Jonathan Heeney

Professor of Comparative Pathology
http://www.vet.cam.ac.uk/directory/jlh66@cam.ac.uk
Jonathan Heeney heads the Laboratory of Viral Zoonotics. We follow viruses wherever they go. Our main interests are in the transmission of viruses between hosts (of the same or different species). We are particularly focused on cross species transmission of viruses in immune predisposed individuals, and the co-evolution of viruses and their hosts including the evolution of immune mechanisms of immunopathology or asymptomatic carrier states.

Publications from Elements

Journal articles

2024 (Published online)

Vishwanath, S., Carnell, GW., Billmeier, M., Ohlendorf, L., Neckermann, P., Asbach, B., George, C., Sans, MS., Chan, A., Olivier, J., Nadesalingam, A., Einhauser, S., Temperton, N., Cantoni, D., Grove, J., Jordan, I., Sandig, V., Tonks, P., Geiger, J., Dohmen, C., Mummert, V., Samuel, AR., Plank, C., Kinsley, R., Wagner, R. and Heeney, JL., 2024 (Published online). Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants npj Vaccines, v. 9
Doi: http://doi.org/10.1038/s41541-024-00950-9

2024 (Accepted for publication)

Heeney, J., Vishwanath, S. and Carnell, G., 2024 (Accepted for publication). Computationally designed Spike antigens induce neutralising responses against the breadth of SARS-COV-2 variants npj Vaccines,

2024

Lord, JM., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, AG., Greening, NJ., McAuley, HJC., Evans, RA., Moss, P., Moore, SC., Turtle, L., Gautam, N., Gilani, A., Bajaj, M., Wain, LV., Brightling, C., Raman, B., Marks, M., Singapuri, A., Elneima, O., Openshaw, PJM., Duggal, NA., PHOSP-COVID Study collaborative group, and ISARIC4C investigators, , 2024. Accelarated immune ageing is associated with COVID-19 disease severity. Immun Ageing, v. 21
Doi: http://doi.org/10.1186/s12979-023-00406-z

Ugwu, CA., Alao, O., John, OG., Akinnawo, B., Ajayi, I., Odebode, O., Bejide, I., Campbell, A., Campbell, J., Adole, JA., B Olawoye, I., Akano, K., Okolie, J., Eromon, P., Olaitan, P., Olagunoye, A., Adebayo, I., Adebayo, V., Babalola, E., Abioye, O., Ajayi, N., Ogah, E., Ukwaja, K., Okoro, S., Oje, O., Kingsley, OC., Eke, M., Onyia, V., Achonduh-Atijegbe, O., Ewah, FE., Obasi, M., Igwe, V., Ayodeji, O., Chukwuyem, A., Owhin, S., Oyejide, N., Abah, S., Ingbian, W., Osoba, M., Alebiosu, A., Nadesalingam, A., Aguinam, ET., Carnell, G., Krause, N., Chan, A., George, C., Kinsley, R., Tonks, P., Temperton, N., Heeney, J. and Happi, C., 2024. Immunological insights into COVID-19 in Southern Nigeria. Front Immunol, v. 15
Doi: http://doi.org/10.3389/fimmu.2024.1305586

Tebit, DM., Nickel, G., Gibson, R., Rodriguez, M., Hathaway, NJ., Bain, K., Reyes-Rodriguez, AL., Ondoa, P., Heeney, JL., Li, Y., Bongorno, J., Canaday, D., McDonald, D., Bailey, JA. and Arts, EJ., 2024. Replicative fitness and pathogenicity of primate lentiviruses in lymphoid tissue, primary human and chimpanzee cells: relation to possible jumps to humans. EBioMedicine, v. 100
Doi: 10.1016/j.ebiom.2023.104965

Kirwan, PD., Hall, VJ., Foulkes, S., Otter, AD., Munro, K., Sparkes, D., Howells, A., Platt, N., Broad, J., Crossman, D., Norman, C., Corrigan, D., Jackson, CH., Cole, M., Brown, CS., Atti, A., Islam, J., SIREN Study Group, , Presanis, AM., Charlett, A., De Angelis, D. and Hopkins, S., 2024. Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort. Lancet Reg Health Eur, v. 36
Doi: http://doi.org/10.1016/j.lanepe.2023.100809

Taquet, M., Skorniewska, Z., Zetterberg, H., Geddes, JR., Mummery, CJ., Chalmers, JD., Ho, L-P., Horsley, A., Marks, M., Poinasamy, K., Raman, B., Leavy, OC., Richardson, M., Elneima, O., McAuley, HJC., Shikotra, A., Singapuri, A., Sereno, M., Saunders, RM., Harris, VC., Houchen-Wolloff, L., Mansoori, P., Greening, NJ., Harrison, EM., Docherty, AB., Lone, NI., Quint, J., Greenhalf, W., Wain, LV., Brightling, CE., Evans, RE., Harrison, PJ., Koychev, I. and PHOSP-COVID Study Collaborative Group, , 2024. Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury. Brain Commun, v. 6
Doi: http://doi.org/10.1093/braincomms/fcad357

Ali, YM., Carnell, GW., Fumagalli, S., Mercurio, D., Seminara, S., Lynch, NJ., Khatri, P., Arachchilage, CH., Mascheroni, L., Kaminski, C., George, CL., Stewart, H., Yabuki, M., Demopulos, G., Heeney, JL. and Schwaeble, W., 2024. Inhibition of the Lectin Pathway of Complement Activation Reduces Acute Respiratory Distress Syndrome Severity in a Mouse Model of SARS-CoV-2 Infection. J Infect Dis, v. 229
Doi: 10.1093/infdis/jiad462

2023 (Accepted for publication)

Stewart, H., Lu, Y., O’Keefe, S., Valpadashi, A., Cruz-Zaragoza, LD., Michel, HA., Nguyen, SK., Carnell, GW., Lukhovitskaya, N., Milligan, R., Adewusi, Y., Jungreis, I., Lulla, V., Matthews, DA., High, S., Rehling, P., Emmott, E., Heeney, JL., Davidson, AD., Edgar, JR., Smith, GL. and Firth, AE., 2023 (Accepted for publication). The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity iScience,
Doi: http://doi.org/10.1016/j.isci.2023.108080

Stewart, H., Johansen, KH., McGovern, N., Palmulli, R., Carnell, GW., Heeney, JL., Okkenhaug, K., Firth, AE., Peden, AA. and Edgar, JR., 2023 (Accepted for publication). Tetherin antagonism by SARS-CoV-2 ORF3a and spike protein enhances virus release EMBO Reports,
Doi: 10.15252/embr.202357224

Vishwanath, S., 2023 (Accepted for publication). A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses Nature Biomedical Engineering,

Heeney, J., 2023 (Accepted for publication). Immune imprinting and next-generation coronavirus vaccines Nature Microbiology,
Doi: http://doi.org/10.1038/s41564-023-01505-9

2023

Barbey, C., Su, J., Billmeier, M., Stefan, N., Bester, R., Carnell, G., Temperton, N., Heeney, J., Protzer, U., Breunig, M., Wagner, R. and Peterhoff, D., 2023. Immunogenicity of a silica nanoparticle-based SARS-CoV-2 vaccine in mice. Eur J Pharm Biopharm, v. 192
Doi: http://doi.org/10.1016/j.ejpb.2023.09.015

Liew, F., Talwar, S., Cross, A., Willett, BJ., Scott, S., Logan, N., Siggins, MK., Swieboda, D., Sidhu, JK., Efstathiou, C., Moore, SC., Davis, C., Mohamed, N., Nunag, J., King, C., Thompson, AAR., Rowland-Jones, SL., Docherty, AB., Chalmers, JD., Ho, L-P., Horsley, A., Raman, B., Poinasamy, K., Marks, M., Kon, OM., Howard, L., Wootton, DG., Dunachie, S., Quint, JK., Evans, RA., Wain, LV., Fontanella, S., de Silva, TI., Ho, A., Harrison, E., Baillie, JK., Semple, MG., Brightling, C., Thwaites, RS., Turtle, L., Openshaw, PJM., ISARIC4C Investigators, and PHOSP-COVID collaborative group, , 2023. SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. EBioMedicine, v. 87
Doi: http://doi.org/10.1016/j.ebiom.2022.104402

Carnell, GW., Billmeier, M., Vishwanath, S., Suau Sans, M., Wein, H., George, CL., Neckermann, P., Del Rosario, JMM., Sampson, AT., Einhauser, S., Aguinam, ET., Ferrari, M., Tonks, P., Nadesalingam, A., Schütz, A., Huang, CQ., Wells, DA., Paloniemi, M., Jordan, I., Cantoni, D., Peterhoff, D., Asbach, B., Sandig, V., Temperton, N., Kinsley, R., Wagner, R. and Heeney, JL., 2023. Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants. Front Immunol, v. 14
Doi: http://doi.org/10.3389/fimmu.2023.1118523

McAuley, HJC., Evans, RA., Bolton, CE., Brightling, CE., Chalmers, JD., Docherty, AB., Elneima, O., Greenhaff, PL., Gupta, A., Harris, VC., Harrison, EM., Ho, L-P., Horsley, A., Houchen-Wolloff, L., Jolley, CJ., Leavy, OC., Lone, NI., Man, WD-C., Marks, M., Parekh, D., Poinasamy, K., Quint, JK., Raman, B., Richardson, M., Saunders, RM., Sereno, M., Shikotra, A., Singapuri, A., Singh, SJ., Steiner, M., Tan, AL., Wain, LV., Welch, C., Whitney, J., Witham, MD., Lord, J., Greening, NJ. and PHOSP-COVID Study Collaborative Group, , 2023. Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. EClinicalMedicine, v. 57
Doi: http://doi.org/10.1016/j.eclinm.2023.101896

Moore, KA., Leighton, T., Ostrowsky, JT., Anderson, CJ., Danila, RN., Ulrich, AK., Lackritz, EM., Mehr, AJ., Baric, RS., Baylor, NW., Gellin, BG., Gordon, JL., Krammer, F., Perlman, S., Rees, HV., Saville, M., Weller, CL., Osterholm, MT. and Coronavirus Vaccines R&D Roadmap Taskforce, , 2023. A research and development (R&D) roadmap for broadly protective coronavirus vaccines: A pandemic preparedness strategy. Vaccine, v. 41
Doi: http://doi.org/10.1016/j.vaccine.2023.02.032

Aguinam, ET., Nadesalingam, A., Chan, A., Smith, P., Paloniemi, M., Cantoni, D., Gronlund, J., Gronlund, H., Carnell, GW., Castillo-Olivares, J., Temperton, N., Blacklaws, B., Heeney, JL. and Baxendale, H., 2023. Differential T-cell and antibody responses induced by mRNA versus adenoviral vectored COVID-19 vaccines in patients with immunodeficiencies. J Allergy Clin Immunol Glob, v. 2
Doi: http://doi.org/10.1016/j.jacig.2023.100091

Brightling, CE., Evans, RA., Singapuri, A., Smith, N., Wain, LV. and PHOSP-COVID Collaborative Group, , 2023. Long COVID research: an update from the PHOSP-COVID Scientific Summit. Lancet Respir Med, v. 11
Doi: http://doi.org/10.1016/S2213-2600(23)00341-7

C-MORE/PHOSP-COVID Collaborative Group, , 2023. Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study. Lancet Respir Med, v. 11
Doi: http://doi.org/10.1016/S2213-2600(23)00262-X

Jackson, C., Stewart, ID., Plekhanova, T., Cunningham, PS., Hazel, AL., Al-Sheklly, B., Aul, R., Bolton, CE., Chalder, T., Chalmers, JD., Chaudhuri, N., Docherty, AB., Donaldson, G., Edwardson, CL., Elneima, O., Greening, NJ., Hanley, NA., Harris, VC., Harrison, EM., Ho, L-P., Houchen-Wolloff, L., Howard, LS., Jolley, CJ., Jones, MG., Leavy, OC., Lewis, KE., Lone, NI., Marks, M., McAuley, HJC., McNarry, MA., Patel, BV., Piper-Hanley, K., Poinasamy, K., Raman, B., Richardson, M., Rivera-Ortega, P., Rowland-Jones, SL., Rowlands, AV., Saunders, RM., Scott, JT., Sereno, M., Shah, AM., Shikotra, A., Singapuri, A., Stanel, SC., Thorpe, M., Wootton, DG., Yates, T., Gisli Jenkins, R., Singh, SJ., Man, WD-C., Brightling, CE., Wain, LV., Porter, JC., Thompson, AAR., Horsley, A., Molyneaux, PL., Evans, RA., Jones, SE., Rutter, MK., Blaikley, JF. and PHOSP-COVID Study Collaborative Group, , 2023. Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. Lancet Respir Med, v. 11
Doi: http://doi.org/10.1016/S2213-2600(23)00124-8

Zheng, B., Vivaldi, G., Daines, L., Leavy, OC., Richardson, M., Elneima, O., McAuley, HJC., Shikotra, A., Singapuri, A., Sereno, M., Saunders, RM., Harris, VC., Houchen-Wolloff, L., Greening, NJ., Pfeffer, PE., Hurst, JR., Brown, JS., Shankar-Hari, M., Echevarria, C., De Soyza, A., Harrison, EM., Docherty, AB., Lone, N., Quint, JK., Chalmers, JD., Ho, L-P., Horsley, A., Marks, M., Poinasamy, K., Raman, B., Heaney, LG., Wain, LV., Evans, RA., Brightling, CE., Martineau, A., Sheikh, A. and PHOSP-COVID Study Collaborative Group, , 2023. Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls. Lancet Reg Health Eur, v. 29
Doi: http://doi.org/10.1016/j.lanepe.2023.100635

Nadesalingam, A., Cantoni, D., Aguinam, ET., Chan, AC., Paloniemi, M., Ohlendorf, L., George, C., Carnell, G., Lyall, J., Ferrari, M., Temperton, N., Wagner, R., Castillo-Olivares, J., Baxendale, H. and Heeney, JL., 2023. Vaccination and protective immunity to SARS-CoV-2 omicron variants in people with immunodeficiencies. Lancet Microbe, v. 4
Doi: http://doi.org/10.1016/S2666-5247(22)00297-X

Cantoni, D., Wilkie, C., Bentley, EM., Mayora-Neto, M., Wright, E., Scott, S., Ray, S., Castillo-Olivares, J., Heeney, JL., Mattiuzzo, G. and Temperton, NJ., 2023. Correlation between pseudotyped virus and authentic virus neutralisation assays, a systematic review and meta-analysis of the literature. Front Immunol, v. 14
Doi: http://doi.org/10.3389/fimmu.2023.1184362

2022 (Published online)

Palmer, P., Del Rosario, JMM., da Costa, KAS., Carnell, GW., Huang, CQ., Heeney, JL., Temperton, NJ. and Wells, DA., 2022 (Published online). AutoPlate: Rapid Dose-Response Curve Analysis for Biological Assays Frontiers in Immunology, v. 12
Doi: 10.3389/fimmu.2021.681636

2022

Cantoni, D., Mayora-Neto, M., Thakur, N., Elrefaey, AME., Newman, J., Vishwanath, S., Nadesalingam, A., Chan, A., Smith, P., Castillo-Olivares, J., Baxendale, H., Charleston, B., Heeney, J., Bailey, D. and Temperton, N., 2022. Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected patients. Commun Biol, v. 5
Doi: http://doi.org/10.1038/s42003-022-03325-9

Ugwu, C., Olumade, T., Nwakpakpa, E., Onyia, V., Odeh, E., Duruiheoma, RO., Ojide, CK., Eke, MA., Nwafor, IE., Chika-Igwenyi, N., Abu, AM., Azuogu, B., Ajayi, N., Ogah, E., Ayodeji, O., Abejegah, C., Adedosu, N., Oyejide, N., Abah, S., Omidele, A., Ingbian, W., Osoba, E., Eromon, P., Oluniyi, P., Ogunsanya, O., Happi, A., Otuh, P., Nadesalingam, A., Carnell, G., Krause, N., Aguinam, E., Kinsley, R., Storisteanu, DML., Tonks, P., Nelson, D., McAlister, C., Boisen, M., Garry, R., Wright, E., Temperton, N., Frost, S., Heeney, JL. and Happi, C., 2022. Humoral and cellular immune responses to Lassa fever virus in Lassa fever survivors and their exposed contacts in Southern Nigeria. Sci Rep, v. 12
Doi: http://doi.org/10.1038/s41598-022-26045-w

Iles, JK., Zmuidinaite, R., Sadee, C., Gardiner, A., Lacey, J., Harding, S., Wallis, G., Patel, R., Roblett, D., Heeney, J., Baxendale, H. and Iles, RK., 2022. Determination of IgG1 and IgG3 SARS-CoV-2 Spike Protein and Nucleocapsid Binding-Who Is Binding Who and Why? Int J Mol Sci, v. 23
Doi: http://doi.org/10.3390/ijms23116050

Perdiguero, B., Asbach, B., Gómez, CE., Köstler, J., Barnett, SW., Koutsoukos, M., Weiss, DE., Cristillo, AD., Foulds, KE., Roederer, M., Montefiori, DC., Yates, NL., Ferrari, G., Shen, X., Sawant, S., Tomaras, GD., Sato, A., Fulp, WJ., Gottardo, R., Ding, S., Heeney, JL., Pantaleo, G., Esteban, M. and Wagner, R., 2022. Early and Long-Term HIV-1 Immunogenicity Induced in Macaques by the Combined Administration of DNA, NYVAC and Env Protein-Based Vaccine Candidates: The AUP512 Study. Front Immunol, v. 13
Doi: http://doi.org/10.3389/fimmu.2022.939627

Happi, AN., Olumade, TJ., Ogunsanya, OA., Sijuwola, AE., Ogunleye, SC., Oguzie, JU., Nwofoke, C., Ugwu, CA., Okoro, SJ., Otuh, PI., Ngele, LN., Ojo, OO., Adelabu, A., Adeleye, RF., Oyejide, NE., Njaka, CS., Heeney, JL. and Happi, CT., 2022. Increased Prevalence of Lassa Fever Virus-Positive Rodents and Diversity of Infected Species Found during Human Lassa Fever Epidemics in Nigeria. Microbiol Spectr, v. 10
Doi: http://doi.org/10.1128/spectrum.00366-22

Atti, A., Insalata, F., Carr, EJ., Otter, AD., Castillo-Olivares, J., Wu, M., Harvey, R., Howell, M., Chan, A., Lyall, J., Temperton, N., Cantoni, D., da Costa, K., Nadesalingam, A., Taylor-Kerr, A., Hettiarachchi, N., Tranquillini, C., Hewson, J., Cole, MJ., Foulkes, S., Munro, K., Monk, EJM., Milligan, ID., Linley, E., Chand, MA., Brown, CS., Islam, J., Semper, A., Charlett, A., Heeney, JL., Beale, R., Zambon, M., Hopkins, S., Brooks, T., Hall, V. and SIREN Study Group and the Crick COVID Immunity Pipeline Consortium, , 2022. Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study. J Infect, v. 85
Doi: http://doi.org/10.1016/j.jinf.2022.09.004

da Costa, KAS., Del Rosario, JMM., Ferrari, M., Vishwanath, S., Asbach, B., Kinsley, R., Wagner, R., Heeney, JL., Carnell, GW. and Temperton, NJ., 2022. Influenza A (N1-N9) and Influenza B (B/Victoria and B/Yamagata) Neuraminidase Pseudotypes as Tools for Pandemic Preparedness and Improved Influenza Vaccine Design. Vaccines (Basel), v. 10
Doi: http://doi.org/10.3390/vaccines10091520

Wells, DA., Cantoni, D., Mayora-Neto, M., Genova, CD., Sampson, A., Ferrari, M., Carnell, G., Nadesalingam, A., Smith, P., Chan, A., Raddi, G., Castillo-Olivares, J., Baxendale, H., Temperton, N. and Heeney, JL., 2022. Human seasonal coronavirus neutralization and COVID-19 severity. J Med Virol, v. 94
Doi: http://doi.org/10.1002/jmv.27937

PHOSP-COVID Collaborative Group, , 2022. Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. Lancet Respir Med, v. 10
Doi: http://doi.org/10.1016/S2213-2600(22)00127-8

Iles, J., Zmuidinaite, R., Sadee, C., Gardiner, A., Lacey, J., Harding, S., Ule, J., Roblett, D., Heeney, J., Baxendale, H. and Iles, RK., 2022. SARS-CoV-2 Spike Protein Binding of Glycated Serum Albumin-Its Potential Role in the Pathogenesis of the COVID-19 Clinical Syndromes and Bias towards Individuals with Pre-Diabetes/Type 2 Diabetes and Metabolic Diseases. Int J Mol Sci, v. 23
Doi: http://doi.org/10.3390/ijms23084126

Ali, YM., Lynch, NJ., Khatri, P., Bamigbola, IE., Chan, ACY., Yabuki, M., Demopulos, GA., Heeney, JL., Pai, S., Baxendale, H. and Schwaeble, WJ., 2022. Secondary Complement Deficiency Impairs Anti-Microbial Immunity to Klebsiella pneumoniae and Staphylococcus aureus During Severe Acute COVID-19. Front Immunol, v. 13
Doi: http://doi.org/10.3389/fimmu.2022.841759

Atti, A., Ferrari, M., Castillo-Olivares, J., Monk, EJM., Gopal, R., Patel, M., Hoschler, K., Cole, MJ., Semper, A., Hewson, J., Otter, AD., Foulkes, S., Islam, J., Mirfenderesky, M., Jain, S., Murira, J., Favager, C., Nastouli, E., Chand, MA., Brown, CS., Heeney, JL., Brooks, T., Hall, VJ., Hopkins, S. and Zambon, M., 2022. Serological profile of first SARS-CoV-2 reinfection cases detected within the SIREN study. J Infect, v. 84
Doi: http://doi.org/10.1016/j.jinf.2021.09.019

Cantoni, D., Mayora-Neto, M., Nadesalingam, A., Wells, DA., Carnell, GW., Ohlendorf, L., Ferrari, M., Palmer, P., Chan, ACY., Smith, P., Bentley, EM., Einhauser, S., Wagner, R., Page, M., Raddi, G., Baxendale, H., Castillo-Olivares, J., Heeney, J. and Temperton, N., 2022. Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds. Front Immunol, v. 13
Doi: http://doi.org/10.3389/fimmu.2022.773982

Heeney, J., Vishwanath, S., Carnell, G., Ferrari, M., Asbach, B., Billmeier, M., George, C., Sans, MS., Neckermann, P., Peterhoff, D., Cantoni, D., Wells, D., Temperton, N. and Frost, S., 2022. Gene delivery of a single,structurally engineered Coronavirus vaccine antigen elicits SARS-CoV-2 Omicron and pan-Sarbecovirus neutralisation Research Square,
Doi: http://doi.org/10.21203/rs.3.rs-995273/v1

Hall, V., Foulkes, S., Insalata, F., Kirwan, P., Saei, A., Atti, A., Wellington, E., Khawam, J., Munro, K., Cole, M., Tranquillini, C., Taylor-Kerr, A., Hettiarachchi, N., Calbraith, D., Sajedi, N., Milligan, I., Themistocleous, Y., Corrigan, D., Cromey, L., Price, L., Stewart, S., de Lacy, E., Norman, C., Linley, E., Otter, AD., Semper, A., Hewson, J., D'Arcangelo, S., Chand, M., Brown, CS., Brooks, T., Islam, J., Charlett, A., Hopkins, S. and SIREN Study Group, , 2022. Protection against SARS-CoV-2 after Covid-19 Vaccination and Previous Infection. N Engl J Med, v. 386
Doi: 10.1056/NEJMoa2118691

Scherer, KM., Mascheroni, L., Carnell, GW., Wunderlich, LCS., Makarchuk, S., Brockhoff, M., Mela, I., Fernandez-Villegas, A., Barysevich, M., Stewart, H., Suau Sans, M., George, CL., Lamb, JR., Kaminski-Schierle, GS., Heeney, JL. and Kaminski, CF., 2022. SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress. Sci Adv, v. 8
Doi: http://doi.org/10.1126/sciadv.abl4895

2021 (Accepted for publication)

Baxendale, HE., Wells, D., Gronlund, J., Nadesalingam, A., Paloniemi, M., Carnell, G., Tonks, P., Ceron-Gutierrez, L., Ebrahimi, S., Sayer, A., Briggs, JAG., Xiong, X., Nathan, JA., Grice, GL., James, LC., Luptak, J., Pai, S., Heeney, JL. and Doffinger, R., 2021 (Accepted for publication). Critical care workers have lower seroprevalence of SARS-CoV-2 IgG compared with non-patient facing staff in first wave of COVID19 The Journal of Critical Care Medicine,
Doi: http://doi.org/10.2478/jccm-2021-0018

Sampson, AT., Heeney, J., Cantoni, D., Ferrari, M., Sans, MS., George, C., Di Genova, C., Mayora Neto, M., Einhauser, S., Asbach, B., Wagner, R., Baxendale, H., Temperton, N. and Carnell, G., 2021 (Accepted for publication). Coronavirus Pseudotypes for All Circulating Human Coronaviruses for Quantification of Cross-Neutralizing Antibody Responses. Viruses, v. 13
Doi: http://doi.org/10.3390/v13081579

Scherer, K., Mascheroni, L., Carnell, G., Wunderlich, L., Makarchuk, S., Brockhoff, M., Mela, I., Fernandez-Villegas, A., Barysevich, M., Stewart, H., Sans, MS., George, C., Lamb, J., Kaminski-Schierle, G., Heeney, J. and Kaminski, C., 2021 (Accepted for publication). SARS-CoV-2 nucleocapsid protein adheres to replication organelles before viral assembly at the Golgi/ERGIC and lysosome-mediated egress Science Advances, v. 8
Doi: http://doi.org/10.1126/sciadv.abl4895

Heeney, J. and Palmer, P., 2021 (Accepted for publication). AutoPlate: Rapid Dose-Response Curve Analysis for Biological Assays Frontiers in Immunology,

2021

IIes, J., Zmuidinaite, R., Sadee, C., Gardiner, A., Lacey, J., Harding, S., Ule, J., Roblett, D. and Iles, R., 2021. SARS-CoV-2 Spike protein binding of glycated serum albumin - its potential role in the pathogenesis of the COVID-19 clinical syndromes and bias towards individuals with pre-diabetes/type 2 diabetes & metabolic diseases
Doi: http://doi.org/10.1101/2021.06.14.21258871

Nadesalingam, A., Cantoni, D., Wells, DA., Aguinam, ET., Ferrari, M., Smith, P., Chan, A., Carnell, G., Ohlendorf, L., Einhauser, S., George, C., Wagner, R., Temperton, N., Castillo-Olivares, J., Baxendale, H., Heeney, JL. and HICC consortium, , 2021. Paucity and discordance of neutralising antibody responses to SARS-CoV-2 VOCs in vaccinated immunodeficient patients and health-care workers in the UK. Lancet Microbe,
Doi: http://doi.org/10.1016/S2666-5247(21)00157-9

Happi, AN., Ogunsanya, OA., Oguzie, JU., Oluniyi, PE., Olono, AS., Heeney, JL. and Happi, CT., 2021. Microbial metagenomic approach uncovers the first rabbit haemorrhagic disease virus genome in Sub-Saharan Africa. Sci Rep, v. 11
Doi: http://doi.org/10.1038/s41598-021-91961-2

Del Rosario, JMM., da Costa, KAS., Asbach, B., Ferrara, F., Ferrari, M., Wells, DA., Mann, GS., Ameh, VO., Sabeta, CT., Banyard, AC., Kinsley, R., Scott, SD., Wagner, R., Heeney, JL., Carnell, GW. and Temperton, NJ., 2021. Exploiting Pan Influenza A and Pan Influenza B Pseudotype Libraries for Efficient Vaccine Antigen Selection Vaccines, v. 9
Doi: http://doi.org/10.3390/vaccines9070741

Ali, YM., Ferrari, M., Lynch, NJ., Yaseen, S., Dudler, T., Gragerov, S., Demopulos, G., Heeney, JL. and Schwaeble, WJ., 2021. Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins. Front Immunol, v. 12
Doi: http://doi.org/10.3389/fimmu.2021.714511

Hauser, A., Carnell, G., Held, K., Sulbaran, G., Tischbierek, N., Rogers, L., Pollakis, G., Tonks, P., Hoelscher, M., Ding, S., Sanders, RW., Geldmacher, C., Sattentau, Q., Weissenhorn, W., Heeney, JL., Peterhoff, D. and Wagner, R., 2021. Stepwise Conformational Stabilization of a HIV-1 Clade C Consensus Envelope Trimer Immunogen Impacts the Profile of Vaccine-Induced Antibody Responses Vaccines, v. 9
Doi: http://doi.org/10.3390/vaccines9070750

Oluniyi, PE., Ajogbasile, F., Oguzie, J., Uwanibe, J., Kayode, A., Happi, A., Ugwu, A., Olumade, T., Ogunsanya, O., Eromon, PE., Folarin, O., Frost, SDW., Heeney, J. and Happi, CT., 2021. VGEA: an RNA viral assembly toolkit. PeerJ, v. 9
Doi: http://doi.org/10.7717/peerj.12129

Bentley, EM., Richardson, S., Derveni, M., Rijal, P., Townsend, AR., Heeney, JL., Mattiuzzo, G. and Wright, E., 2021. Cross-Neutralisation of Novel Bombali Virus by Ebola Virus Antibodies and Convalescent Plasma Using an Optimised Pseudotype-Based Neutralisation Assay. Trop Med Infect Dis, v. 6
Doi: http://doi.org/10.3390/tropicalmed6030155

Carnell, G., Ciazynska, K., Wells, D., Xiong, X., Aguinam, E., McLaughlin, S., Mallery, D., Ebrahimi, S., Ceron-Gutierrez, L., James, L., Doffinger, R., Heeney, J. and Briggs, J., 2021. SARS-CoV-2 spike protein arrested in the closed state induces potent neutralizing responses bioRxiv,
Doi: http://doi.org/10.1101/2021.01.14.426695

Lai, M., Maori, E., Quaranta, P., Matteoli, G., Maggi, F., Sgarbanti, M., Crucitta, S., Pacini, S., Turriziani, O., Antonelli, G., Heeney, JL., Freer, G. and Pistello, M., 2021. CRISPR/Cas9 Ablation of Integrated HIV-1 Accumulates Proviral DNA Circles with Reformed Long Terminal Repeats. J Virol, v. 95
Doi: http://doi.org/10.1128/JVI.01358-21

Cantoni, D., Mayora-Neto, M., Nadesalingham, A., Wells, D., Carnell, G., Ohlendorf, L., Ferarri, M., Palmer, P., Chan, ACY., Smith, P., Bentley, E., Einhauser, S., Wagner, R., Page, M., Raddi, G., Baxendale, H., Castillo-Olivares, J., Heeney, J. and Temperton, N., 2021. Neutralisation hierarchy of SARS-CoV-2 Variants of Concern using standardised, quantitative neutralisation assays reveals a correlation with disease severity; towards deciphering protective antibody thresholds medRxiv,
Doi: http://doi.org/10.1101/2021.05.24.21257729

Evans, RA., McAuley, H., Harrison, EM., Shikotra, A., Singapuri, A., Sereno, M., Elneima, O., Docherty, AB., Lone, NI., Leavy, OC., Daines, L., Baillie, JK., Brown, JS., Chalder, T., De Soyza, A., Diar Bakerly, N., Easom, N., Geddes, JR., Greening, NJ., Hart, N., Heaney, LG., Heller, S., Howard, L., Hurst, JR., Jacob, J., Jenkins, RG., Jolley, C., Kerr, S., Kon, OM., Lewis, K., Lord, JM., McCann, GP., Neubauer, S., Openshaw, PJM., Parekh, D., Pfeffer, P., Rahman, NM., Raman, B., Richardson, M., Rowland, M., Semple, MG., Shah, AM., Singh, SJ., Sheikh, A., Thomas, D., Toshner, M., Chalmers, JD., Ho, L-P., Horsley, A., Marks, M., Poinasamy, K., Wain, LV., Brightling, CE. and PHOSP-COVID Collaborative Group, , 2021. Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. Lancet Respir Med, v. 9
Doi: http://doi.org/10.1016/S2213-2600(21)00383-0

da Costa, KAS., Del Rosario, JM., Ferrari, M., Vishwanath, S., Asbach, B., Kinsley, R., Wagner, R., Heeney, J., Carnell, G. and Temperton, N., 2021. Influenza A (N1-N9) and Influenza B (B/Vic and B/Yam) Neuraminidase Pseudotypes as Tools for Pandemic Preparedness and Improved Influenza Vaccine design bioRxiv,
Doi: http://doi.org/10.1101/2021.09.19.460966

Hall, VJ., Foulkes, S., Charlett, A., Atti, A., Monk, EJM., Simmons, R., Wellington, E., Cole, MJ., Saei, A., Oguti, B., Munro, K., Wallace, S., Kirwan, PD., Shrotri, M., Vusirikala, A., Rokadiya, S., Kall, M., Zambon, M., Ramsay, M., Brooks, T., Brown, CS., Chand, MA., Hopkins, S. and SIREN Study Group, , 2021. SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN). Lancet, v. 397
Doi: http://doi.org/10.1016/S0140-6736(21)00675-9

Castillo-Olivares, J., Wells, D., Ferrari, M., Chan, A., Smith, P., Nadesalingam, A., Paloniemi, M., Carnell, G., Ohlendorf, L., Cantoni, D., Mayora-Neto, M., Palmer, P., Tonks, P., Temperton, N., Wagner, R., Neckermann, P., Peterhoff, D., Doffinger, R., Kempster, S., Otter, A., Semper, A., Brooks, T., Page, M., Albecka, A., James, L., Briggs, J., Schwaeble, W., Baxendale, H. and Heeney, J., 2021. Towards Internationally standardised humoral Immune Correlates of Protection from SARS-CoV-2 infection and COVID-19 disease medRxiv,
Doi: http://doi.org/10.1101/2021.05.21.21257572

Nadesalingam, A., Cantoni, D., Wells, D., Aguinam, E., Ferrari, M., Smith, P., Chan, A., Carnell, G., Ohlendorf, L., Einhauser, S., Wagner, R., Temperton, N., Castillo-Olivares, J., Baxendale, H., Heeney, J. and the HICC consortium, , 2021. Breadth of neutralising antibody responses to SARS-CoV-2 variants of concern is augmented by vaccination following prior infection: studies in UK healthcare workers and immunodeficient patients medRxiv,
Doi: http://doi.org/10.1101/2021.06.03.21257901

Wells, D., Cantoni, D., Mayora-Neto, M., Di Genova, C., Sampson, A., Ferrari, M., Carnell, G., Nadesalingam, A., Smith, P., Chan, A., Raddi, G., Castillo-Olivares, J., Baxendale, H., Temperton, N. and Heeney, J., 2021. Endemic Seasonal Coronavirus Neutralisation and COVID-19 severity medRxiv,
Doi: http://doi.org/10.1101/2021.09.29.21264328

Carnell, GW., Ciazynska, KA., Wells, DA., Xiong, X., Aguinam, ET., McLaughlin, SH., Mallery, D., Ebrahimi, S., Ceron-Gutierrez, L., Asbach, B., Einhauser, S., Wagner, R., James, LC., Doffinger, R., Heeney, JL. and Briggs, JAG., 2021. SARS-CoV-2 spike protein stabilized in the closed state induces potent neutralizing responses. J Virol,
Doi: http://doi.org/10.1128/JVI.00203-21

Castillo-Olivares, J., Wells, DA., Ferrari, M., Chan, ACY., Smith, P., Nadesalingam, A., Paloniemi, M., Carnell, GW., Ohlendorf, L., Cantoni, D., Mayora-Neto, M., Palmer, P., Tonks, P., Temperton, NJ., Peterhoff, D., Neckermann, P., Wagner, R., Doffinger, R., Kempster, S., Otter, AD., Semper, A., Brooks, T., Albecka, A., James, LC., Page, M., Schwaeble, W., Baxendale, H. and Heeney, JL., 2021. Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases. Front Immunol, v. 12
Doi: http://doi.org/10.3389/fimmu.2021.748291

Cantoni, D., Mayora-Neto, M., Thakur, N., Elrefaey, AME., Newman, J., Vishwanath, S., Nadesalingam, A., Chan, A., Smith, P., Castillo-Olivares, J., Baxendale, H., Charleston, B., Heeney, J., Bailey, D. and Temperton, N., 2021. Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected Patients
Doi: http://doi.org/10.1101/2021.08.17.456606

Hall, VJ., Foulkes, S., Saei, A., Andrews, N., Oguti, B., Charlett, A., Wellington, E., Stowe, J., Gillson, N., Atti, A., Islam, J., Karagiannis, I., Munro, K., Khawam, J., Chand, MA., Brown, CS., Ramsay, M., Lopez-Bernal, J., Hopkins, S. and SIREN Study Group, , 2021. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study. Lancet, v. 397
Doi: http://doi.org/10.1016/S0140-6736(21)00790-X

2020 (Accepted for publication)

Iles, RK., Zmuidinaite, R., Iles, JK., Carnell, G., Sampson, A. and Heeney, JL., 2020 (Accepted for publication). A clinical MALDI-ToF Mass spectrometry assay for SARS-CoV-2: Rational design and multi-disciplinary team work. Diagnostics (MDPI),
Doi: http://doi.org/10.3390/diagnostics10100746

2020

Favara, DM., Ceron-Gutierrez, ML., Carnell, GW., Heeney, JL., Corrie, P. and Doffinger, R., 2020. Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens. Emerg Microbes Infect, v. 9
Doi: http://doi.org/10.1080/22221751.2020.1858699

Iles, R., Zmuidinaite, R., Iles, J., Carnell, G., Sampson, A. and Heeney, J., 2020. A clinical MALDI-ToF Mass spectrometry assay for SARS-CoV-2: Rational design and multi-disciplinary team work medRxiv,
Doi: http://doi.org/10.1101/2020.08.22.20176669

Happi, A., Ogunsanya, O., Oguzie, J., Oluniyi, P., Olono, A., Heeney, J. and Happi, C., 2020. Microbial Metagenomic Approach Uncovers the First Rabbit Haemorrhagic Disease Virus genome in Sub-Saharan Africa
Doi: http://doi.org/10.1101/2020.11.19.390559

Iles, RK., Zmuidinaite, R., Iles, JK., Carnell, G., Sampson, A. and Heeney, JL., 2020. Development of a Clinical MALDI-ToF Mass Spectrometry Assay for SARS-CoV-2: Rational Design and Multi-Disciplinary Team Work Diagnostics, v. 10
Doi: http://doi.org/10.3390/diagnostics10100746

2019

Kibler, KV., Asbach, B., Perdiguero, B., García-Arriaza, J., Yates, NL., Parks, R., Stanfield-Oakley, S., Ferrari, G., Montefiori, DC., Tomaras, GD., Roederer, M., Foulds, KE., Forthal, DN., Seaman, MS., Self, S., Gottardo, R., Phogat, S., Tartaglia, J., Barnett, S., Cristillo, AD., Weiss, D., Galmin, L., Ding, S., Heeney, JL., Esteban, M., Wagner, R., Pantaleo, G. and Jacobs, BL., 2019. Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC. J Virol, v. 93
Doi: http://doi.org/10.1128/JVI.01513-18

Maori, E., Navarro, IC., Boncristiani, H., Seilly, DJ., Rudolph, KLM., Sapetschnig, A., Lin, C-C., Ladbury, JE., Evans, JD., Heeney, JL. and Miska, EA., 2019. A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly Molecular Cell,
Doi: http://doi.org/10.1016/j.molcel.2019.03.010

2017 (Accepted for publication)

Heeney, JL., 2017 (Accepted for publication). c B and T Cell Immune Functions in Nonhuman Primates ... Journal of Virology, v. 91
Doi: http://doi.org/10.1128/JVI.02182-16

2017

Schmidt, F., Liegeois, F., Greenwood, EJD., LeBreton, M., Lester, J., Deleplancque, L., Peeters, M., Aghokeng, A., Tamoufe, U., Diffo, JLD., Takuo, JM., Wolfe, ND., Leroy, E., Rouet, F. and Heeney, JL., 2017. Phyloepidemiological analysis reveals that viral divergence led to the paucity of SIVmus/gsn/mon infections in wild populations Journal of Virology, v. 91
Doi: http://doi.org/10.1128/JVI.01884-16

García-Arriaza, J., Perdiguero, B., Heeney, JL., Seaman, MS., Montefiori, DC., Yates, NL., Tomaras, GD., Ferrari, G., Foulds, KE., Roederer, M., Self, SG., Borate, B., Gottardo, R., Phogat, S., Tartaglia, J., Barnett, SW., Burke, B., Cristillo, AD., Weiss, DE., Lee, C., Kibler, KV., Jacobs, BL., Wagner, R., Ding, S., Pantaleo, G. and Esteban, M., 2017. c B and T Cell Immune Functions in Nonhuman Primates. ... J Virol, v. 91
Doi: http://doi.org/10.1128/JVI.02182-16

Shen, X., Bogers, WM., Yates, NL., Ferrari, G., Dey, AK., Williams, WT., Jaeger, FH., Wiehe, K., Sawant, S., Alam, SM., LaBranche, CC., Montefiori, DC., Martin, L., Srivastava, I., Heeney, J., Barnett, SW. and Tomaras, GD., 2017. Crosslinking of a CD4 Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques Journal of Virology,
Doi: http://doi.org/10.1128/JVI.00401-17

Heeney, JL., 2017. Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site Journal of Virology,

Heeney, JL., 2017. Crosslinking of a CD4 Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques Journal of Virology,

2016

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M., Freed, EO., Liu, S-L., Müller, J., Münch, J., Sewald, X., Uchil, P., Ladinsky, M., Beloor, J., Pi, R., Herrmann, C., Motamedi, N., Murooka, T., Brehm, M., Greiner, D., Mempel, T., Bjorkman, P., Kumar, P., Mothes, W., Joas, S., Parrish, E., Gnanadurai, CW., Lump, E., Stürzel, CM., Parrish, NF., Sauermann, U., Töpfer, K., Schultheiss, T., Bosinger, S., Silvestri, G., Apetrei, C., Huot, N., Müller-Trutwin, M., Sauter, D., Hahn, BH., Stahl-Hennig, C., Kirchhoff, F., Schumann, G., Jung-Klawitter, S., Fuchs, NV., Upton, KR., Muñoz-Lopez, M., Shukla, R., Wang, J., Garcia-Canadas, M., Lopez-Ruiz, C., Gerhardt, DJ., Sebe, A., Grabundzija, I., Gerdes, P., Merkert, S., Pulgarin, A., Bock, A., Held, U., Witthuhn, A., Haase, A., Wolvetang, EJ., Martin, U., Ivics, Z., Izsvák, Z., Garcia-Perez, J., Faulkner, GJ., Hurst, T., Katzourakis, A., Magiorkinis, G., Schott, K., Derua, R., Seifried, J., Reuter, A., Schmitz, H., Tondera, C., Brandariz-Nuñez, A., Diaz-Griffero, F., Janssens, V., König, R., Baldauf, H-M., Stegmann, L., Schwarz, S-M., Trotard, M., Martin, M., Lenzi, G., Burggraf, M., Pan, X., Fregoso, OI., Lim, ES., Abraham, L., Erikson, E., Nguyen, L., Ambiel, I., Rutsch, F., Kim, B., Emerman, M., Fackler, OT., Wittmann, S., Behrendt, R., Volkmann, B., Eissmann, K., Gramberg, T., Bolduan, S., Koppensteiner, H., Regensburg, S., Brack-Werner, R., Draenert, R., Schindler, M., Ducroux, A., Xu, S., Ponnurangam, A., Franz, S., Malassa, A., Ewald, E., Goffinet, C., Fung, S-Y., Chan, C-P., Yuen, C-K., Kok, K-H., Chan, C-P., Jin, D-Y., Dittmer, U., Kmiec, D., Iyer, S., Stürzel, C., Hahn, B., Ariumi, Y., Yasuda-Inoue, M., Kawano, K., Tateishi, S., Turelli, P., Compton, A., Roy, N., Porrot, F., Billet, A., Casartelli, N., Yount, J., Liang, C., Schwartz, O., Magnus, C., Reh, L., Moore, P., Uhr, T., Weber, J., Morris, L., Trkola, A., Grindberg, RV., Schlaepfer, E., Schreiber, G., Simon, V., Speck, RF., Debyser, Z., Vranckx, L., Demeulemeester, J., Saleh, S., Verdin, E., Cereseto, A., Christ, F., Gijsbers, R., Wang, G., Zhao, N., Das, AT., Köstler, J., Perdiguero, B., Esteban, M., Jacobs, BL., Montefiori, DC., LaBranche, CC., Yates, NL., Tomaras, GD., Ferrari, G., Foulds, KE., Roederer, M., Landucci, G., Forthal, DN., Seaman, MS., Hawkins, N., Self, SG., Phogat, S., Tartaglia, J., Barnett, SW., Burke, B., Cristillo, AD., Ding, S., Heeney, JL., Pantaleo, G., Stab, V., Ensser, A., Tippler, B., Burton, D., Tenbusch, M., Überla, K., Alter, G., Lofano, G., Dugast, A-S., Kulkarni, V., Suscovich, T., Opazo, T., Barraza, F., Herrera, D., Garces, A., Schwenke, T., Tapia, D., Cancino, J., Arriagada, G., Haußner, C., Damm, D., Rohrhofer, A., Schmidt, B., Eichler, J., Midgley, R., Wheeldon, J., Piguet, V., Khopkar, P., Rohamare, M., Kulkarni, S., Godinho-Santos, A., Hance, A., Goncalves, J., Mammano, F., Gasser, R., Hamoudi, M., Pellicciotta, M., Zhou, Z., Visdeloup, C., Colin, P., Braibant, M., Lagane, B., Negroni, M., Wamara, J., Bannert, N., Mesplede, T., Osman, N., Anstett, K., Liang, JC., Pham, HT., Wainberg, M., Shao, W., Shan, J., Kearney, M., Wu, X., Maldarelli, F., Mellors, J., Luke, B., Coffin, J., Hughes, S., Fricke, T., Opp, S., Shepard, C., Ivanov, D., Valle-Casuso, J., Kanja, M., Cappy, P., Negroni, M., Lener, D., Knyazhanskaya, E., Anisenko, A., Zatsepin, T., Gottikh, M., Komkov, A., Minervina, A., Nugmanov, G., Nazarov, V., Khodosevich, K., Mamedov, I., Lebedev, Y., Colomer-Lluch, M., Serra-Moreno, R., Sarracino, A., Gharu, L., Pasternak, A., Marcello, A., McCartin, AM., Kulkarni, A., Le Douce, V., Gautier, V., Baeyens, A., Naessens, E., Van Nuffel, A., Weening, K., Reilly, A-M., Claeys, E., Trypsteen, W., Vandekerckhove, L., Eyckerman, S., Gevaert, K., Verhasselt, B., Mok, HP., Norton, N., Fun, A., Hirst, J., Wills, M., Miklik, D., Senigl, F., Hejnar, J., Sakuragi, J-I., Sakuragi, S., Yokoyama, M., Shioda, T., Sato, H., Bodem, J., Moschall, R., Denk, S., Erkelenz, S., Schenk, C., Schaal, H., Donhauser, N., Socher, E., Millen, S., Sticht, H., Gross, C., Mann, M., Wei, G., Betts, MJ., Liu, Y., Kehl, T., Russell, RB., Löchelt, M., Hohn, O., Mostafa, S., Hanke, K., Norley, S., Chen, C-Y., Shingai, M., Borrego, P., Taveira, N., Strebel, K., Hellmund, C., Meng, B., Friedrich, M., Hahn, F., Setz, C., Rauch, P., Fraedrich, K., Matthaei, A., Henklein, P., Traxdorf, M., Fossen, T., Schubert, U., Khwaja, A., Galilee, M., Alian, A., Schwalbe, B., Hauser, H., Schreiber, M., Scherpenisse, M., Cho, Y-K., Kim, J., Jeong, D., Trejbalova, K., Benesova, M., Kucerova, D., Vernerova, Z., Amouroux, R., Hajkova, P., Elleder, D., Hron, T., Farkasova, H., Padhi, A., Paces, J., Zhu, H., Gifford, R., Murcia, P., Carrozza, ML., Niewiadomska, A-M., Mazzei, M., Abi-Said, M., Hughes, J., Hué, S., Gifford, R., Obasa, A., Jacobs, G., Engelbrecht, S., Mack, K., Starz, K., Geyer, M., Bibollet-Ruche, F., Stürzel, C., Leoz, M., Plantier, JC., Argaw-Denboba, A., Balestrieri, E., Serafino, A., Bucci, I., Cipriani, C., Spadafora, C., Sinibaldi-Vallebona, P., Matteucci, C., Jayashree, SN., Neogi, U., Chhangani, AK., Rathore, SS., Mathur, BRJ., Abati, A., Koç, BT., Oğuzoğlu, TÇ., Shimauchi, T., Caucheteux, S., Turpin, J., Finsterbusch, K., Tokura, Y., Souriant, S., Balboa, L., Pingris, K., Kviatcowsky, D., Raynaud-Messina, B., Cougoule, C., Mercier, I., Kuroda, M., González-Montaner, P., Inwentarz, S., Moraña, EJ., del Carmen Sasiain, M., Neyrolles, O., Maridonneau-Parini, I., Lugo-Villarino, G., Vérollet, C., Herrmann, A., Thomas, D., Bouzas, NF., Lahaye, X., Bhargava, A., Satoh, T., Gentili, M., Cerboni, S., Silvin, A., Conrad, C., Ahmed-Belkacem, H., Rodriguez, EC., Guichou, J-F., Bosquet, N., Piel, M., Le Grand, R., King, M., Pawlotsky, J-M., Manel, N., Hofmann, H., Vanwalscappel, B., Bloch, N., Landau, N., Indik, S., Hagen, B., Valle-Casuso, JC., Allouch, A., David, A., Barré-Sinoussi, F., Benkirane, M., Pancino, G., Saez-Cirion, A., Lee, W-Y., Sloan, R., Schulte, B., Opp, S., Blomberg, J., Vargiu, L., Rodriguez-Tomé, P., Tramontano, E., Sperber, G., Kumari, N., Ammosova, T., Diaz, S., Oneal, P., Nekhai, S., Fahrny, A., Gers-Huber, G., Audigé, A., Jayaprakash, A., Sachidanandam, R., Hernandez, M., Dillon-White, M., Souriant, S., Pingris, K., Raynaud-Messina, B., Cougoule, C., Mercier, I., Neyrolles, O., Maridonneau-Parini, I., Lugo-Villarino, G., Maze, E., Ham, C., Almond, N., Towers, G., Belshaw, R., de Sousa-Pereira, P., Abrantes, J., Pizzato, M., Esteves, PJ., Kahle, T., Schmitt, S., Merkel, L., Reuter, N., Stamminger, T., Rosa, ID., Bishop, K., Spinazzola, A., Groom, H., Vieyres, G., Müsken, M., Zillinger, T., Hornung, V., Barchet, W., Häussler, S., Pietschmann, T., Javed, A., Leuchte, N., Salinas, G., Opitz, L., Sopper, S., Mummert, C., Hofmann, C., Hückelhoven, AG., Bergmann, S., Müller-Schmucker, SM., Harrer, EG., Dörrie, J., Schaft, N., Harrer, T., Cardinaux, L., Zahno, M-L., Vogt, H-R., Zanoni, R., Bertoni, G., Muenchhoff, M., Goulder, P., Keppler, O., Rebensburg, S., Helfer, M., Zhang, Y., Chen, H., Bernier, A., Gosselin, A., Routy, J-P., Wöhrl, B., Schneider, A., Corona, A., Spöring, I., Jordan, M., Buchholz, B., Maccioni, E., Di Santo, R., Schweimer, K., Schölz, C., Weinert, B., Wagner, S., Beli, P., Miyake, Y., Qi, J., Jensen, L., Streicher, W., McCarthy, A., Westwood, N., Lain, S., Cox, J., Matthias, P., Mann, M., Bradner, J., Choudhary, C., Stern, M., Valletta, E., Frezza, C., Marino-Merlo, F., Grelli, S., Serafino, AL., Mastino, A., Macchi, B., Kaulfuß, M., Windmann, S., Bayer, W., Mikasi, S., Jacobs, G., Heß, R., Bonsmann, MSG., Kirschning, C., Lepenies, B., Kolenbrander, A., Temchura, V., Iijima, K., Kobayashi, J. and Ishizaka, Y., 2016. Proceedings of the Frontiers of Retrovirology Conference 2016 Retrovirology, v. 13

Asbach, B., Kliche, A., Köstler, J., Perdiguero, B., Esteban, M., Jacobs, BL., Montefiori, DC., LaBranche, CC., Yates, NL., Tomaras, GD., Ferrari, G., Foulds, KE., Roederer, M., Landucci, G., Forthal, DN., Seaman, MS., Hawkins, N., Self, SG., Sato, A., Gottardo, R., Phogat, S., Tartaglia, J., Barnett, SW., Burke, B., Cristillo, AD., Weiss, DE., Francis, J., Galmin, L., Ding, S., Heeney, JL., Pantaleo, G. and Wagner, R., 2016. Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens. J Virol, v. 90
Doi: http://doi.org/10.1128/JVI.03135-15

Rollier, CS., Verschoor, EJ., Verstrepen, BE., Drexhage, JAR., Paranhos-Baccala, G., Liljeström, P., Sutter, G., Arribillaga, L., Lasarte, JJ., Bartosch, B., Cosset, F-L., Inchauspe, G. and Heeney, JL., 2016. T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates. Gene Ther, v. 23
Doi: http://doi.org/10.1038/gt.2016.55

2015

García-Arriaza, J., Perdiguero, B., Heeney, J., Seaman, M., Montefiori, DC., Labranche, C., Yates, NL., Shen, X., Tomaras, GD., Ferrari, G., Foulds, KE., McDermott, A., Kao, S-F., Roederer, M., Hawkins, N., Self, S., Yao, J., Farrell, P., Phogat, S., Tartaglia, J., Barnett, SW., Burke, B., Cristillo, A., Weiss, D., Lee, C., Kibler, K., Jacobs, B., Asbach, B., Wagner, R., Ding, S., Pantaleo, G. and Esteban, M., 2015. Head-to-Head Comparison of Poxvirus NYVAC and ALVAC Vectors Expressing Identical HIV-1 Clade C Immunogens in Prime-Boost Combination with Env Protein in Nonhuman Primates. J Virol, v. 89
Doi: http://doi.org/10.1128/JVI.01265-15

Daly, GM., Leggett, RM., Rowe, W., Stubbs, S., Wilkinson, M., Ramirez-Gonzalez, RH., Caccamo, M., Bernal, W. and Heeney, JL., 2015. Host Subtraction, Filtering and Assembly Validations for Novel Viral Discovery Using Next Generation Sequencing Data. PLoS One, v. 10
Doi: http://doi.org/10.1371/journal.pone.0129059

Greenwood, EJD., Schmidt, F., Kondova, I., Niphuis, H., Hodara, VL., Clissold, L., McLay, K., Guerra, B., Redrobe, S., Giavedoni, LD., Lanford, RE., Murthy, KK., Rouet, F. and Heeney, JL., 2015. Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes) Shares Features of Both Pathogenic and Non-pathogenic Lentiviral Infections. PLoS Pathog, v. 11
Doi: http://doi.org/10.1371/journal.ppat.1005146

Heeney, JL., 2015. Ebola: Hidden reservoirs. Nature, v. 527
Doi: http://doi.org/10.1038/527453a

Bogers, WM., Oostermeijer, H., Mooij, P., Koopman, G., Verschoor, EJ., Davis, D., Ulmer, JB., Brito, LA., Cu, Y., Banerjee, K., Otten, GR., Burke, B., Dey, A., Heeney, JL., Shen, X., Tomaras, GD., Labranche, C., Montefiori, DC., Liao, H-X., Haynes, B., Geall, AJ. and Barnett, SW., 2015. Potent immune responses in rhesus macaques induced by nonviral delivery of a self-amplifying RNA vaccine expressing HIV type 1 envelope with a cationic nanoemulsion. J Infect Dis, v. 211
Doi: http://doi.org/10.1093/infdis/jiu522

Mooij, P., Koopman, G., Drijfhout, JW., Nieuwenhuis, IG., Beenhakker, N., Koestler, J., Bogers, WMJM., Wagner, R., Esteban, M., Pantaleo, G., Heeney, JL., Jacobs, BL. and Melief, CJM., 2015. Synthetic long peptide booster immunization in rhesus macaques primed with replication-competent NYVAC-C-KC induces a balanced CD4/CD8 T-cell and antibody response against the conserved regions of HIV-1. J Gen Virol, v. 96
Doi: http://doi.org/10.1099/vir.0.000074

Sholukh, AM., Watkins, JD., Vyas, HK., Gupta, S., Lakhashe, SK., Thorat, S., Zhou, M., Hemashettar, G., Bachler, BC., Forthal, DN., Villinger, F., Sattentau, QJ., Weiss, RA., Agatic, G., Corti, D., Lanzavecchia, A., Heeney, JL. and Ruprecht, RM., 2015. Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge. Vaccine, v. 33
Doi: http://doi.org/10.1016/j.vaccine.2015.02.020

Sholukh, AM., Watkins, JD., Vyas, HK., Gupta, S., Lakhashe, SK., Thorat, S., Zhou, M., Hemashettar, G., Bachler, BC., Forthal, DN., Villinger, F., Sattentau, QJ., Weiss, RA., Agatic, G., Corti, D., Lanzavecchia, A., Heeney, JL. and Ruprecht, RM., 2015. Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: Complete protection of rhesus monkeys from mucosal SHIV challenge Vaccine, v. 33
Doi: http://doi.org/10.1016/j.vaccine.2015.02.020

Swamy, M., Abeler-Dörner, L., Chettle, J., Mahlakõiv, T., Goubau, D., Chakravarty, P., Ramsay, G., Reis e Sousa, C., Staeheli, P., Blacklaws, BA., Heeney, JL. and Hayday, AC., 2015. Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance. Nat Commun, v. 6
Doi: http://doi.org/10.1038/ncomms8090

2014

Benen, TD., Tonks, P., Kliche, A., Kapzan, R., Heeney, JL. and Wagner, R., 2014. Development and immunological assessment of VLP-based immunogens exposing the membrane-proximal region of the HIV-1 gp41 protein. J Biomed Sci, v. 21
Doi: http://doi.org/10.1186/s12929-014-0079-x

Lai, RPJ., Hock, M., Radzimanowski, J., Tonks, P., Hulsik, DL., Effantin, G., Seilly, DJ., Dreja, H., Kliche, A., Wagner, R., Barnett, SW., Tumba, N., Morris, L., LaBranche, CC., Montefiori, DC., Seaman, MS., Heeney, JL. and Weissenhorn, W., 2014. A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1. J Biol Chem, v. 289
Doi: http://doi.org/10.1074/jbc.M114.569566

Veldhoen, M. and Heeney, JL., 2014. A helminth-mediated viral awakening. Trends Immunol, v. 35
Doi: http://doi.org/10.1016/j.it.2014.08.004

Shortland, A., Chettle, J., Archer, J., Wood, K., Bailey, D., Goodfellow, I., Blacklaws, BA. and Heeney, JL., 2014. Pathology caused by persistent murine norovirus infection. J Gen Virol, v. 95
Doi: http://doi.org/10.1099/vir.0.059188-0

Greenwood, EJD., Schmidt, F., Liégeois, F., Kondova, I., Herbert, A., Ngoubangoye, B., Rouet, F. and Heeney, JL., 2014. Loss of memory CD4+ T-cells in semi-wild mandrills (Mandrillus sphinx) naturally infected with species-specific simian immunodeficiency virus SIVmnd-1. J Gen Virol, v. 95
Doi: http://doi.org/10.1099/vir.0.059808-0

Swamy, M., Abeler-Doerner, L., Goubau, D., Chettle, J., Mahlakoiv, T., Chakravarty, P., Reis e Sousa, C., Staeheli, P., Blacklaws, B., Heeney, JL. and Hayday, AC., 2014. Intraepithelial lymphocytes prime the innate antiviral response of the intestinal epithelium through type I and III interferons IMMUNOLOGY, v. 143

Veldhoen, M. and Heeney, JL., 2014. A helminth-mediated viral awakening Trends in Immunology, v. 35
Doi: http://doi.org/10.1016/j.it.2014.08.004

Greenwood, EJD., Schmidt, F., Liégeois, F., Kondova, I., Herbert, A., Ngoubangoye, B., Rouet, F. and Heeney, JL., 2014. Loss of memory CD4<sup>+</sup> T-cells in semi-wild mandrills (Mandrillus sphinx) naturally infected with speciesspecific simian immunodeficiency virus SIVmnd-1 Journal of General Virology, v. 95
Doi: http://doi.org/10.1099/vir.0.059808-0

Bexfield, NH., Watson, PJ., Heaney, J., Heeney, JL. and Tiley, L., 2014. Canine hepacivirus is not associated with chronic liver disease in dogs Journal of Viral Hepatitis, v. 21
Doi: http://doi.org/10.1111/jvh.12150

Verstrepen, BE., Verschoor, EJ., Fagrouch, ZC., Mooij, P., de Groot, NG., Bontrop, RE., Bogers, WM., Heeney, JL. and Koopman, G., 2014. Strong vaccine-induced CD8 T-cell responses have cytolytic function in a chimpanzee clearing HCV infection. PLoS One, v. 9
Doi: http://doi.org/10.1371/journal.pone.0095103

Sopper, S., Mätz-Rensing, K., Mühl, T., Heeney, J., Stahl-Hennig, C. and Sauermann, U., 2014. Host factors determine differential disease progression after infection with nef-deleted simian immunodeficiency virus. J Gen Virol, v. 95
Doi: http://doi.org/10.1099/vir.0.066563-0

Liégeois, F., Schmidt, F., Boué, V., Butel, C., Mouacha, F., Ngari, P., Ondo, BM., Leroy, E., Heeney, JL., Delaporte, E., Peeters, M. and Rouet, F., 2014. Full-length genome analyses of two new simian immunodeficiency virus (SIV) strains from mustached monkeys (C. Cephus) in Gabon illustrate a complex evolutionary history among the SIVmus/mon/gsn lineage. Viruses, v. 6
Doi: http://doi.org/10.3390/v6072880

2013

Baker, KS., Leggett, RM., Bexfield, NH., Alston, M., Daly, G., Todd, S., Tachedjian, M., Holmes, CEG., Crameri, S., Wang, L-F., Heeney, JL., Suu-Ire, R., Kellam, P., Cunningham, AA., Wood, JLN., Caccamo, M. and Murcia, PR., 2013. Metagenomic study of the viruses of African straw-coloured fruit bats: detection of a chiropteran poxvirus and isolation of a novel adenovirus. Virology, v. 441
Doi: http://doi.org/10.1016/j.virol.2013.03.014

Bexfield, NH., Watson, PJ., Heaney, J., Heeney, JL. and Tiley, L., 2013. Canine hepacivirus is not associated with chronic liver disease in dogs Journal of Viral Hepatitis,

Watkins, JD., Sholukh, AM., Mukhtar, MM., Siddappa, NB., Lakhashe, SK., Kim, M., Reinherz, EL., Gupta, S., Forthal, DN., Sattentau, QJ., Villinger, F., Corti, D., Ruprecht, RM. and CAVD Project Group, , 2013. Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS, v. 27
Doi: http://doi.org/10.1097/QAD.0b013e328360eac6

Varela, M., Verschoor, E., Lai, RPJ., Hughes, J., Mooj, P., McKinley, TJ., Fitzmaurice, TJ., Landskron, L., Willett, BJ., Frost, SDW., Bogers, WM. and Heeney, JL., 2013. Genetic Imprint of Vaccination on Simian/Human Immunodeficiency Virus Type 1 Transmitted Viral Genomes in Rhesus Macaques PLoS ONE, v. 8
Doi: http://doi.org/10.1371/journal.pone.0070814

Davis, D., Koornstra, W., Fagrouch, Z., Verschoor, EJ., Heeney, JL. and Bogers, WMJM., 2013. In Vitro Neutralization of Low Dose Inocula at Physiological Concentrations of a Monoclonal Antibody Which Protects Macaques against SHIV Challenge PLoS ONE, v. 8
Doi: http://doi.org/10.1371/journal.pone.0072702

2012

Bogers, WM., Oostermeijer, H., Mooij, P., Koopman, G., Verschoor, E., Davis, D., Heeney, JL., Cu, Y., Banerjee, K., Burke, B., Dey, A., Geall, A. and Barnett, SW., 2012. Macaques primed with self-amplifying RNA vaccines expressing HIV-1 envelope and boosted with recombinant protein show potent T- and B-cell responses RETROVIROLOGY, v. 9
Doi: http://doi.org/10.1186/1742-4690-9-S2-P24

Lai, RPJ. and Heeney, JL., 2012. Perspectives in HIV vaccine development: What we have learned and how we proceed forward Journal of AIDS and Clinical Research, v. 3
Doi: http://doi.org/10.4172/2155-6113.S8-004

Liégeois, F., Verrier, D., Greenwood, E., Schmidt, F., Heeney, J. and Rouet, F., 2012. Control of simian immunodeficiency virus SIVmnd-1 RNA plasma viremia after coinfection or superinfection with SIVmnd-1 in SIVmnd-2-infected mandrills and vice versa. J Virol, v. 86
Doi: http://doi.org/10.1128/JVI.06590-11

Koopman, G., Beenhakker, N., Hofman, S., Walther-Jallow, L., Mäkitalo, B., Mooij, P., Anderson, J., Verschoor, E., Bogers, WMJ., Heeney, JL. and Spetz, A-L., 2012. Immunization with apoptotic pseudovirus transduced cells induces both cellular and humoral responses: a proof of concept study in macaques. Vaccine, v. 30
Doi: http://doi.org/10.1016/j.vaccine.2012.01.082

Dey, AK., Burke, B., Sun, Y., Hartog, K., Heeney, JL., Montefiori, D., Srivastava, IK. and Barnett, SW., 2012. Use of a polyanionic carbomer, Carbopol971P, in combination with MF59, improves antibody responses to HIV-1 envelope glycoprotein. Vaccine, v. 30
Doi: http://doi.org/10.1016/j.vaccine.2012.02.027

Koopman, G., Beenhakker, N., Hofman, S., Walther-Jallow, L., Mäkitalo, B., Mooij, P., Anderson, J., Verschoor, E., Bogers, WMJ., Heeney, JL. and Spetz, A-L., 2012. Immunization with apoptotic pseudovirus transduced cells induces both cellular and humoral responses: A proof of concept study in macaques Vaccine, v. 30

Lai, RPJ., Seaman, MS., Tonks, P., Wegmann, F., Seilly, DJ., Frost, SDW., LaBranche, CC., Montefiori, DC., Dey, AK., Srivastava, IK., Sattentau, Q., Barnett, SW. and Heeney, JL., 2012. Mixed adjuvant formulations reveal a new combination that elicit antibody response comparable to Freund's adjuvants. PLoS One, v. 7
Doi: http://doi.org/10.1371/journal.pone.0035083

Dey, AK., Burke, B., Sun, Y., Hartog, K., Heeney, JL., Montefiori, D., Srivastava, IK. and Barnett, SW., 2012. Use of a polyanionic carbomer, Carbopol971P, in combination with MF59, improves antibody responses to HIV-1 envelope glycoprotein Vaccine, v. 30
Doi: http://doi.org/10.1016/j.vaccine.2012.02.027

Koopman, G., Beenhakker, N., Hofman, S., Walther-Jallow, L., Mäkitalo, B., Mooij, P., Anderson, J., Verschoor, E., Bogers, WMJ., Heeney, JL. and Spetz, AL., 2012. Immunization with apoptotic pseudovirus transduced cells induces both cellular and humoral responses: A proof of concept study in macaques Vaccine, v. 30
Doi: http://doi.org/10.1016/j.vaccine.2012.01.082

Bexfield, NH., Watson, PJ., Aguirre-Hernandez, J., Sargan, DR., Tiley, L., Heeney, JL. and Kennedy, LJ., 2012. DLA class II alleles and haplotypes are associated with risk for and protection from chronic hepatitis in the English Springer spaniel. PLoS One, v. 7
Doi: http://doi.org/10.1371/journal.pone.0042584

2011

McFadden, N., Bailey, D., Carrara, G., Benson, A., Chaudhry, Y., Shortland, A., Heeney, J., Yarovinsky, F., Simmonds, P., Macdonald, A. and Goodfellow, I., 2011. Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4. PLoS Pathog, v. 7
Doi: http://doi.org/10.1371/journal.ppat.1002413

Lai, RPJ., Yan, J., Heeney, J., McClure, MO., Göttlinger, H., Luban, J. and Pizzato, M., 2011. Nef decreases HIV-1 sensitivity to neutralizing antibodies that target the membrane-proximal external region of TMgp41. PLoS Pathog, v. 7
Doi: http://doi.org/10.1371/journal.ppat.1002442

Davis, D., Koornstra, W., Mortier, D., Fagrouch, Z., Verschoor, EJ., Heeney, JL. and Bogers, WMJM., 2011. Protection in macaques immunized with HIV-1 candidate vaccines can be predicted using the kinetics of their neutralizing antibodies. PLoS One, v. 6
Doi: http://doi.org/10.1371/journal.pone.0028974

Daly, GM., Bexfield, N., Heaney, J., Stubbs, S., Mayer, AP., Palser, A., Kellam, P., Drou, N., Caccamo, M., Tiley, L., Alexander, GJM., Bernal, W. and Heeney, JL., 2011. A viral discovery methodology for clinical biopsy samples utilising massively parallel next generation sequencing. PLoS One, v. 6
Doi: http://doi.org/10.1371/journal.pone.0028879

Watkins, JD., Siddappa, NB., Lakhashe, SK., Humbert, M., Sholukh, A., Hemashettar, G., Wong, YL., Yoon, JK., Wang, W., Novembre, FJ., Villinger, F., Ibegbu, C., Patel, K., Corti, D., Agatic, G., Vanzetta, F., Bianchi, S., Heeney, JL., Sallusto, F., Lanzavecchia, A. and Ruprecht, RM., 2011. An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV. PLoS One, v. 6
Doi: http://doi.org/10.1371/journal.pone.0018207

Varela, M., Landskron, L., Lai, RPJ., McKinley, TJ., Bogers, WM., Verschoor, EJ., Dubbes, R., Barnett, SW., Frost, SDW. and Heeney, JL., 2011. Molecular evolution analysis of the human immunodeficiency virus type 1 envelope in simian/human immunodeficiency virus-infected macaques: implications for challenge dose selection. J Virol, v. 85
Doi: http://doi.org/10.1128/JVI.05290-11

Verstrepen, BE., Depla, E., Rollier, CS., Mares, G., Drexhage, JAR., Priem, S., Verschoor, EJ., Koopman, G., Granier, C., Dreux, M., Cosset, FL., Maertens, G. and Heeney, JL., 2011. Clearance of genotype 1b hepatitis C virus in chimpanzees in the presence of vaccine-induced E1-neutralizing antibodies. J Infect Dis, v. 204
Doi: http://doi.org/10.1093/infdis/jir423

Rosenwirth, B., Kondova, I., Niphuis, H., Greenwood, EJD., Schmidt, F., Verschoor, EJ., Wittmann, S., Heeney, JL., Bogers, WMJM., Fickenscher, H. and Koopman, G., 2011. Herpesvirus saimiri infection of rhesus macaques: a model for acute rhadinovirus-induced t-cell transformation and oncogenesis. J Med Virol, v. 83
Doi: http://doi.org/10.1002/jmv.22197

2010

Groenewoud, MJ., Fagrouch, Z., van Gessel, S., Niphuis, H., Bulavaite, A., Warren, KS., Heeney, JL. and Verschoor, EJ., 2010. Characterization of novel polyomaviruses from Bornean and Sumatran orang-utans. J Gen Virol, v. 91
Doi: http://doi.org/10.1099/vir.0.017673-0

Draper, SJ. and Heeney, JL., 2010. Viruses as vaccine vectors for infectious diseases and cancer. Nat Rev Microbiol, v. 8
Doi: http://doi.org/10.1038/nrmicro2240

Corti, D., Langedijk, JPM., Hinz, A., Seaman, MS., Vanzetta, F., Fernandez-Rodriguez, BM., Silacci, C., Pinna, D., Jarrossay, D., Balla-Jhagjhoorsingh, S., Willems, B., Zekveld, MJ., Dreja, H., O'Sullivan, E., Pade, C., Orkin, C., Jeffs, SA., Montefiori, DC., Davis, D., Weissenhorn, W., McKnight, A., Heeney, JL., Sallusto, F., Sattentau, QJ., Weiss, RA. and Lanzavecchia, A., 2010. Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals. PLoS One, v. 5
Doi: http://doi.org/10.1371/journal.pone.0008805

Krashias, G., Simon, A-K., Wegmann, F., Kok, W-L., Ho, L-P., Stevens, D., Skehel, J., Heeney, JL., Moghaddam, AE. and Sattentau, QJ., 2010. Potent adaptive immune responses induced against HIV-1 gp140 and influenza virus HA by a polyanionic carbomer. Vaccine, v. 28
Doi: http://doi.org/10.1016/j.vaccine.2010.01.046

Rutjens, E., Mazza, S., Biassoni, R., Koopman, G., Ugolotti, E., Fogli, M., Dubbes, R., Costa, P., Mingari, MC., Greenwood, EJD., Moretta, L., De Maria, A. and Heeney, JL., 2010. CD8+ NK cells are predominant in chimpanzees, characterized by high NCR expression and cytokine production, and preserved in chronic HIV-1 infection. Eur J Immunol, v. 40
Doi: http://doi.org/10.1002/eji.200940062

Rutjens, E., Mazza, S., Biassoni, R., Koopman, G., Ugolotti, E., Fogli, M., Dubbes, R., Costa, P., Mingari, MC., Greenwood, EJD., Moretta, L., De Maria, A. and Heeney, JL., 2010. CD8(+) NK cells are predominant in chimpanzees, characterized by high NCR expression and cytokine production, and preserved in chronic HIV-1 infection (vol 40, pg 1440, 2010) EUR J IMMUNOL, v. 40

Nieuwenhuis, I., Beenhakker, N., Bogers, WMJM., Otting, N., Bontrop, RE., Dubois, P., Mooij, P., Heeney, JL. and Koopman, G., 2010. No difference in Gag and Env immune-response profiles between vaccinated and non-vaccinated rhesus macaques that control immunodeficiency virus replication. J Gen Virol, v. 91
Doi: http://doi.org/10.1099/vir.0.022772-0

Rutjens, E., Mazza, S., Biassoni, R., Koopman, G., Ugolotti, E., Fogli, M., Dubbes, R., Costa, P., Mingari, MC., Greenwood, EJD., Moretta, L., De Maria, A. and Heeney, JL., 2010. Erratum: CD8+ NK cells are predominant in chimpanzees, characterized by high NCR expression and cytokine production, and preserved in chronic HIV-1 infection (European Journal of Immunology (2010) 40, 5 DOI: 10.1002/eji. 200940062) European Journal of Immunology, v. 40
Doi: http://doi.org/10.1002/eji.201090030

2009

Weiss, RA. and Heeney, JL., 2009. Infectious diseases: An ill wind for wild chimps? Nature, v. 460
Doi: http://doi.org/10.1038/460470a

De Maria, A., Ugolotti, E., Rutjens, E., Mazza, S., Radic, L., Faravelli, A., Koopman, G., Di Marco, E., Costa, P., Ensoli, B., Cafaro, A., Mingari, MC., Moretta, L., Heeney, J. and Biassoni, R., 2009. NKp44 expression, phylogenesis and function in non-human primate NK cells INT IMMUNOL, v. 21
Doi: http://doi.org/10.1093/intimm/dxn144

Koopman, G., Beenhakker, N., Hofman, S., Walther-Jallow, L., Makitalo, B., Mooij, P., Heeney, JL., Anderson, J., Verschoor, E., Bogers, WM. and Spetz, A., 2009. Use of autologous apoptotic pseudovirus infected cells for vaccination against HIV, evaluation in macaques RETROVIROLOGY, v. 6

Koopman, G., Mortier, D., Hofman, S., Koutsoukos, M., Bogers, WMJM., Wahren, B., Voss, G. and Heeney, JL., 2009. Acute-phase CD4+ T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian-human immunodeficiency virus strain 89.6p-infected macaques. J Gen Virol, v. 90
Doi: http://doi.org/10.1099/vir.2008.006148-0

Mooij, P., Balla-Jhagjhoorsingh, SS., Beenhakker, N., van Haaften, P., Baak, I., Nieuwenhuis, IG., Heidari, S., Wolf, H., Frachette, M-J., Bieler, K., Sheppard, N., Harari, A., Bart, P-A., Liljeström, P., Wagner, R., Pantaleo, G. and Heeney, JL., 2009. Comparison of human and rhesus macaque T-cell responses elicited by boosting with NYVAC encoding human immunodeficiency virus type 1 clade C immunogens. J Virol, v. 83
Doi: http://doi.org/10.1128/JVI.02345-08

Mee, ET., Berry, N., Ham, C., Sauermann, U., Maggiorella, MT., Martinon, F., Verschoor, EJ., Heeney, JL., Le Grand, R., Titti, F., Almond, N. and Rose, NJ., 2009. Mhc haplotype H6 is associated with sustained control of SIVmac251 infection in Mauritian cynomolgus macaques. Immunogenetics, v. 61
Doi: http://doi.org/10.1007/s00251-009-0369-8

Davis, D., Verschoor, E., Mortier, D., Fagrouch, Z., Deuzing, I., Burke, B., Srivastava, I., Kan, E., Sun, Y., Barnett, S., Heeney, J. and Bogers, W., 2009. Exposure of HIV-1 pseudovirus to soluble CD4 increases the breadth of neutralization with sera from macaques immunized with recombinant glycoproteins RETROVIROLOGY, v. 6

2008

McCormack, S., Stohr, W., Barber, T., Bart, PA., Harari, A., Moog, C., Ciuffreda, D., Cellerai, C., Cowen, M., Gamboni, R., Burnet, S., Legg, K., Brodnicki, E., Wolf, H., Wagner, R., Heeney, J., Frachette, MJ., Tartaglia, J., Babiker, A., Pantaleo, G. and Weber, J., 2008. EV02: A Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone VACCINE, v. 26
Doi: http://doi.org/10.1016/j.vaccine.2008.02.072

Verschoor, EJ., Groenewoud, MJ., Fagrouch, Z., Kewalapat, A., van Gessel, S., Kik, MJL. and Heeney, JL., 2008. Molecular characterization of the first polyomavirus from a New World primate: squirrel monkey polyomavirus. J Gen Virol, v. 89
Doi: http://doi.org/10.1099/vir.0.83287-0

Cranage, M., Sharpe, S., Herrera, C., Cope, A., Dennis, M., Berry, N., Ham, C., Heeney, J., Rezk, N., Kashuba, A., Anton, P., McGowan, I. and Shattock, R., 2008. Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel PLOS MED, v. 5
Doi: http://doi.org/10.1371/journal.pmed.0050157

Mooij, P., Balla-Jhagjhoorsingh, SS., Koopman, G., Beenhakker, N., van Haaften, P., Baak, I., Nieuwenhuis, IG., Kondova, I., Wagner, R., Wolf, H., Gómez, CE., Nájera, JL., Jiménez, V., Esteban, M. and Heeney, JL., 2008. Differential CD4+ versus CD8+ T-cell responses elicited by different poxvirus-based human immunodeficiency virus type 1 vaccine candidates provide comparable efficacies in primates. J Virol, v. 82
Doi: http://doi.org/10.1128/JVI.02216-07

Verschoor, EJ., Niphuis, H., Fagrouch, Z., Christian, P., Sasnauskas, K., Pizarro, MC. and Heeney, JL., 2008. Seroprevalence of SV40-like polyomavirus infections in captive and free-ranging macaque species. J Med Primatol, v. 37
Doi: http://doi.org/10.1111/j.1600-0684.2007.00276.x

Koopman, G., Mortier, D., Hofman, S., Mathy, N., Koutsoukos, M., Ertl, P., Overend, P., van Wely, C., Thomsen, LL., Wahren, B., Voss, G. and Heeney, JL., 2008. Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA, protein or mixed-modality immunization: increased protection from pathogenic simian-human immunodeficiency virus viraemia with protein/DNA combination. J Gen Virol, v. 89
Doi: http://doi.org/10.1099/vir.0.83384-0

Corbett, M., Bogers, WM., Heeney, JL., Gerber, S., Genin, C., Didierlaurent, A., Oostermeijer, H., Dubbes, R., Braskamp, G., Lerondel, S., Gomez, CE., Esteban, M., Wagner, R., Kondova, I., Mooij, P., Balla-Jhagjhoorsingh, S., Beenhakker, N., Koopman, G., van der Burg, S., Kraehenbuhl, J-P. and Le Pape, A., 2008. Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic. Proc Natl Acad Sci U S A, v. 105
Doi: http://doi.org/10.1073/pnas.0705191105

Wilson, SJ., Webb, BLJ., Ylinen, LMJ., Verschoor, E., Heeney, JL. and Towers, GJ., 2008. Independent evolution of an antiviral TRIMCyp in rhesus macaques. Proc Natl Acad Sci U S A, v. 105
Doi: http://doi.org/10.1073/pnas.0709003105

Rutjens, E., Vermeulen, J., Verstrepen, B., Hofman, S., Prins, JM., Srivastava, I., Heeney, JL. and Koopman, G., 2008. Chimpanzee CD4+ T cells are relatively insensitive to HIV-1 envelope-mediated inhibition of CD154 up-regulation. Eur J Immunol, v. 38
Doi: http://doi.org/10.1002/eji.200737792

Verstrepen, BE., Bins, AD., Rollier, CS., Mooij, P., Koopman, G., Sheppard, NC., Sattentau, Q., Wagner, R., Wolf, H., Schumacher, TNM., Heeney, JL. and Haanen, JBAG., 2008. Improved HIV-1 specific T-cell responses by short-interval DNA tattooing as compared to intramuscular immunization in non-human primates. Vaccine, v. 26
Doi: http://doi.org/10.1016/j.vaccine.2008.03.091

Wilson, SJ., Webb, BLJ., Maplanka, C., Newman, RM., Verschoor, EJ., Heeney, JL. and Towers, GJ., 2008. Rhesus macaque TRIM5 alleles have divergent antiretroviral specificities. J Virol, v. 82
Doi: http://doi.org/10.1128/JVI.00307-08

Cadogan, M., Austen, B., Heeney, JL. and Dalgleish, AG., 2008. HLA homology within the C5 domain promotes peptide binding by HIV type 1 gp120. AIDS Res Hum Retroviruses, v. 24
Doi: http://doi.org/10.1089/aid.2007.0194

Harari, A., Bart, PA., Stohr, WF., Tapia, G., Garcia, M., Medjitna-Rais, E., Burnet, S., Cellerai, C., Erlwein, O., Barber, T., Moog, C., Liljestrom, P., Wagner, R., Wolf, H., Kraehenbuhl, JP., Esteban, M., Heeney, J., Frachette, MJ., Tartaglia, J., McCormack, S., Babiker, A., Weber, J. and Pantaleo, G., 2008. An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses J EXP MED, v. 205
Doi: http://doi.org/10.1084/jem.20071331

Bogers, WMJM., Davis, D., Baak, I., Kan, E., Hofman, S., Sun, Y., Mortier, D., Lian, Y., Oostermeijer, H., Fagrouch, Z., Dubbes, R., van der Maas, M., Mooij, P., Koopman, G., Verschoor, E., Langedijk, JPM., Zhao, J., Brocca-Cofano, E., Robert-Guroff, M., Srivastava, I., Barnett, S. and Heeney, JL., 2008. Systemic neutralizing antibodies induced by long interval mucosally primed systemically boosted immunization correlate with protection from mucosal SHIV challenge VIROLOGY, v. 382
Doi: http://doi.org/10.1016/j.virol.2008.09.016

Stolte-Leeb, N., Bieler, K., Kostler, J., Heeney, J., Ten Haaft, P., Suh, YS., Hunsmann, G., Stahl-Hennig, C. and Wagner, R., 2008. Better protective effects in rhesus macaques by combining systemic and mucosal application of a dual component vector vaccine after rectal SHIV89.6P challenge compared to systemic vaccination alone VIRAL IMMUNOL, v. 21
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Bart, PA., Goodall, R., Barber, T., Harari, A., Guimaraes-Walker, A., Khonkarly, M., Sheppard, NC., Bangala, Y., Frachette, MJ., Wagner, R., Liljestrom, P., Kraehenbuhl, JP., Girard, M., Goudsmit, J., Esteban, M., Heeney, J., Sattentau, Q., McCormack, S., Babiker, A., Pantaleo, G. and Weber, J., 2008. EV01: A phase I trial in healthy HIV negative volunteers to evaluate a clade CHIV vaccine, NYVAC-C undertaken by the EuroVacc Consortium VACCINE, v. 26
Doi: http://doi.org/10.1016/j.vaccine.2008.03.083

2007

Bona, R., Macchia, I., Baroncelli, S., Negri, DRM., Leone, P., Pavone-Cossut, MR., Catone, S., Buffa, V., Ciccozzi, M., Heeney, J., Fagrouch, Z., Titti, F. and Cara, A., 2007. T cell receptor excision circles (TRECs) analysis during acute intrarectal infection of cynomolgus monkeys with pathogenic chimeric simian human immunodeficiency virus. Virus Res, v. 126
Doi: http://doi.org/10.1016/j.virusres.2007.01.020

Uberla, K., Rosenwirth, B., Ten Haaft, P., Heeney, J., Sutter, G. and Erfle, V., 2007. Therapeutic immunization with Modified Vaccinia Virus Ankara (MVA) vaccines in SIV-infected rhesus monkeys undergoing antiretroviral therapy. J Med Primatol, v. 36
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Koopman, G., Bogers, WMJM., van Gils, M., Koornstra, W., Barnett, S., Morein, B., Lehner, T. and Heeney, JL., 2007. Comparison of intranasal with targeted lymph node immunization using PR8-Flu ISCOM adjuvanted HIV antigens in macaques J MED VIROL, v. 79
Doi: http://doi.org/10.1002/jmw.20860

Mooij, P., Balla-Jaghjoorsingh, S., Beenhakker, N., van Haaften, P., Baak, I., Nieuwenhuis, I., Harari, A., Pantaleo, G., Frachette, MJ., Heidari, S., Wolf, H., Wagner, R., Lijestrom, P. and Heeney, JL., 2007. The impact of priming on memory of clinical HIV-1 clade CNYVAC based vaccine candidates in rhesus macaques J MED PRIMATOL, v. 36

Mooij, P., Balla-Jaghjoorsingh, S., Beenhakker, N., van Haaften, P., Baak, I., Nieuwenhuis, I., Gomez, CE., Najera, JL., Jimenez, MV., Wagner, R., Esteban, M. and Heeney, JL., 2007. Head-to-head comparison of immunogenicity and efficacy in macaques of MVA and NYVAC vectors expressing HIV-1 ENV and SIV GAG/POL/NEF J MED PRIMATOL, v. 36

Koopman, G., Mortier, D., Hofman, S., Mathy, N., Koutsoukos, M., Thomsen, LL., Ertl, P., Voss, G. and Heeney, JL., 2007. DNA induced TH1 biased immune responses are more effective against the pathogenic effects of SHIV challenge than the broader and stronger immune responses induced by protein J MED PRIMATOL, v. 36

Rutjens, E., Mazza, S., Biassoni, R., Koopman, G., Radic, L., Fogli, M., Costa, P., Mingari, MC., Moretta, L., Heeney, J. and De Maria, A., 2007. Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals. (vol 178, pg 1702, 2007) J IMMUNOL, v. 179

Uberla, K., Rosenwirth, B., ten Haaft, P., Heeney, J., Sutter, G. and Erfle, V., 2007. Therapeutic immunization with Modified Vaccinia Virus Ankara (MVA) vaccines in SIV-infected rhesus monkeys undergoing antiretroviral therapy J MED PRIMATOL, v. 36
Doi: http://doi.org/10.1111/j.1600-0684.2006.00190

Pöhlmann, S., Münch, J., Aziz, S., Reeves, JD., Otto, C., Leslie, GJ., Hofmann, H., Puffer, BA., Baribaud, F., Marzi, A., Gramberg, T., Chen, Z., Stolte, N., Haaft, PT., Heeney, JL., Stahl-Hennig, C., Mätz-Rensing, K., Schneider, T., Doms, RW. and Kirchhoff, F., 2007. A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo. Virology, v. 360
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Larrea, E., Riezu-Boj, JI., Gil-Guerrero, L., Casares, N., Aldabe, R., Sarobe, P., Civeira, MP., Heeney, JL., Rollier, C., Verstrepen, B., Wakita, T., Borrás-Cuesta, F., Lasarte, JJ. and Prieto, J., 2007. Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. J Virol, v. 81
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Rollier, CS., Paranhos-Baccala, G., Verschoor, EJ., Verstrepen, BE., Drexhage, JAR., Fagrouch, Z., Berland, J-L., Komurian-Pradel, F., Duverger, B., Himoudi, N., Staib, C., Meyr, M., Whelan, M., Whelan, JA., Adams, VC., Larrea, E., Riezu, JI., Lasarte, JJ., Bartosch, B., Cosset, F-L., Spaan, WJM., Diepolder, HM., Pape, GR., Sutter, G., Inchauspe, G. and Heeney, JL., 2007. Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity. Hepatology, v. 45
Doi: http://doi.org/10.1002/hep.21573

Aspinall, R., Pido-Lopez, J., Imami, N., Henson, SM., Ngom, PT., Morre, M., Niphuis, H., Remarque, E., Rosenwirth, B. and Heeney, JL., 2007. Old rhesus macaques treated with interleukin-7 show increased TREC levels and respond well to influenza vaccination. Rejuvenation Res, v. 10
Doi: http://doi.org/10.1089/rej.2006.9098

Rollman, E., Mathy, N., Bråve, A., Boberg, A., Kjerrström, A., van Wely, C., Engström, G., Johansson, S., Aperia, K., Eriksson, LE., Benthin, R., Ertl, P., Heeney, J., Hinkula, J., Voss, G. and Wahren, B., 2007. Evaluation of immunogenicity and efficacy of combined DNA and adjuvanted protein vaccination in a human immunodeficiency virus type 1/murine leukemia virus pseudotype challenge model. Vaccine, v. 25
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Koopman, G., Bogers, WMJM., van Gils, M., Koornstra, W., Barnett, S., Morein, B., Lehner, T. and Heeney, JL., 2007. Comparison of intranasal with targeted lymph node immunization using PR8-Flu ISCOM adjuvanted HIV antigens in macaques. J Med Virol, v. 79
Doi: http://doi.org/10.1002/jmv.20860

Baroncelli, S., Negri, DRM., Rovetto, C., Belli, R., Ciccozzi, M., Catone, S., Michelini, Z., Borghi, M., Leone, P., Fagrouch, Z., Heeney, J. and Cara, A., 2007. Characterization of alpha-defensins plasma levels in Macaca fascicularis and correlations with virological parameters during SHIV89.6Pcy11 experimental infection. AIDS Res Hum Retroviruses, v. 23
Doi: http://doi.org/10.1089/aid.2006.0142

2006

Xu, R., Srivastava, IK., Kuller, L., Zarkikh, I., Kraft, Z., Fagrouch, Z., Letvin, NL., Heeney, JL., Barnett, SW. and Stamatatos, L., 2006. Immunization with HIV-1 SF162-derived Envelope gp140 proteins does not protect macaques from heterologous simian-human immunodeficiency virus SHIV89.6P infection. Virology, v. 349
Doi: http://doi.org/10.1016/j.virol.2006.01.043

Heeney, JL., Rutjens, E., Verschoor, EJ., Niphuis, H., ten Haaft, P., Rouse, S., McClure, H., Balla-Jhagjhoorsingh, S., Bogers, W., Salas, M., Cobb, K., Kestens, L., Davis, D., van der Groen, G., Courgnaud, V., Peeters, M. and Murthy, KK., 2006. Transmission of simian immunodeficiency virus SIVcpz and the evolution of infection in the presence and absence of concurrent human immunodeficiency virus type 1 infection in chimpanzees. J Virol, v. 80
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Heeney, JL., Dalgleish, AG. and Weiss, RA., 2006. Origins of HIV and the evolution of resistance to AIDS. Science, v. 313
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Heeney, JL., 2006. Zoonotic viral diseases and the frontier of early diagnosis, control and prevention. J Intern Med, v. 260
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Heeney, JL. and Plotkin, SA., 2006. Immunological correlates of protection from HIV infection and disease. Nat Immunol, v. 7
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Dalgleish, A., Austen, B., Heeney, J. and Cadogan, M., 2006. The C5 region of HIV-1 gp120 binds specific RETROVIROLOGY, v. 3

Cafaro, A., Baroncelli, S., Maggiorella, MT., Fanales-Belasio, E., Moretti, S., Michelini, Z., Negri, DRM., Sernicola, L., Tripiciano, A., Macchia, I., Caputo, A., Heeney, J., Ciccozzi, M., Rezza, G., Comini, A., Butto, S., Fiorelli, V., Cara, A., Titti, F. and Ensoli, B., 2006. Protection against aids in Tat-protein vaccinated monkeys after rechallenge with a high dose of sHIV89.6Pcy243 in the absence of detectable anti-ENV and anti-Gag antibodies and anti-Gag cellular responses J MED PRIMATOL, v. 35

Suh, YS., Park, KS., Sauermann, U., Franz, M., Norley, S., Wilfingseder, D., Stoiber, H., Fagrouch, Z., Heeney, J., Hunsmann, G., Stahl-Hennig, C. and Sung, YC., 2006. Reduction of viral loads by multigenic DNA priming and adenovirus boosting in the SIVmac-macaque model. Vaccine, v. 24
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Brenner, M., Münch, J., Schindler, M., Wildum, S., Stolte, N., Stahl-Hennig, C., Fuchs, D., Mätz-Rensing, K., Franz, M., Heeney, J., Ten Haaft, P., Swigut, T., Hrecka, K., Skowronski, J. and Kirchhoff, F., 2006. Importance of the N-distal AP-2 binding element in Nef for simian immunodeficiency virus replication and pathogenicity in rhesus macaques. J Virol, v. 80
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Stolte-Leeb, N., Sauermann, U., Norley, S., Fagrouch, Z., Heeney, J., Franz, M., Hunsmann, G. and Stahl-Hennig, C., 2006. Sustained conservation of CD4+ T cells in multiprotein triple modality-immunized rhesus macaques after intrarectal challenge with simian immunodeficiency virus. Viral Immunol, v. 19
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Heeney, JL., 2006. Preclinical primate studies of HIV-1-envelope-based vaccines: towards human clinical trials. Curr Opin HIV AIDS, v. 1
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2005

Rockx, BHG., Bogers, WMJM., Heeney, JL., van Amerongen, G. and Koopmans, MPG., 2005. Experimental norovirus infections in non-human primates. J Med Virol, v. 75
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Koopman, G., Mortier, D., Niphuis, H., Farese, AM., Kahn, LE., Mann, D., Wagner, R., MacVittie, TJ., Woulfe, SL. and Heeney, JL., 2005. Systemic mobilization of antigen presenting cells, with a chimeric Flt-3 and G-CSF receptor agonist, during immunization of Macaca mulatta with HIV-1 antigens is insufficient to modulate immune responses or vaccine efficacy. Vaccine, v. 23
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Rollier, C., Verschoor, EJ., Paranhos-Baccala, G., Drexhage, JAR., Verstrepen, BE., Berland, J-L., Himoudi, N., Barnfield, C., Liljestrom, P., Lasarte, JJ., Ruiz, J., Inchauspe, G. and Heeney, JL., 2005. Modulation of vaccine-induced immune responses to hepatitis C virus in rhesus macaques by altering priming before adenovirus boosting. J Infect Dis, v. 192
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2004

Haaft, PT., Verschoor, EJ., Verstrepen, B., Niphuis, H., Dubbes, R., Koornstra, W., Bogers, W., Rosenwirth, B. and Heeney, JL., 2004. Readily acquired secondary infections of human and simian immunodeficiency viruses following single intravenous exposure in non-human primates. J Gen Virol, v. 85
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Wolf, H., Wagner, R., Wild, J., Deml, L., Bieler, K., Stahl-Hennig, C., Heeney, J. and Shao, Y., 2004. Development of HIV-vaccines for prevention and therapy from basic research to practice: Perspective from Europe Medizinische Welt, v. 55

Rollier, C., Depla, E., Drexhage, JAR., Verschoor, EJ., Verstrepen, BE., Fatmi, A., Brinster, C., Fournillier, A., Whelan, JA., Whelan, M., Jacobs, D., Maertens, G., Inchauspé, G. and Heeney, JL., 2004. Control of heterologous hepatitis C virus infection in chimpanzees is associated with the quality of vaccine-induced peripheral T-helper immune response. J Virol, v. 78
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Verschoor, EJ., Fagrouch, Z., Bontjer, I., Niphuis, H. and Heeney, JL., 2004. A novel simian immunodeficiency virus isolated from a Schmidt's guenon (Cercopithecus ascanius schmidti). J Gen Virol, v. 85
Doi: http://doi.org/10.1099/vir.0.19427-0

Davis, D., Donners, H., Willems, B., Lövgren-Bengtsson, K., Akerblom, L., Vanham, G., Barnett, S., Morein, B., Heeney, JL. and van der Groen, G., 2004. Neutralization of primary HIV-1 SF13 can be detected in extended incubation phase assays with sera from monkeys immunized with recombinant HIV-1 SF2 gp120. Vaccine, v. 22
Doi: http://doi.org/10.1016/j.vaccine.2003.08.031

Tenner-Racz, K., Stahl Hennig, C., Uberla, K., Stoiber, H., Ignatius, R., Heeney, J., Steinman, RM. and Racz, P., 2004. Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus. Proc Natl Acad Sci U S A, v. 101
Doi: http://doi.org/10.1073/pnas.0308677101

Mooij, P., Nieuwenhuis, IG., Knoop, CJ., Doms, RW., Bogers, WMJM., Ten Haaft, PJF., Niphuis, H., Koornstra, W., Bieler, K., Köstler, J., Morein, B., Cafaro, A., Ensoli, B., Wagner, R. and Heeney, JL., 2004. Qualitative T-helper responses to multiple viral antigens correlate with vaccine-induced immunity to simian/human immunodeficiency virus infection. J Virol, v. 78
Doi: http://doi.org/10.1128/jvi.78.7.3333-3342.2004

Negri, DRM., Baroncelli, S., Catone, S., Comini, A., Michelini, Z., Maggiorella, MT., Sernicola, L., Crostarosa, F., Belli, R., Mancini, MG., Farcomeni, S., Fagrouch, Z., Ciccozzi, M., Boros, S., Liljestrom, P., Norley, S., Heeney, J. and Titti, F., 2004. Protective efficacy of a multicomponent vector vaccine in cynomolgus monkeys after intrarectal simian immunodeficiency virus challenge. J Gen Virol, v. 85
Doi: http://doi.org/10.1099/vir.0.79794-0

Balla-Jhagjhoorsingh, SS., Koopman, G., Mooij, P., Koornstra, W., McCormack, S., Weber, J., Pantaleo, G. and Heeney, JL., 2004. Long-term persistence of HIV-1 vaccine-induced CD4+CD45RA-CD62L-CCR7- memory T-helper cells. AIDS, v. 18
Doi: http://doi.org/10.1097/00002030-200404090-00001

Cara, A., Maggiorella, MT., Bona, R., Sernicola, L., Baroncelli, S., Negri, DRM., Leone, P., Fagrouch, Z., Heeney, J., Titti, F., Cafaro, A. and Ensoli, B., 2004. Circular viral DNA detection and junction sequence analysis from PBMC of SHIV-infected cynomolgus monkeys with undetectable virus plasma RNA. Virology, v. 324
Doi: http://doi.org/10.1016/j.virol.2004.04.006

Bogers, WMJM., Bergmeier, LA., Ma, J., Oostermeijer, H., Wang, Y., Kelly, CG., Ten Haaft, P., Singh, M., Heeney, JL. and Lehner, T., 2004. A novel HIV-CCR5 receptor vaccine strategy in the control of mucosal SIV/HIV infection. AIDS, v. 18
Doi: http://doi.org/10.1097/00002030-200401020-00003

Maggiorella, MT., Baroncelli, S., Michelini, Z., Fanales-Belasio, E., Moretti, S., Sernicola, L., Cara, A., Negri, DRM., Buttò, S., Fiorelli, V., Tripiciano, A., Scoglio, A., Caputo, A., Borsetti, A., Ridolfi, B., Bona, R., ten Haaft, P., Macchia, I., Leone, P., Pavone-Cossut, MR., Nappi, F., Ciccozzi, M., Heeney, J., Titti, F., Cafaro, A. and Ensoli, B., 2004. Long-term protection against SHIV89.6P replication in HIV-1 Tat vaccinated cynomolgus monkeys. Vaccine, v. 22
Doi: http://doi.org/10.1016/j.vaccine.2004.03.009

Koopman, G., Niphuis, H., Haaksma, AGM., Farese, AM., Casey, DB., Kahn, LE., Mann, D., MacVittie, TJ., Woulfe, SL. and Heeney, JL., 2004. Increase in plasmacytoid and myeloid dendritic cells by progenipoietin-1, a chimeric Flt-3 and G-CSF receptor agonist, in SIV-Infected rhesus macaques. Hum Immunol, v. 65
Doi: http://doi.org/10.1016/j.humimm.2004.01.013

Apetrei, C., Gormus, B., Pandrea, I., Metzger, M., ten Haaft, P., Martin, LN., Bohm, R., Alvarez, X., Koopman, G., Murphey-Corb, M., Veazey, RS., Lackner, AA., Baskin, G., Heeney, J. and Marx, PA., 2004. Direct inoculation of simian immunodeficiency virus from sooty mangabeys in black mangabeys (Lophocebus aterrimus): first evidence of AIDS in a heterologous African species and different pathologic outcomes of experimental infection. J Virol, v. 78
Doi: http://doi.org/10.1128/JVI.78.21.11506-11518.2004

Kirchhoff, F., Schindler, M., Bailer, N., Renkema, GH., Saksela, K., Knoop, V., Müller-Trutwin, MC., Santiago, ML., Bibollet-Ruche, F., Dittmar, MT., Heeney, JL., Hahn, BH. and Münch, J., 2004. Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors. J Virol, v. 78
Doi: http://doi.org/10.1128/JVI.78.13.6864-6874.2004

Michelini, Z., Negri, DRM., Baroncelli, S., Catone, S., Comini, A., Maggiorella, MT., Sernicola, L., Crostarosa, F., Belli, R., Mancini, MG., Farcomeni, S., Fagrouch, Z., Ciccozzi, M., Rovetto, C., Liljestrom, P., Norley, S., Heeney, J. and Titti, F., 2004. T-cell-mediated protective efficacy of a systemic vaccine approach in cynomolgus monkeys after SIV mucosal challenge. J Med Primatol, v. 33
Doi: http://doi.org/10.1111/j.1600-0684.2004.00076.x

Mäkitalo, B., Lundholm, P., Hinkula, J., Nilsson, C., Karlén, K., Mörner, A., Sutter, G., Erfle, V., Heeney, JL., Wahren, B., Biberfeld, G. and Thorstensson, R., 2004. Enhanced cellular immunity and systemic control of SHIV infection by combined parenteral and mucosal administration of a DNA prime MVA boost vaccine regimen. J Gen Virol, v. 85
Doi: http://doi.org/10.1099/vir.0.79869-0

Heeney, JL., 2004. Requirement of diverse T-helper responses elicited by HIV vaccines: induction of highly targeted humoral and CTL responses. Expert Rev Vaccines, v. 3
Doi: http://doi.org/10.1586/14760584.3.4.s53

Sharpe, SA., Cope, A., Dowall, S., Berry, N., Ham, C., Heeney, JL., Hopkins, D., Easterbrook, L., Dennis, M., Almond, N. and Cranage, M., 2004. Macaques infected long-term with attenuated simian immunodeficiency virus (SIVmac) remain resistant to wild-type challenge, despite declining cytotoxic T lymphocyte responses to an immunodominant epitope. J Gen Virol, v. 85
Doi: http://doi.org/10.1099/vir.0.80050-0

Bogers, WMJM., Bergmeier, LA., Oostermeijer, H., ten Haaft, P., Wang, Y., Kelly, CG., Singh, M., Heeney, JL. and Lehner, T., 2004. CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection. Vaccine, v. 22
Doi: http://doi.org/10.1016/j.vaccine.2004.02.050

Koopman, G., Mortier, D., Hofman, S., Niphuis, H., Fagrouch, Z., Norley, S., Sutter, G., Liljeström, P. and Heeney, JL., 2004. Vaccine protection from CD4+ T-cell loss caused by simian immunodeficiency virus (SIV) mac251 is afforded by sequential immunization with three unrelated vaccine vectors encoding multiple SIV antigens. J Gen Virol, v. 85
Doi: http://doi.org/10.1099/vir.0.80226-0

Verschoor, EJ., Langenhuijzen, S., Bontjer, I., Fagrouch, Z., Niphuis, H., Warren, KS., Eulenberger, K. and Heeney, JL., 2004. The phylogeography of orangutan foamy viruses supports the theory of ancient repopulation of Sumatra. J Virol, v. 78
Doi: http://doi.org/10.1128/JVI.78.22.12712-12716.2004

2003

Voss, G., Manson, K., Montefiori, D., Watkins, DI., Heeney, J., Wyand, M., Cohen, J. and Bruck, C., 2003. Prevention of disease induced by a partially heterologous AIDS virus in rhesus monkeys by using an adjuvanted multicomponent protein vaccine. J Virol, v. 77
Doi: http://doi.org/10.1128/jvi.77.2.1049-1058.2003

Rollier, C., Drexhage, JAR., Verstrepen, BE., Verschoor, EJ., Bontrop, RE., Koopman, G. and Heeney, JL., 2003. Chronic hepatitis C virus infection established and maintained in chimpanzees independent of dendritic cell impairment. Hepatology, v. 38
Doi: http://doi.org/10.1053/jhep.2003.50426

Stahl-Hennig, C., Gundlach, BR., Dittmer, U., ten Haaft, P., Heeney, J., Zou, W., Emilie, D., Sopper, S. and Uberla, K., 2003. Replication, immunogenicity, and protective properties of live-attenuated simian immunodeficiency viruses expressing interleukin-4 or interferon-gamma. Virology, v. 305
Doi: http://doi.org/10.1006/viro.2002.1763

Diepolder, HM., Gruener, NH. and Heeney, J., 2003. Of chimps and men--finding the path to an HCV vaccine. Hepatology, v. 37
Doi: http://doi.org/10.1002/hep.510370634

Rutjens, E., Balla-Jhagjhoorsingh, S., Verschoor, E., Bogers, W., Koopman, G. and Heeney, J., 2003. Lentivirus infections and mechanisms of disease resistance in chimpanzees Frontiers in Bioscience, v. 8

Kuate, S., Stahl-Hennig, C., ten Haaft, P., Heeney, J. and Uberla, K., 2003. Single-cycle immunodeficiency viruses provide strategies for uncoupling in vivo expression levels from viral replicative capacity and for mimicking live-attenuated SIV vaccines. Virology, v. 313
Doi: http://doi.org/10.1016/s0042-6822(03)00388-x

Ondoa, P., Vereecken, C., Fransen, K., Colebunders, R., van der Groen, G., Heeney, JL. and Kestens, L., 2003. Human and simian immunodeficiency virus-infected chimpanzees do not have increased intracellular levels of beta-chemokines in contrast to infected humans. J Med Virol, v. 69
Doi: http://doi.org/10.1002/jmv.10289

Niphuis, H., Verschoor, EJ., Bontjer, I., Peeters, M. and Heeney, JL., 2003. Reduced transmission and prevalence of simian T-cell lymphotropic virus in a closed breeding colony of chimpanzees (Pan troglodytes verus). J Gen Virol, v. 84
Doi: http://doi.org/10.1099/vir.0.18778-0

t'Hart, BA., Vervoordeldonk, M., Heeney, JL. and Tak, PP., 2003. Gene therapy in nonhuman primate models of human autoimmune disease. Gene Ther, v. 10
Doi: http://doi.org/10.1038/sj.gt.3302017

Santiago, ML., Lukasik, M., Kamenya, S., Li, Y., Bibollet-Ruche, F., Bailes, E., Muller, MN., Emery, M., Goldenberg, DA., Lwanga, JS., Ayouba, A., Nerrienet, E., McClure, HM., Heeney, JL., Watts, DP., Pusey, AE., Collins, DA., Wrangham, RW., Goodall, J., Brookfield, JFY., Sharp, PM., Shaw, GM. and Hahn, BH., 2003. Foci of endemic simian immunodeficiency virus infection in wild-living eastern chimpanzees (Pan troglodytes schweinfurthii). J Virol, v. 77
Doi: http://doi.org/10.1128/jvi.77.13.7545-7562.2003

Balla-Jhagjhoorsingh, SS., Verschoor, EJ., de Groot, N., Teeuwsen, VJP., Bontrop, RE. and Heeney, JL., 2003. Specific nature of cellular immune responses elicited by chimpanzees against HIV-1. Hum Immunol, v. 64
Doi: http://doi.org/10.1016/s0198-8859(03)00088-0

Verschoor, EJ., Langenhuijzen, S., van den Engel, S., Niphuis, H., Warren, KS. and Heeney, JL., 2003. Structural and evolutionary analysis of an orangutan foamy virus. J Virol, v. 77
Doi: http://doi.org/10.1128/jvi.77.15.8584-8587.2003

2002

Rosenwirth, B., Oostermeijer, H., Steeneveld, E., Koornstra, W., ten Haaft, P., Niphuis, H., Doms, R., Letvin, N., Wagner, R., Sutter, G., Moss, B., Liljestrom, P. and Heeney, JL., 2002. The chimeric combo vaccine strategy: a study evaluating immunogenicity and efficacy to protect against simian/human immunodeficiency virus infection in rhesus macaques. ANTIVIR RES, v. 53

Santiago, ML., Rodenburg, CM., Kamenya, S., Bibollet-Ruche, F., Gao, F., Bailes, E., Meleth, S., Soong, S-J., Kilby, JM., Moldoveanu, Z., Fahey, B., Muller, MN., Ayouba, A., Nerrienet, E., McClure, HM., Heeney, JL., Pusey, AE., Collins, DA., Boesch, C., Wrangham, RW., Goodall, J., Sharp, PM., Shaw, GM. and Hahn, BH., 2002. SIVcpz in wild chimpanzees. Science, v. 295
Doi: http://doi.org/10.1126/science.295.5554.465

Ondoa, P., Vingerhoets, J., Vereecken, C., van der Groen, G., Heeney, JL. and Kestens, L., 2002. In vitro replication of SIVcpz is suppressed by beta-chemokines and CD8+ T cells but not by natural killer cells of infected chimpanzees. AIDS Res Hum Retroviruses, v. 18
Doi: http://doi.org/10.1089/088922202753519151

Heeney, JL., 2002. The critical role of CD4(+) T-cell help in immunity to HIV. Vaccine, v. 20
Doi: http://doi.org/10.1016/s0264-410x(02)00078-6

van der Meide, PH., Villinger, F., Ansari, AA., Groenestein, RJ., de Labie, MCDC., van den Hout, YJM., Koornstra, WH., Bogers, WMJM. and Heeney, JL., 2002. Stimulation of both humoral and cellular immune responses to HIV-1 gp120 by interleukin-12 in Rhesus macaques. Vaccine, v. 20
Doi: http://doi.org/10.1016/s0264-410x(02)00101-9

de Groot, NG., Otting, N., Doxiadis, GGM., Balla-Jhagjhoorsingh, SS., Heeney, JL., van Rood, JJ., Gagneux, P. and Bontrop, RE., 2002. Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees. Proc Natl Acad Sci U S A, v. 99
Doi: http://doi.org/10.1073/pnas.182420799

Münch, J., Janardhan, A., Stolte, N., Stahl-Hennig, C., Ten Haaft, P., Heeney, JL., Swigut, T., Kirchhoff, F. and Skowronski, J., 2002. T-cell receptor:CD3 down-regulation is a selected in vivo function of simian immunodeficiency virus Nef but is not sufficient for effective viral replication in rhesus macaques. J Virol, v. 76
Doi: http://doi.org/10.1128/jvi.76.23.12360-12364.2002

Nilsson, C., Sutter, G., Walther-Jallow, L., Ten Haaft, P., Åkerblom, L., Heeney, J., Erfle, V., Böttiger, P., Biberfeld, G. and Thorstensson, R., 2002. Immunization with recombinant modified vaccinia virus Ankara can modify mucosal simian immunodeficiency virus infection and delay disease progression in macaques. J Gen Virol, v. 83
Doi: http://doi.org/10.1099/0022-1317-83-4-807

Ondoa, P., Davis, D., Kestens, L., Vereecken, C., Garcìa Ribas, S., Fransen, K., Heeney, J. and van der Groen, G., 2002. In vitro susceptibility to infection with SIVcpz and HIV-1 is lower in chimpanzee than in human peripheral blood mononuclear cells. J Med Virol, v. 67
Doi: http://doi.org/10.1002/jmv.10078

2001

Landay, A. and Heeney, JL., 2001. Vaccines and immunology. Recent advances in HIV/AIDS vaccine development. AIDS, v. 15 Suppl 5
Doi: http://doi.org/10.1097/00002030-200100005-00013

Rosenwirth, B., Kuhn, EM., Heeney, JL., Hurpin, C., Tartaglia, J., Bonnet, MC., Moingeon, P. and Erdile, L., 2001. Safety and immunogenicity of ALVAC wild-type human p53 (vCP207) by the intravenous route in rhesus macaques. Vaccine, v. 19
Doi: http://doi.org/10.1016/s0264-410x(00)00416-3

De Groot, NG., Otting, N., Doxiadis, GGM., Balla-Jhagjhoorsingh, S., Heeney, JL. and Bontrop, RE., 2001. Evidence for a severe reduction in the MHC class I gene repertoire in chimpanzees: Implications for AIDS research European Journal of Immunogenetics, v. 28

Ensser, A., Glykofrydes, D., Niphuis, H., Kuhn, EM., Rosenwirth, B., Heeney, JL., Niedobitek, G., Müller-Fleckenstein, I. and Fleckenstein, B., 2001. Independence of herpesvirus-induced T cell lymphoma from viral cyclin D homologue. J Exp Med, v. 193
Doi: http://doi.org/10.1084/jem.193.5.637

Barre-Sinoussi, F., Berkley, S., Bhamarapravati, N., Birx, D., Bloom, B., Carvalheiro, J., Ganguly, N., Johnston, M., Kazatchkine, M., Makgoba, WM., Monico, SM., Nathanson, N., Schild, G., Wigzell, H., Yamasaki, S., Aubertin, AM., Bartos, M., Bermann, P., Bradac, J., Burke, D., Cao, H., Desrosiers, R., Ensoli, B., Fenyö, EM., Ferrari, G., Galvao-Castro, B., Godal, T., Goudsmit, J., Frachette, MJ., Ginsberg, R., Heeney, J., Holmes, H., Jin, X., Kalish, M., Klein, M., Korber, B., Liu, M., McMichael, A., McCutchan, F., Mhalu, F., Moscola, J., Moss, R., Mathieson, B., Mbidde, E., M'Boup, S., Mullins, J., Musonda, R., Numberg, J., Owili, M., Peeters, M., Pletschette, M., Redfield, R., Roudil, MP., Salk, P., Scarlatti, G., Schultz, A., Sheppard, H., Stamatos, L., Sutthent, R., Takebe, Y., Tramont, E., Van der Groen, G., Virelizier, JL., Voss, G., Walker, B., Weber, J., Wyatt, R., Young, P., Zolla-Pazner, S., Seck, AC., Dias-Ferrao, V., Esparza, J., Melgaard, B., Osmanov, S., Pattou, C., Piot, P., Ntounga, RS. and Toure, C., 2001. Approaches to the development of broadly protective HIV vaccines: Challenges posed by the genetic, biological and antigenic variability of HIV-1 AIDS, v. 15
Doi: http://doi.org/10.1097/00002030-200104130-00030

Koopman, G., Dalgleish, AG., Bhogal, BS., Haaksma, AG. and Heeney, JL., 2001. Changes in dendritic cell subsets in the lymph nodes of rhesus macaques after application of glucocorticoids. Hum Immunol, v. 62
Doi: http://doi.org/10.1016/s0198-8859(00)00247-0

Spring, M., Stahl-Hennig, C., Stolte, N., Bischofberger, N., Heeney, J., ten Haaft P, , Tenner-Ràcz, K., Ràcz, P., Lorenzen, D., Hunsmann, G. and Dittmer, U., 2001. Enhanced cellular immune response and reduced CD8(+) lymphocyte apoptosis in acutely SIV-infected Rhesus macaques after short-term antiretroviral treatment. Virology, v. 279
Doi: http://doi.org/10.1006/viro.2000.0720

Verschoor, EJ., Warren, KS., Langenhuijzen, S., Heriyanto, , Swan, RA. and Heeney, JL., 2001. Analysis of two genomic variants of orang-utan hepadnavirus and their relationship to other primate hepatitis B-like viruses. J Gen Virol, v. 82
Doi: http://doi.org/10.1099/0022-1317-82-4-893

Polyanskaya, N., Bergmeier, LA., Sharpe, SA., Cook, N., Leech, S., Hall, G., Dennis, M., ten Haaft, P., Heeney, J., Manca, F., Lehner, T. and Cranage, MP., 2001. Mucosal exposure to subinfectious doses of SIV primes gut-associated antibody-secreting cells and T cells: lack of enhancement by nonneutralizing antibody. Virology, v. 279
Doi: http://doi.org/10.1006/viro.2000.0704

Warren, KS., Verschoor, EJ., Langenhuijzen, S., Heriyanto, , Swan, RA., Vigilant, L. and Heeney, JL., 2001. Speciation and intrasubspecific variation of Bornean orangutans, Pongo pygmaeus pygmaeus. Mol Biol Evol, v. 18
Doi: http://doi.org/10.1093/oxfordjournals.molbev.a003826

Nilsson, C., Mäkitalo, B., Berglund, P., Bex, F., Liljeström, P., Sutter, G., Erfle, V., ten Haaft, P., Heeney, J., Biberfeld, G. and Thorstensson, R., 2001. Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara. Vaccine, v. 19
Doi: http://doi.org/10.1016/s0264-410x(01)00034-2

Czub, S., Koutsilieri, E., Sopper, S., Czub, M., Stahl-Hennig, C., Müller, JG., Pedersen, V., Gsell, W., Heeney, JL., Gerlach, M., Gosztonyi, G., Riederer, P. and ter Meulen, V., 2001. Enhancement of central nervous system pathology in early simian immunodeficiency virus infection by dopaminergic drugs. Acta Neuropathol, v. 101
Doi: http://doi.org/10.1007/s004010000313

Zuber, B., Böttiger, D., Benthin, R., ten Haaft, P., Heeney, J., Wahren, B. and Oberg, B., 2001. An in vivo model for HIV resistance development. AIDS Res Hum Retroviruses, v. 17
Doi: http://doi.org/10.1089/088922201300119734

Holterman, L., Dubbes, R., Mullins, J., Learn, G., Niphuis, H., Koornstra, W., Koopman, G., Kuhn, EM., Wade-Evans, A., Rosenwirth, B., Haaijman, J. and Heeney, J., 2001. Characteristics of a pathogenic molecular clone of an end-stage serum-derived variant of simian immunodeficiency virus (SIV(F359)). J Virol, v. 75
Doi: http://doi.org/10.1128/JVI.75.19.9328-9338.2001

Balla-Jhagjhoorsingh, SS., Mooij, P., ten Haaft, PJ., Bogers, WM., Teeuwsen, VJ., Koopman, G. and Heeney, JL., 2001. Protection from secondary human immunodeficiency virus type 1 infection in chimpanzees suggests the importance of antigenic boosting and a possible role for cytotoxic T cells. J Infect Dis, v. 184
Doi: http://doi.org/10.1086/322019

Walther-Jallow, L., Nilsson, C., Söderlund, J., Ten Haaft, P., Mäkitalo, B., Biberfeld, P., Böttiger, P., Heeney, J., Biberfeld, G. and Thorstensson, R., 2001. Cross-protection against mucosal simian immunodeficiency virus (SIVsm) challenge in human immunodeficiency virus type 2-vaccinated cynomolgus monkeys. J Gen Virol, v. 82
Doi: http://doi.org/10.1099/0022-1317-82-7-1601

ten Haaft, P., Almond, N., Biberfeld, G., Cafaro, A., Cranage, M., Ensoli, B., Hunsmann, G., Polyanskaya, N., Stahl-Hennig, C., Thortensson, R., Titti, F. and Heeney, J., 2001. Comparison of early plasma RNA loads in different macaque species and the impact of different routes of exposure on SIV/SHIV infection. J Med Primatol, v. 30
Doi: http://doi.org/10.1034/j.1600-0684.2001.d01-54.x

Münch, J., Adam, N., Finze, N., Stolte, N., Stahl-Hennig, C., Fuchs, D., Ten Haaft, P., Heeney, JL. and Kirchhoff, F., 2001. Simian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques. J Virol, v. 75
Doi: http://doi.org/10.1128/jvi.75.17.8137-8146.2001

Negri, DR., Baroncelli, S., Michelini, Z., Macchia, I., Belli, R., Catone, S., Incitti, F., ten Haaft, P., Corrias, F., Cranage, MP., Polyanskaya, N., Norley, S., Heeney, J., Verani, P. and Titti, F., 2001. Effect of vaccination with recombinant modified vaccinia virus Ankara expressing structural and regulatory genes of SIV(macJ5) on the kinetics of SIV replication in cynomolgus monkeys. J Med Primatol, v. 30
Doi: http://doi.org/10.1034/j.1600-0684.2001.d01-53.x

ten Haaft, P., Murthy, K., Salas, M., McClure, H., Dubbes, R., Koornstra, W., Niphuis, H., Davis, D., van der Groen, G. and Heeney, J., 2001. Differences in early virus loads with different phenotypic variants of HIV-1 and SIV(cpz) in chimpanzees. AIDS, v. 15
Doi: http://doi.org/10.1097/00002030-200111090-00003

Rizzo, P., Matker, C., Powers, A., Setlak, P., Heeney, JL. and Carbone, M., 2001. No evidence of HIV and SIV sequences in two separate lots of polio vaccines used in the first U.S. polio vaccine campaign. Virology, v. 287
Doi: http://doi.org/10.1006/viro.2001.0955

Ondoa, P., Davis, D., Willems, B., Heyndrickx, L., Kestens, L., van der Berg, I., Coppens, S., Janssens, W., Heeney, J. and van der Groen, G., 2001. Genetic variability of the V1 and V2 env domains of SIVcpz-ant and neutralization pattern of plasma viruses in a chimpanzee infected naturally. J Med Virol, v. 65
Doi: http://doi.org/10.1002/jmv.2102

Gotch, F., Heeney, J. and Manca, F., 2001. Special issue: The third international summit meeting on: "Immunological correlates of protection from HIV infection and disease", Sestri Levante, Italy, 30 November-3 December 2000. IMMUNOL LETT, v. 79

Geijtenbeek, TB., Koopman, G., van Duijnhoven, GC., van Vliet, SJ., van Schijndel, AC., Engering, A., Heeney, JL. and van Kooyk, Y., 2001. Rhesus macaque and chimpanzee DC-SIGN act as HIV/SIV gp120 trans-receptors, similar to human DC-SIGN. Immunol Lett, v. 79
Doi: http://doi.org/10.1016/s0165-2478(01)00279-6

Heeney, J., Drexhage, J., Verstrepen, B., Rollier, C., Mares, G., Jacobs, D., Depla, E., Maertens, G., Brinster, C., Fournillier, A., Verschoor, E. and Inchauspe, G., 2001. Vaccination of chimpanzees with a multicomponent DNA-protein prime-boost regimen provides an enhanced recovery following heterologous HCV challenge. HEPATOLOGY, v. 34

Mooij, P. and Heeney, JL., 2001. Rational development of prophylactic HIV vaccines based on structural and regulatory proteins. Vaccine, v. 20
Doi: http://doi.org/10.1016/s0264-410x(01)00373-5

Ondoa, P., Kestens, L., Davis, D., Vereecken, C., Willems, B., Fransen, K., Vingerhoets, J., Zissis, G., ten Haaft, P., Heeney, J. and van der Groen, G., 2001. Longitudinal comparison of virus load parameters and CD8 T-cell suppressive capacity in two SIVcpz-infected chimpanzees. J Med Primatol, v. 30
Doi: http://doi.org/10.1034/j.1600-0684.2001.d01-56.x

Koopman, G., Niphuis, H., Newman, W., Kishimoto, TK., Maino, VC. and Heeney, JL., 2001. Decreased expression of IL-2 in central and effector CD4 memory cells during progression to AIDS in rhesus macaques. AIDS, v. 15
Doi: http://doi.org/10.1097/00002030-200112070-00003

2000

Beaumont, T., Broersen, S., van Nuenen, A., Huisman, HG., de Roda Husman, AM., Heeney, JL. and Schuitemaker, H., 2000. Increased neutralization sensitivity and reduced replicative capacity of human immunodeficiency virus type 1 after short-term in vivo or in vitro passage through chimpanzees. J Virol, v. 74
Doi: http://doi.org/10.1128/jvi.74.17.7699-7707.2000

Heeney, JL., Koopman, G., Rosenwirth, B., Bogers, W., van Dijk, J., Nieuwenhuis, I., Niphuis, H., ten Haaft, P., Hanke, T., Rhodes, G., Berglund, P., Burny, A., Bex, F., Sutter, G. and Liljeström, P., 2000. A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens. J Med Primatol, v. 29
Doi: http://doi.org/10.1034/j.1600-0684.2000.290320.x

Holterman, L., Verschoor, EJ., Rosenwirth, B. and Heeney, JL., 2000. Primate lentiviruses and AIDS research AIDS Reviews, v. 2

Heeney, JL. and Hahn, BH., 2000. Vaccines and immunology: elucidating immunity to HIV-1 and current prospects for AIDS vaccine development. AIDS, v. 14 Suppl 3

Glykofrydes, D., Niphuis, H., Kuhn, EM., Rosenwirth, B., Heeney, JL., Bruder, J., Niedobitek, G., Müller-Fleckenstein, I., Fleckenstein, B. and Ensser, A., 2000. Herpesvirus saimiri vFLIP provides an antiapoptotic function but is not essential for viral replication, transformation, or pathogenicity. J Virol, v. 74
Doi: http://doi.org/10.1128/jvi.74.24.11919-11927.2000

Demuth, M., Czub, S., Sauer, U., Koutsilieri, E., Haaft, P., Heeney, J., Stahl-Hennig, C., ter Meulen, V. and Sopper, S., 2000. Relationship between viral load in blood, cerebrospinal fluid, brain tissue and isolated microglia with neurological disease in macaques infected with different strains of SIV. J Neurovirol, v. 6
Doi: http://doi.org/10.3109/13550280009015822

Holterman, L., Dubbes, R., Mullins, J., Haaijman, J. and Heeney, J., 2000. A strategy for cloning infectious molecular clones of retroviruses from serum or plasma. J Virol Methods, v. 84
Doi: http://doi.org/10.1016/s0166-0934(99)00136-6

Rosenwirth, B., ten Haaft, P., Bogers, WM., Nieuwenhuis, IG., Niphuis, H., Kuhn, EM., Bischofberger, N., Heeney, JL. and Uberla, K., 2000. Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques. J Virol, v. 74
Doi: http://doi.org/10.1128/jvi.74.4.1704-1711.2000

Mooij, P., Bogers, WM., Oostermeijer, H., Koornstra, W., Ten Haaft, PJ., Verstrepen, BE., Van Der Auwera, G. and Heeney, JL., 2000. Evidence for viral virulence as a predominant factor limiting human immunodeficiency virus vaccine efficacy. J Virol, v. 74
Doi: http://doi.org/10.1128/jvi.74.9.4017-4027.2000

Mori, K., Yasutomi, Y., Sawada, S., Villinger, F., Sugama, K., Rosenwith, B., Heeney, JL., Uberla, K., Yamazaki, S., Ansari, AA. and Rübsamen-Waigmann, H., 2000. ulting in efficient containment of infection. ... J Virol, v. 74
Doi: http://doi.org/10.1128/jvi.74.13.5747-5753.2000

Rosenwirth, B., ten Haaft, P., Bogers, WMJM., Nieuwenhuis, IG., Niphuis, H., Kuhn, EM., Bischofberger, N., Heeney, JL. and Uberla, K., 2000. Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques ANTIVIR RES, v. 46

Holterman, L., Niphuis, H., Koornstra, W., Dubbes, R., ten Haaft, P. and Heeney, JL., 2000. The rate of progression to AIDS is independent of virus dose in simian immunodeficiency virus-infected macaques. J Gen Virol, v. 81
Doi: http://doi.org/10.1099/0022-1317-81-7-1719

1999

Ohnimus, H., Heinkelein, M., Heeney, JL., Walker, CM. and Jassoy, C., 1999. Lysis of HIV envelope glycoprotein-expressing cells by CD4+ T lymphocytes from chimpanzees. J Acquir Immune Defic Syndr Hum Retrovirol, v. 20
Doi: http://doi.org/10.1097/00042560-199902010-00015

Verschoor, EJ., Mooij, P., Oostermeijer, H., van der Kolk, M., ten Haaft, P., Verstrepen, B., Sun, Y., Morein, B., Akerblom, L., Fuller, DH., Barnett, SW. and Heeney, JL., 1999. Comparison of immunity generated by nucleic acid-, MF59-, and ISCOM-formulated human immunodeficiency virus type 1 vaccines in Rhesus macaques: evidence for viral clearance. J Virol, v. 73
Doi: http://doi.org/10.1128/JVI.73.4.3292-3300.1999

Koopman, G., Haaksma, AG., ten Velden, J., Hack, CE. and Heeney, JL., 1999. The relative resistance of HIV type 1-infected chimpanzees to AIDS correlates with the maintenance of follicular architecture and the absence of infiltration by CD8+ cytotoxic T lymphocytes. AIDS Res Hum Retroviruses, v. 15
Doi: http://doi.org/10.1089/088922299311330

Carl, S., Iafrate, AJ., Lang, SM., Stahl-Hennig, C., Kuhn, EM., Fuchs, D., Mätz-Rensing, K., ten Haaft, P., Heeney, JL., Skowronski, J. and Kirchhoff, F., 1999. The acidic region and conserved putative protein kinase C phosphorylation site in Nef are important for SIV replication in rhesus macaques. Virology, v. 257
Doi: http://doi.org/10.1006/viro.1999.9645

Cafaro, A., Caputo, A., Fracasso, C., Maggiorella, MT., Goletti, D., Baroncelli, S., Pace, M., Sernicola, L., Koanga-Mogtomo, ML., Betti, M., Borsetti, A., Belli, R., Akerblom, L., Corrias, F., Buttò, S., Heeney, J., Verani, P., Titti, F. and Ensoli, B., 1999. Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine. Nat Med, v. 5
Doi: http://doi.org/10.1038/9488

Heeney, JL., Beverley, P., McMichael, A., Shearer, G., Strominger, J., Wahren, B., Weber, J. and Gotch, F., 1999. Immune correlates of protection from HIV and AIDS - more answers but yet more questions. Immunol Today, v. 20
Doi: http://doi.org/10.1016/s0167-5699(98)01437-6

Lehner, T., Wang, Y., Doyle, C., Tao, L., Bergmeier, LA., Mitchell, E., Bogers, WM., Heeney, J. and Kelly, CG., 1999. Induction of inhibitory antibodies to the CCR5 chemokine receptor and their complementary role in preventing SIV infection in macaques. Eur J Immunol, v. 29
Doi: http://doi.org/10.1002/(SICI)1521-4141(199908)29:08<2427::AID-IMMU2427>3.0.CO;2-…

Warren, KS., Heeney, JL., Swan, RA., Heriyanto, and Verschoor, EJ., 1999. A new group of hepadnaviruses naturally infecting orangutans (Pongo pygmaeus). J Virol, v. 73
Doi: http://doi.org/10.1128/JVI.73.9.7860-7865.1999

Kirchhoff, F., Münch, J., Carl, S., Stolte, N., Mätz-Rensing, K., Fuchs, D., Haaft, PT., Heeney, JL., Swigut, T., Skowronski, J. and Stahl-Hennig, C., 1999. The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo. J Virol, v. 73
Doi: http://doi.org/10.1128/JVI.73.10.8371-8383.1999

Verschoor, EJ., Langenhuijzen, S. and Heeney, JL., 1999. TT viruses (TTV) of non-human primates and their relationship to the human TTV genotypes. J Gen Virol, v. 80 ( Pt 9)
Doi: http://doi.org/10.1099/0022-1317-80-9-2491

Balla-Jhagjhoorsingh, S., Mooij, P., Koopman, G., Haaksma, T., Teeuwsen, V., Heeney, J. and Bontrop, R., 1999. Differential cytotoxic T-lymphocyte (CTL) responses in HIV-1 immunised sibling chimpanzees with shared MHC haplotypes. Immunol Lett, v. 66
Doi: http://doi.org/10.1016/s0165-2478(98)00152-7

Pöhlmann, S., Stolte, N., Münch, J., Ten Haaft, P., Heeney, JL., Stahl-Hennig, C. and Kirchhoff, F., 1999. Co-receptor usage of BOB/GPR15 in addition to CCR5 has no significant effect on replication of simian immunodeficiency virus in vivo. J Infect Dis, v. 180
Doi: http://doi.org/10.1086/315097

Heeney, J., Akerblom, L., Barnett, S., Bogers, W., Davis, D., Fuller, D., Koopman, G., Lehner, T., Mooij, P., Morein, B., de Giuli Morghen, C., Rosenwirth, B., Verschoor, E., Wagner, R. and Wolf, H., 1999. HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates. Immunol Lett, v. 66
Doi: http://doi.org/10.1016/s0165-2478(98)00157-6

Holterman, L., Niphuis, H., Ten Haaft, PJF., Goudsmit, J., Baskin, G. and Heeney, JL., 1999. Specific passage of simian immunodeficiency virus from end-stage disease results in accelerated progression to AIDS in rhesus macaques. J Gen Virol, v. 80 ( Pt 12)
Doi: http://doi.org/10.1099/0022-1317-80-12-3089

Rosenwirth, B., Bogers, WM., Nieuwenhuis, IG., Haaft, PT., Niphuis, H., Kuhn, EM., Bischofberger, N., Erfle, V., Sutter, G., Berglund, P., Liljestrom, P., Uberla, K. and Heeney, JL., 1999. An anti-HIV strategy combining chemotherapy and therapeutic vaccination. J Med Primatol, v. 28
Doi: http://doi.org/10.1111/j.1600-0684.1999.tb00270.x

Verschoor, EJ., Davis, D., van Gils, M., Koopman, G., Mooij, P., Oostermeijer, H., Haaft, PT., Verstrepen, B., Rosenwirth, B., Morein, B., Barnett, SW. and Heeney, JL., 1999. Efforts to broaden HIV-1-specific immunity by boosting with heterologous peptides or envelope protein and the influence of prior exposure to virus. J Med Primatol, v. 28
Doi: http://doi.org/10.1111/j.1600-0684.1999.tb00273.x

Balla-Jhagjhoorsingh, SS., Koopman, G., Mooij, P., Haaksma, TG., Teeuwsen, VJ., Bontrop, RE. and Heeney, JL., 1999. Conserved CTL epitopes shared between HIV-infected human long-term survivors and chimpanzees. J Immunol, v. 162

1998

Ten Haaft, P., Verstrepen, B., Uberla, K., Rosenwirth, B. and Heeney, J., 1998. A pathogenic threshold of virus load defined in simian immunodeficiency virus- or simian-human immunodeficiency virus-infected macaques. J Virol, v. 72
Doi: http://doi.org/10.1128/JVI.72.12.10281-10285.1998

Verschoor, EJ., Warren, KS., Niphuis, H., Heriyanto, , Swan, RA. and Heeney, JL., 1998. Characterization of a simian T-lymphotropic virus from a wild-caught orang-utan (Pongo pygmaeus) from Kalimantan, Indonesia. J Gen Virol, v. 79 ( Pt 1)
Doi: http://doi.org/10.1099/0022-1317-79-1-51

Edmonson, P., Murphey-Corb, M., Martin, LN., Delahunty, C., Heeney, J., Kornfeld, H., Donahue, PR., Learn, GH., Hood, L. and Mullins, JI., 1998. Evolution of a simian immunodeficiency virus pathogen. J Virol, v. 72
Doi: http://doi.org/10.1128/JVI.72.1.405-414.1998

Mooij, P., van der Kolk, M., Bogers, WM., ten Haaft, PJ., Van Der Meide, P., Almond, N., Stott, J., Deschamps, M., Labbe, D., Momin, P., Voss, G., Von Hoegen, P., Bruck, C. and Heeney, JL., 1998. A clinically relevant HIV-1 subunit vaccine protects rhesus macaques from in vivo passaged simian-human immunodeficiency virus infection. AIDS, v. 12
Doi: http://doi.org/10.1097/00002030-199805000-00002

Knappe, A., Thurau, M., Niphuis, H., Hiller, C., Wittmann, S., Kuhn, EM., Rosenwirth, B., Fleckenstein, B., Heeney, J. and Fickenscher, H., 1998. T-cell lymphoma caused by herpesvirus saimiri C488 independently of ie14/vsag, a viral gene with superantigen homology. J Virol, v. 72
Doi: http://doi.org/10.1128/JVI.72.4.3469-3471.1998

Wang, Y., Tao, L., Mitchell, E., Bogers, WM., Doyle, C., Bravery, CA., Bergmeier, LA., Kelly, CG., Heeney, JL. and Lehner, T., 1998. Generation of CD8 suppressor factor and beta chemokines, induced by xenogeneic immunization, in the prevention of simian immunodeficiency virus infection in macaques. Proc Natl Acad Sci U S A, v. 95
Doi: http://doi.org/10.1073/pnas.95.9.5223

Knappe, A., Hiller, C., Niphuis, H., Fossiez, F., Thurau, M., Wittmann, S., Kuhn, EM., Lebecque, S., Banchereau, J., Rosenwirth, B., Fleckenstein, B., Heeney, J. and Fickenscher, H., 1998. The interleukin-17 gene of herpesvirus saimiri. J Virol, v. 72
Doi: http://doi.org/10.1128/JVI.72.7.5797-5801.1998

Warren, KS., Niphuis, H., Heriyanto, , Verschoor, EJ., Swan, RA. and Heeney, JL., 1998. Seroprevalence of specific viral infections in confiscated orangutans (Pongo pygmaeus). J Med Primatol, v. 27
Doi: http://doi.org/10.1111/j.1600-0684.1998.tb00066.x

Bartholeyns, J., Romet-Lemonne, JL., Chokri, M., Buyse, M., Velu, T., Bruyns, C., Van de Winkel, JJ., Heeney, J., Koopman, G., Malmsten, M., De Groote, D., Monsigny, M., Midoux, P. and Alarcon, B., 1998. Cellular vaccines. Res Immunol, v. 149
Doi: http://doi.org/10.1016/s0923-2494(99)80032-7

Wagner, R., Teeuwsen, VJ., Deml, L., Notka, F., Haaksma, AG., Jhagjhoorsingh, SS., Niphuis, H., Wolf, H. and Heeney, JL., 1998. Cytotoxic T cells and neutralizing antibodies induced in rhesus monkeys by virus-like particle HIV vaccines in the absence of protection from SHIV infection. Virology, v. 245
Doi: http://doi.org/10.1006/viro.1998.9104

Almond, NM. and Heeney, JL., 1998. AIDS vaccine development in primate models. AIDS, v. 12 Suppl A

Valli, PJ., Lukashov, VV., Heeney, JL. and Goudsmit, J., 1998. Shortening of the symptom-free period in rhesus macaques is associated with decreasing nonsynonymous variation in the env variable regions of simian immunodeficiency virus SIVsm during passage. J Virol, v. 72
Doi: http://doi.org/10.1128/JVI.72.9.7494-7500.1998

Warren, KS., Swan, RA., Hobbs, RP., Heriyanto, , Kuhn, EM. and Heeney, JL., 1998. Platynosomum fastosum in ex-captive orangutans from Indonesia. J Wildl Dis, v. 34
Doi: http://doi.org/10.7589/0090-3558-34.3.644

Heeney, JL., Teeuwsen, VJ., van Gils, M., Bogers, WM., De Giuli Morghen, C., Radaelli, A., Barnett, S., Morein, B., Akerblom, L., Wang, Y., Lehner, T. and Davis, D., 1998. beta-chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV-1 vaccinated macaques. Proc Natl Acad Sci U S A, v. 95
Doi: http://doi.org/10.1073/pnas.95.18.10803

Heeney, JL., van Gils, ME., van der Meide, P., de Giuli Morghen, C., Ghioni, C., Gimelli, M., Raddelli, A., Davis, D., Akerblom, L. and Morein, B., 1998. The role of type-1 and type-2 T-helper immune responses in HIV-1 vaccine protection. J Med Primatol, v. 27
Doi: http://doi.org/10.1111/j.1600-0684.1998.tb00226.x

Bogers, WM., Koornstra, WH., Dubbes, RH., ten Haaft, PJ., Verstrepen, BE., Jhagjhoorsingh, SS., Haaksma, AG., Niphuis, H., Laman, JD., Norley, S., Schuitemaker, H., Goudsmit, J., Hunsmann, G., Heeney, JL. and Wigzell, H., 1998. Characteristics of primary infection of a European human immunodeficiency virus type 1 clade B isolate in chimpanzees. J Gen Virol, v. 79 ( Pt 12)
Doi: http://doi.org/10.1099/0022-1317-79-12-2895

1997

Schmidt, M., Herchenröder, O., Heeney, J. and Rethwilm, A., 1997. Long terminal repeat U3 length polymorphism of human foamy virus. Virology, v. 230
Doi: http://doi.org/10.1006/viro.1997.8463

Ozwara, H., Niphuis, H., Buijs, L., Jonker, M., Heeney, JL., Bambra, CS., Thomas, AW. and Langermans, JA., 1997. reus). ... J Med Primatol, v. 26
Doi: http://doi.org/10.1111/j.1600-0684.1997.tb00048.x

Schmidt, M., Niewiesk, S., Heeney, J., Aguzzi, A. and Rethwilm, A., 1997. Mouse model to study the replication of primate foamy viruses. J Gen Virol, v. 78 ( Pt 8)
Doi: http://doi.org/10.1099/0022-1317-78-8-1929

Heeney, JL., Bruck, C., Goudsmit, J., Montagnier, L., Schultz, A., Tyrrell, D. and Zolla-Pazner, S., 1997. Immune correlates of protection from HIV infection and AIDS. Immunol Today, v. 18
Doi: http://doi.org/10.1016/s0167-5699(97)80005-9

Lehner, T., Biberfeld, P., Boucher, C., Darbyshire, J., Fenyö, EM., Heeney, JL., Jager, JC., Lundgren, JD., Newell, ML., Rösch, P., Rossi, P. and Virelizier, JL., 1997. European contribution to the science, prevention and management of HIV infection. Vaccine, v. 15
Doi: http://doi.org/10.1016/s0264-410x(97)00014-5

Vernau, W., Jacobs, RM., Valli, VE. and Heeney, JL., 1997. The immunophenotypic characterization of bovine lymphomas. Vet Pathol, v. 34
Doi: http://doi.org/10.1177/030098589703400307

ten Haaft, PJ., Murthy, KK., Verstrepen, BE., Eichberg, JW. and Heeney, JL., 1997. Intact CCR-5 coreceptors in HIV-1-infected chimpanzees. AIDS, v. 11
Doi: http://doi.org/10.1097/00002030-199710001-00001

Bogers, WM., Dubbes, R., ten Haaft, P., Niphuis, H., Cheng-Mayer, C., Stahl-Hennig, C., Hunsmann, G., Kuwata, T., Hayami, M., Jones, S., Ranjbar, S., Almond, N., Stott, J., Rosenwirth, B. and Heeney, JL., 1997. Comparison of in vitro and in vivo infectivity of different clade B HIV-1 envelope chimeric simian/human immunodeficiency viruses in Macaca mulatta. Virology, v. 236
Doi: http://doi.org/10.1006/viro.1997.8744

Baskin, GB., Bontrop, RE., Niphuis, H., Noort, R., Rice, J. and Heeney, JL., 1997. Correlation of major histocompatibility complex with opportunistic infections in simian immunodeficiency virus-infected rhesus monkeys. Lab Invest, v. 77

Davis, D., Morein, B., Akerblom, L., Lövgren-Bengtsson, K., van Gils, ME., Bogers, WM., Teeuwsen, VJ. and Heeney, JL., 1997. A recombinant prime, peptide boost vaccination strategy can focus the immune response on to more than one epitope even though these may not be immunodominant in the complex immunogen. Vaccine, v. 15
Doi: http://doi.org/10.1016/s0264-410x(97)00084-4

Nyambi, PN., Lewi, P., Peeters, M., Janssens, W., Heyndrickx, L., Fransen, K., Andries, K., Vanden Haesevelde, M., Heeney, J., Piot, P. and van der Groen, G., 1997. Study of the dynamics of neutralization escape mutants in a chimpanzee naturally infected with the simian immunodeficiency virus SIVcpz-ant. J Virol, v. 71
Doi: http://doi.org/10.1128/JVI.71.3.2320-2330.1997

Gougeon, ML., Lecoeur, H., Boudet, F., Ledru, E., Marzabal, S., Boullier, S., Roué, R., Nagata, S. and Heeney, J., 1997. Lack of chronic immune activation in HIV-infected chimpanzees correlates with the resistance of T cells to Fas/Apo-1 (CD95)-induced apoptosis and preservation of a T helper 1 phenotype. J Immunol, v. 158

Buijs, L., Bogers, WM., Eichberg, JW. and Heeney, JL., 1997. CD8+ cell-mediated immune responses: relation to disease resistance and susceptibility in lentivirus-infected primates. J Med Primatol, v. 26
Doi: http://doi.org/10.1111/j.1600-0684.1997.tb00044.x

1996

Heeney, J., Bogers, W., Buijs, L., Dubbes, R., ten Haaft, P., Koornstra, W., Niphuis, H., Nara, P. and Teeuwsen, V., 1996. Immune strategies utilized by lentivirus infected chimpanzees to resist progression to AIDS. Immunol Lett, v. 51
Doi: http://doi.org/10.1016/0165-2478(96)02554-0

von Laer, D., Neumann-Haefelin, D., Heeney, JL. and Schweizer, M., 1996. Lymphocytes are the major reservoir for foamy viruses in peripheral blood. Virology, v. 221
Doi: http://doi.org/10.1006/viro.1996.0371

Ehret, A., Westendorp, MO., Herr, I., Debatin, KM., Heeney, JL., Frank, R. and Krammer, PH., 1996. Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis. J Virol, v. 70
Doi: http://doi.org/10.1128/JVI.70.9.6502-6507.1996

Bontrop, RE., Otting, N., Niphuis, H., Noort, R., Teeuwsen, V. and Heeney, JL., 1996. The role of major histocompatibility complex polymorphisms on SIV infection in rhesus macaques. Immunol Lett, v. 51
Doi: http://doi.org/10.1016/0165-2478(96)02552-7

Holterman, L., Mullins, JI., Haaijman, JJ. and Heeney, JL., 1996. Direct amplification and cloning of up to 5-kb lentivirus genomes from serum. Biotechniques, v. 21
Doi: http://doi.org/10.2144/96212rr06

Schellekens, H., Niphuis, H., Buijs, L., Douw van der Krap, P., Hochkeppel, HK. and Heeney, JL., 1996. The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques. Antiviral Res, v. 32
Doi: http://doi.org/10.1016/0166-3542(95)00955-8

Heeney, JL., 1996. Primate models for AIDS vaccine development. AIDS, v. 10 Suppl A
Doi: http://doi.org/10.1097/00002030-199601001-00016

Copeland, KF. and Heeney, JL., 1996. T helper cell activation and human retroviral pathogenesis. Microbiol Rev, v. 60
Doi: http://doi.org/10.1128/mr.60.4.722-742.1996

Wagner, R., Deml, L., Teeuwsen, V., Heeney, J., Yiming, S. and Wolf, H., 1996. A recombinant HIV-1 virus-like particle vaccine: from concepts to a field study. Antibiot Chemother (1971), v. 48
Doi: http://doi.org/10.1159/000425160

Rösener, M., Hahn, H., Kranz, M., Heeney, J. and Rethwilm, A., 1996. Absence of serological evidence for foamy virus infection in patients with amyotrophic lateral sclerosis. J Med Virol, v. 48
Doi: http://doi.org/10.1002/(SICI)1096-9071(199603)48:3<222::AID-JMV2>3.0.CO;2-A

Gougeon, ML., Lecoeur, H., Heeney, J. and Boudet, F., 1996. Comparative analysis of apoptosis in HIV-infected humans and chimpanzees: relation with lymphocyte activation. Immunol Lett, v. 51
Doi: http://doi.org/10.1016/0165-2478(96)02558-8

Broliden, K., Hinkula, J., Tolfvenstam, T., Niphuis, H. and Heeney, J., 1996. Antibody-dependent cellular cytotoxicity to clinical isolates of HIV-1 and SIVcpz: comparison of human and chimpanzees. AIDS, v. 10
Doi: http://doi.org/10.1097/00002030-199609000-00004

Wagner, R., Deml, L., Notka, F., Wolf, H., Schirmbeck, R., Reimann, J., Teeuwsen, V. and Heeney, J., 1996. Safety and immunogenicity of recombinant human immunodeficiency virus-like particles in rodents and rhesus macaques. Intervirology, v. 39
Doi: http://doi.org/10.1159/000150480

1995

Heeney, JL., 1995. AIDS: a disease of impaired Th-cell renewal? Immunol Today, v. 16
Doi: http://doi.org/10.1016/0167-5699(95)80043-3

KESTENS, L., VINGERHOETS, J., PEETERS, M., VANHAM, G., VEREECKEN, C., PENNE, G., NIPHUIS, H., VANEERD, P., VANDERGROEN, G., GIGASE, P. and HEENEY, J., 1995. PHENOTYPIC AND FUNCTIONAL PARAMETERS OF CELLULAR-IMMUNITY IN A CHIMPANZEE WITH A NATURALLY ACQUIRED SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION J INFECT DIS, v. 172

Copeland, KF., Hendrikx, PJ., Haaksma, AG., Fiering, S., Van Lier, R., Goudsmit, J. and Heeney, JL., 1995. Comparison of the response to T-cell activation by integrated HIV-1 and HTLV-1 LTR-lacZ vectors. Virology, v. 209
Doi: http://doi.org/10.1006/viro.1995.1295

Baskin, GB., Roberts, ED., Kuebler, D., Martin, LN., Blauw, B., Heeney, J. and Zurcher, C., 1995. Squamous epithelial proliferative lesions associated with rhesus Epstein-Barr virus in simian immunodeficiency virus-infected rhesus monkeys. J Infect Dis, v. 172
Doi: http://doi.org/10.1093/infdis/172.2.535

Peeters, M., Janssens, W., Vanden Haesevelde, M., Fransen, K., Willems, B., Heyndrickx, L., Kestens, L., Piot, P., Van der Groen, G. and Heeney, J., 1995. Virologic and serologic characteristics of a natural chimpanzee lentivirus infection. Virology, v. 211
Doi: http://doi.org/10.1006/viro.1995.1407

DORMONT, D., LEGRAND, R., CRANAGE, M., GREENAWAY, P., HUNSMANN, G., STAHLHENNIG, C., ROSSI, G., VERANI, P., STOTT, J., KITCHIN, P., OSTERHAUS, A., DEVRIES, P., KURTH, R., NORLEY, S., HEENEY, J., BIBERFELD, G. and PUTKONEN, P., 1995. PROTECTION OF MACAQUES AGAINST SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION WITH INACTIVATED VACCINES - COMPARISON OF ADJUVANTS, DOSES AND CHALLENGE VIRUSES VACCINE, v. 13

ten Haaft, P., Cornelissen, M., Goudsmit, J., Koornstra, W., Dubbes, R., Niphuis, H., Peeters, M., Thiriart, C., Bruck, C. and Heeney, JL., 1995. Virus load in chimpanzees infected with human immunodeficiency virus type 1: effect of pre-exposure vaccination. J Gen Virol, v. 76 ( Pt 4)
Doi: http://doi.org/10.1099/0022-1317-76-4-1015

VANELS, CACM., VANBAALEN, CA., DINGS, M., KEET, RPC., HEENEY, JL. and OSTERHAUS, ADME., 1995. HUMAN AND RHESUS MACAQUE CTL RECOGNIZE SIMILAR REGIONS OF HIV AND SIV GAG PROTEINS J CELL BIOCHEM,

Hulskotte, EG., Rimmelzwaan, GF., Boes, J., Bosch, ML., Heeney, JL., Norley, SG., de Vries, P. and Osterhaus, AD., 1995. Antigenicity and immunogenicity of recombinant envelope glycoproteins of SIVmac32H with different in vivo passage histories. Vaccine, v. 13
Doi: http://doi.org/10.1016/0264-410x(95)00053-4

van der Meide, PH., Groenestein, RJ., de Labie, MC., Heeney, J., Pala, P. and Slaoui, M., 1995. Enumeration of lymphokine-secreting cells as a quantitative measure for cellular immune responses in rhesus macaques. J Med Primatol, v. 24
Doi: http://doi.org/10.1111/j.1600-0684.1995.tb00181.x

Bogers, WM., Niphuis, H., ten Haaft, P., Laman, JD., Koornstra, W. and Heeney, JL., 1995. Protection from HIV-1 envelope-bearing chimeric simian immunodeficiency virus (SHIV) in rhesus macaques infected with attenuated SIV: consequences of challenge. AIDS, v. 9

1994

Copeland, KF., Haaksma, AG., Goudsmit, J., Krammer, PH. and Heeney, JL., 1994. Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax. AIDS Res Hum Retroviruses, v. 10
Doi: http://doi.org/10.1089/aid.1994.10.1259

Copeland, KF., Haaksma, AG., Derse, D. and Heeney, JL., 1994. Detection of human T-cell leukaemia virus 1 permissive cells using cell lines producing selectable recombinant virions. J Virol Methods, v. 50
Doi: http://doi.org/10.1016/0166-0934(94)90178-3

Heeney, JL., Holterman, L., ten Haaft, P., Dubbes, R., Koornstra, W., Teeuwsen, V., Bourquin, P., Norley, S. and Niphuis, H., 1994. Vaccine protection and reduced virus load from heterologous macaque-propagated SIV challenge. AIDS Res Hum Retroviruses, v. 10 Suppl 2

de Vries, P., Heeney, JL., Boes, J., Dings, ME., Hulskotte, EG., Dubbes, R., Koornstra, W., ten Haaft, P., Akerblom, L. and Eriksson, S., 1994. Protection of rhesus macaques from SIV infection by immunization with different experimental SIV vaccines. Vaccine, v. 12
Doi: http://doi.org/10.1016/0264-410x(94)90154-6

Bruck, C., Thiriart, C., Fabry, L., Francotte, M., Pala, P., Van Opstal, O., Culp, J., Rosenberg, M., De Wilde, M., Heidt, P. and Heeney, J., 1994. HIV-1 envelope-elicited neutralizing antibody titres correlate with protection and virus load in chimpanzees. Vaccine, v. 12
Doi: http://doi.org/10.1016/0264-410x(94)90185-6

Niphuis, H., Dubbes, RH., ten Haaft, PJ., Koornstra, WH., Bontrop, RE., Cranage, MP. and Heeney, JL., 1994. Infectivity and virulence of cell-associated SIVmac after single passage in vivo. AIDS, v. 8
Doi: http://doi.org/10.1097/00002030-199412000-00016

Di Rienzo, AM., Furlini, G., Olivier, R., Ferris, S., Heeney, J. and Montagnier, L., 1994. Different proliferative response of human and chimpanzee lymphocytes after contact with human immunodeficiency virus type 1 gp120. Eur J Immunol, v. 24
Doi: http://doi.org/10.1002/eji.1830240106

van Akker, R., Balls, M., Eichberg, JW., Goodall, J., Heeney, JL., Osterhaus, AD., Prince, AM. and Spruit, I., 1994. Chimpanzees in AIDS research: a biomedical and bioethical perspective. J Med Primatol, v. 23
Doi: http://doi.org/10.1111/j.1600-0684.1994.tb00095.x

Copeland, KF., Haaksma, AG., Goudsmit, J. and Heeney, JL., 1994. Calcium-mediated inhibition of phorbol ester and Tax trans-activation of the human T cell leukaemia virus type 1. J Gen Virol, v. 75 ( Pt 7)
Doi: http://doi.org/10.1099/0022-1317-75-7-1623

Heeney, JL., van Els, C., de Vries, P., ten Haaft, P., Otting, N., Koornstra, W., Boes, J., Dubbes, R., Niphuis, H., Dings, M., Cranage, M., Norley, S., Jonker, M., Bontrop, RE. and Osterhaus, A., 1994. Major histocompatibility complex class I-associated vaccine protection from simian immunodeficiency virus-infected peripheral blood cells. J Exp Med, v. 180
Doi: http://doi.org/10.1084/jem.180.2.769

1993

van Akker, R., Balls, M., Eichberg, JW., Goodall, J., Heeney, JL., Osterhaus, AD., Prince, AM. and Spruit, I., 1993. Chimpanzees in AIDS research: a biomedical and bioethical perspective. J Med Primatol, v. 22

Gougeon, ML., Garcia, S., Heeney, J., Tschopp, R., Lecoeur, H., Guetard, D., Rame, V., Dauguet, C. and Montagnier, L., 1993. Programmed cell death in AIDS-related HIV and SIV infections. AIDS Res Hum Retroviruses, v. 9
Doi: http://doi.org/10.1089/aid.1993.9.553

HEENEY, J., CRANAGE, M., NORLEY, S., DEVRIES, P., VANELS, C. and OSTERHAUS, A., 1993. COMPARISON OF PARAMETERS OF VACCINE PROTECTION OR FAILURE FROM CHALLENGE WITH SIV-INFECTED PERIPHERAL-BLOOD CELLS AIDS RES HUM RETROV, v. 9

Heeney, J., Jonker, R., Koornstra, W., Dubbes, R., Niphuis, H., Di Rienzo, AM., Gougeon, ML. and Montagnier, L., 1993. The resistance of HIV-infected chimpanzees to progression to AIDS correlates with absence of HIV-related T-cell dysfunction. J Med Primatol, v. 22

BRUCK, C., THIRIART, C., DELERS, A., FABRY, L., FRANCOTTE, M., VANOPSTAL, O., CULP, J., ROSENBERG, M., DEWILDE, M., HEIDT, P. and HEENEY, J., 1993. COMPARISON OF VACCINE PROTECTION IN CHIMPANZEES IMMUNIZED WITH 2 DIFFERENT FORMS OF RECOMBINANT HIV-1 ENVELOPE GLYCOPROTEIN AIDS RES HUM RETROV, v. 9

PEETERS, M., KESTENS, L., FRANSEN, K., NKENGASONG, J., HEENEY, J., VANDENHAESEVELDE, M., SAMAN, E., PIOT, P. and VANDERGROEN, G., 1993. GENETIC, ANTIGENIC AND BIOLOGICAL CHARACTERISTICS OF SIVCPZ-ANT ISOLATES, DERIVED FROM A NATURALLY INFECTED CHIMPANZEE J ACQ IMMUN DEF SYND, v. 6

Copeland, KF., Haaksma, AG., Derse, D., Goudsmit, J. and Heeney, JL., 1993. Cytochemical analysis of human T cell leukaemia virus I LTR-regulated beta-galactosidase gene expression using a novel integrated cell system. J Virol Methods, v. 45
Doi: http://doi.org/10.1016/0166-0934(93)90100-6

Buijs, L., van der Meide, P. and Heeney, JL., 1993. The role of CD8 cells in HIV infection. Immunodeficiency, v. 5

Schuitemaker, H., Meyaard, L., Kootstra, NA., Dubbes, R., Otto, SA., Tersmette, M., Heeney, JL. and Miedema, F., 1993. Lack of T cell dysfunction and programmed cell death in human immunodeficiency virus type 1-infected chimpanzees correlates with absence of monocytotropic variants. J Infect Dis, v. 168
Doi: http://doi.org/10.1093/infdis/168.5.1140

1992

Stevens, HP., Holterman, L., Haaksma, AG., Jonker, M. and Heeney, JL., 1992. Lymphoproliferative disorders developing after transplantation and their relation to simian T-cell leukemia virus infection. Transpl Int, v. 5 Suppl 1
Doi: http://doi.org/10.1007/978-3-642-77423-2_131

Osterhaus, A., de Vries, P. and Heeney, J., 1992. AIDS vaccine developments. Nature, v. 355
Doi: http://doi.org/10.1038/355684b0

Osterhaus, A., de Vries, P., Morein, B., Akerblom, L. and Heeney, J., 1992. Comparison of protection afforded by whole virus ISCOM versus MDP adjuvanted formalin-inactivated SIV vaccines from IV cell-free or cell-associated homologous challenge. AIDS Res Hum Retroviruses, v. 8
Doi: http://doi.org/10.1089/aid.1992.8.1507

Vernau, W., Valli, VE., Dukes, TW., Jacobs, RM., Shoukri, M. and Heeney, JL., 1992. Classification of 1,198 cases of bovine lymphoma using the National Cancer Institute Working Formulation for human non-Hodgkin's lymphomas. Vet Pathol, v. 29
Doi: http://doi.org/10.1177/030098589202900301

GOUDSMIT, J., BAKKER, M., MELOEN, R., DEWOLF, F., THIRIART, C., BRUCK, C., NARA, P., MCENTEE, M., NARAYAN, O. and HEENEY, J., 1992. CHARACTERIZATION OF TYPE-SPECIFIC ANTIBODY-RESPONSES TO THE V2 NEUTRALIZATION DOMAIN OF SIVMAC251 DURING SERIAL SIVMAC251 AND SIVDELTAB670 INVIVO PASSAGE AIDS RES HUM RETROV, v. 8

Le Grand, R., Vaslin, B., Vogt, G., Roques, P., Humbert, M., Dormont, D. and Aubertin, AM., 1992. AIDS vaccine developments [11] Nature, v. 355
Doi: http://doi.org/10.1038/355684a0

Heeney, JL., Valli, PJ., Jacobs, RM. and Valli, VE., 1992. Evidence for bovine leukemia virus infection of peripheral blood monocytes and limited antigen expression in bovine lymphoid tissue. Lab Invest, v. 66

Jacobs, RM., Song, Z., Poon, H., Heeney, JL., Taylor, JA., Jefferson, B., Vernau, W. and Valli, VE., 1992. Proviral detection and serology in bovine leukemia virus-exposed normal cattle and cattle with lymphoma. Can J Vet Res, v. 56

Heeney, JL., de Vries, P., Dubbes, R., Koornstra, W., Niphuis, H., ten Haaft, P., Boes, J., Dings, ME., Morein, B. and Osterhaus, AD., 1992. Comparison of protection from homologous cell-free vs cell-associated SIV challenge afforded by inactivated whole SIV vaccines. J Med Primatol, v. 21

1991

Stevens, HP., Hovius, SE., Heeney, JL., van Nierop, PW. and Jonker, M., 1991. Immunologic aspects and complications of composite tissue allografting for upper extremity reconstruction: a study in the rhesus monkey. Transplant Proc, v. 23

Jacobs, RM., Heeney, JL., Godkin, MA., Leslie, KE., Taylor, JA., Davies, C. and Valli, VE., 1991. Production and related variables in bovine leukaemia virus-infected cows. Vet Res Commun, v. 15
Doi: http://doi.org/10.1007/BF00346546

SLACHMUYLDERS, JFAM., VISSER, TP., DUBBES, R., HEENEY, JL. and WAGEMAKER, G., 1991. BONE-MARROW CD34 POSITIVE HEMATOPOIETIC PROGENITOR CELLS REMAIN UNINFECTED EARLY IN SIV INFECTION OF RHESUS-MONKEYS EXP HEMATOL, v. 19

VANGILS, FCJM., WIELENGA, JJ., VANDENBOS, C., BURGER, H., HEENEY, JL. and WAGEMAKER, G., 1991. INTERLEUKIN-3 HYPERSTIMULATION SYNDROME IN RHESUS-MONKEYS EXP HEMATOL, v. 19

Laman, JD., Kors, N., Heeney, JL., Boersma, WJ. and Claassen, E., 1991. Fixation of cryo-sections under HIV-1 inactivating conditions: integrity of antigen binding sites and cell surface antigens. Histochemistry, v. 96
Doi: http://doi.org/10.1007/BF00315990

1990

Heeney, JL. and Valli, VE., 1990. Transformed phenotype of enzootic bovine lymphoma reflects differentiation-linked leukemogenesis. Lab Invest, v. 62

Heeney, JL., Evermann, JF., McKeirnan, AJ., Marker-Kraus, L., Roelke, ME., Bush, M., Wildt, DE., Meltzer, DG., Colly, L. and Lukas, J., 1990. Prevalence and implications of feline coronavirus infections of captive and free-ranging cheetahs (Acinonyx jubatus). J Virol, v. 64
Doi: http://doi.org/10.1128/JVI.64.5.1964-1972.1990

Wagemaker, G., van Gils, FC., Burger, H., Dorssers, LC., van Leen, RW., Persoon, NL., Wielenga, JJ., Heeney, JL. and Knol, E., 1990. Highly increased production of bone marrow-derived blood cells by administration of homologous interleukin-3 to rhesus monkeys. Blood, v. 76

1989

Heeney, JL. and Valli, VE., 1989. A rapid stick test for the diagnosis of bovine leukemia virus infection from serum or milk. Can Vet J, v. 30

Evermann, JF., Heeney, JL., McKeirnan, AJ. and O'Brien, SJ., 1989. Comparative features of a coronavirus isolated from a cheetah with feline infectious peritonitis. Virus Res, v. 13
Doi: http://doi.org/10.1016/0168-1702(89)90084-1

1988

Heeney, JL., Valli, VE. and Montesanti, J., 1988. Alterations in humoral immune response to bovine leukaemia virus antigens in cattle with lymphoma. J Gen Virol, v. 69 ( Pt 3)
Doi: http://doi.org/10.1099/0022-1317-69-3-659

Evermann, JF., Heeney, JL., Roelke, ME., McKeirnan, AJ. and O'Brien, SJ., 1988. Biological and pathological consequences of feline infectious peritonitis virus infection in the cheetah. Arch Virol, v. 102
Doi: http://doi.org/10.1007/BF01310822

Heeney, JL., Valli, VE. and Montesanti, J., 1988. Alterations in humoral immune response to bovine leukaemia virus antigens in cattle with lymphoma. The Journal of general virology, v. 69 ( Pt 3)
Doi: http://doi.org/10.1099/0022-1317-69-3-659

1985

Heeney, JL. and Valli, VE., 1985. Bovine ocular squamous cell carcinoma: an epidemiological perspective. Can J Comp Med, v. 49

1983

Heeney, JL., Singh, A., Stirtzinger, T. and Valli, VE., 1983. Bovine ocular squamous cell carcinoma: Ultrastructural characteristics in vitro Veterinary Research Communications, v. 6
Doi: http://doi.org/10.1007/BF02214914

Heeney, JL., Singh, A., Stirtzinger, T. and Valli, VE., 1983. Bovine ocular squamous cell carcinoma: ultrastructural characteristics in vitro. Vet Res Commun, v. 6
Doi: http://doi.org/10.1007/BF02214914

Conference proceedings

2022

Auld, B., Frost, S., Wells, D., Heeney, J., Banyard, A., Schellenberger, P. and Wright, E., 2022. Evaluation of Bioinformatically Designed, Historical Glycoproteins to Aid Pan-Lyssavirus Vaccine Development INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v. 116
Doi: http://doi.org/10.1016/j.ijid.2021.12.170

2019

Asbach, B., Kibler, KV., Köstler, J., Perdiguero, B., Yates, NL., Stanfield-Oakley, S., Tomaras, GD., Kao, S-F., Foulds, KE., Roederer, M., Seaman, MS., Montefiori, DC., Parks, R., Ferrari, G., Forthal, DN., Phogat, S., Tartaglia, J., Barnett, SW., Self, SG., Gottardo, R., Cristillo, AD., Weiss, DE., Galmin, L., Ding, S., Heeney, JL., Esteban, M., Jacobs, BL., Pantaleo, G. and Wagner, R., 2019. Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost. J Virol, v. 93
Doi: http://doi.org/10.1128/JVI.01529-18

2015 (No publication date)

Heeney, JL., Mathy, NL., Mooij, P., Manson, K., Watkins, D., Wyand, M. and Voss, G., 2015 (No publication date). Functional characterization of Tat-containing AIDS vaccines and their efficacy against SHIV-induced disease in rhesus monkeys.

2013

Heeney, JL., Wagner, R., Esteban, M., Jacobs, B., Foulds, K., Roederer, M., Self, S., Barnett, S., Phogat, S., Montefiori, D., Tomaris, G. and Pantaleo, G., 2013. Rapid Appearance of Vaccine-Induced Potentially Protective Anti-Env Antibody Responses with Early Co-administration of gp120 with NYVAC or DNA AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 29

Heeney, JL., Jacobs, B., Esteban, M., Wagner, R., Foulds, K., Roederer, M., Self, S., Barnett, S., Tartaglia, J., Montefiori, D., Tomaras, G. and Pantaleo, G., 2013. Increased HIV-1 Immunogenicity of Replication Competent NYVAC AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 29

2012

Blacklaws, B., Chettle, J., Shortland, A., Zaccone, P., Newland, S., Gibbs, S., Tonks, P., Man, S., Tourlomousis, P., Cooke, A., Bryant, C. and Heeney, J., 2012. The role of type I interferon in persistent murine norovirus infection IMMUNOLOGY, v. 137

2011

Dey, AK., Zambonelli, C., Nandi, A., Stephenson, S., Sirokman, K., Hilt, S., Martinez-Guzman, D., Cisto, J., Ramesh, P., Wininger, M., Sun, Y., Legg, H., Hartog, K., Lai, RPJ., Heeney, J., Montefiori, D., Carfi, A. and Barnett, SW., 2011. Evaluations of Subtype C HIV-1 Envelope Glycoproteins as Immunogens for Vaccine Development AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 27

Davis, D., Koornstra, W., Heeney, J. and Bogers, W., 2011. In Vitro Neutralization Kinetics of the Human Monoclonal Antibody IgG1 b12 Which Is Protective In The SHIV Rhesus Macaque Challenge Model AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 27

Mooij, P., Nieuwenhuis, I., Beenhakker, N., Hofman, S., Esteban, M., Jacobs, B., Kibler, K., Koopman, G., Bogers, WMJM., Pantaleo, G. and Heeney, JL., 2011. IMPROVED IMMUNOGENICITY AGAINST HIV-1 CLADE C ANTIGENS BY USING NYVAC-C WITH RESTORED REPLICATION COMPETENCE J MED PRIMATOL, v. 40

Nieuwenhuis, I., Beenhakker, N., Bogers, WMJM., Otting, N., Bontrop, RE., Dubois, P., Mooij, P., Koopman, G. and Heeney, JL., 2011. NO DIFFERENCE IN IMMUNE RESPONSE PROFILES BETWEEN VACCINATED AND NON VACCINATED RHESUS MACAQUES THAT CONTROL IMMUNODEFICIENCY VIRUS REPLICATION J MED PRIMATOL, v. 40

Mooij, P., Nieuwenhuis, I., Beenhakker, N., Quakkelaar, ED., Heeney, JL., Esteban, M., Jacobs, B., Pantaleo, G., Bogers, WM., Melief, C. and Koopman, G., 2011. Boosting of Replication Competent NYVAC Primed HIV-1-Specific T-Cell Responses by HIV Synthetic Long Peptides (SLP) AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 27

2010

Mooij, P., Nieuwenhuis, I., Beenhakker, N., Hofman, S., Esteban, M., Jacobs, B., Kibler, K., Koopman, G., Bogers, W., Pantaleo, G. and Heeney, J., 2010. Improved immunogenicity against HIV-1 clade C antigens by using NYVAC-C with restored replication competence AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 26

Bogers, WM., Davis, D., Mooij, P., Koopman, G., Verschoor, E., Martin, G., Martin, L., Lai, RPJ., Dey, A., Sun, Y., Siddappa, N., Ruprecht, R., Montefiori, D., Burke, B., Srivastava, I., Heeney, JL. and Barnett, S., 2010. HIV-1 envelope-CD4 receptor complexes elicit broad T- and B-cell immune responses as well as cross-reactive neutralizing antibodies in rhesus macaques AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 26

Davis, D., Koornstra, W., Heeney, JL., Barnett, SW. and Bogers, WM., 2010. Cross-neutralization of heterologous isolates by sera from rhesus macaques immunized with candidate HIV-1 vaccines AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 26

Nieuwenhuis, I., Beenhakker, N., Bogers, WM., Otting, N., Bontrop, RE., Dubois, P., Mooij, P., Koopman, G. and Heeney, JL., 2010. No difference in immune response profiles between vaccinated and non vaccinated rhesus macaques that control immunodeficiency virus replication AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 26

Lai, RP., Tonks, P., Seilly, DJ., Dey, AK., Sarkar, P., Montefiori, DC., Seaman, MS., Weissenhorn, W., Jeffs, SA., Wagner, R., Barnett, SW., Srivastava, IK. and Heeney, JL., 2010. Neutralizing antibody responses to HIV-1 are dependent on conformational integrity of gp140 immunogens AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 26

2008

Davis, D., Koornstra, W., Mortier, D., Fagrouch, Z., Verschoor, E., Robert-Guroff, M., Srivastava, I., Barnett, S., Heeney, J. and Bogers, W., 2008. Events during the Absorption Phase of a Neutralization Assay are Predictive of Protection in the SHIV - Rhesus Macaque Model AIDS RESEARCH AND HUMAN RETROVIRUSES, v. 24

2007

Wagner, R., Wild, J., Bieler, K., Wolf, H., Mooij, P., Heeney, J., Weber, J., Harrari, A. and Pantaleo, G., 2007. Development and immunogenicity of RNA- and codon-optimized HIV candidate Vaccines in phase I clinical trials HUMAN GENE THERAPY, v. 18

2006

Kraehenbuhl, JP., Gerber, S., Corbett, M., Bogers, W., Heeney, JL. and Le Pape, A., 2006. Aerosol immunization with the attenuated poxvirus nyvac-c in macaques: deposition, safety, and immunogenecity FEBS JOURNAL, v. 273

2003

Depla, E., Mares, G., Priem, S., Verschoor, E., Verstrepen, B., Drexhage, J., Heeney, J. and Maertens, G., 2003. Acute resolving infection after E1 but not after E2 prophylactic vaccination and heterologous challenge with 100 CID50 of HCV subtype 1b strain HC-J4. HEPATOLOGY, v. 38

1999

Depla, E., Priem, S., Verschoor, E., Roskams, T., Desmet, V., Fuller, S., Vandeponseele, P., Bosman, F., Van Doorn, LJ., Heeney, J., Kos, A. and Maertens, G., 1999. 1332therapeutic vaccination of chronically infected chimpanzees with the HCV E1 protein. HEPATOLOGY, v. 30

Theses / dissertations

2021 (No publication date)

Ugwu, A., 2021 (No publication date). Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology

Books

2017

Heeney, JL. and Friedemann, S., 2017. Plagues
Doi: http://doi.org/10.1017/9781108147910

Heeney, JL. and Friedemann, S., 2017. Preface
Doi: http://doi.org/10.1017/9781108147910.002

2001

Gotch, F., Heeney, J. and Manca, F., 2001. Immunology Letters: Editorial
Doi: http://doi.org/10.1016/S0165-2478(01)00259-0

1996

Heeney, JL., 1996. Special issue: Immunological correlates of protection from HIV infection and disease

Heeney, JL., 1996. Immunological correlates of protection from HIV infection and disease
Doi: http://doi.org/10.1016/S0165-2478(96)90005-X

Book chapters

2017

Heeney, JL., 2017. Ebola: The plague of 2014/2015
Doi: http://doi.org/10.1017/9781108147910.003

2014

Greenwood, EJD., Schmidt, F. and Heeney, JL., 2014. Chapter 5 Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes)
Doi: http://doi.org/10.1016/b978-0-12-404734-1.00005-x

Heeney, JL., Greenwood, EJD. and Schmidt, F., 2014. Simian Immunodeficiency Virus infection of Chimpanzees (Pan troglodytes)

2013

Greenwood, EJD., Schmidt, F. and Heeney, JL., 2013. The evolution of SIV in primates and the emergence of the pathogen of AIDS
Doi: http://doi.org/10.1007/978-1-4614-7181-3_10

Heeney, JL., Greenwood, EJD. and Schmidt, F., 2013. The Evolution of SIV in primates and the emergence of the pathogen of AIDS
Doi: http://doi.org/10.1007/978-1-4614-7181-3

2010

Heeney, JL. and Verschoor, EJ., 2010. Simian Exogenous Retroviruses

2000

Heeney, J., 2000. HIV vaccine induced immune responses which correlate with protection: Evolving a novel strategy for optimising vaccine efficacy

1998

Heeney, JL., Mooij, P., Bogers, W., Davis, D., Morein, B., Morghen, CD., Lehner, T., Voss, G., Bruck, C., Koopman, G. and Rosenwirth, B., 1998. Multiple immune effector mechanisms as correlates of HIV-1 vaccine protection

1996

tenHaaft, P., Holterman, L., Niphuis, H., Dubbes, R., Koornstra, W. and Heeney, J., 1996. Evidence of circulating pathogenic SIV following challenge of macaques vaccinated with live attenuated SIV

Holterman, L., tenHaaft, P., Niphuis, H. and Heeney, J., 1996. Rapid cloning of 5-kb fragments directly from lentivirus-infected macaque serum: Utility for DNA vaccination

1995

HEENEY, J., TEEUWSEN, V., NIPHUIS, H., VANELS, C., OSTERHAUS, A. and BONTROP, R., 1995. Role of Mamu-A26 in protection from SIV infection and disease

1994

HEENEY, J., TENHAAFT, P., DUBBES, R., KOORNSTRA, W., NIPHUIS, H., HEIDT, P., CORNELISSEN, M., GOUDSMIT, J., CULP, J., ROSENBERG, M., THIRIART, C., PALA, P., FABRY, L., FRANCOTTE, M., VANOPSTAL, O., DEWILDE, M. and BRUCK, C., 1994. PROTECTION FROM HIV-1 INFECTION AND VIRUS LOAD IS RELATED TO PRECHALLENGE NEUTRALIZATION TITERS IN HIV-1 VACCINATED CHIMPANZEES

HEENEY, J., DUBBES, R., SCHUITEMAKER, H., MEYAARD, L., KOOTSTRA, N., OTTO, S., TERSMETTE, M. and MIEDEMA, F., 1994. MECHANISMS OF DISEASE RESISTANCE OF HIV-1-INFECTED CHIMPANZEES - LACK OF MONOCYTOTROPIC ISOLATES AND T-CELL DYSFUNCTION

1993

VANWELY, M., VANTEEFFELEN, MEJM., WAGEMAKER, G., SLACHMUYLDERS, JFAM., DUBBES, RH., TENHAAFT, PJF. and HEENEY, JL., 1993. ISOLATION OF UNINFECTED IMMATURE HEMATOPOIETIC-CELLS FROM BONE-MARROW OF SIV-INFECTED RHESUS-MONKEYS

1992

GOUDSMIT, J., BAKKER, M., DEWOLF, F., LANGEDIJK, H., MELOEN, R., THIRIART, C., BRUCK, C., MCENTEE, M., NARAYAN, O., NARA, P. and HEENEY, J., 1992. CHARACTERIZATION OF THE SEROLOGICAL RESPONSES IN EXPERIMENTALLY INFECTED RHESUS-MONKEYS BY COMPETITION WITH NEUTRALIZING AND NONNEUTRALIZING MOUSE MONOCLONAL-ANTIBODIES AND PEPTIDE REACTIVITY

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