E., Wolanska, DP., L'Heureux, J., Mobegi, FM., Smith, DGE., Everest, P., Zomer, A., Williams, N., Wigley, P., Humphrey, T., Maskell, DJ. and Grant, AJ., 2017. Genome-wide fitness analyses of the foodborne pathogen Campylobacter jejuni in in vitro and in vivo models. Scientific Reports, v. 7
    Doi: http://doi.org/10.1038/s41598-017-01133-4
  • Oshota, O., Conway, M., Fookes, M., Schreiber, F., Chaudhuri, R., Yu, L., Morgan, F., Clare, S., Choudhary, J., Thomson, N., Lio, P., Maskell, D., Mastroeni, P. and Grant, AJ., 2017. Transcriptome and proteome analysis of Salmonella enterica serovar Typhimurium systemic infection of wild type and immune-deficient mice PLoS ONE, v. 12
    Doi: http://doi.org/10.1371/journal.pone.0181365
  • Rossi, O., Dybowski, R., Maskell, DJ., Grant, AJ., Restif, O. and Mastroeni, P., 2017. Within-host spatiotemporal dynamics of systemic Salmonella infection during and after antimicrobial treatment Journal of Antimicrobial Chemotherapy,
    Doi: http://doi.org/10.1093/jac/dkx294
  • Bateman, MD., de Vries, SPW., Gupta, S., Guardabassi, L., Cavaco, LM., Grant, AJ. and Holmes, MA., 2017. Genome and Plasmid Sequences of Escherichia coli KV7, an Extended-Spectrum β-Lactamase Isolate Derived from Feces of a Healthy Pig. Genome Announc, v. 5
    Doi: http://doi.org/10.1128/genomeA.00595-17
  • 2016

  • Goh, YS., Armour, KL., Clark, MR., Grant, AJ. and Mastroeni, P., 2016. Igg Subclasses Targeting the Flagella of Salmonella enterica Serovar Typhimurium Can Mediate Phagocytosis and Bacterial Killing. J Vaccines Vaccin, v. 7
    Doi: http://doi.org/10.4172/2157-7560.1000322
  • Rosconi, F., de Vries, SPW., Baig, A., Fabiano, E. and Grant, AJ., 2016. Essential Genes for In Vitro Growth of the Endophyte Herbaspirillum seropedicae SmR1 as Revealed by Transposon Insertion Site Sequencing. Appl Environ Microbiol, v. 82
    Doi: http://doi.org/10.1128/AEM.02281-16
  • Giacomin, P., Zakrzewski, M., Jenkins, TP., Su, X., Al-Hallaf, R., Croese, J., de Vries, S., Grant, A., Mitreva, M., Loukas, A., Krause, L. and Cantacessi, C., 2016. Changes in duodenal tissue-associated microbiota following hookworm infection and consecutive gluten challenges in humans with coeliac disease Scientific Reports, v. 6
    Doi: http://doi.org/10.1038/srep36797
  • Esson, D., Mather, AE., Scanlan, E., Gupta, S., de Vries, SPW., Bailey, D., Harris, SR., McKinley, TJ., Méric, G., Berry, SK., Mastroeni, P., Sheppard, SK., Christie, G., Thomson, NR., Parkhill, J., Maskell, DJ. and Grant, AJ., 2016. Genomic variations leading to alterations in cell morphology of $\textit{Campylobacter}$ spp Scientific Reports, v. 6
    Doi: http://doi.org/10.1038/srep38303
  • Grant, AJ., Oshota, O., Chaudhuri, RR., Mayho, M., Peters, SE., Clare, S., Maskell, DJ. and Mastroeni, P., 2016. Genes Required for the Fitness of Salmonella enterica Serovar Typhimurium during Infection of Immunodeficient gp91-/- phox Mice. Infect Immun, v. 84
    Doi: http://doi.org/10.1128/IAI.01423-15
  • 2015

  • Giuliano, A., Meiring, T., Grant, AJ. and Watson, PJ., 2015. Acute Hepatic Necrosis Caused by Salmonella enterica Serotype I 4,5,12:-:1,2 in a Dog. J Clin Microbiol, v. 53
    Doi: http://doi.org/10.1128/JCM.01256-15
  • Kanji, A., Jones, MA., Maskell, DJ. and Grant, AJ., 2015. Campylobacter jejuni PflB is required for motility and colonisation of the chicken gastrointestinal tract. Microb Pathog, v. 89
    Doi: http://doi.org/10.1016/j.micpath.2015.09.010
  • de Vries, SPW., Gupta, S., Baig, A., L'Heureux, J., Pont, E., Wolanska, DP., Maskell, DJ. and Grant, AJ., 2015. Motility defects in Campylobacter jejuni defined gene deletion mutants caused by second-site mutations. Microbiology, v. 161
    Doi: http://doi.org/10.1099/mic.0.000184
  • Dybowski, R., Restif, O., Goupy, A., Maskell, DJ., Mastroeni, P. and Grant, AJ., 2015. Single passage in mouse organs enhances the survival and spread of Salmonella enterica. J R Soc Interface, v. 12
    Doi: http://doi.org/10.1098/rsif.2015.0702
  • 2014

  • Kaiser, P., Regoes, RR., Dolowschiak, T., Wotzka, SY., Lengefeld, J., Slack, E., Grant, AJ., Ackermann, M. and Hardt, W-D., 2014. Cecum lymph node dendritic cells harbor slow-growing bacteria phenotypically tolerant to antibiotic treatment. PLoS Biol, v. 12
    Doi: http://doi.org/10.1371/journal.pbio.1001793
  • Coward, C., Restif, O., Dybowski, R., Grant, AJ., Maskell, DJ. and Mastroeni, P., 2014. The effects of vaccination and immunity on bacterial infection dynamics in vivo. PLoS Pathog, v. 10
    Doi: http://doi.org/10.1371/journal.ppat.1004359
  • 2013

  • Restif, O., Goh, YS., Palayret, M., Grant, AJ., McKinley, TJ., Clark, MR. and Mastroeni, P., 2013. Quantification of the effects of antibodies on the extra- and intracellular dynamics of Salmonella enterica. J R Soc Interface, v. 10
    Doi: http://doi.org/10.1098/rsif.2012.0866
  • Kaiser, P., Slack, E., Grant, AJ., Hardt, WD. and Regoes, RR., 2013. Lymph Node Colonization Dynamics after Oral Salmonella Typhimurium Infection in Mice PLoS Pathogens, v. 9
    Doi: http://doi.org/10.1371/journal.ppat.1003532
  • Mastroeni, P. and Grant, A., 2013. Dynamics of spread of Salmonella enterica in the systemic compartment. Microbes Infect, v. 15
    Doi: http://doi.org/10.1016/j.micinf.2013.10.003
  • Mastroeni, P. and Grant, A., 2013. Dynamics of spread of Salmonella enterica in the systemic compartment Microbes and Infection, v. 15
    Doi: http://doi.org/10.1016/j.micinf.2013.10.003
  • 2012

  • Staniewicz, L., Donald, AM., Stokes, DJ., Thomson, N., Sivaniah, E., Grant, A., Bulmer, D. and Khan, A., 2012. The application of STEM and in situ controlled dehydration to bacterial systems using ESEM. Scanning, v. 34
    Doi: http://doi.org/10.1002/sca.21000
  • Staniewicz, L., Donald, AM., Stokes, DJ., Thomson, N., Sivaniah, E., Grant, A., Bulmer, D. and Khan, A., 2012. The application of STEM and in situ controlled dehydration to bacterial systems using ESEM Scanning, v. 34
    Doi: http://doi.org/10.1002/sca.21000
  • Periaswamy, B., Maier, L., Vishwakarma, V., Slack, E., Kremer, M., Andrews-Polymenis, HL., McClelland, M., Grant, AJ., Suar, M. and Hardt, WD., 2012. Live Attenuated S. Typhimurium Vaccine with Improved Safety in Immuno-Compromised Mice PLoS ONE, v. 7
    Doi: http://doi.org/10.1371/journal.pone.0045433
  • Holt, JP., Grant, AJ., Coward, C., Maskell, DJ. and Quinlan, JJ., 2012. Identification of Cj1051c as a Major determinant for the restriction barrier of Campylobacter jejuni StrainNCTC11168 Applied and Environmental Microbiology, v. 78
    Doi: http://doi.org/10.1128/AEM.01799-12
  • Grant, AJ., Morgan, FJE., McKinley, TJ., Foster, GL., Maskell, DJ. and Mastroeni, P., 2012. Attenuated Salmonella Typhimurium lacking the pathogenicity island-2 type 3 secretion system grow to high bacterial numbers inside phagocytes in mice. PLoS Pathog, v. 8
    Doi: http://doi.org/10.1371/journal.ppat.1003070
  • Bulmer, DM., Kharraz, L., Grant, AJ., Dean, P., Morgan, FJE., Karavolos, MH., Doble, AC., McGhie, EJ., Koronakis, V., Daniel, RA., Mastroeni, P. and Khan, CMA., 2012. The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella. PLoS Pathog, v. 8
    Doi: http://doi.org/10.1371/journal.ppat.1002500
  • 2011

  • Mastroeni, P., Morgan, FJE., McKinley, TJ., Shawcroft, E., Clare, S., Maskell, DJ. and Grant, AJ., 2011. Enhanced virulence of Salmonella enterica serovar typhimurium after passage through mice. Infect Immun, v. 79
    Doi: http://doi.org/10.1128/IAI.00954-10
  • Goh, YS., Grant, AJ., Restif, O., McKinley, TJ., Armour, KL., Clark, MR. and Mastroeni, P., 2011. Human IgG isotypes and activating Fcγ receptors in the interaction of Salmonella enterica serovar Typhimurium with phagocytic cells. Immunology, v. 133
    Doi: http://doi.org/10.1111/j.1365-2567.2011.03411.x
  • Wheeler, DW., Thompson, AJ., Corletto, F., Reckless, J., Loke, JCT., Lapaque, N., Grant, AJ., Mastroeni, P., Grainger, DJ., Padgett, CL., O'Brien, JA., Miller, NGA., Trowsdale, J., Lummis, SCR., Menon, DK. and Beech, JS., 2011. Anaesthetic impairment of immune function is mediated via GABA(A) receptors. PLoS One, v. 6
    Doi: http://doi.org/10.1371/journal.pone.0017152
  • Janis, C., Grant, AJ., McKinley, TJ., Morgan, FJE., John, VF., Houghton, J., Kingsley, RA., Dougan, G. and Mastroeni, P., 2011. In vivo regulation of the Vi antigen in Salmonella and induction of immune responses with an in vivo-inducible promoter. Infect Immun, v. 79
    Doi: http://doi.org/10.1128/IAI.01265-10
  • Mastroeni, P. and Grant, AJ., 2011. Spread of Salmonella enterica in the body during systemic infection: unravelling host and pathogen determinants. Expert Rev Mol Med, v. 13
    Doi: http://doi.org/10.1017/S1462399411001840
  • Chaudhuri, RR., Yu, L., Kanji, A., Perkins, TT., Gardner, PP., Choudhary, J., Maskell, DJ. and Grant, AJ., 2011. Quantitative RNA-seq analysis of the campylobacter jejuni transcriptome Microbiology, v. 157
    Doi: 10.1099/mic.0.050278-0
  • Jansen, AM., Hall, LJ., Clare, S., Goulding, D., Holt, KE., Grant, AJ., Mastroeni, P., Dougan, G. and Kingsley, RA., 2011. A Salmonella Typhimurium-Typhi genomic chimera: a model to study Vi polysaccharide capsule function in vivo. PLoS Pathog, v. 7
    Doi: http://doi.org/10.1371/journal.ppat.1002131
  • 2010

  • Buckley, AM., Wang, J., Hudson, DL., Grant, AJ., Jones, MA., Maskell, DJ. and Stevens, MP., 2010. Evaluation of live-attenuated Salmonella vaccines expressing Campylobacter antigens for control of C. jejuni in poultry. Vaccine, v. 28
    Doi: http://doi.org/10.1016/j.vaccine.2009.10.018
  • Javed, MA., Grant, AJ., Bagnall, MC., Maskell, DJ., Newell, DG. and Manning, G., 2010. Transposon mutagenesis in a hyper-invasive clinical isolate of Campylobacter jejuni reveals a number of genes with potential roles in invasion. Microbiology (Reading), v. 156
    Doi: http://doi.org/10.1099/mic.0.033399-0
  • Osman, D., Waldron, KJ., Denton, H., Taylor, CM., Grant, AJ., Mastroeni, P., Robinson, NJ. and Cavet, JS., 2010. Copper homeostasis in Salmonella is atypical and copper-CueP is a major periplasmic metal complex. J Biol Chem, v. 285
    Doi: http://doi.org/10.1074/jbc.M110.145953
  • 2009

  • Wright, JA., Grant, AJ., Hurd, D., Harrison, M., Guccione, EJ., Kelly, DJ. and Maskell, DJ., 2009. Metabolite and transcriptome analysis of Campylobacter jejuni in vitro growth reveals a stationary-phase physiological switch. Microbiology (Reading), v. 155
    Doi: http://doi.org/10.1099/mic.0.021790-0
  • Mastroeni, P., Grant, A., Restif, O. and Maskell, D., 2009. A dynamic view of the spread and intracellular distribution of Salmonella enterica. Nat Rev Microbiol, v. 7
    Doi: http://doi.org/10.1038/nrmicro2034
  • Grant, AJ., Foster, GL., McKinley, TJ., Brown, SP., Clare, S., Maskell, DJ. and Mastroeni, P., 2009. Bacterial growth rate and host factors as determinants of intracellular bacterial distributions in systemic Salmonella enterica infections. Infect Immun, v. 77
    Doi: http://doi.org/10.1128/IAI.00827-09
  • 2008

  • Foster, GL., Barr, TA., Grant, AJ., McKinley, TJ., Bryant, CE., MacDonald, A., Gray, D., Yamamoto, M., Akira, S., Maskell, DJ. and Mastroeni, P., 2008. Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88. Immunology, v. 124
    Doi: http://doi.org/10.1111/j.1365-2567.2007.02798.x
  • Grant, AJ., Sheppard, M., Deardon, R., Brown, SP., Foster, G., Bryant, CE., Maskell, DJ. and Mastroeni, P., 2008. Caspase-3-dependent phagocyte death during systemic Salmonella enterica serovar Typhimurium infection of mice. Immunology, v. 125
    Doi: http://doi.org/10.1111/j.1365-2567.2008.02814.x
  • Grant, AJ., Restif, O., McKinley, TJ., Sheppard, M., Maskell, DJ. and Mastroeni, P., 2008. Modelling within-host spatiotemporal dynamics of invasive bacterial disease. PLoS Biol, v. 6
    Doi: 10.1371/journal.pbio.0060074
  • 2007

  • Conlan, AJK., Coward, C., Grant, AJ., Maskell, DJ. and Gog, JR., 2007. Campylobacter jejuni colonization and transmission in broiler chickens: a modelling perspective. J R Soc Interface, v. 4
    Doi: http://doi.org/10.1098/rsif.2007.1015
  • Beech, JS., Wheeler, DW., Reckless, J., Grant, AJ., Price, J., Mastroeni, P., Grainger, DJ. and Menon, DK., 2007. The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro. J Neuroimmunol, v. 184
    Doi: http://doi.org/10.1016/j.jneuroim.2006.12.015
  • Coward, C., Van Diemen, PM., Conlan, AJK., Grant, AJ., Stevens, MP., Gog, JR., Jones, MA. and Maskell, DJ., 2007. Competition between isogenic Campylobacter jejuni strains results in unpredictable population structures ZOONOSES PUBLIC HLTH, v. 54
  • 2006

  • Coward, C., Grant, AJ., Swift, C., Philp, J., Towler, R., Heydarian, M., Frost, JA. and Maskell, DJ., 2006. Phase-variable surface structures are required for infection of Campylobacter jejuni by bacteriophages. Appl Environ Microbiol, v. 72
    Doi: http://doi.org/10.1128/AEM.00184-06
  • Brown, SP., Cornell, SJ., Sheppard, M., Grant, AJ., Maskell, DJ., Grenfell, BT. and Mastroeni, P., 2006. Intracellular demography and the dynamics of Salmonella enterica infections. PLoS biology, v. 4
    Doi: http://doi.org/10.1371/journal.pbio.0040349
  • Grant, AJ., Woodward, J. and Maskell, DJ., 2006. Development of an ex vivo organ culture model using human gastro-intestinal tissue and Campylobacter jejuni. FEMS Microbiol Lett, v. 263
    Doi: http://doi.org/10.1111/j.1574-6968.2006.00449.x
  • Brown, SP., Cornell, SJ., Sheppard, M., Grant, AJ., Maskell, DJ., Grenfell, BT. and Mastroeni, P., 2006. Intracellular demography and the dynamics of Salmonella enterica infections. PLoS Biol, v. 4
    Doi: http://doi.org/10.1371/journal.pbio.0040349
  • 2005

  • Grant, AJ., Coward, C., Jones, MA., Woodall, CA., Barrow, PA. and Maskell, DJ., 2005. Signature-tagged transposon mutagenesis studies demonstrate the dynamic nature of cecal colonization of 2-week-old chickens by Campylobacter jejuni. Appl Environ Microbiol, v. 71
    Doi: http://doi.org/10.1128/AEM.71.12.8031-8041.2005
  • 2003

  • Grant, AJ., Farris, M., Alefounder, P., Williams, PH., Woodward, MJ. and O'Connor, CD., 2003. Co-ordination of pathogenicity island expression by the BipA GTPase in enteropathogenic Escherichia coli (EPEC). Mol Microbiol, v. 48
    Doi: http://doi.org/10.1046/j.1365-2958.2003.t01-1-03447.x
  • 2001

  • Owens, RM., Grant, A., Davies, N. and O'Connor, CD., 2001. Copurification of the Lac repressor with polyhistidine-tagged proteins in immobilized metal affinity chromatography. Protein Expr Purif, v. 21
    Doi: http://doi.org/10.1006/prep.2000.1384
  • Grant, AJ., Haigh, R., Williams, P. and O'Connor, CD., 2001. An in vitro transposon system for highly regulated gene expression: construction of Escherichia coli strains with arabinose-dependent growth at low temperatures. Gene, v. 280
    Doi: http://doi.org/10.1016/s0378-1119(01)00769-7
  • 1998

  • Farris, M., Grant, A., Richardson, TB. and O'Connor, CD., 1998. BipA: a tyrosine-phosphorylated GTPase that mediates interactions between enteropathogenic Escherichia coli (EPEC) and epithelial cells. Mol Microbiol, v. 28
    Doi: http://doi.org/10.1046/j.1365-2958.1998.00793.x
  • Farris, M., Grant, A., Jane, S., Chad, J. and O'Connor, CD., 1998. BipA affects Ca++ fluxes and phosphorylation of the translocated intimin receptor (Tir/Hp90) in host epithelial cells infected with enteropathogenic E. coli. Biochem Soc Trans, v. 26
    Doi: http://doi.org/10.1042/bst026s225
  • Datasets

    2022 (No publication date)

  • Kalmar, L., Gupta, S., Kean, I., Ba, X., Hadjirin, N., Lay, E., de Vries, S., Bateman, M., Bartlett, H., Hernandez-Garcia, J., Tucker, A., Restiff, O., Stevens, M., Wood, J., Maskell, D., Grant, A. and Holmes, M., 2022 (No publication date). Final Hi-C metagenomics assemblies from faecal samples on high- and low-antibiotics usage farms
  • Internet publications

    2016

  • Dybowski, R., Restif, O., Goupy, A., Maskell, DJ., Mastroeni, P. and Grant, AJ., 2016. Correction to 'Single passage in mouse organs enhances the survival and spread of Salmonella enterica'.
    Doi: http://doi.org/10.1098/rsif.2016.0040