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Cambridge Public Health

 

Research into the pathogenesis and treatment of stroke using molecular genetic and imaging (MRI and Transcranial Doppler) techniques and clinical trials. Particular interest in genetic epidemiological of stroke and involement in Stroke Genetics consortia (WTCCC2 Ischaemic Stroke GWAS, International Genetics Stroke Consortium, Metastroke).

Publications from Elements

Journal articles

2019 (Accepted for publication)

  • Traylor, M., Anderson, C., Rutten-Jacobs, L., Falcone, G., Comeau, M., Ay, H., Sudlow, C., Xu, H., Mitchell, B., Cole, J., Rexrode, K., Jimenez-Conde, J., Schmidt, R., Grewal, R., Sacco, R., Ribases, M., Rundek, T., Rosand, J., Dichgans, M., Lee, J-M., Langefeld, C., Kittner, S., Markus, H., Woo, D. and Malik, R., 2019 (Accepted for publication). The Subtype Specificity of Genetic Loci Associated with Stroke in 16,664 cases and 32,792 controls Circulation: Genomic and Precision Medicine,
  • 2019

  • Drazyk, AM., Tan, RYY., Tay, J., Traylor, M., Das, T. and Markus, HS., 2019. Encephalopathy in a Large Cohort of British Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Patients. Stroke,
    Doi: http://doi.org/10.1161/STROKEAHA.118.023661
  • van Leijsen, EMC., Tay, J., van Uden, IWM., Kooijmans, ECM., Bergkamp, MI., van der Holst, HM., Ghafoorian, M., Platel, B., Norris, DG., Kessels, RPC., Markus, HS., Tuladhar, AM. and de Leeuw, F-E., 2019. Memory decline in elderly with cerebral small vessel disease explained by temporal interactions between white matter hyperintensities and hippocampal atrophy. Hippocampus, v. 29
    Doi: http://doi.org/10.1002/hipo.23039
  • Sweeney, MD., Montagne, A., Sagare, AP., Nation, DA., Schneider, LS., Chui, HC., Harrington, MG., Pa, J., Law, M., Wang, DJJ., Jacobs, RE., Doubal, FN., Ramirez, J., Black, SE., Nedergaard, M., Benveniste, H., Dichgans, M., Iadecola, C., Love, S., Bath, PM., Markus, HS., Al-Shahi Salman, R., Allan, SM., Quinn, TJ., Kalaria, RN., Werring, DJ., Carare, RO., Touyz, RM., Williams, SCR., Moskowitz, MA., Katusic, ZS., Lutz, SE., Lazarov, O., Minshall, RD., Rehman, J., Davis, TP., Wellington, CL., González, HM., Yuan, C., Lockhart, SN., Hughes, TM., Chen, CLH., Sachdev, P., O'Brien, JT., Skoog, I., Pantoni, L., Gustafson, DR., Biessels, GJ., Wallin, A., Smith, EE., Mok, V., Wong, A., Passmore, P., Barkof, F., Muller, M., Breteler, MMB., Román, GC., Hamel, E., Seshadri, S., Gottesman, RF., van Buchem, MA., Arvanitakis, Z., Schneider, JA., Drewes, LR., Hachinski, V., Finch, CE., Toga, AW., Wardlaw, JM. and Zlokovic, BV., 2019. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement, v. 15
    Doi: http://doi.org/10.1016/j.jalz.2018.07.222
  • Badran, A., Hollocks, MJ., Brookes, RL., Morris, RG. and Markus, HS., 2019. Framingham vascular age is associated with worse cognitive performance in the middle-aged and elderly. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn, v. 26
    Doi: http://doi.org/10.1080/13825585.2018.1499866
  • Rutten, JW., Van Eijsden, BJ., Duering, M., Jouvent, E., Opherk, C., Pantoni, L., Federico, A., Dichgans, M., Markus, HS., Chabriat, H. and Lesnik Oberstein, SAJ., 2019. The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1-6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7-34 pathogenic variant. Genet Med, v. 21
    Doi: http://doi.org/10.1038/s41436-018-0088-3
  • Debette, S., Schilling, S., Duperron, M-G., Larsson, SC. and Markus, HS., 2019. Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury: A Systematic Review and Meta-analysis. JAMA Neurology, v. 76
    Doi: http://doi.org/10.1001/jamaneurol.2018.3122
  • Wing, SC. and Markus, HS., 2019. Interpreting CT perfusion in stroke. Pract Neurol, v. 19
    Doi: http://doi.org/10.1136/practneurol-2018-001917
  • 2018 (Accepted for publication)

  • Traylor, MS. and Markus, H., 2018 (Accepted for publication). Causal Impact of Type 2 Diabetes on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis Stroke,
  • Rutten-Jacobs, L., Tozer, DJ., During, M., Malik, R., Dichgans, M., Markus, H. and Traylor, M., 2018 (Accepted for publication). Genetic study of white matter integrity in UK Biobank (N=8,448) and the overlap with stroke, depression and dementia Stroke,
  • Traylor, MS., 2018 (Accepted for publication). Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: followup study of 306,473 UK Biobank participants British Medical Journal,
  • Walsh, J. and Markus, HS., 2018 (Accepted for publication). Telemedicine for follow-up of rare neurological disease: development and evaluation in CADASIL Stroke,
    Doi: http://doi.org/10.1161/STROKEAHA.118.023779Stroke
  • Traylor, MS. and Markus, H., 2018 (Accepted for publication). Genetic association study of white matter integrity in 8,448 UK Biobank individuals and the genetic overlap with stroke, depression and Alzheimer’s disease Stroke,
  • Markus, HS. and Schmidt, R., 2018 (Accepted for publication). Genetics of Vascular Cognitive Impairment Stroke,
  • Markus, HS. and Larsson, S., 2018 (Accepted for publication). Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer’s Disease? A Systematic Review and Meta-Analysis Journal of Alzheimer's Disease,
  • Rubinsztein, DC., Anttlla, V. and hundreds of other authors, , 2018 (Accepted for publication). Analysis of Shared Heritability in Common Disorders of the Brain Science,
  • Cole, JW., Xu, H., Ryan, K., Jaworek, T., Dueker, N., McArdle, P., Gaynor, B., Cheng, Y-C., O'Connell, J., Bevan, S., Malik, R., Ahmed, NU., Amouyel, P., Anjum, S., Bis, JC., Crosslin, D., Danesh, J., Engelter, ST., Fornage, M., Frossard, P., Gieger, C., Giese, A-K., Grond-Ginsbach, C., Kee Ho, W., Holliday, E., Hopewell, J., Hussain, M., Iqbal, W., Jabeen, S., Jannes, J., Kamal, A., Kamatani, Y., Kanse, S., Kloss, M., Lathrop, M., Leys, D., Lindgren, A., Longstreth Jr, WT., Mahmood, K., Meisinger, C., Metso, TM., Mosley Jr, T., Muller-Nurasyid, M., Norrving, B., Parati, E., Peters, A., Pezzini, A., Quereshi, I., Rashreed, A., Rauf, A., Salam, T., Shen, J., Slowik, A., Stanne, T., Strauch, K., Tatlisumak, T., Thijs, VN., Tiedt, S., Traylor, M., Waldenberger, M., Walters, M., Zhao, W., Boncoraglio, G., Debette, S., Jern, C., Levi, C., Markus, H., Meschia, J., Rolfs, A., Rothwell, P., Saleheen, D., Seshadri, S., Sharma, P., Sudlow, C., Worrall, B., METASTROKE Consortium of the ISGC, , WTCCC-2 Consortium, , Stine, OC., Kittner, SJ. and Mitchell, BD., 2018 (Accepted for publication). Genetics of the Thrombomodulin-Endothelial Cell Protein C Receptor System and the Risk of Early-Onset Ischemic Stroke PLoS ONE,
  • Markus, HS., 2018 (Accepted for publication). Identifying preclinical vascular dementia in symptomatic small vessel disease using MRI Neuroimage : Clinical,
    Doi: http://doi.org/10.1016/j.nicl.2018.06.023
  • Tay, J., Tuladhar, AM., Hollocks, MJ., Brookes, RL., Tozer, DJ., Barrick, TR., Husain, M., de Leeuw, F-E. and Markus, HS., 2018 (Accepted for publication). Apathy is associated with large-scale white matter network disruption in small vessel disease Neurology,
  • Lawrence, A., Tozer, DJ., Stamatakis, E. and Markus, H., 2018 (Accepted for publication). A comparison of functional and tractography based networks in cerebral small vessel disease NeuroImage: Clinical,
  • Tozer, DJ., Zeestraten, E., Lawrence, AJ., Barrick, T. and Markus, HS., 2018 (Accepted for publication). Texture Analysis of T1 weighted and fluid attenuated inversion recovery images detects abnormalities which correlate with disease progression in small vessel disease Stroke, v. 49
    Doi: http://doi.org/10.1161/STROKEAHA.117.019970
  • Lisiecka, DM., Tozer, D., Morris, RG., Lawrence, AJ., Barrick, TR. and Markus, HS., 2018 (Accepted for publication). Involvement of the reward network is associated with apathy in cerebral small vessel disease Journal of Affective Disorders,
  • Traylor, MS., 2018 (Accepted for publication). Genetic variation in PLEKHG1 is associated with white matter hyperintensities (N=11,226) Neurology,
  • Markus, HS., Lawrence, A., Zeestraten, E., Benjamin, P., Lambert, C., Morris, R. and Barrick, T., 2018 (Accepted for publication). Longitudinal decline in structural networks predicts dementia in cerebral small vessel disease Neurology,
  • Larsson, SC., Traylor, M., Mishra, A., Howson, JMM., Michaëlsson, K. and Markus, HS., 2018 (Accepted for publication). Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and its Subtypes: A Mendelian Randomization Study Stroke,
  • 2018

  • Bath, PM., Woodhouse, LJ., Appleton, JP., Beridze, M., Christensen, H., Dineen, RA., Flaherty, K., Duley, L., England, TJ., Havard, D., Heptinstall, S., James, M., Kasonde, C., Krishnan, K., Markus, HS., Montgomery, AA., Pocock, S., Randall, M., Ranta, A., Robinson, TG., Scutt, P., Venables, GS. and Sprigg, N., 2018. Triple versus guideline antiplatelet therapy to prevent recurrence after acute ischaemic stroke or transient ischaemic attack: the TARDIS RCT. Health Technol Assess, v. 22
    Doi: http://doi.org/10.3310/hta22480
  • Franceschini, N., Giambartolomei, C., de Vries, PS., Finan, C., Bis, JC., Huntley, RP., Lovering, RC., Tajuddin, SM., Winkler, TW., Graff, M., Kavousi, M., Dale, C., Smith, AV., Hofer, E., van Leeuwen, EM., Nolte, IM., Lu, L., Scholz, M., Sargurupremraj, M., Pitkänen, N., Franzén, O., Joshi, PK., Noordam, R., Marioni, RE., Hwang, S-J., Musani, SK., Schminke, U., Palmas, W., Isaacs, A., Correa, A., Zonderman, AB., Hofman, A., Teumer, A., Cox, AJ., Uitterlinden, AG., Wong, A., Smit, AJ., Newman, AB., Britton, A., Ruusalepp, A., Sennblad, B., Hedblad, B., Pasaniuc, B., Penninx, BW., Langefeld, CD., Wassel, CL., Tzourio, C., Fava, C., Baldassarre, D., O'Leary, DH., Teupser, D., Kuh, D., Tremoli, E., Mannarino, E., Grossi, E., Boerwinkle, E., Schadt, EE., Ingelsson, E., Veglia, F., Rivadeneira, F., Beutner, F., Chauhan, G., Heiss, G., Snieder, H., Campbell, H., Völzke, H., Markus, HS., Deary, IJ., Jukema, JW., de Graaf, J., Price, J., Pott, J., Hopewell, JC., Liang, J., Thiery, J., Engmann, J., Gertow, K., Rice, K., Taylor, KD., Dhana, K., Kiemeney, LALM., Lind, L., Raffield, LM., Launer, LJ., Holdt, LM., Dörr, M., Dichgans, M., Traylor, M., Sitzer, M., Kumari, M., Kivimaki, M., Nalls, MA., Melander, O., Raitakari, O., Franco, OH., Rueda-Ochoa, OL., Roussos, P., Whincup, PH., Amouyel, P., Giral, P., Anugu, P., Wong, Q., Malik, R., Rauramaa, R., Burkhardt, R., Hardy, R., Schmidt, R., de Mutsert, R., Morris, RW., Strawbridge, RJ., Wannamethee, SG., Hägg, S., Shah, S., McLachlan, S., Trompet, S., Seshadri, S., Kurl, S., Heckbert, SR., Ring, S., Harris, TB., Lehtimäki, T., Galesloot, TE., Shah, T., de Faire, U., Plagnol, V., Rosamond, WD., Post, W., Zhu, X., Zhang, X., Guo, X., Saba, Y., MEGASTROKE Consortium, , Dehghan, A., Seldenrijk, A., Morrison, AC., Hamsten, A., Psaty, BM., van Duijn, CM., Lawlor, DA., Mook-Kanamori, DO., Bowden, DW., Schmidt, H., Wilson, JF., Wilson, JG., Rotter, JI., Wardlaw, JM., Deanfield, J., Halcox, J., Lyytikäinen, L-P., Loeffler, M., Evans, MK., Debette, S., Humphries, SE., Völker, U., Gudnason, V., Hingorani, AD., Björkegren, JLM., Casas, JP. and O'Donnell, CJ., 2018. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun, v. 9
    Doi: http://doi.org/10.1038/s41467-018-07340-5
  • Larsson, SC., Traylor, M., Markus, HS. and Michaëlsson, K., 2018. Serum Parathyroid Hormone, 25-Hydroxyvitamin D, and Risk of Alzheimer's Disease: A Mendelian Randomization Study. Nutrients, v. 10
    Doi: http://doi.org/10.3390/nu10091243
  • Brookes, RL., Crichton, S., Wolfe, CDA., Yi, Q., Li, L., Hankey, GJ., Rothwell, PM. and Markus, HS., 2018. Sodium Valproate, a Histone Deacetylase Inhibitor, Is Associated With Reduced Stroke Risk After Previous Ischemic Stroke or Transient Ischemic Attack. Stroke, v. 49
    Doi: http://doi.org/10.1161/STROKEAHA.117.016674
  • Hindy, G., Engström, G., Larsson, SC., Traylor, M., Markus, HS., Melander, O., Orho-Melander, M. and Stroke Genetics Network (SiGN), , 2018. Role of Blood Lipids in the Development of Ischemic Stroke and its Subtypes: A Mendelian Randomization Study. Stroke, v. 49
    Doi: http://doi.org/10.1161/STROKEAHA.117.019653
  • Farmery, JHR., Smith, ML., NIHR BioResource - Rare Diseases, and Lynch, AG., 2018. Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data. Sci Rep, v. 8
    Doi: http://doi.org/10.1038/s41598-018-31524-0
  • Hollocks, MJ., Brookes, RL., Morris, RG. and Markus, HS., 2018. The Brief Memory and Executive Test (BMET): A cognitive screening tool to detect and differentiate vascular cognitive impairment and Alzheimer's disease. Int J Geriatr Psychiatry, v. 33
    Doi: http://doi.org/10.1002/gps.4787
  • Bath, PM., Woodhouse, LJ., Appleton, JP., Beridze, M., Christensen, H., Dineen, RA., Duley, L., England, TJ., Flaherty, K., Havard, D., Heptinstall, S., James, M., Krishnan, K., Markus, HS., Montgomery, AA., Pocock, SJ., Randall, M., Ranta, A., Robinson, TG., Scutt, P., Venables, GS., Sprigg, N. and TARDIS Investigators, , 2018. Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet, v. 391
    Doi: http://doi.org/10.1016/S0140-6736(17)32849-0
  • Horsburgh, K., Wardlaw, JM., van Agtmael, T., Allan, SM., Ashford, MLJ., Bath, PM., Brown, R., Berwick, J., Cader, MZ., Carare, RO., Davis, JB., Duncombe, J., Farr, TD., Fowler, JH., Goense, J., Granata, A., Hall, CN., Hainsworth, AH., Harvey, A., Hawkes, CA., Joutel, A., Kalaria, RN., Kehoe, PG., Lawrence, CB., Lockhart, A., Love, S., Macleod, MR., Macrae, IM., Markus, HS., McCabe, C., McColl, BW., Meakin, PJ., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, TJ., Rajani, R., Saksida, LM., Smith, C., Smith, KJ., Touyz, RM., Trueman, RC., Wang, T., Williams, A., Williams, SCR. and Work, LM., 2018. Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology. Clin Sci (Lond), v. 132
    Doi: http://doi.org/10.1042/CS20171620
  • Bersano, A., Bedini, G., Markus, HS., Vitali, P., Colli-Tibaldi, E., Taroni, F., Gellera, C., Baratta, S., Mosca, L., Carrera, P., Ferrari, M., Cereda, C., Grieco, G., Lanfranconi, S., Mazucchelli, F., Zarcone, D., De Lodovici, ML., Bono, G., Boncoraglio, GB., Parati, EA., Calloni, MV., Perrone, P., Bordo, BM., Motto, C., Agostoni, E., Pezzini, A., Padovani, A., Micieli, G., Cavallini, A., Molini, G., Sasanelli, F., Sessa, M., Comi, G., Checcarelli, N., Carmerlingo, M., Corato, M., Marcheselli, S., Fusi, L., Grampa, G., Uccellini, D., Beretta, S., Ferrarese, C., Incorvaia, B., Tadeo, CS., Adobbati, L., Silani, V., Faragò, G., Trobia, N., Grond-Ginsbach, C., Candelise, L. and Lombardia GENS-group, , 2018. The role of clinical and neuroimaging features in the diagnosis of CADASIL. Journal of Neurology, v. 265
    Doi: http://doi.org/10.1007/s00415-018-9072-8
  • Campbell, BCV., van Zwam, WH., Goyal, M., Menon, BK., Dippel, DWJ., Demchuk, AM., Bracard, S., White, P., Dávalos, A., Majoie, CBLM., van der Lugt, A., Ford, GA., de la Ossa, NP., Kelly, M., Bourcier, R., Donnan, GA., Roos, YBWEM., Bang, OY., Nogueira, RG., Devlin, TG., van den Berg, LA., Clarençon, F., Burns, P., Carpenter, J., Berkhemer, OA., Yavagal, DR., Pereira, VM., Ducrocq, X., Dixit, A., Quesada, H., Epstein, J., Davis, SM., Jansen, O., Rubiera, M., Urra, X., Micard, E., Lingsma, HF., Naggara, O., Brown, S., Guillemin, F., Muir, KW., van Oostenbrugge, RJ., Saver, JL., Jovin, TG., Hill, MD., Mitchell, PJ. and HERMES collaborators, , 2018. Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data. Lancet Neurol, v. 17
    Doi: http://doi.org/10.1016/S1474-4422(17)30407-6
  • Le Heron, C., Manohar, S., Plant, O., Muhammed, K., Griffanti, L., Nemeth, A., Douaud, G., Markus, HS. and Husain, M., 2018. Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease. Brain, v. 141
    Doi: http://doi.org/10.1093/brain/awy257
  • Nannucci, S., Rinnoci, V., Pracucci, G., MacKinnon, AD., Pescini, F., Adib-Samii, P., Bianchi, S., Dotti, MT., Federico, A., Inzitari, D., Markus, HS. and Pantoni, L., 2018. Location, number and factors associated with cerebral microbleeds in an Italian-British cohort of CADASIL patients. PLoS One, v. 13
    Doi: http://doi.org/10.1371/journal.pone.0190878
  • Bonati, LH., Gregson, J., Dobson, J., McCabe, DJH., Nederkoorn, PJ., van der Worp, HB., de Borst, GJ., Richards, T., Cleveland, T., Müller, MD., Wolff, T., Engelter, ST., Lyrer, PA., Brown, MM. and International Carotid Stenting Study investigators, , 2018. Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial. Lancet Neurol, v. 17
    Doi: http://doi.org/10.1016/S1474-4422(18)30195-9
  • Larsson, SC., Traylor, M., Mishra, A., Howson, JMM., Michaëlsson, K., Markus, HS. and MEGASTROKE Project of the International Stroke Genetics Consortium, , 2018. Serum 25-Hydroxyvitamin D Concentrations and Ischemic Stroke and Its Subtypes. Stroke, v. 49
    Doi: http://doi.org/10.1161/STROKEAHA.118.022242
  • Woo, D., Anderson, CD., Maguire, J., Fornage, M., Lee, J-M., Seshadri, S., Markus, HS., Majersik, JJ., Jimenez-Conde, J., Crawford, K., Lindgren, AG. and Debette, S., 2018. Top research priorities for stroke genetics. Lancet Neurol, v. 17
    Doi: http://doi.org/10.1016/S1474-4422(18)30243-6
  • Malik, R., Rannikmäe, K., Traylor, M., Georgakis, MK., Sargurupremraj, M., Markus, HS., Hopewell, JC., Debette, S., Sudlow, CLM., Dichgans, M. and MEGASTROKE consortium and the International Stroke Genetics Consortium, , 2018. Genome-wide meta-analysis identifies 3 novel loci associated with stroke. Ann Neurol, v. 84
    Doi: http://doi.org/10.1002/ana.25369
  • Drazyk, AM. and Markus, HS., 2018. Recent advances in the management of symptomatic vertebral artery stenosis. Curr Opin Neurol, v. 31
    Doi: http://doi.org/10.1097/WCO.0000000000000515
  • Benjamin, P., Trippier, S., Lawrence, AJ., Lambert, C., Zeestraten, E., Williams, OA., Patel, B., Morris, RG., Barrick, TR., MacKinnon, AD. and Markus, HS., 2018. Lacunar Infarcts, but Not Perivascular Spaces, Are Predictors of Cognitive Decline in Cerebral Small-Vessel Disease. Stroke, v. 49
    Doi: http://doi.org/10.1161/STROKEAHA.117.017526
  • Larsson, SC., Traylor, M. and Markus, HS., 2018. Circulating Vitamin K₁ Levels in Relation to Ischemic Stroke and Its Subtypes: A Mendelian Randomization Study. Nutrients, v. 10
    Doi: http://doi.org/10.3390/nu10111575
  • Corovic, A., Kelly, S. and Markus, HS., 2018. Cerebral amyloid angiopathy associated with inflammation: A systematic review of clinical and imaging features and outcome. Int J Stroke, v. 13
    Doi: http://doi.org/10.1177/1747493017741569
  • Naylor, AR., Ricco, J-B., de Borst, GJ., Debus, S., de Haro, J., Halliday, A., Hamilton, G., Kakisis, J., Kakkos, S., Lepidi, S., Markus, HS., McCabe, DJ., Roy, J., Sillesen, H., van den Berg, JC., Vermassen, F., Esvs Guidelines Committee, , Kolh, P., Chakfe, N., Hinchliffe, RJ., Koncar, I., Lindholt, JS., Vega de Ceniga, M., Verzini, F., Esvs Guideline Reviewers, , Archie, J., Bellmunt, S., Chaudhuri, A., Koelemay, M., Lindahl, A-K., Padberg, F. and Venermo, M., 2018. Editor's Choice - Management of Atherosclerotic Carotid and Vertebral Artery Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS). Eur J Vasc Endovasc Surg, v. 55
    Doi: http://doi.org/10.1016/j.ejvs.2017.06.021
  • 2017 (Accepted for publication)

  • Croall, I., Tozer, D., Moynihan, B., Khan, U., O'Brien, J., Morris, R., Cambridge, V., Barrick, T., Blamire, A., Ford, G. and Markus, HS., 2017 (Accepted for publication). Effect of Standard vs Intensive Blood Pressure Control on Cerebral Blood Flow in Small Vessel Disease The PRESERVE Randomized Clinical Trial JAMA Neurology,
    Doi: http://doi.org/10.1001/jamaneurol.2017.5153
  • Farmery, , Smith, M. and Lynch, AG., 2017 (Accepted for publication). Telomerecat: A ploidy­agnostic method for estimating telomere length from whole genome sequencing data Scientific Reports,
  • Traylor, M., Curtis, C., Patel, H., Breen, G., Hyuck Lee, S., Xu, X., Newhouse, S., Dobson, R., Steer, S., Cope, AP., Markus, HS., Lewis, CM. and Scott, IC., 2017 (Accepted for publication). Genetic and environmental risk factors for rheumatoid arthritis in a UK African ancestry population: the GENRA case-control study Rheumatology,
    Doi: http://doi.org/10.1093/rheumatology/kex048
  • Danesh, J. and Howson, J., 2017 (Accepted for publication). Multi-ancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes Nature Genetics,
    Doi: http://doi.org/10.1038/s41588-018-0058-3
  • Lohner, V., Brookes, RL., Hollocks, MJ., Morris, RG. and Markus, HS., 2017 (Accepted for publication). Apathy, but not depression, is associated with executive dysfunction in cerebral small vessel disease. PLoS One, v. 12
    Doi: http://doi.org/10.1371/journal.pone.0176943
  • Markus, HS., Larsson, SC., Kuker, W., Schulz, UG., Ford, I., Rothwell, PM. and Clifton, A., 2017 (Accepted for publication). Stenting for symptomatic vertebral artery stenosis: The Vertebral Artery Ischaemia Stenting Trial Neurology,
    Doi: http://doi.org/10.1212/WNL.0000000000004385
  • Evans, NR., Tarkin, JM., Buscombe, JR., Markus, HS., Rudd, JHF. and Warburton, EA., 2017 (Accepted for publication). PET imaging of the neurovascular interface in cerebrovascular disease Nature Reviews Neurology, v. 13
    Doi: http://doi.org/10.1038/nrneurol.2017.129
  • Brookes, RL., Crichton, S., Wolfe, CDA., Yi, Q., Li, L., Hankey, GJ., Rothwell, PM. and Markus, HS., 2017 (Accepted for publication). Sodium valproate, an HDAC inhibitor, is associated with reduced stroke risk after previous ischaemic stroke or TIA Stroke,
  • Jacobs, LCA. and Markus, HS., 2017 (Accepted for publication). Vascular Risk Factor Profiles Differ Between MRI Defined Subtypes of Younger Onset Lacunar Stroke Stroke, v. 48
    Doi: http://doi.org/10.1161/STROKEAHA.117.017813
  • 2017

  • Rutten-Jacobs, LCA., Markus, HS. and UK Young Lacunar Stroke DNA Study, , 2017. Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke. Stroke, v. 48
    Doi: http://doi.org/10.1161/STROKEAHA.117.017813
  • Di Donato, I., Bianchi, S., De Stefano, N., Dichgans, M., Dotti, MT., Duering, M., Jouvent, E., Korczyn, AD., Lesnik-Oberstein, SAJ., Malandrini, A., Markus, HS., Pantoni, L., Penco, S., Rufa, A., Sinanović, O., Stojanov, D. and Federico, A., 2017. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects. BMC Med, v. 15
    Doi: http://doi.org/10.1186/s12916-017-0778-8
  • Williams, OA., Zeestraten, EA., Benjamin, P., Lambert, C., Lawrence, AJ., Mackinnon, AD., Morris, RG., Markus, HS., Charlton, RA. and Barrick, TR., 2017. Diffusion tensor image segmentation of the cerebrum provides a single measure of cerebral small vessel disease severity related to cognitive change. Neuroimage Clin, v. 16
    Doi: http://doi.org/10.1016/j.nicl.2017.08.016
  • Larsson, SC., Traylor, M., Malik, R., Dichgans, M., Burgess, S., Markus, HS. and CoSTREAM Consortium, on behalf of the International Genomics of Alzheimer’s Project, , 2017. Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis. BMJ, v. 359
  • Arno, G., Carss, KJ., Hull, S., Zihni, C., Robson, AG., Fiorentino, A., UK Inherited Retinal Disease Consortium, , Hardcastle, AJ., Holder, GE., Cheetham, ME., Plagnol, V., NIHR Bioresource - Rare Diseases Consortium, , Moore, AT., Raymond, FL., Matter, K., Balda, MS. and Webster, AR., 2017. Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration. Am J Hum Genet, v. 100
    Doi: http://doi.org/10.1016/j.ajhg.2016.12.014
  • Larsson, SC., Traylor, M., Burgess, S. and Markus, HS., 2017. Genetically-Predicted Adult Height and Alzheimer's Disease Journal of Alzheimer's Disease, v. 60
    Doi: http://doi.org/10.3233/JAD-170528
  • Malik, R., Dau, T., Gonik, M., Sivakumar, A., Deredge, DJ., Edeleva, EV., Götzfried, J., van der Laan, SW., Pasterkamp, G., Beaufort, N., Seixas, S., Bevan, S., Lincz, LF., Holliday, EG., Burgess, AI., Rannikmäe, K., Minnerup, J., Kriebel, J., Waldenberger, M., Müller-Nurasyid, M., Lichtner, P., Saleheen, D., International Stroke Genetics Consortium, , Rothwell, PM., Levi, C., Attia, J., Sudlow, CLM., Braun, D., Markus, HS., Wintrode, PL., Berger, K., Jenne, DE. and Dichgans, M., 2017. Common coding variant in SERPINA1 increases the risk for large artery stroke. Proc Natl Acad Sci U S A, v. 114
    Doi: http://doi.org/10.1073/pnas.1616301114
  • Tan, Y., Traylor, M., Rutten-Jacobs, L. and Markus, H., 2017. New insights into mechanisms of small vessel disease stroke from genetics Clinical Science, v. 131
    Doi: http://doi.org/10.1042/CS20160825
  • Hainsworth, AH., Minett, T., Andoh, J., Forster, G., Bhide, I., Barrick, TR., Elderfield, K., Jeevahan, J., Markus, HS. and Bridges, LR., 2017. Neuropathology of White Matter Lesions, Blood-Brain Barrier Dysfunction, and Dementia. Stroke, v. 48
    Doi: http://doi.org/10.1161/STROKEAHA.117.018101
  • Traylor, M., Rutten-Jacobs, L., Curtis, C., Patel, H., Breen, G., Newhouse, S., Lewis, CM. and Markus, HS., 2017. Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study. Neurol Genet, v. 3
    Doi: http://doi.org/10.1212/NXG.0000000000000142
  • Vassos, E., Di Forti, M., Coleman, J., Iyegbe, C., Prata, D., Euesden, J., O'Reilly, P., Curtis, C., Kolliakou, A., Patel, H., Newhouse, S., Traylor, M., Ajnakina, O., Mondelli, V., Marques, TR., Gardner-Sood, P., Aitchison, KJ., Powell, J., Atakan, Z., Greenwood, KE., Smith, S., Ismail, K., Pariante, C., Gaughran, F., Dazzan, P., Markus, HS., David, AS., Lewis, CM., Murray, RM. and Breen, G., 2017. An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis. Biol Psychiatry, v. 81
    Doi: http://doi.org/10.1016/j.biopsych.2016.06.028
  • Zeestraten, EA., Lawrence, AJ., Lambert, C., Benjamin, P., Brookes, RL., Mackinnon, AD., Morris, RG., Barrick, TR. and Markus, HS., 2017. Change in multimodal MRI markers predicts dementia risk in cerebral small vessel disease. Neurology, v. 89
    Doi: http://doi.org/10.1212/WNL.0000000000004594
  • Thomas, LC., Hall, LA., Attia, JR., Holliday, EG., Markus, HS. and Levi, CR., 2017. Seasonal Variation in Spontaneous Cervical Artery Dissection: Comparing between UK and Australian Sites. J Stroke Cerebrovasc Dis, v. 26
    Doi: http://doi.org/10.1016/j.jstrokecerebrovasdis.2016.09.006
  • Lubitz, SA., Parsons, OE., Anderson, CD., Benjamin, EJ., Malik, R., Weng, L-C., Dichgans, M., Sudlow, CL., Rothwell, PM., Rosand, J., Ellinor, PT., Markus, HS. and Traylor, M., 2017. Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms Stroke, v. 48
    Doi: http://doi.org/10.1161/STROKEAHA.116.016198
  • Rannikmäe, K., Sivakumaran, V., Millar, H., Malik, R., Anderson, CD., Chong, M., Dave, T., Falcone, GJ., Fernandez-Cadenas, I., Jimenez-Conde, J., Lindgren, A., Montaner, J., O'Donnell, M., Paré, G., Radmanesh, F., Rost, NS., Slowik, A., Söderholm, M., Traylor, M., Pulit, SL., Seshadri, S., Worrall, BB., Woo, D., Markus, HS., Mitchell, BD., Dichgans, M., Rosand, J., Sudlow, CLM. and Stroke Genetics Network (SiGN), METASTROKE Collaboration, and International Stroke Genetics Consortium (ISGC), , 2017. COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls. Neurology, v. 89
    Doi: http://doi.org/10.1212/WNL.0000000000004560
  • Bath, PM., Appleton, JP., Beridze, M., Christensen, H., Dineen, RA., Duley, L., England, TJ., Heptinstall, S., James, M., Krishnan, K., Markus, HS., Pocock, S., Ranta, A., Robinson, TG., Flaherty, K., Scutt, P., Venables, GS., Woodhouse, LJ. and Sprigg, N., 2017. Baseline characteristics of the 3096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischemic Stroke' trial. Int J Stroke, v. 12
    Doi: http://doi.org/10.1177/1747493016677988
  • Croall, ID., Lohner, V., Moynihan, B., Khan, U., Hassan, A., O'Brien, JT., Morris, RG., Tozer, DJ., Cambridge, VC., Harkness, K., Werring, DJ., Blamire, AM., Ford, GA., Barrick, TR. and Markus, HS., 2017. Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies Clinical Science, v. 131
    Doi: http://doi.org/10.1042/CS20170146
  • Phuah, C-L., Dave, T., Malik, R., Raffeld, MR., Ayres, AM., Goldstein, JN., Viswanathan, A., Greenberg, SM., Jagiella, JM., Hansen, BM., Norrving, B., Jimenez-Conde, J., Roquer, J., Pichler, A., Enzinger, C., Montaner, J., Fernandez-Cadenas, I., Lindgren, A., Slowik, A., Schmidt, R., Biffi, A., Rost, N., Langefeld, CD., Markus, HS., Mitchell, BD., Worrall, BB., Kittner, SJ., Woo, D., Dichgans, M., Rosand, J., Anderson, CD., METASTROKE, , NINDS-SiGN Consortium, and International Stroke Genetics Consortium, , 2017. Genetic variants influencing elevated myeloperoxidase levels increase risk of stroke. Brain, v. 140
    Doi: http://doi.org/10.1093/brain/awx220
  • McGlasson, S., Rannikmäe, K., Bevan, S., Logan, C., Bicknell, LS., Jury, A., UK Young Lacunar Stroke Study, , Jackson, AP., Markus, HS., Sudlow, C. and Hunt, DPJ., 2017. Rare variants of the 3'-5' DNA exonuclease TREX1 in early onset small vessel stroke. Wellcome Open Res, v. 2
    Doi: http://doi.org/10.12688/wellcomeopenres.12631.1
  • Muir, KW., Ford, GA., Messow, C-M., Ford, I., Murray, A., Clifton, A., Brown, MM., Madigan, J., Lenthall, R., Robertson, F., Dixit, A., Cloud, GC., Wardlaw, J., Freeman, J., White, P. and PISTE Investigators, , 2017. Endovascular therapy for acute ischaemic stroke: the Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) randomised, controlled trial. J Neurol Neurosurg Psychiatry, v. 88
    Doi: http://doi.org/10.1136/jnnp-2016-314117
  • Wiener, E., Martin, P., Mehta, S. and Markus, HS., 2017. Cervical artery dissection and iliac artery aneurysm in an SMAD-4 mutation carrier. Neurol Genet, v. 3
    Doi: http://doi.org/10.1212/NXG.0000000000000191
  • Larsson, SC. and Markus, HS., 2017. Branched-chain amino acids and Alzheimer's disease: a Mendelian randomization analysis. Sci Rep, v. 7
    Doi: http://doi.org/10.1038/s41598-017-12931-1
  • Burgess, S., Haycock, P., Markus, HS. and Willeit, P., 2017. Mendelian randomization study of the association between telomere length and risk of cancer and non-neoplastic diseases JAMA - Journal of the American Medical Association,
    Doi: http://doi.org/10.1001/jamaoncol.2016.5945
  • Larsson, SC., Scott, RA., Traylor, M., Langenberg, CC., Hindy, G., Melander, O., Orho-Melander, M., Seshadri, S., Wareham, NJ., Markus, HS. and METASTROKE Collaboration and NINDS Stroke Genetics Network (SiGN), , 2017. Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study Neurology, v. 89
    Doi: http://doi.org/10.1212/WNL.0000000000004173
  • Tuladhar, AM., Lawrence, A., Norris, DG., Barrick, TR., Markus, HS. and de Leeuw, F-E., 2017. Disruption of rich club organisation in cerebral small vessel disease. Hum Brain Mapp, v. 38
    Doi: http://doi.org/10.1002/hbm.23479
  • Markus, HS., 2017. Cerebrovascular abnormalities in Alzheimer's dementia: a more tractable treatment target? Brain, v. 140
    Doi: http://doi.org/10.1093/brain/awx161
  • Larsson, SC., King, A., Madigan, J., Levi, C., Norris, JW. and Markus, HS., 2017. Prognosis of carotid dissecting aneurysms: Results from CADISS and a systematic review Neurology, v. 88
    Doi: http://doi.org/10.1212/WNL.0000000000003617
  • Carss, KJ., Arno, G., Erwood, M., Stephens, J., Sanchis-Juan, A., Hull, S., Megy, K., Grozeva, D., Dewhurst, E., Malka, S., Plagnol, V., Penkett, C., Stirrups, K., Rizzo, R., Wright, G., Josifova, D., Bitner-Glindzicz, M., Scott, RH., Clement, E., Allen, L., Armstrong, R., Brady, AF., Carmichael, J., Chitre, M., Henderson, RHH., Hurst, J., MacLaren, RE., Murphy, E., Paterson, J., Rosser, E., Thompson, DA., Wakeling, E., Ouwehand, WH., Michaelides, M., Moore, AT., NIHR-BioResource Rare Diseases Consortium, , Webster, AR. and Raymond, FL., 2017. Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease American Journal of Human Genetics, v. 100
    Doi: http://doi.org/10.1016/j.ajhg.2016.12.003
  • Metoki, A., Brookes, RL., Zeestraten, E., Lawrence, AJ., Morris, RG., Barrick, TR., Markus, HS. and Charlton, RA., 2017. Mnemonic function in small vessel disease and associations with white matter tract microstructure. Neuropsychologia, v. 104
    Doi: http://doi.org/10.1016/j.neuropsychologia.2017.07.027
  • Mok, VCT., Lam, BYK., Wong, A., Ko, H., Markus, HS. and Wong, LKS., 2017. Early-onset and delayed-onset poststroke dementia - revisiting the mechanisms. Nat Rev Neurol, v. 13
    Doi: http://doi.org/10.1038/nrneurol.2017.16
  • 2016

  • Tuladhar, AM., van Uden, IWM., Rutten-Jacobs, LCA., Lawrence, A., van der Holst, H., van Norden, A., de Laat, K., van Dijk, E., Claassen, JAHR., Kessels, RPC., Markus, HS., Norris, DG. and de Leeuw, F-E., 2016. Structural network efficiency predicts conversion to dementia. Neurology, v. 86
    Doi: http://doi.org/10.1212/WNL.0000000000002502
  • Markus, H., 2016. Stroke: causes and clinical features Medicine (United Kingdom), v. 44
    Doi: http://doi.org/10.1016/j.mpmed.2016.06.006
  • Benjamin, P., Zeestraten, E., Lambert, C., Ster, IC., Williams, OA., Lawrence, AJ., Patel, B., MacKinnon, AD., Barrick, TR. and Markus, HS., 2016. Progression of MRI markers in cerebral small vessel disease: Sample size considerations for clinical trials. J Cereb Blood Flow Metab, v. 36
    Doi: http://doi.org/10.1038/jcbfm.2015.113
  • Lambert, C., Benjamin, P., Zeestraten, E., Lawrence, AJ., Barrick, TR. and Markus, HS., 2016. Longitudinal patterns of leukoaraiosis and brain atrophy in symptomatic small vessel disease. Brain, v. 139
    Doi: http://doi.org/10.1093/brain/aww009
  • Seppälä, I., Kleber, ME., Bevan, S., Lyytikäinen, L-P., Oksala, N., Hernesniemi, JA., Mäkelä, K-M., Rothwell, PM., Sudlow, C., Dichgans, M., Mononen, N., Vlachopoulou, E., Sinisalo, J., Delgado, GE., Laaksonen, R., Koskinen, T., Scharnagl, H., Kähönen, M., Markus, HS., März, W. and Lehtimäki, T., 2016. Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. Sci Rep, v. 6
    Doi: http://doi.org/10.1038/srep23207
  • Surendran, P., Drenos, F., Young, R., Warren, H., Cook, JP., Manning, AK., Grarup, N., Sim, X., Barnes, DR., Witkowska, K., Staley, JR., Tragante, V., Tukiainen, T., Yaghootkar, H., Masca, N., Freitag, DF., Ferreira, T., Giannakopoulou, O., Tinker, A., Harakalova, M., Mihailov, E., Liu, C., Kraja, AT., Fallgaard Nielsen, S., Rasheed, A., Samuel, M., Zhao, W., Bonnycastle, LL., Jackson, AU., Narisu, N., Swift, AJ., Southam, L., Marten, J., Huyghe, JR., Stančáková, A., Fava, C., Ohlsson, T., Matchan, A., Stirrups, KE., Bork-Jensen, J., Gjesing, AP., Kontto, J., Perola, M., Shaw-Hawkins, S., Havulinna, AS., Zhang, H., Donnelly, LA., Groves, CJ., Rayner, NW., Neville, MJ., Robertson, NR., Yiorkas, AM., Herzig, K-H., Kajantie, E., Zhang, W., Willems, SM., Lannfelt, L., Malerba, G., Soranzo, N., Trabetti, E., Verweij, N., Evangelou, E., Moayyeri, A., Vergnaud, A-C., Nelson, CP., Poveda, A., Varga, TV., Caslake, M., de Craen, AJ., Trompet, S., Luan, J., Scott, RA., Harris, SE., Liewald, DC., Marioni, R., Menni, C., Farmaki, A-E., Hallmans, G., Renström, F., Huffman, JE., Hassinen, M., Burgess, S., Vasan, RS., Felix, JF., CHARGE-Heart Failure Consortium, , Uria-Nickelsen, M., Malarstig, A., Reily, DF., Hoek, M., Vogt, T., Lin, H., Lieb, W., EchoGen Consortium, , Traylor, M., Markus, HF., METASTROKE Consortium, , Highland, HM., Justice, AE., Marouli, E., GIANT Consortium, , Lindström, J., Uusitupa, M., Komulainen, P., Lakka, TA., Rauramaa, R., Polasek, O., Rudan, I., Rolandsson, O., Franks, PW., Dedoussis, G., Spector, TD., EPIC-InterAct Consortium, , Jousilahti, P., Männistö, S., Deary, IJ., Starr, JM., Langenberg, C., Wareham, NJ., Brown, MJ., Dominiczak, AF., Connell, JM., Jukema, JW., Sattar, N., Ford, I., Packard, CJ., Esko, T., Mägi, R., Metspalu, A., de Boer, RA., van der Meer, P., van der Harst, P., Lifelines Cohort Study, , Gambaro, G., Ingelsson, E., Lind, L., de Bakker, PI., Numans, ME., Brandslund, I., Christensen, C., Petersen, ER., Korpi-Hyövälti, E., Oksa, H., Chambers, JC., Kooner, JS., Blakemore, AI., Franks, S., Jarvelin, M-R., Husemoen, LL., Linneberg, A., Skaaby, T., Thuesen, B., Karpe, F., Tuomilehto, J., Doney, AS., Morris, AD., Palmer, CN., Holmen, OL., Hveem, K., Willer, CJ., Tuomi, T., Groop, L., Käräjämäki, A., Palotie, A., Ripatti, S., Salomaa, V., Alam, DS., Shafi Majumder, AA., Di Angelantonio, E., Chowdhury, R., McCarthy, MI., Poulter, N., Stanton, AV., Sever, P., Amouyel, P., Arveiler, D., Blankenberg, S., Ferrières, J., Kee, F., Kuulasmaa, K., Müller-Nurasyid, M., Veronesi, G., Virtamo, J., Deloukas, P., Wellcome Trust Case Control Consortium, , Elliott, P., Understanding Society Scientific Group, , Zeggini, E., Kathiresan, S., Melander, O., Kuusisto, J., Laakso, M., Padmanabhan, S., Porteous, D., Hayward, C., Scotland, G., Collins, FS., Mohlke, KL., Hansen, T., Pedersen, O., Boehnke, M., Stringham, HM., EPIC-CVD Consortium, , Frossard, P., Newton-Cheh, C., CHARGE+ Exome Chip Blood Pressure Consortium, , Tobin, MD., Nordestgaard, BG., T2D-GENES Consortium, , GoT2DGenes Consortium, , ExomeBP Consortium, , CHD Exome+ Consortium, , Caulfield, MJ., Mahajan, A., Morris, AP., Tomaszewski, M., Samani, NJ., Saleheen, D., Asselbergs, FW., Lindgren, CM., Danesh, J., Wain, LV., Butterworth, AS., Howson, JM. and Munroe, PB., 2016. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet, v. 48
    Doi: http://doi.org/10.1038/ng.3654
  • Hollocks, MJ., Brookes, R., Morris, RG. and Markus, HS., 2016. Associations between the Brief Memory and Executive Test (BMET), Activities of Daily Living, and Quality of Life in Patients with Cerebral Small Vessel Disease. J Int Neuropsychol Soc, v. 22
    Doi: http://doi.org/10.1017/S1355617716000187
  • Ehret, GB., Ferreira, T., Chasman, DI., Jackson, AU., Schmidt, EM., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, LA., Kanoni, S., Petersen, A-K., Pihur, V., Strawbridge, RJ., Shungin, D., Hughes, MF., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S., Kleber, ME., Guo, X., Lyytikäinen, L-P., Fava, C., Eriksson, N., Nolte, IM., Magnusson, PK., Salfati, EL., Rallidis, LS., Theusch, E., Smith, AJP., Folkersen, L., Witkowska, K., Pers, TH., Joehanes, R., Kim, SK., Lataniotis, L., Jansen, R., Johnson, AD., Warren, H., Kim, YJ., Zhao, W., Wu, Y., Tayo, BO., Bochud, M., CHARGE-EchoGen consortium, , CHARGE-HF consortium, , Wellcome Trust Case Control Consortium, , Absher, D., Adair, LS., Amin, N., Arking, DE., Axelsson, T., Baldassarre, D., Balkau, B., Bandinelli, S., Barnes, MR., Barroso, I., Bevan, S., Bis, JC., Bjornsdottir, G., Boehnke, M., Boerwinkle, E., Bonnycastle, LL., Boomsma, DI., Bornstein, SR., Brown, MJ., Burnier, M., Cabrera, CP., Chambers, JC., Chang, I-S., Cheng, C-Y., Chines, PS., Chung, R-H., Collins, FS., Connell, JM., Döring, A., Dallongeville, J., Danesh, J., de Faire, U., Delgado, G., Dominiczak, AF., Doney, ASF., Drenos, F., Edkins, S., Eicher, JD., Elosua, R., Enroth, S., Erdmann, J., Eriksson, P., Esko, T., Evangelou, E., Evans, A., Fall, T., Farrall, M., Felix, JF., Ferrières, J., Ferrucci, L., Fornage, M., Forrester, T., Franceschini, N., Duran, OHF., Franco-Cereceda, A., Fraser, RM., Ganesh, SK., Gao, H., Gertow, K., Gianfagna, F., Gigante, B., Giulianini, F., Goel, A., Goodall, AH., Goodarzi, MO., Gorski, M., Gräßler, J., Groves, C., Gudnason, V., Gyllensten, U., Hallmans, G., Hartikainen, A-L., Hassinen, M., Havulinna, AS., Hayward, C., Hercberg, S., Herzig, K-H., Hicks, AA., Hingorani, AD., Hirschhorn, JN., Hofman, A., Holmen, J., Holmen, OL., Hottenga, J-J., Howard, P., Hsiung, CA., Hunt, SC., Ikram, MA., Illig, T., Iribarren, C., Jensen, RA., Kähönen, M., Kang, H., Kathiresan, S., Keating, BJ., Khaw, K-T., Kim, YK., Kim, E., Kivimaki, M., Klopp, N., Kolovou, G., Komulainen, P., Kooner, JS., Kosova, G., Krauss, RM., Kuh, D., Kutalik, Z., Kuusisto, J., Kvaløy, K., Lakka, TA., Lee, NR., Lee, I-T., Lee, W-J., Levy, D., Li, X., Liang, K-W., Lin, H., Lin, L., Lindström, J., Lobbens, S., Männistö, S., Müller, G., Müller-Nurasyid, M., Mach, F., Markus, HS., Marouli, E., McCarthy, MI., McKenzie, CA., Meneton, P., Menni, C., Metspalu, A., Mijatovic, V., Moilanen, L., Montasser, ME., Morris, AD., Morrison, AC., Mulas, A., Nagaraja, R., Narisu, N., Nikus, K., O'Donnell, CJ., O'Reilly, PF., Ong, KK., Paccaud, F., Palmer, CD., Parsa, A., Pedersen, NL., Penninx, BW., Perola, M., Peters, A., Poulter, N., Pramstaller, PP., Psaty, BM., Quertermous, T., Rao, DC., Rasheed, A., Rayner, NWNWR., Renström, F., Rettig, R., Rice, KM., Roberts, R., Rose, LM., Rossouw, J., Samani, NJ., Sanna, S., Saramies, J., Schunkert, H., Sebert, S., Sheu, WH-H., Shin, Y-A., Sim, X., Smit, JH., Smith, AV., Sosa, MX., Spector, TD., Stančáková, A., Stanton, A., Stirrups, KE., Stringham, HM., Sundstrom, J., Swift, AJ., Syvänen, A-C., Tai, E-S., Tanaka, T., Tarasov, KV., Teumer, A., Thorsteinsdottir, U., Tobin, MD., Tremoli, E., Uitterlinden, AG., Uusitupa, M., Vaez, A., Vaidya, D., van Duijn, CM., van Iperen, EPA., Vasan, RS., Verwoert, GC., Virtamo, J., Vitart, V., Voight, BF., Vollenweider, P., Wagner, A., Wain, LV., Wareham, NJ., Watkins, H., Weder, AB., Westra, H-J., Wilks, R., Wilsgaard, T., Wilson, JF., Wong, TY., Yang, T-P., Yao, J., Yengo, L., Zhang, W., Zhao, JH., Zhu, X., Bovet, P., Cooper, RS., Mohlke, KL., Saleheen, D., Lee, J-Y., Elliott, P., Gierman, HJ., Willer, CJ., Franke, L., Hovingh, GK., Taylor, KD., Dedoussis, G., Sever, P., Wong, A., Lind, L., Assimes, TL., Njølstad, I., Schwarz, PE., Langenberg, C., Snieder, H., Caulfield, MJ., Melander, O., Laakso, M., Saltevo, J., Rauramaa, R., Tuomilehto, J., Ingelsson, E., Lehtimäki, T., Hveem, K., Palmas, W., März, W., Kumari, M., Salomaa, V., Chen, Y-DI., Rotter, JI., Froguel, P., Jarvelin, M-R., Lakatta, EG., Kuulasmaa, K., Franks, PW., Hamsten, A., Wichmann, H-E., Palmer, CNA., Stefansson, K., Ridker, PM., Loos, RJF., Chakravarti, A., Deloukas, P., Morris, AP., Newton-Cheh, C. and Munroe, PB., 2016. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet, v. 48
    Doi: http://doi.org/10.1038/ng.3667
  • Pasterkamp, G., van der Laan, SW., Haitjema, S., Foroughi Asl, H., Siemelink, MA., Bezemer, T., van Setten, J., Dichgans, M., Malik, R., Worrall, BB., Schunkert, H., Samani, NJ., de Kleijn, DPV., Markus, HS., Hoefer, IE., Michoel, T., de Jager, SCA., Björkegren, JLM., den Ruijter, HM. and Asselbergs, FW., 2016. Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype. Arterioscler Thromb Vasc Biol, v. 36
    Doi: http://doi.org/10.1161/ATVBAHA.115.306958
  • Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC), , 2016. Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies. Lancet Neurol, v. 15
    Doi: http://doi.org/10.1016/S1474-4422(16)00102-2
  • Brookes, RL., Hollocks, MJ., Tan, RYY., Morris, RG. and Markus, HS., 2016. Brief Screening of Vascular Cognitive Impairment in Patients With Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Without Dementia. Stroke, v. 47
    Doi: http://doi.org/10.1161/STROKEAHA.116.013761
  • Traylor, M., Rutten-Jacobs, LCA., Thijs, V., Holliday, EG., Levi, C., Bevan, S., Malik, R., Boncoraglio, G., Sudlow, C., Rothwell, PM., Dichgans, M. and Markus, HS., 2016. Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke. Stroke, v. 47
    Doi: http://doi.org/10.1161/STROKEAHA.115.011625
  • Malik, R., Traylor, M., Pulit, SL., Bevan, S., Hopewell, JC., Holliday, EG., Zhao, W., Abrantes, P., Amouyel, P., Attia, JR., Battey, TWK., Berger, K., Boncoraglio, GB., Chauhan, G., Cheng, Y-C., Chen, W-M., Clarke, R., Cotlarciuc, I., Debette, S., Falcone, GJ., Ferro, JM., Gamble, DM., Ilinca, A., Kittner, SJ., Kourkoulis, CE., Lemmens, R., Levi, CR., Lichtner, P., Lindgren, A., Liu, J., Meschia, JF., Mitchell, BD., Oliveira, SA., Pera, J., Reiner, AP., Rothwell, PM., Sharma, P., Slowik, A., Sudlow, CLM., Tatlisumak, T., Thijs, V., Vicente, AM., Woo, D., Seshadri, S., Saleheen, D., Rosand, J., Markus, HS., Worrall, BB., Dichgans, M., ISGC Analysis Group, , METASTROKE collaboration, , Wellcome Trust Case Control Consortium 2 (WTCCC2), and NINDS Stroke Genetics Network (SiGN), , 2016. Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. Neurology, v. 86
    Doi: http://doi.org/10.1212/WNL.0000000000002528
  • Gulli, G., Rutten-Jacobs, LCA., Kalra, L., Rudd, AG., Wolfe, CDA. and Markus, HS., 2016. Differences in the distribution of stroke subtypes in a UK black stroke population - final results from the South London Ethnicity and Stroke Study. BMC Med, v. 14
    Doi: http://doi.org/10.1186/s12916-016-0618-2
  • Traylor, M., Anderson, CD., Hurford, R., Bevan, S. and Markus, HS., 2016. Oxidative phosphorylation and lacunar stroke: Genome-wide enrichment analysis of common variants. Neurology, v. 86
    Doi: http://doi.org/10.1212/WNL.0000000000002260
  • Rosenberg, GA., Wallin, A., Wardlaw, JM., Markus, HS., Montaner, J., Wolfson, L., Iadecola, C., Zlokovic, BV., Joutel, A., Dichgans, M., Duering, M., Schmidt, R., Korczyn, AD., Grinberg, LT., Chui, HC. and Hachinski, V., 2016. Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab, v. 36
    Doi: http://doi.org/10.1038/jcbfm.2015.172
  • Østergaard, L., Engedal, TS., Moreton, F., Hansen, MB., Wardlaw, JM., Dalkara, T., Markus, HS. and Muir, KW., 2016. Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline. J Cereb Blood Flow Metab, v. 36
    Doi: http://doi.org/10.1177/0271678X15606723
  • Bersano, A., Markus, HS., Quaglini, S., Arbustini, E., Lanfranconi, S., Micieli, G., Boncoraglio, GB., Taroni, F., Gellera, C., Baratta, S., Penco, S., Mosca, L., Grasso, M., Carrera, P., Ferrari, M., Cereda, C., Grieco, G., Corti, S., Ronchi, D., Bassi, MT., Obici, L., Parati, EA., Pezzini, A., De Lodovici, ML., Verrengia, EP., Bono, G., Mazucchelli, F., Zarcone, D., Calloni, MV., Perrone, P., Bordo, BM., Colombo, A., Padovani, A., Cavallini, A., Beretta, S., Ferrarese, C., Motto, C., Agostoni, E., Molini, G., Sasanelli, F., Corato, M., Marcheselli, S., Sessa, M., Comi, G., Checcarelli, N., Guidotti, M., Uccellini, D., Capitani, E., Tancredi, L., Arnaboldi, M., Incorvaia, B., Tadeo, CS., Fusi, L., Grampa, G., Merlini, G., Trobia, N., Comi, GP., Braga, M., Vitali, P., Baron, P., Grond-Ginsbach, C., Candelise, L. and Lombardia GENS Group*, , 2016. Clinical Pregenetic Screening for Stroke Monogenic Diseases: Results From Lombardia GENS Registry. Stroke, v. 47
    Doi: http://doi.org/10.1161/STROKEAHA.115.012281
  • Larsson, SC., Wallin, A., Wolk, A. and Markus, HS., 2016. Differing association of alcohol consumption with different stroke types: a systematic review and meta-analysis. BMC Med, v. 14
    Doi: http://doi.org/10.1186/s12916-016-0721-4
  • Cheng, Y-C., Stanne, TM., Giese, A-K., Ho, WK., Traylor, M., Amouyel, P., Holliday, EG., Malik, R., Xu, H., Kittner, SJ., Cole, JW., O'Connell, JR., Danesh, J., Rasheed, A., Zhao, W., Engelter, S., Grond-Ginsbach, C., Kamatani, Y., Lathrop, M., Leys, D., Thijs, V., Metso, TM., Tatlisumak, T., Pezzini, A., Parati, EA., Norrving, B., Bevan, S., Rothwell, PM., Sudlow, C., Slowik, A., Lindgren, A., Walters, MR., WTCCC-2 Consortium, , Jannes, J., Shen, J., Crosslin, D., Doheny, K., Laurie, CC., Kanse, SM., Bis, JC., Fornage, M., Mosley, TH., Hopewell, JC., Strauch, K., Müller-Nurasyid, M., Gieger, C., Waldenberger, M., Peters, A., Meisinger, C., Ikram, MA., Longstreth, WT., Meschia, JF., Seshadri, S., Sharma, P., Worrall, B., Jern, C., Levi, C., Dichgans, M., Boncoraglio, GB., Markus, HS., Debette, S., Rolfs, A., Saleheen, D. and Mitchell, BD., 2016. Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke, v. 47
    Doi: http://doi.org/10.1161/STROKEAHA.115.011328
  • Kenyan Bacteraemia Study Group, , Wellcome Trust Case Control Consortium 2 (WTCCC2), , Rautanen, A., Pirinen, M., Mills, TC., Rockett, KA., Strange, A., Ndungu, AW., Naranbhai, V., Gilchrist, JJ., Bellenguez, C., Freeman, C., Band, G., Bumpstead, SJ., Edkins, S., Giannoulatou, E., Gray, E., Dronov, S., Hunt, SE., Langford, C., Pearson, RD., Su, Z., Vukcevic, D., Macharia, AW., Uyoga, S., Ndila, C., Mturi, N., Njuguna, P., Mohammed, S., Berkley, JA., Mwangi, I., Mwarumba, S., Kitsao, BS., Lowe, BS., Morpeth, SC., Khandwalla, I., Kilifi Bacteraemia Surveillance Group, , Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Jankowski, J., Markus, HS., Mathew, CG., Palmer, CNA., Plomin, R., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Deloukas, P., Peltonen, L., Williams, TN., Scott, JAG., Chapman, SJ., Donnelly, P., Hill, AVS. and Spencer, CCA., 2016. Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children. Am J Hum Genet, v. 98
    Doi: http://doi.org/10.1016/j.ajhg.2016.03.025
  • Zeestraten, EA., Benjamin, P., Lambert, C., Lawrence, AJ., Williams, OA., Morris, RG., Barrick, TR. and Markus, HS., 2016. Application of Diffusion Tensor Imaging Parameters to Detect Change in Longitudinal Studies in Cerebral Small Vessel Disease. PLoS One, v. 11
    Doi: http://doi.org/10.1371/journal.pone.0147836
  • Tan, RYY. and Markus, HS., 2016. CADASIL: Migraine, Encephalopathy, Stroke and Their Inter-Relationships. PLoS One, v. 11
    Doi: http://doi.org/10.1371/journal.pone.0157613
  • Traylor, M., Malik, R., Nalls, MA., Cotlarciuc, I., Radmanesh, F., Thorleifsson, G., Hanscombe, KB., Langefeld, C., Saleheen, D., Rost, NS., Yet, I., Spector, TD., Bell, JT., Hannon, E., Mill, J., Chauhan, G., Debette, S., Bis, JC., Longstreth, WT., Ikram, MA., Launer, LJ., Seshadri, S., METASTROKE, UK Young Lacunar DNA Study, NINDS Stroke Genetics Network, Neurology Working Group of the CHARGE Consortium, Monica Anne Hamilton-Bruce, , Jimenez-Conde, J., Cole, JW., Schmidt, R., Słowik, A., Lemmens, R., Lindgren, A., Melander, O., Grewal, RP., Sacco, RL., Rundek, T., Rexrode, K., Arnett, DK., Johnson, JA., Benavente, OR., Wasssertheil-Smoller, S., Lee, J-M., Pulit, SL., Wong, Q., Rich, SS., de Bakker, PIW., McArdle, PF., Woo, D., Anderson, CD., Xu, H., Heitsch, L., Fornage, M., Jern, C., Stefansson, K., Thorsteinsdottir, U., Gretarsdottir, S., Lewis, CM., Sharma, P., Sudlow, CLM., Rothwell, PM., Boncoraglio, GB., Thijs, V., Levi, C., Meschia, JF., Rosand, J., Kittner, SJ., Mitchell, BD., Dichgans, M., Worrall, BB., Markus, HS. and International Stroke Genetics Consortium, , 2016. Genetic Variation at 16q24.2 is associated with small vessel stroke Annals of Neurology,
    Doi: http://doi.org/10.1002/ana.24840
  • Traylor, M., Zhang, CR., Adib-Samii, P., Devan, WJ., Parsons, OE., Lanfranconi, S., Gregory, S., Cloonan, L., Falcone, GJ., Radmanesh, F., Fitzpatrick, K., Kanakis, A., Barrick, TR., Moynihan, B., Lewis, CM., Boncoraglio, GB., Lemmens, R., Thijs, V., Sudlow, C., Wardlaw, J., Rothwell, PM., Meschia, JF., Worrall, BB., Levi, C., Bevan, S., Furie, KL., Dichgans, M., Rosand, J., Markus, HS., Rost, N. and International Stroke Genetics Consortium, , 2016. Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology, v. 86
    Doi: http://doi.org/10.1212/WNL.0000000000002263
  • Gesierich, B., Opherk, C., Rosand, J., Gonik, M., Malik, R., Jouvent, E., Hervé, D., Adib-Samii, P., Bevan, S., Pianese, L., Silvestri, S., Dotti, MT., De Stefano, N., van der Grond, J., Boon, EMJ., Pescini, F., Rost, N., Pantoni, L., Oberstein, SAL., Federico, A., Ragno, M., Markus, HS., Tournier-Lasserve, E., Chabriat, H., Dichgans, M., Duering, M. and Ewers, M., 2016. APOE ɛ2 is associated with white matter hyperintensity volume in CADASIL. J Cereb Blood Flow Metab, v. 36
    Doi: http://doi.org/10.1038/jcbfm.2015.85
  • Prins, BP., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., Stuart, PE., Guterriez Achury, J., Mistry, V., Bradfield, JP., Valdes, AM., Bras, J., Shatunov, A., PAGE Consortium, , International Stroke Genetics Consortium, , Systemic Sclerosis consortium, , Treat OA consortium, , DIAGRAM Consortium, , CARDIoGRAMplusC4D Consortium, , ALS consortium, , International Parkinson’s Disease Genomics Consortium, , Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, , CKDGen consortium, , GERAD1 Consortium, , International Consortium for Blood Pressure, , Schizophrenia Working Group of the Psychiatric Genomics Consortium, , Inflammation Working Group of the CHARGE Consortium, , Lu, C., Han, B., Raychaudhuri, S., Bevan, S., Mayes, MD., Tsoi, LC., Evangelou, E., Nair, RP., Grant, SFA., Polychronakos, C., Radstake, TRD., van Heel, DA., Dunstan, ML., Wood, NW., Al-Chalabi, A., Dehghan, A., Hakonarson, H., Markus, HS., Elder, JT., Knight, J., Arking, DE., Spector, TD., Koeleman, BPC., van Duijn, CM., Martin, J., Morris, AP., Weersma, RK., Wijmenga, C., Munroe, PB., Perry, JRB., Pouget, JG., Jamshidi, Y., Snieder, H. and Alizadeh, BZ., 2016. Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study. PLoS Med, v. 13
    Doi: http://doi.org/10.1371/journal.pmed.1001976
  • Rutten-Jacobs, LCA., Traylor, M., Adib-Samii, P., Thijs, V., Sudlow, C., Rothwell, PM., Boncoraglio, G., Dichgans, M., Meschia, J., Maguire, J., Levi, C., Rost, NS., Rosand, J., Hassan, A., Bevan, S. and Markus, HS., 2016. Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype. Stroke, v. 47
    Doi: http://doi.org/10.1161/STROKEAHA.115.011545
  • Deng, QQ., Tang, J., Chen, C., Markus, H., Huang, YN., Zhao, H., Ratanakorn, D., Wong, KSL. and Fu, JH., 2016. The curative effect comparison of two kinds of therapeutic regimens on decreasing the relative intensity of microembolic signal in CLAIR trial. J Neurol Sci, v. 367
    Doi: http://doi.org/10.1016/j.jns.2016.05.042
  • Robinson, PC., Leo, PJ., Pointon, JJ., Harris, J., Cremin, K., Bradbury, LA., Wellcome Trust Case Control Consortium, , Australasian Osteoporosis Genetics Consortium (AOGC), , Stebbings, S., Harrison, AA., Evans, DM., Duncan, EL., Wordsworth, BP., Brown, MA. and Australasian Osteoporosis Genetics Consortium AOGC, , 2016. The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis. Genes Immun, v. 17
    Doi: http://doi.org/10.1038/gene.2015.49
  • Traylor, M., Adib-Samii, P., Harold, D., Alzheimer's Disease Neuroimaging Initiative, , International Stroke Genetics Consortium (ISGC), UK Young Lacunar Stroke DNA resource, , Dichgans, M., Williams, J., Lewis, CM., Markus, HS., METASTROKE, and International Genomics of Alzheimer's Project (IGAP), investigators, , 2016. Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease. Ann Neurol, v. 79
    Doi: http://doi.org/10.1002/ana.24621
  • 2015

  • Oakeshott, P., Reid, F., Poulton, A., Markus, H., Whitaker, RH. and Hunt, GM., 2015. Neurological level at birth predicts survival to the mid-40s and urological deaths in open spina bifida: a complete prospective cohort study. Dev Med Child Neurol, v. 57
    Doi: http://doi.org/10.1111/dmcn.12698
  • Tan, RYY. and Markus, HS., 2015. Monogenic causes of stroke: now and the future. J Neurol, v. 262
    Doi: http://doi.org/10.1007/s00415-015-7794-4
  • Lambert, C., Sam Narean, J., Benjamin, P., Zeestraten, E., Barrick, TR. and Markus, HS., 2015. Characterising the grey matter correlates of leukoaraiosis in cerebral small vessel disease. Neuroimage Clin, v. 9
    Doi: http://doi.org/10.1016/j.nicl.2015.07.002
  • Debette, S., Kamatani, Y., Metso, TM., Kloss, M., Chauhan, G., Engelter, ST., Pezzini, A., Thijs, V., Markus, HS., Dichgans, M., Wolf, C., Dittrich, R., Touzé, E., Southerland, AM., Samson, Y., Abboud, S., Béjot, Y., Caso, V., Bersano, A., Gschwendtner, A., Sessa, M., Cole, J., Lamy, C., Medeiros, E., Beretta, S., Bonati, LH., Grau, AJ., Michel, P., Majersik, JJ., Sharma, P., Kalashnikova, L., Nazarova, M., Dobrynina, L., Bartels, E., Guillon, B., van den Herik, EG., Fernandez-Cadenas, I., Jood, K., Nalls, MA., De Leeuw, F-E., Jern, C., Cheng, Y-C., Werner, I., Metso, AJ., Lichy, C., Lyrer, PA., Brandt, T., Boncoraglio, GB., Wichmann, H-E., Gieger, C., Johnson, AD., Böttcher, T., Castellano, M., Arveiler, D., Ikram, MA., Breteler, MMB., Padovani, A., Meschia, JF., Kuhlenbäumer, G., Rolfs, A., Worrall, BB., International Stroke Genetics Consortium, , Ringelstein, E-B., Zelenika, D., Tatlisumak, T., Lathrop, M., Leys, D., Amouyel, P., Dallongeville, J. and CADISP Group, , 2015. Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection. Nat Genet, v. 47
    Doi: http://doi.org/10.1038/ng.3154
  • Hinze, S., Goonasekera, M., Nannucci, S., Quaghebeur, G., Briley, D., Markus, HS. and Sen, A., 2015. Longitudinally extensive spinal cord infarction in CADASIL. Pract Neurol, v. 15
    Doi: http://doi.org/10.1136/practneurol-2014-000870
  • Traylor, M., Rutten-Jacobs, LCA., Holliday, EG., Malik, R., Sudlow, C., Rothwell, PM., Maguire, JM., Koblar, SA., Bevan, S., Boncoraglio, G., Dichgans, M., Levi, C., Lewis, CM. and Markus, HS., 2015. Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex. Stroke, v. 46
    Doi: http://doi.org/10.1161/STROKEAHA.115.009816
  • Debette, S., Compter, A., Labeyrie, M-A., Uyttenboogaart, M., Metso, TM., Majersik, JJ., Goeggel-Simonetti, B., Engelter, ST., Pezzini, A., Bijlenga, P., Southerland, AM., Naggara, O., Béjot, Y., Cole, JW., Ducros, A., Giacalone, G., Schilling, S., Reiner, P., Sarikaya, H., Welleweerd, JC., Kappelle, LJ., de Borst, GJ., Bonati, LH., Jung, S., Thijs, V., Martin, JJ., Brandt, T., Grond-Ginsbach, C., Kloss, M., Mizutani, T., Minematsu, K., Meschia, JF., Pereira, VM., Bersano, A., Touzé, E., Lyrer, PA., Leys, D., Chabriat, H., Markus, HS., Worrall, BB., Chabrier, S., Baumgartner, R., Stapf, C., Tatlisumak, T., Arnold, M. and Bousser, M-G., 2015. Epidemiology, pathophysiology, diagnosis, and management of intracranial artery dissection. Lancet Neurol, v. 14
    Doi: http://doi.org/10.1016/S1474-4422(15)00009-5
  • Hollocks, MJ., Lawrence, AJ., Brookes, RL., Barrick, TR., Morris, RG., Husain, M. and Markus, HS., 2015. Differential relationships between apathy and depression with white matter microstructural changes and functional outcomes. Brain, v. 138
    Doi: http://doi.org/10.1093/brain/awv304
  • Adib-Samii, P., Devan, W., Traylor, M., Lanfranconi, S., Zhang, CR., Cloonan, L., Falcone, GJ., Radmanesh, F., Fitzpatrick, K., Kanakis, A., Rothwell, PM., Sudlow, C., Boncoraglio, GB., Meschia, JF., Levi, C., Dichgans, M., Bevan, S., Rosand, J., Rost, NS. and Markus, HS., 2015. Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke. Stroke, v. 46
    Doi: http://doi.org/10.1161/STROKEAHA.114.006849
  • Alassar, A., Soppa, G., Edsell, M., Rich, P., Roy, D., Chis Ster, I., Joyce, R., Valencia, O., Barrick, T., Howe, F., Moat, N., Morris, R., Markus, HS. and Jahangiri, M., 2015. Incidence and mechanisms of cerebral ischemia after transcatheter aortic valve implantation compared with surgical aortic valve replacement. Ann Thorac Surg, v. 99
    Doi: http://doi.org/10.1016/j.athoracsur.2014.09.054
  • Achterberg, S., Kappelle, LJ., de Bakker, PIW., Traylor, M., Algra, A. and SMART Study Group and the METASTROKE Consortium, , 2015. No Additional Prognostic Value of Genetic Information in the Prediction of Vascular Events after Cerebral Ischemia of Arterial Origin: The PROMISe Study. PLoS One, v. 10
    Doi: http://doi.org/10.1371/journal.pone.0119203
  • Badran, A., Hollocks, M., Brookes, R., Morris, R. and Markus, H., 2015. The effects of cardiovascular risk on age-related cognitive decline in healthy older adults INTERNATIONAL JOURNAL OF STROKE, v. 10
  • Malik, R., Freilinger, T., Winsvold, BS., Anttila, V., Vander Heiden, J., Traylor, M., de Vries, B., Holliday, EG., Terwindt, GM., Sturm, J., Bis, JC., Hopewell, JC., Ferrari, MD., Rannikmae, K., Wessman, M., Kallela, M., Kubisch, C., Fornage, M., Meschia, JF., Lehtimäki, T., Sudlow, C., Clarke, R., Chasman, DI., Mitchell, BD., Maguire, J., Kaprio, J., Farrall, M., Raitakari, OT., Kurth, T., Ikram, MA., Reiner, AP., Longstreth, WT., Rothwell, PM., Strachan, DP., Sharma, P., Seshadri, S., Quaye, L., Cherkas, L., Schürks, M., Rosand, J., Ligthart, L., Boncoraglio, GB., Davey Smith, G., van Duijn, CM., Stefansson, K., Worrall, BB., Nyholt, DR., Markus, HS., van den Maagdenberg, AMJM., Cotsapas, C., Zwart, JA., Palotie, A., International Headache Genetics Consortium, , Dichgans, M. and METASTROKE Collaboration of the International Stroke Genetics Consortium, , 2015. Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. Neurology, v. 84
    Doi: http://doi.org/10.1212/WNL.0000000000001606
  • Adib-Samii, P., Devan, W., Traylor, M., Lanfranconi, S., Zhang, CR., Cloonan, L., Falcone, GJ., Radmanesh, F., Fitzpatrick, K., Kanakis, A., Rothwell, PM., Sudlow, C., Boncoraglio, GB., Meschia, JF., Levi, C., Dichgans, M., Bevan, S., Rosand, J., Rost, NS. and Markus, HS., 2015. Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke Stroke, v. 46
    Doi: http://doi.org/10.1161/STROKEAHA.114.006849
  • Oakeshott, P., Reid, F., Poulton, A., Markus, H., Whitaker, RH. and Hunt, GM., 2015. Neurological level at birth predicts survival to the mid-40s and urological deaths in open spina bifida: A complete prospective cohort study Developmental Medicine and Child Neurology, v. 57
    Doi: http://doi.org/10.1111/dmcn.12698
  • Holliday, EG., Traylor, M., Malik, R., Bevan, S., Falcone, G., Hopewell, JC., Cheng, Y-C., Cotlarciuc, I., Bis, JC., Boerwinkle, E., Boncoraglio, GB., Clarke, R., Cole, JW., Fornage, M., Furie, KL., Ikram, MA., Jannes, J., Kittner, SJ., Lincz, LF., Maguire, JM., Meschia, JF., Mosley, TH., Nalls, MA., Oldmeadow, C., Parati, EA., Psaty, BM., Rothwell, PM., Seshadri, S., Scott, RJ., Sharma, P., Sudlow, C., Wiggins, KL., Worrall, BB., Rosand, J., Mitchell, BD., Dichgans, M., Markus, HS., Levi, C., Attia, J., Wray, NR., Australian Stroke Genetics Collaborative, , Wellcome Trust Case Control Consortium 2, and International Stroke Genetics Consortium, , 2015. Genetic overlap between diagnostic subtypes of ischemic stroke. Stroke, v. 46
    Doi: http://doi.org/10.1161/STROKEAHA.114.007930
  • Interleukin 1 Genetics Consortium, , 2015. Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol, v. 3
    Doi: http://doi.org/10.1016/S2213-8587(15)00034-0
  • Benjamin, P., Viessmann, O., Mackinnon, AD., Jezzard, P. and Markus, HS., 2015. 7 Tesla MRI in cerebral small vessel disease International Journal of Stroke, v. 10
    Doi: http://doi.org/10.1111/ijs.12490
  • Karaszewski, B., Houlden, H., Smith, EE., Markus, HS., Charidimou, A., Levi, C. and Werring, DJ., 2015. What causes intracerebral bleeding after thrombolysis for acute ischaemic stroke? Recent insights into mechanisms and potential biomarkers. J Neurol Neurosurg Psychiatry, v. 86
    Doi: http://doi.org/10.1136/jnnp-2014-309705
  • Hanscombe, KB., Traylor, M., Hysi, PG., Bevan, S., Dichgans, M., Rothwell, PM., Worrall, BB., Seshadri, S., Sudlow, C., METASTROKE Consortium, , Wellcome Trust Case Control Consortium 2, , Williams, FMK., Markus, HS. and Lewis, CM., 2015. Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke. Stroke, v. 46
    Doi: http://doi.org/10.1161/STROKEAHA.115.009387
  • CADISS trial investigators, , Markus, HS., Hayter, E., Levi, C., Feldman, A., Venables, G. and Norris, J., 2015. Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial. Lancet Neurol, v. 14
    Doi: http://doi.org/10.1016/S1474-4422(15)70018-9
  • Lawrence, AJ., Brookes, RL., Zeestraten, EA., Barrick, TR., Morris, RG. and Markus, HS., 2015. Pattern and Rate of Cognitive Decline in Cerebral Small Vessel Disease: A Prospective Study. PLoS One, v. 10
    Doi: http://doi.org/10.1371/journal.pone.0135523
  • Traylor, M., Markus, H. and Lewis, CM., 2015. Homogeneous case subgroups increase power in genetic association studies. Eur J Hum Genet, v. 23
    Doi: http://doi.org/10.1038/ejhg.2014.194
  • Brookes, RL., Hollocks, MJ., Khan, U., Morris, RG. and Markus, HS., 2015. The Brief Memory and Executive Test (BMET) for detecting vascular cognitive impairment in small vessel disease: a validation study. BMC Med, v. 13
    Doi: http://doi.org/10.1186/s12916-015-0290-y
  • Benjamin, P., Viessmann, O., MacKinnon, AD., Jezzard, P. and Markus, HS., 2015. 7 Tesla MRI in cerebral small vessel disease. Int J Stroke, v. 10
    Doi: http://doi.org/10.1111/ijs.12490
  • Traylor, M., Bevan, S., Baron, J-C., Hassan, A., Lewis, CM. and Markus, HS., 2015. Genetic Architecture of Lacunar Stroke. Stroke, v. 46
    Doi: http://doi.org/10.1161/STROKEAHA.115.009485
  • Alassar, A., Soppa, G., Edsell, M., Rich, P., Roy, D., Chis Ster, I., Joyce, R., Valencia, O., Barrick, T., Howe, F., Moat, N., Morris, R., Markus, HS. and Jahangiri, M., 2015. Incidence and mechanisms of cerebral ischemia after transcatheter aortic valve implantation compared with surgical aortic valve replacement Annals of Thoracic Surgery, v. 99
    Doi: http://doi.org/10.1016/j.athoracsur.2014.09.054
  • Rutten-Jacobs, LCA., Traylor, M., Adib-Samii, P., Thijs, V., Sudlow, C., Rothwell, PM., Boncoraglio, G., Dichgans, M., Bevan, S., Meschia, J., Levi, C., Rost, NS., Rosand, J., Hassan, A. and Markus, HS., 2015. Common NOTCH3 Variants and Cerebral Small-Vessel Disease. Stroke, v. 46
    Doi: http://doi.org/10.1161/STROKEAHA.114.008540
  • Kilarski, LL., Rutten-Jacobs, LCA., Bevan, S., Baker, R., Hassan, A., Hughes, DA., Markus, HS. and UK Young Lacunar Stroke DNA Study, , 2015. Prevalence of CADASIL and Fabry Disease in a Cohort of MRI Defined Younger Onset Lacunar Stroke. PLoS One, v. 10
    Doi: http://doi.org/10.1371/journal.pone.0136352
  • Rutten-Jacobs, LCA., Traylor, M., Thijs, V., Sudlow, C., Rothwell, PM., Boncoraglio, G., Dichgans, M., Levi, C., Bevan, S. and Markus, HM., 2015. Association of MTHFR genotype with lacunar stroke supports causal role for homocysteine INTERNATIONAL JOURNAL OF STROKE, v. 10
  • King, A., Madigan, J., Clifton, A., Norris, J. and Markus, HS., 2015. Pseudoaneurysms in cervical artery dissection: Results from a multicenter randomized trial - Cervical Artery Dissection in Stroke Study (CADISS) INTERNATIONAL JOURNAL OF STROKE, v. 10
  • Rannikmäe, K., Davies, G., Thomson, PA., Bevan, S., Devan, WJ., Falcone, GJ., Traylor, M., Anderson, CD., Battey, TWK., Radmanesh, F., Deka, R., Woo, JG., Martin, LJ., Jimenez-Conde, J., Selim, M., Brown, DL., Silliman, SL., Kidwell, CS., Montaner, J., Langefeld, CD., Slowik, A., Hansen, BM., Lindgren, AG., Meschia, JF., Fornage, M., Bis, JC., Debette, S., Ikram, MA., Longstreth, WT., Schmidt, R., Zhang, CR., Yang, Q., Sharma, P., Kittner, SJ., Mitchell, BD., Holliday, EG., Levi, CR., Attia, J., Rothwell, PM., Poole, DL., Boncoraglio, GB., Psaty, BM., Malik, R., Rost, N., Worrall, BB., Dichgans, M., Van Agtmael, T., Woo, D., Markus, HS., Seshadri, S., Rosand, J., Sudlow, CLM., METASTROKE Consortium, , CHARGE WMH Group, , ISGC ICH GWAS Study Collaboration, , WMH in Ischemic Stroke GWAS Study Collaboration, and International Stroke Genetics Consortium, , 2015. Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology, v. 84
    Doi: http://doi.org/10.1212/WNL.0000000000001309
  • Brookes, RL., Hollocks, MJ., Khan, U., Morris, RG. and Markus, HS., 2015. The Brief Memory and Executive Test (BMET) for detecting vascular cognitive impairment in small vessel disease: a validation study. BMC Med, v. 13
    Doi: http://doi.org/10.1186/s12916-015-0290-y
  • King, A., Madigan, J., Clifton, A., Norris, J. and Markus, HS., 2015. Neuro-radiological confirmation of dissection: Lessons learned from a multicenter randomized trial - Cervical Artery Dissection in Stroke Study (CADISS) INTERNATIONAL JOURNAL OF STROKE, v. 10
  • Traylor, M., Markus, H. and Lewis, CM., 2015. Homogeneous case subgroups increase power in genetic association studies European Journal of Human Genetics, v. 23
    Doi: http://doi.org/10.1038/ejhg.2014.194
  • Markus, HS., 2015. The Cervical Artery Dissection in Stroke Study (CADISS) - One year follow-up results INTERNATIONAL JOURNAL OF STROKE, v. 10
  • 2014

  • Opherk, C., Gonik, M., Duering, M., Malik, R., Jouvent, E., Hervé, D., Adib-Samii, P., Bevan, S., Pianese, L., Silvestri, S., Dotti, MT., De Stefano, N., Liem, M., Boon, EMJ., Pescini, F., Pachai, C., Bracoud, L., Müller-Myhsok, B., Meitinger, T., Rost, N., Pantoni, L., Lesnik Oberstein, S., Federico, A., Ragno, M., Markus, HS., Tournier-Lasserve, E., Rosand, J., Chabriat, H. and Dichgans, M., 2014. Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL. Stroke, v. 45
    Doi: http://doi.org/10.1161/STROKEAHA.113.004461
  • Psychosis Endophenotypes International Consortium, , Wellcome Trust Case-Control Consortium 2, , Bramon, E., Pirinen, M., Strange, A., Lin, K., Freeman, C., Bellenguez, C., Su, Z., Band, G., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, SC., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, SJ., Arranz, MJ., Bakker, S., Bender, S., Bruggeman, R., Cahn, W., Chandler, D., Collier, DA., Crespo-Facorro, B., Dazzan, P., de Haan, L., Di Forti, M., Dragović, M., Giegling, I., Hall, J., Iyegbe, C., Jablensky, A., Kahn, RS., Kalaydjieva, L., Kravariti, E., Lawrie, S., Linszen, DH., Mata, I., McDonald, C., McIntosh, A., Myin-Germeys, I., Ophoff, RA., Pariante, CM., Paunio, T., Picchioni, M., Psychiatric Genomics Consortium, , Ripke, S., Rujescu, D., Sauer, H., Shaikh, M., Sussmann, J., Suvisaari, J., Tosato, S., Toulopoulou, T., Van Os, J., Walshe, M., Weisbrod, M., Whalley, H., Wiersma, D., Blackwell, JM., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Jankowski, JAZ., Markus, HS., Mathew, CG., Palmer, CNA., Plomin, R., Rautanen, A., Sawcer, SJ., Trembath, RC., Wood, NW., Barroso, I., Peltonen, L., Lewis, CM., Murray, RM., Donnelly, P., Powell, J. and Spencer, CCA., 2014. A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation. Biol Psychiatry, v. 75
    Doi: http://doi.org/10.1016/j.biopsych.2013.03.033
  • Benjamin, P., Lawrence, AJ., Lambert, C., Mackinnon, A., Barrick, T. and Markus, HS., 2014. Progression of Brain Atrophy in Cerebral Small Vessel Disease. Results from the SCANS study. CEREBROVASCULAR DISEASES, v. 37
  • Bridges, LR., Andoh, J., Lawrence, AJ., Khoong, CHL., Poon, W., Esiri, MM., Markus, HS. and Hainsworth, AH., 2014. Blood-brain barrier dysfunction and cerebral small vessel disease (arteriolosclerosis) in brains of older people. J Neuropathol Exp Neurol, v. 73
    Doi: http://doi.org/10.1097/NEN.0000000000000124
  • Valenti, R., Pantoni, L. and Markus, HS., 2014. Treatment of vascular risk factors in patients with a diagnosis of Alzheimer's disease: a systematic review. BMC Med, v. 12
    Doi: http://doi.org/10.1186/s12916-014-0160-z
  • Lau, AY., Zhao, Y., Chen, C., Leung, TW., Fu, J., Huang, Y., Suwanwela, NC., Han, Z., Tan, KS., Ratanakorn, D., Markus, HS., Wong, KS. and CLAIR Study Investigators, , 2014. Dual antiplatelets reduce microembolic signals in patients with transient ischemic attack and minor stroke: subgroup analysis of CLAIR study. Int J Stroke, v. 9 Suppl A100
    Doi: http://doi.org/10.1111/ijs.12003
  • Williams, FMK., Carter, AM., Hysi, PG., Surdulescu, G., Hodgkiss, D., Soranzo, N., Traylor, M., Bevan, S., Dichgans, M., Rothwell, PMW., Sudlow, C., Farrall, M., Silander, K., Kaunisto, M., Wagner, P., Saarela, O., Kuulasmaa, K., Virtamo, J., Salomaa, V., Amouyel, P., Arveiler, D., Ferrieres, J., Wiklund, P-G., Ikram, MA., Hofman, A., Boncoraglio, GB., Parati, EA., Helgadottir, A., Gretarsdottir, S., Thorsteinsdottir, U., Thorleifsson, G., Stefansson, K., Seshadri, S., DeStefano, A., Gschwendtner, A., Psaty, B., Longstreth, W., Mitchell, BD., Cheng, Y-C., Clarke, R., Ferrario, M., Bis, JC., Levi, C., Attia, J., Holliday, EG., Scott, RJ., Fornage, M., Sharma, P., Furie, KL., Rosand, J., Nalls, M., Meschia, J., Mosely, TH., Evans, A., Palotie, A., Markus, HS., Grant, PJ. and Spector, TD., 2014. Ischemic stroke is associated with the ABO locus: The EuroCLOT study (vol 73, pg 16, 2013) ANNALS OF NEUROLOGY, v. 75
    Doi: http://doi.org/10.1002/ana.24105
  • Brookes, RL., Herbert, V., Paul, S., Hannesdottir, K., Markus, HS. and Morris, RG., 2014. Executive dysfunction, awareness deficits and quality of life in patients with cerebral small vessel disease: a structural equation model. Neuropsychology, v. 28
    Doi: http://doi.org/10.1037/neu0000015
  • Williams, FMK., Carter, AM., Hysi, PG., Surdulescu, G., Hodgkiss, D., Soranzo, N., Traylor, M., Bevan, S., Dichgans, M., Rothwell, PMW., Sudlow, C., Farrall, M., Silander, K., Kaunisto, M., Wagner, P., Saarela, O., Kuulasmaa, K., Virtamo, J., Salomaa, V., Amouyel, P., Arveiler, D., Ferrieres, J., Wiklund, PG., Ikram, MA., Hofman, A., Boncoraglio, GB., Parati, EA., Helgadottir, A., Gretarsdottir, S., Thorsteinsdottir, U., Thorleifsson, G., Stefansson, K., Seshadri, S., DeStefano, A., Gschwendtner, A., Psaty, B., Longstreth, W., Mitchell, BD., Cheng, YC., Clarke, R., Ferrario, M., Bis, JC., Levi, C., Attia, J., Holliday, EG., Scott, RJ., Fornage, M., Sharma, P., Furie, KL., Rosand, J., Nalls, M., Meschia, J., Mosely, TH., Evans, A., Palotie, A., Markus, HS., Grant, PJ. and Spector, TD., 2014. Erratum: Ischemic stroke is associated with the ABO locus: The EuroCLOT study (Annals of Neurology (2013) 73 (16-31)) Annals of Neurology, v. 75
    Doi: http://doi.org/10.1002/ana.24105
  • McArdle, PF., Kittner, SJ., Ay, H., Brown, RD., Meschia, JF., Rundek, T., Wassertheil-Smoller, S., Woo, D., Andsberg, G., Biffi, A., Brenner, DA., Cole, JW., Corriveau, R., de Bakker, PIW., Delavaran, H., Dichgans, M., Grewal, RP., Gwinn, K., Huq, M., Jern, C., Jimenez-Conde, J., Jood, K., Kaplan, RC., Katschnig, P., Katsnelson, M., Labovitz, DL., Lemmens, R., Li, L., Lindgren, A., Markus, HS., Peddareddygari, LR., Pedersén, A., Pera, J., Redfors, P., Roquer, J., Rosand, J., Rost, NS., Rothwell, PM., Sacco, RL., Sharma, P., Slowik, A., Sudlow, C., Thijs, V., Tiedt, S., Valenti, R., Worrall, BB. and NINDS SiGN Study, , 2014. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Neurology, v. 83
    Doi: http://doi.org/10.1212/WNL.0000000000000942
  • Dregan, A., Charlton, J., Wolfe, CDA., Gulliford, MC. and Markus, HS., 2014. Is sodium valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case-control study. Pharmacoepidemiol Drug Saf, v. 23
    Doi: http://doi.org/10.1002/pds.3651
  • Cotlarciuc, I., Malik, R., Holliday, EG., Ahmadi, KR., Paré, G., Psaty, BM., Fornage, M., Hasan, N., Rinne, PE., Ikram, MA., Markus, HS., Rosand, J., Mitchell, BD., Kittner, SJ., Meschia, JF., van Meurs, JBJ., Uitterlinden, AG., Worrall, BB., Dichgans, M., Sharma, P. and METASTROKE and the International Stroke Genetics Consortium, , 2014. Effect of genetic variants associated with plasma homocysteine levels on stroke risk. Stroke, v. 45
    Doi: http://doi.org/10.1161/STROKEAHA.114.005208
  • Herbert, V., Brookes, RL., Markus, HS. and Morris, RG., 2014. Verbal fluency in cerebral small vessel disease and Alzheimer's disease. J Int Neuropsychol Soc, v. 20
    Doi: http://doi.org/10.1017/S1355617714000101
  • Lawrence, AJ., Chung, AW., Morris, RG., Markus, HS. and Barrick, TR., 2014. Structural network efficiency is associated with cognitive impairment in small-vessel disease. Neurology, v. 83
    Doi: http://doi.org/10.1212/WNL.0000000000000612
  • Rothwell, PM. and Markus, HS., 2014. Improved medical treatment in secondary prevention of stroke. Lancet, v. 383
    Doi: http://doi.org/10.1016/S0140-6736(13)62191-1
  • Benjamin, P., Lawrence, AJ., Lambert, C., Patel, B., Chung, AW., MacKinnon, AD., Morris, RG., Barrick, TR. and Markus, HS., 2014. Strategic lacunes and their relationship to cognitive impairment in cerebral small vessel disease. Neuroimage Clin, v. 4
    Doi: http://doi.org/10.1016/j.nicl.2014.05.009
  • Hayes, DF., Markus, HS., Leslie, RD. and Topol, EJ., 2014. Personalized medicine: risk prediction, targeted therapies and mobile health technology. BMC Med, v. 12
    Doi: http://doi.org/10.1186/1741-7015-12-37
  • Springelkamp, H., Höhn, R., Mishra, A., Hysi, PG., Khor, C-C., Loomis, SJ., Bailey, JNC., Gibson, J., Thorleifsson, G., Janssen, SF., Luo, X., Ramdas, WD., Vithana, E., Nongpiur, ME., Montgomery, GW., Xu, L., Mountain, JE., Gharahkhani, P., Lu, Y., Amin, N., Karssen, LC., Sim, K-S., van Leeuwen, EM., Iglesias, AI., Verhoeven, VJM., Hauser, MA., Loon, S-C., Despriet, DDG., Nag, A., Venturini, C., Sanfilippo, PG., Schillert, A., Kang, JH., Landers, J., Jonasson, F., Cree, AJ., van Koolwijk, LME., Rivadeneira, F., Souzeau, E., Jonsson, V., Menon, G., Blue Mountains Eye Study—GWAS group, , Weinreb, RN., de Jong, PTVM., Oostra, BA., Uitterlinden, AG., Hofman, A., Ennis, S., Thorsteinsdottir, U., Burdon, KP., NEIGHBORHOOD Consortium, , Wellcome Trust Case Control Consortium 2 (WTCCC2), , Spector, TD., Mirshahi, A., Saw, S-M., Vingerling, JR., Teo, Y-Y., Haines, JL., Wolfs, RCW., Lemij, HG., Tai, E-S., Jansonius, NM., Jonas, JB., Cheng, C-Y., Aung, T., Viswanathan, AC., Klaver, CCW., Craig, JE., Macgregor, S., Mackey, DA., Lotery, AJ., Stefansson, K., Bergen, AAB., Young, TL., Wiggs, JL., Pfeiffer, N., Wong, T-Y., Pasquale, LR., Hewitt, AW., van Duijn, CM. and Hammond, CJ., 2014. Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nat Commun, v. 5
    Doi: http://doi.org/10.1038/ncomms5883
  • Traylor, M., Mäkelä, K-M., Kilarski, LL., Holliday, EG., Devan, WJ., Nalls, MA., Wiggins, KL., Zhao, W., Cheng, Y-C., Achterberg, S., Malik, R., Sudlow, C., Bevan, S., Raitoharju, E., METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2), , Oksala, N., Thijs, V., Lemmens, R., Lindgren, A., Slowik, A., Maguire, JM., Walters, M., Algra, A., Sharma, P., Attia, JR., Boncoraglio, GB., Rothwell, PM., de Bakker, PIW., Bis, JC., Saleheen, D., Kittner, SJ., Mitchell, BD., Rosand, J., Meschia, JF., Levi, C., Dichgans, M., Lehtimäki, T., Lewis, CM. and Markus, HS., 2014. A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. PLoS Genet, v. 10
    Doi: http://doi.org/10.1371/journal.pgen.1004469
  • Postmus, I., Trompet, S., Deshmukh, HA., Barnes, MR., Li, X., Warren, HR., Chasman, DI., Zhou, K., Arsenault, BJ., Donnelly, LA., Wiggins, KL., Avery, CL., Griffin, P., Feng, Q., Taylor, KD., Li, G., Evans, DS., Smith, AV., de Keyser, CE., Johnson, AD., de Craen, AJM., Stott, DJ., Buckley, BM., Ford, I., Westendorp, RGJ., Slagboom, PE., Sattar, N., Munroe, PB., Sever, P., Poulter, N., Stanton, A., Shields, DC., O'Brien, E., Shaw-Hawkins, S., Chen, Y-DI., Nickerson, DA., Smith, JD., Dubé, MP., Boekholdt, SM., Hovingh, GK., Kastelein, JJP., McKeigue, PM., Betteridge, J., Neil, A., Durrington, PN., Doney, A., Carr, F., Morris, A., McCarthy, MI., Groop, L., Ahlqvist, E., Welcome Trust Case Control Consortium, , Bis, JC., Rice, K., Smith, NL., Lumley, T., Whitsel, EA., Stürmer, T., Boerwinkle, E., Ngwa, JS., O'Donnell, CJ., Vasan, RS., Wei, W-Q., Wilke, RA., Liu, C-T., Sun, F., Guo, X., Heckbert, SR., Post, W., Sotoodehnia, N., Arnold, AM., Stafford, JM., Ding, J., Herrington, DM., Kritchevsky, SB., Eiriksdottir, G., Launer, LJ., Harris, TB., Chu, AY., Giulianini, F., MacFadyen, JG., Barratt, BJ., Nyberg, F., Stricker, BH., Uitterlinden, AG., Hofman, A., Rivadeneira, F., Emilsson, V., Franco, OH., Ridker, PM., Gudnason, V., Liu, Y., Denny, JC., Ballantyne, CM., Rotter, JI., Adrienne Cupples, L., Psaty, BM., Palmer, CNA., Tardif, J-C., Colhoun, HM., Hitman, G., Krauss, RM., Wouter Jukema, J. and Caulfield, MJ., 2014. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun, v. 5
    Doi: http://doi.org/10.1038/ncomms6068
  • Markus, HS. and Bevan, S., 2014. Mechanisms and treatment of ischaemic stroke - Insights from genetic associations Nature Reviews Neurology, v. 10
    Doi: http://doi.org/10.1038/nrneurol.2014.196
  • Davis, OSP., Band, G., Pirinen, M., Haworth, CMA., Meaburn, EL., Kovas, Y., Harlaar, N., Docherty, SJ., Hanscombe, KB., Trzaskowski, M., Curtis, CJC., Strange, A., Freeman, C., Bellenguez, C., Su, Z., Pearson, R., Vukcevic, D., Langford, C., Deloukas, P., Hunt, S., Gray, E., Dronov, S., Potter, SC., Tashakkori-Ghanbaria, A., Edkins, S., Bumpstead, SJ., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Jankowski, JAZ., Markus, HS., Mathew, CG., Palmer, CNA., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Barroso, I., Peltonen, L., Dale, PS., Petrill, SA., Schalkwyk, LS., Craig, IW., Lewis, CM., Price, TS., Wellcome Trust Case Control Consortium 2, , Donnelly, P., Plomin, R. and Spencer, CCA., 2014. The correlation between reading and mathematics ability at age twelve has a substantial genetic component. Nat Commun, v. 5
    Doi: http://doi.org/10.1038/ncomms5204
  • Kilarski, LL., Achterberg, S., Devan, WJ., Traylor, M., Malik, R., Lindgren, A., Pare, G., Sharma, P., Slowik, A., Thijs, V., Walters, M., Worrall, BB., Sale, MM., Algra, A., Kappelle, LJ., Wijmenga, C., Norrving, B., Sandling, JK., Rönnblom, L., Goris, A., Franke, A., Sudlow, C., Rothwell, PM., Levi, C., Holliday, EG., Fornage, M., Psaty, B., Gretarsdottir, S., Thorsteinsdottir, U., Seshadri, S., Mitchell, BD., Kittner, S., Clarke, R., Hopewell, JC., Bis, JC., Boncoraglio, GB., Meschia, J., Ikram, MA., Hansen, BM., Montaner, J., Thorleifsson, G., Stefanson, K., Rosand, J., de Bakker, PIW., Farrall, M., Dichgans, M., Markus, HS., Bevan, S. and GARNET Collaborative Research Group, Wellcome Trust Case Control Consortium 2, Australian Stroke Genetic Collaborative, the METASTROKE Consortium, and the International Stroke Genetics Consortium, , 2014. Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology, v. 83
    Doi: http://doi.org/10.1212/WNL.0000000000000707
  • Brookes, RL., Herbert, V., Lawrence, AJ., Morris, RG. and Markus, HS., 2014. Depression in small-vessel disease relates to white matter ultrastructural damage, not disability. Neurology, v. 83
    Doi: http://doi.org/10.1212/WNL.0000000000000882
  • Reinhard, M., Schwarzer, G., Briel, M., Altamura, C., Palazzo, P., King, A., Bornstein, NM., Petersen, N., Motschall, E., Hetzel, A., Marshall, RS., Klijn, CJM., Silvestrini, M., Markus, HS. and Vernieri, F., 2014. Cerebrovascular reactivity predicts stroke in high-grade carotid artery disease: An individual patient data meta-analysis CEREBROVASCULAR DISEASES, v. 37
  • Reinhard, M., Schwarzer, G., Briel, M., Altamura, C., Palazzo, P., King, A., Bornstein, NM., Petersen, N., Motschall, E., Hetzel, A., Marshall, RS., Klijn, CJM., Silvestrini, M., Markus, HS. and Vernieri, F., 2014. Cerebrovascular reactivity predicts stroke in high-grade carotid artery disease. Neurology, v. 83
    Doi: http://doi.org/10.1212/WNL.0000000000000888
  • O'Brien, JT. and Markus, HS., 2014. Vascular risk factors and Alzheimer's disease. BMC Med, v. 12
    Doi: http://doi.org/10.1186/s12916-014-0218-y
  • Alex, D., Wolfe, CDA., Gulliford, MC. and Markus, HS., 2014. Is sodium valproate, an HDAC inhibitor, associated with reduced stroke risk? A nested case-control study INTERNATIONAL JOURNAL OF STROKE, v. 9
  • Wong, KSL., Wang, Y., Leng, X., Mao, C., Tang, J., Bath, PMW., Markus, HS., Gorelick, PB., Liu, L., Lin, W. and Wang, Y., 2014. Response to letter regarding article, "early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis". Circulation, v. 130
    Doi: http://doi.org/10.1161/CIRCULATIONAHA.114.009357
  • Dichgans, M., Malik, R., König, IR., Rosand, J., Clarke, R., Gretarsdottir, S., Thorleifsson, G., Mitchell, BD., Assimes, TL., Levi, C., O'Donnell, CJ., Fornage, M., Thorsteinsdottir, U., Psaty, BM., Hengstenberg, C., Seshadri, S., Erdmann, J., Bis, JC., Peters, A., Boncoraglio, GB., März, W., Meschia, JF., Kathiresan, S., Ikram, MA., McPherson, R., Stefansson, K., Sudlow, C., Reilly, MP., Thompson, JR., Sharma, P., Hopewell, JC., Chambers, JC., Watkins, H., Rothwell, PM., Roberts, R., Markus, HS., Samani, NJ., Farrall, M., Schunkert, H., METASTROKE Consortium, , CARDIoGRAM Consortium, , C4D Consortium, and International Stroke Genetics Consortium, , 2014. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke, v. 45
    Doi: http://doi.org/10.1161/STROKEAHA.113.002707
  • Markus, HS. and Bevan, S., 2014. Mechanisms and treatment of ischaemic stroke--insights from genetic associations. Nat Rev Neurol, v. 10
    Doi: http://doi.org/10.1038/nrneurol.2014.196
  • Malik, R., Bevan, S., Nalls, MA., Holliday, EG., Devan, WJ., Cheng, Y-C., Ibrahim-Verbaas, CA., Verhaaren, BFJ., Bis, JC., Joon, AY., de Stefano, AL., Fornage, M., Psaty, BM., Ikram, MA., Launer, LJ., van Duijn, CM., Sharma, P., Mitchell, BD., Rosand, J., Meschia, JF., Levi, C., Rothwell, PM., Sudlow, C., Markus, HS., Seshadri, S., Dichgans, M. and Wellcome Trust Case Control Consortium 2, , 2014. Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. Stroke, v. 45
    Doi: http://doi.org/10.1161/STROKEAHA.113.002938
  • Rannikmaae, K., Davies, G., Thomson, P., Devan, W., Bevan, S., Traylor, M., Falcone, GJ., Anderson, C., Rost, N., Woo, D., Markus, H., Seshadri, S., Rosand, J., Van Agtmael, T. and Sudlow, CLM., 2014. The contribution of variants in collagen IV genes to common cerebrovascular phenotypes CEREBROVASCULAR DISEASES, v. 37
  • Ay, H., Arsava, EM., Andsberg, G., Benner, T., Brown, RD., Chapman, SN., Cole, JW., Delavaran, H., Dichgans, M., Engström, G., Giralt-Steinhauer, E., Grewal, RP., Gwinn, K., Jern, C., Jimenez-Conde, J., Jood, K., Katsnelson, M., Kissela, B., Kittner, SJ., Kleindorfer, DO., Labovitz, DL., Lanfranconi, S., Lee, J-M., Lehm, M., Lemmens, R., Levi, C., Li, L., Lindgren, A., Markus, HS., McArdle, PF., Melander, O., Norrving, B., Peddareddygari, LR., Pedersén, A., Pera, J., Rannikmäe, K., Rexrode, KM., Rhodes, D., Rich, SS., Roquer, J., Rosand, J., Rothwell, PM., Rundek, T., Sacco, RL., Schmidt, R., Schürks, M., Seiler, S., Sharma, P., Slowik, A., Sudlow, C., Thijs, V., Woodfield, R., Worrall, BB. and Meschia, JF., 2014. Pathogenic ischemic stroke phenotypes in the NINDS-stroke genetics network. Stroke, v. 45
    Doi: http://doi.org/10.1161/STROKEAHA.114.007362
  • Mäkelä, K-M., Traylor, M., Oksala, N., Kleber, ME., Seppälä, I., Lyytikäinen, L-P., Hernesniemi, JA., Kähönen, M., Bevan, S., Rothwell, PM., Sudlow, C., Dichgans, M., Wellcome Trust Case Control Consortium 2 (WTCCC2), , Delgado, G., Grammer, TB., Scharnagl, H., Markus, HS., März, W. and Lehtimäki, T., 2014. Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events. Atherosclerosis, v. 234
    Doi: http://doi.org/10.1016/j.atherosclerosis.2014.03.002
  • Dregan, A., Charlton, J., Wolfe, CDA., Gulliford, MC. and Markus, HS., 2014. Is Sodium Valproate, an HDAC inhibitor, associated with reduced stroke risk? A nested case-control study CEREBROVASCULAR DISEASES, v. 37
  • Holliday, EG., Traylor, M., Malik, R., Bevan, S., Maguire, J., Koblar, SA., Sturm, J., Hankey, GJ., Oldmeadow, C., McEvoy, M., Sudlow, C., Rothwell, PM., Coresh, J., Hamet, P., Tremblay, J., Turner, ST., de Andrade, M., Rao, M., Schmidt, R., Crick, PA., Robino, A., Peralta, CA., Jukema, JW., Mitchell, P., Rosas, SE., Wang, JJ., Scott, RJ., Dichgans, M., Mitchell, BD., Kao, WHL., Fox, CS., Levi, C., Attia, J., Markus, HS. and CKDGen Consortium and the International Stroke Genetics Consortium, , 2014. Polygenic overlap between kidney function and large artery atherosclerotic stroke. Stroke, v. 45
    Doi: http://doi.org/10.1161/STROKEAHA.114.006609
  • 2013 (No publication date)

  • Traylor, M., Farrall, M., Holliday, EG., Sudlow, C., Hopewell, JC., Cheng, Y-C., Fornage, M., Ikram, MA., Malik, R., Bevan, S., Thorsteinsdottir, U., Nalls, MA., Longstreth, WT., Wiggins, KL., Yadav, S., Parati, EA., DeStefano, AL., Worrall, BB., Kittner, SJ., Khan, MS., Reiner, AP., Helgadottir, A., Achterberg, S., Fernandez-Cadenas, I., Abboud, S., Schmidt, R., Walters, M., Chen, W-M., Ringelstein, EB., O Donnell, M., Ho, WK., Pera, J., Lemmens, R., Norrving, B., Higgins, P., Benn, M., Sale, M., Kuhlenbaumer, G., Doney, ASF., Vicente, AM., Delavaran, H., Algra, A., Davies, G., Oliveira, SA., Palmer, CNA., Deary, I., Schmidt, H., Pandolfo, M., Montaner, J., Carty, C., de Bakker, PIW., Kostulas, K., Ferro, JM., van Zuydam, NR., Valdimarsson, E., Nordestgaard, BG., Lindgren, A., Thijs, V., slowik, A., Salaheen, D., Pare, G., Berger, K., Thorliefsson, G., Collaborative, TAG., WTCCC2, , Hofman, A., Mosley, TH., Mitchell, BD., Furie, K., Clarke, R., Levi, C., Seshadri, S., Gschwendtner, A., Boncoraglio, GB., Sharma, P., Bis, JC., Gretarsdottir, S., Psaty, BM., Rothwell, PM., Rosand, J., Meschia, JF., Stefansson, K., Dichgans, M., Markus, HS. and Consortium, TISG., 2013 (No publication date). Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genomewide association studies Lancet Neurology,
  • 2013

  • Thomas, J., Parsons, O., Traylor, M., Li, L., Bevan, S., Sudlow, C., Rothwell, P., Markus, H., Levi, CR., Holliday, L. and Attia, J., 2013. The impact of CCS and TOAST classification systems on genetic associations with ischaemic stroke INTERNATIONAL JOURNAL OF STROKE, v. 8
  • Lawrence, AJ., Patel, B., Morris, RG., MacKinnon, AD., Rich, PM., Barrick, TR. and Markus, HS., 2013. Mechanisms of Cognitive Impairment in Cerebral Small Vessel Disease: Multimodal MRI Results from the St George's Cognition and Neuroimaging in Stroke (SCANS) Study PLoS ONE, v. 8
    Doi: http://doi.org/10.1371/journal.pone.0061014
  • Benjamin, P., Lawrence, A., Patel, B., Chung, A., Mackinnon, AD., Lambert, C., Morris, RG., Barrick, TR. and Markus, HS., 2013. Thalamic lacunes in regions with connectivity to the prefrontal cortex are associated with impaired processing speed in cerebral small vessel disease CEREBROVASCULAR DISEASES, v. 35
  • Markus, HS., Mäkelä, KM., Bevan, S., Raitoharju, E., Oksala, N., Bis, JC., O'Donnell, C., Hainsworth, A. and Lehtimäki, T., 2013. Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis Stroke, v. 44
    Doi: http://doi.org/10.1161/STROKEAHA.111.000217
  • Charlton, RA., Barrick, TR., Markus, HS. and Morris, RG., 2013. Verbal working and long-term episodic memory associations with white matter microstructure in normal aging investigated using tract-based spatial statistics. Psychol Aging, v. 28
    Doi: http://doi.org/10.1037/a0032668
  • Gulli, G., Marquardt, L., Rothwell, PM. and Markus, HS., 2013. Stroke risk after posterior circulation stroke/transient ischemic attack and its relationship to site of vertebrobasilar stenosis: Pooled data analysis from prospective studies Stroke, v. 44
    Doi: http://doi.org/10.1161/STROKEAHA.112.669929
  • Adib-Samii, P., Rost, N., Traylor, M., Devan, W., Biffi, A., Lanfranconi, S., Fitzpatrick, K., Bevan, S., Kanakis, A., Valant, V., Gschwendtner, A., Malik, R., Richie, A., Gamble, D., Segal, H., Parati, EA., Ciusani, E., Holliday, EG., Maguire, J., Wardlaw, J., Worrall, B., Bis, J., Wiggins, KL., Longstreth, W., Kittner, SJ., Cheng, Y-C., Mosley, T., Falcone, GJ., Furie, KL., Leiva-Salinas, C., Lau, BC., Khan, MS., Sharma, P., Fornage, M., Mitchell, BD., Psaty, BM., Sudlow, C., Levi, C., Boncoraglio, GB., Rothwell, PM., Meschia, J., Dichgans, M., Rosand, J. and Markus, HS., 2013. 17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status STROKE, v. 44
    Doi: http://doi.org/10.1161/STROKEAHA.113.679936
  • Wong, KS., Wang, Y., Leng, X., Mao, C., Tang, J., Bath, PMW., Markus, HS., Gorelick, PB., Liu, L., Lin, W. and Wang, Y., 2013. Early Dual versus Mono Antiplatelet Therapy for Acute Non-Cardioembolic Ischemic Stroke or Transient Ischemic Attack: An Updated Systematic Review and Meta-Analysis CEREBROVASCULAR DISEASES, v. 36
  • Wang, X., Lin, WH., Zhao, YD., Chen, XY., Leung, TW., Chen, C., Fu, J., Markus, H., Hao, Q., Wong, KS. and CLAIR Study Investigators, , 2013. The effectiveness of dual antiplatelet treatment in acute ischemic stroke patients with intracranial arterial stenosis: a subgroup analysis of CLAIR study. Int J Stroke, v. 8
    Doi: http://doi.org/10.1111/j.1747-4949.2012.00828.x
  • Parsons, O., Traylor, M., Linxin, L., Bevan, S., Sudlow, C., Rothwell, PM., Levi, C. and Markus, HS., 2013. Impact of stroke classification systems on strength of genetic associations with ischaemic stroke CEREBROVASCULAR DISEASES, v. 35
  • Patel, B., Lawrence, AJ., Chung, AW., Rich, P., MacKinnon, AD., Morris, RG., Barrick, TR. and Markus, HS., 2013. Cerebral microbleeds and cognition in patients with symptomatic small vessel disease Stroke, v. 44
    Doi: http://doi.org/10.1161/STROKEAHA.112.670216
  • Ripke, S., O'Dushlaine, C., Chambert, K., Moran, JL., Kähler, AK., Akterin, S., Bergen, SE., Collins, AL., Crowley, JJ., Fromer, M., Kim, Y., Lee, SH., Magnusson, PKE., Sanchez, N., Stahl, EA., Williams, S., Wray, NR., Xia, K., Bettella, F., Borglum, AD., Bulik-Sullivan, BK., Cormican, P., Craddock, N., de Leeuw, C., Durmishi, N., Gill, M., Golimbet, V., Hamshere, ML., Holmans, P., Hougaard, DM., Kendler, KS., Lin, K., Morris, DW., Mors, O., Mortensen, PB., Neale, BM., O'Neill, FA., Owen, MJ., Milovancevic, MP., Posthuma, D., Powell, J., Richards, AL., Riley, BP., Ruderfer, D., Rujescu, D., Sigurdsson, E., Silagadze, T., Smit, AB., Stefansson, H., Steinberg, S., Suvisaari, J., Tosato, S., Verhage, M., Walters, JT., Multicenter Genetic Studies of Schizophrenia Consortium, , Levinson, DF., Gejman, PV., Kendler, KS., Laurent, C., Mowry, BJ., O'Donovan, MC., Owen, MJ., Pulver, AE., Riley, BP., Schwab, SG., Wildenauer, DB., Dudbridge, F., Holmans, P., Shi, J., Albus, M., Alexander, M., Campion, D., Cohen, D., Dikeos, D., Duan, J., Eichhammer, P., Godard, S., Hansen, M., Lerer, FB., Liang, K-Y., Maier, W., Mallet, J., Nertney, DA., Nestadt, G., Norton, N., O'Neill, FA., Papadimitriou, GN., Ribble, R., Sanders, AR., Silverman, JM., Walsh, D., Williams, NM., Wormley, B., Psychosis Endophenotypes International Consortium, , Arranz, MJ., Bakker, S., Bender, S., Bramon, E., Collier, D., Crespo-Facorro, B., Hall, J., Iyegbe, C., Jablensky, A., Kahn, RS., Kalaydjieva, L., Lawrie, S., Lewis, CM., Lin, K., Linszen, DH., Mata, I., McIntosh, A., Murray, RM., Ophoff, RA., Powell, J., Rujescu, D., Van Os, J., Walshe, M., Weisbrod, M., Wiersma, D., Wellcome Trust Case Control Consortium 2, , Donnelly, P., Barroso, I., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, AP., Deloukas, P., Duncanson, A., Jankowski, J., Markus, HS., Mathew, CG., Palmer, CNA., Plomin, R., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Spencer, CCA., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, RD., Strange, A., Su, Z., Vukcevic, D., Donnelly, P., Langford, C., Hunt, SE., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, SJ., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, OT., Liddle, J., Potter, SC., Ravindrarajah, R., Ricketts, M., Tashakkori-Ghanbaria, A., Waller, MJ., Weston, P., Widaa, S., Whittaker, P., Barroso, I., Deloukas, P., Mathew, CG., Blackwell, JM., Brown, MA., Corvin, AP., McCarthy, MI., Spencer, CCA., Bramon, E., Corvin, AP., O'Donovan, MC., Stefansson, K., Scolnick, E., Purcell, S., McCarroll, SA., Sklar, P., Hultman, CM. and Sullivan, PF., 2013. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet, v. 45
    Doi: http://doi.org/10.1038/ng.2742
  • Bevan, S. and Markus, HS., 2013. Genetic profiles in ischaemic stroke Current Atherosclerosis Reports, v. 15
    Doi: http://doi.org/10.1007/s11883-013-0342-8
  • King, A., Shipley, M., Markus, H. and Investigators, ACES., 2013. The effect of medical treatments on stroke risk in asymptomatic carotid stenosis. Stroke, v. 44
    Doi: http://doi.org/10.1161/STROKEAHA.112.673608
  • Meschia, JF., Arnett, DK., Ay, H., Brown, RD., Benavente, OR., Cole, JW., de Bakker, PIW., Dichgans, M., Doheny, KF., Fornage, M., Grewal, RP., Gwinn, K., Jern, C., Conde, JJ., Johnson, JA., Jood, K., Laurie, CC., Lee, J-M., Lindgren, A., Markus, HS., McArdle, PF., McClure, LA., Mitchell, BD., Schmidt, R., Rexrode, KM., Rich, SS., Rosand, J., Rothwell, PM., Rundek, T., Sacco, RL., Sharma, P., Shuldiner, AR., Slowik, A., Wassertheil-Smoller, S., Sudlow, C., Thijs, VNS., Woo, D., Worrall, BB., Wu, O., Kittner, SJ. and NINDS SiGN Study, , 2013. Stroke Genetics Network (SiGN) study: design and rationale for a genome-wide association study of ischemic stroke subtypes. Stroke, v. 44
    Doi: http://doi.org/10.1161/STROKEAHA.113.001857
  • Markus, HS., van der Worp, HB. and Rothwell, PM., 2013. Posterior circulation ischaemic stroke and transient ischaemic attack: diagnosis, investigation, and secondary prevention. Lancet Neurol, v. 12
    Doi: http://doi.org/10.1016/S1474-4422(13)70211-4
  • Sabater-Lleal, M., Huang, J., Chasman, D., Naitza, S., Dehghan, A., Johnson, AD., Teumer, A., Reiner, AP., Folkersen, L., Basu, S., Rudnicka, AR., Trompet, S., Mälarstig, A., Baumert, J., Bis, JC., Guo, X., Hottenga, JJ., Shin, S-Y., Lopez, LM., Lahti, J., Tanaka, T., Yanek, LR., Oudot-Mellakh, T., Wilson, JF., Navarro, P., Huffman, JE., Zemunik, T., Redline, S., Mehra, R., Pulanic, D., Rudan, I., Wright, AF., Kolcic, I., Polasek, O., Wild, SH., Campbell, H., Curb, JD., Wallace, R., Liu, S., Eaton, CB., Becker, DM., Becker, LC., Bandinelli, S., Räikkönen, K., Widen, E., Palotie, A., Fornage, M., Green, D., Gross, M., Davies, G., Harris, SE., Liewald, DC., Starr, JM., Williams, FMK., Grant, PJ., Spector, TD., Strawbridge, RJ., Silveira, A., Sennblad, B., Rivadeneira, F., Uitterlinden, AG., Franco, OH., Hofman, A., van Dongen, J., Willemsen, G., Boomsma, DI., Yao, J., Swords Jenny, N., Haritunians, T., McKnight, B., Lumley, T., Taylor, KD., Rotter, JI., Psaty, BM., Peters, A., Gieger, C., Illig, T., Grotevendt, A., Homuth, G., Völzke, H., Kocher, T., Goel, A., Franzosi, MG., Seedorf, U., Clarke, R., Steri, M., Tarasov, KV., Sanna, S., Schlessinger, D., Stott, DJ., Sattar, N., Buckley, BM., Rumley, A., Lowe, GD., McArdle, WL., Chen, M-H., Tofler, GH., Song, J., Boerwinkle, E., Folsom, AR., Rose, LM., Franco-Cereceda, A., Teichert, M., Ikram, MA., Mosley, TH., Bevan, S., Dichgans, M., Rothwell, PM., Sudlow, CLM., Hopewell, JC., Chambers, JC., Saleheen, D., Kooner, JS., Danesh, J., Nelson, CP., Erdmann, J., Reilly, MP., Kathiresan, S., Schunkert, H., Morange, P-E., Ferrucci, L., Eriksson, JG., Jacobs, D., Deary, IJ., Soranzo, N., Witteman, JCM., de Geus, EJC., Tracy, RP., Hayward, C., Koenig, W., Cucca, F., Jukema, JW., Eriksson, P., Seshadri, S., Markus, HS., Watkins, H., Samani, NJ., VTE Consortium, , STROKE Consortium, , Wellcome Trust Case Control Consortium 2 (WTCCC2), , C4D Consortium, , CARDIoGRAM Consortium, , Wallaschofski, H., Smith, NL., Tregouet, D., Ridker, PM., Tang, W., Strachan, DP., Hamsten, A. and O'Donnell, CJ., 2013. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation, v. 128
    Doi: http://doi.org/10.1161/CIRCULATIONAHA.113.002251
  • LeishGEN Consortium, , Wellcome Trust Case Control Consortium 2, , Fakiola, M., Strange, A., Cordell, HJ., Miller, EN., Pirinen, M., Su, Z., Mishra, A., Mehrotra, S., Monteiro, GR., Band, G., Bellenguez, C., Dronov, S., Edkins, S., Freeman, C., Giannoulatou, E., Gray, E., Hunt, SE., Lacerda, HG., Langford, C., Pearson, R., Pontes, NN., Rai, M., Singh, SP., Smith, L., Sousa, O., Vukcevic, D., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Jankowski, J., Markus, HS., Mathew, CG., Palmer, CNA., Plomin, R., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Wilson, ME., Deloukas, P., Peltonen, L., Christiansen, F., Witt, C., Jeronimo, SMB., Sundar, S., Spencer, CCA., Blackwell, JM. and Donnelly, P., 2013. Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Nat Genet, v. 45
    Doi: http://doi.org/10.1038/ng.2518
  • Kaudewitz, D., Lee, R., Willeit, P., McGregor, R., Markus, HS., Kiechl, S., Zampetaki, A., Storey, RF., Channon, KM. and Mayr, M., 2013. Impact of intravenous heparin on quantification of circulating microRNAs in patients with coronary artery disease. Thromb Haemost, v. 110
    Doi: http://doi.org/10.1160/TH13-05-0368
  • Moynihan, B., Paul, S. and Markus, HS., 2013. User Experience of a Centralized Hyperacute Stroke Service: A Prospective Evaluation. Stroke,
    Doi: http://doi.org/10.1161/STROKEAHA.113.001675
  • Yadav, S., Cotlarciuc, I., Munroe, PB., Khan, MS., Nalls, MA., Bevan, S., Cheng, YC., Chen, WM., Malik, R., McCarthy, NS., Holliday, EG., Speed, D., Hasan, N., Pucek, M., Rinne, PE., Sever, P., Stanton, A., Shields, DC., Maguire, JM., McEvoy, M., Scott, RJ., Ferrucci, L., Macleod, MJ., Attia, J., Markus, HS., Sale, MM., Worrall, BB., Mitchell, BD., Dichgans, M., Sudlow, C., Meschia, JF., Rothwell, PM., Caulfield, M., Sharma, P. and Consortium, ISG., 2013. Genome-Wide Analysis of Blood Pressure Variability and Ischemic Stroke. Stroke,
    Doi: http://doi.org/10.1161/STROKEAHA.113.002186
  • Bevan, S. and Markus, HS., 2013. Genetic Profiles in Ischaemic Stroke Current Atherosclerosis Reports, v. 15
    Doi: http://doi.org/10.1007/s11883-013-0342-8
  • Willeit, P., Zampetaki, A., Dudek, K., Kaudewitz, D., King, A., Kirkby, NS., Crosby-Nwaobi, R., Prokopi, M., Drozdov, I., Langley, SR., Sivaprasad, S., Markus, HS., Mitchell, JA., Warner, TD., Kiechl, S. and Mayr, M., 2013. Circulating MicroRNAs as novel biomarkers for platelet activation Circulation Research, v. 112
    Doi: http://doi.org/10.1161/CIRCRESAHA.111.300539
  • Bonati, LH., Ederle, J., Dobson, J., Engelter, S., Featherstone, RL., Gaines, PA., Beard, JD., Venables, GS., Markus, HS., Clifton, A., Sandercock, P. and Brown, MM., 2013. Length of carotid stenosis predicts peri-procedural stroke or death and restenosis in patients randomized to endovascular treatment or endarterectomy International Journal of Stroke,
  • Brookes, RL., Hannesdottir, K., Markus, HS. and Morris, RG., 2013. Lack of awareness of neuropsychological deficit in cerebral small vessel disease: The relationship with executive and episodic memory functions JOURNAL OF NEUROPSYCHOLOGY, v. 7
    Doi: http://doi.org/10.1111/j.1748-6653.2012.02032.x
  • Blue Mountains Eye Study (BMES), and Wellcome Trust Case Control Consortium 2 (WTCCC2), , 2013. Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. Hum Mol Genet, v. 22
    Doi: http://doi.org/10.1093/hmg/ddt293
  • Williams, FMK., Carter, AM., Hysi, PG., Surdulescu, G., Hodgkiss, D., Soranzo, N., Traylor, M., Bevan, S., Dichgans, M., Rothwell, PMW., Sudlow, C., Farrall, M., Silander, K., Kaunisto, M., Wagner, P., Saarela, O., Kuulasmaa, K., Virtamo, J., Salomaa, V., Amouyel, P., Arveiler, D., Ferrieres, J., Wiklund, P-G., Ikram, MA., Hofman, A., Boncoraglio, GB., Parati, EA., Helgadottir, A., Gretarsdottir, S., Thorsteinsdottir, U., Thorleifsson, G., Stefansson, K., Seshadri, S., DeStefano, A., Gschwendtner, A., Psaty, B., Longstreth, W., Mitchell, BD., Cheng, Y-C., Clarke, R., Ferrario, M., Bis, JC., Levi, C., Attia, J., Holliday, EG., Scott, RJ., Fornage, M., Sharma, P., Furie, KL., Rosand, J., Nalls, M., Meschia, J., Mosely, TH., Evans, A., Palotie, A., Markus, HS., Grant, PJ. and Spector, TD., 2013. Ischemic Stroke Is Associated with the ABO Locus: The EuroCLOT Study ANNALS OF NEUROLOGY, v. 73
    Doi: http://doi.org/10.1002/ana.23838
  • Bevan, S. and Markus, HS., 2013. Genetic profiles in ischaemic stroke. Curr Atheroscler Rep, v. 15
    Doi: http://doi.org/10.1007/s11883-013-0342-8
  • Mechelli, R., Umeton, R., Policano, C., Annibali, V., Coarelli, G., Ricigliano, VAG., Vittori, D., Fornasiero, A., Buscarinu, MC., International Multiple Sclerosis Genetics Consortium, , Wellcome Trust Case Control Consortium,2, , Romano, S., Salvetti, M. and Ristori, G., 2013. A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis. PLoS One, v. 8
    Doi: http://doi.org/10.1371/journal.pone.0063300
  • Kerry, SM., Markus, HS., Khong, TK., Cloud, GC., Tulloch, J., Coster, D., Ibison, J. and Oakeshott, P., 2013. Home blood pressure monitoring with nurse-led telephone support among patients with hypertension and a history of stroke: A community-based randomized controlled trial CMAJ. Canadian Medical Association Journal, v. 185
    Doi: http://doi.org/10.1503/cmaj.120832
  • Wong, KSL., Wang, Y., Leng, X., Mao, C., Tang, J., Bath, PMW., Markus, HS., Gorelick, PB., Liu, L., Lin, W. and Wang, Y., 2013. Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation, v. 128
    Doi: http://doi.org/10.1161/CIRCULATIONAHA.113.003187
  • Markus, HS., 2013. WellcomeTrust genome-wide association study of ischemic stroke. Stroke; a journal of cerebral circulation, v. 44
    Doi: http://doi.org/10.1161/STROKEAHA.112.680652
  • Traylor, M., Bevan, S., Rothwell, PM., Sudlow, C., Dichgans, M., Markus, HS. and Lewis, CM., 2013. Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes Genetic Epidemiology, v. 37
    Doi: http://doi.org/10.1002/gepi.21729
  • 2012

  • Gulli, G. and Markus, HS., 2012. The use of FAST and ABCD2 scores in posterior circulation, compared with anterior circulation, stroke and transient ischemic attack Journal of Neurology, Neurosurgery and Psychiatry, v. 83
    Doi: http://doi.org/10.1136/jnnp.2010.222091
  • Geeganage, CM., Diener, HC., Algra, A., Chen, C., Topol, EJ., Dengler, R., Markus, HS., Bath, MW. and Bath, PMW., 2012. Dual or mono antiplatelet therapy for patients with acute ischemic stroke or transient ischemic attack: Systematic review and meta-analysis of randomized controlled trials Stroke, v. 43
    Doi: http://doi.org/10.1161/STROKEAHA.111.637686
  • ISGC, ISGC., WTCCC2, WTCCC., Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, CC., Burgess, AI., Pirinen, M., Jackson, CA., Traylor, M., Strange, A., Su, Z., Band, G., Syme, PD., Malik, R., Pera, J., Norrving, B., Lemmens, R., Freeman, C., Schanz, R., James, T., Poole, D., Murphy, L., Segal, H., Cortellini, L., Cheng, YC., Woo, D., Nalls, MA., Müller-Myhsok, B., Meisinger, C., Seedorf, U., Ross-Adams, H., Boonen, S., Wloch-Kopec, D., Valant, V., Slark, J., Furie, K., Delavaran, H., Langford, C., Deloukas, P., Edkins, S., Hunt, S., Gray, E., Dronov, S., Peltonen, L., Gretarsdottir, S., Thorleifsson, G., Thorsteinsdottir, U., Stefansson, K., Boncoraglio, GB., Parati, EA., Attia, J., Holliday, E., Levi, C., Franzosi, MG., Goel, A., Helgadottir, A., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Jankowski, J., Mathew, CG., Palmer, CN., Plomin, R., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Worrall, BB., Kittner, SJ., Mitchell, BD., Kissela, B., Meschia, JF., Thijs, V., Lindgren, A., Macleod, MJ., Slowik, A., Walters, M., Rosand, J., Sharma, P., Farrall, M., Sudlow, CL., Rothwell, PM., Dichgans, M., Donnelly, P. and Markus, HS., 2012. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet, v. 44
    Doi: http://doi.org/10.1038/ng.1081
  • Brookes, RL., Hannesdottir, K., Lawrence, R., Morris, RG. and Markus, HS., 2012. Brief memory and executive test: Evaluation of a new screening test for cognitive impairment due to small vessel disease Age and Ageing, v. 41
    Doi: http://doi.org/10.1093/ageing/afr172
  • Holliday, EG., Maguire, JM., Evans, T-J., Koblar, SA., Jannes, J., Sturm, JW., Hankey, GJ., Baker, R., Golledge, J., Parsons, MW., Malik, R., McEvoy, M., Biros, E., Lewis, MD., Lincz, LF., Peel, R., Oldmeadow, C., Smith, W., Moscato, P., Barlera, S., Bevan, S., Bis, JC., Boerwinkle, E., Boncoraglio, GB., Brott, TG., Brown Jr, RD., Cheng, Y-C., Cole, JW., Cotlarciuc, I., Devan, WJ., Fornage, M., Furie, KL., Grétarsdóttir, S., Gschwendtner, A., Ikram, MA., Longstreth Jr, WT., Meschia, JF., Mitchell, BD., Mosley, TH., Nalls, MA., Parati, EA., Psaty, BM., Sharma, P., Stefansson, K., Thorleifsson, G., Thorsteinsdottir, U., Traylor, M., Verhaaren, BFJ., Wiggins, KL., Worrall, BB., Sudlow, C., Rothwell, PM., Farrall, M., Dichgans, M., Rosand, J., Markus, HS., Scott, RJ., Levi, C. and Attia, J., 2012. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke Nature Genetics,
  • Giwa, MO., Williams, J., Elderfield, K., Jiwa, NS., Bridges, LR., Kalaria, RN., Markus, HS., Esiri, MM. and Hainsworth, AH., 2012. Neuropathologic evidence of endothelial changes in cerebral small vessel disease NEUROLOGY, v. 78
    Doi: http://doi.org/10.1212/WNL.0b013e3182407968
  • Paul, S., Markus, H. and Moynihan, B., 2012. Patient and carer perspectives on the London hyper-acute stroke unit model INTERNATIONAL JOURNAL OF STROKE, v. 7
  • Su, Z., Gay, LJ., Strange, A., Palles, C., Band, G., Whiteman, DC., Lescai, F., Langford, C., Nanji, M., Edkins, S., van der Winkel, A., Levine, D., Sasieni, P., Bellenguez, C., Howarth, K., Freeman, C., Trudgill, N., Tucker, AT., Pirinen, M., Peppelenbosch, MP., van der Laan, LJW., Kuipers, EJ., Drenth, JPH., Peters, WH., Reynolds, JV., Kelleher, DP., McManus, R., Grabsch, H., Prenen, H., Bisschops, R., Krishnadath, K., Siersema, PD., van Baal, JWPM., Middleton, M., Petty, R., Gillies, R., Burch, N., Bhandari, P., Paterson, S., Edwards, C., Penman, I., Vaidya, K., Ang, Y., Murray, I., Patel, P., Ye, W., Mullins, P., Wu, AH., Bird, NC., Dallal, H., Shaheen, NJ., Murray, LJ., Koss, K., Bernstein, L., Romero, Y., Hardie, LJ., Zhang, R., Winter, H., Corley, DA., Panter, S., Risch, HA., Reid, BJ., Sargeant, I., Gammon, MD., Smart, H., Dhar, A., McMurtry, H., Ali, H., Liu, G., Casson, AG., Chow, W-H., Rutter, M., Tawil, A., Morris, D., Nwokolo, C., Isaacs, P., Rodgers, C., Ragunath, K., MacDonald, C., Haigh, C., Monk, D., Davies, G., Wajed, S., Johnston, D., Gibbons, M., Cullen, S., Church, N., Langley, R., Griffin, M., Alderson, D., Deloukas, P., Hunt, SE., Gray, E., Dronov, S., Potter, SC., Tashakkori-Ghanbaria, A., Anderson, M., Brooks, C., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Duncanson, A., Markus, HS., Mathew, CG., Palmer, CNA., Plomin, R., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, N., Trynka, G., Wijmenga, C., Cazier, J-B., Atherfold, P., Nicholson, AM., Gellatly, NL., Glancy, D., Cooper, SC., Cunningham, D., Lind, T., Hapeshi, J., Ferry, D., Rathbone, B., Brown, J., Love, S., Attwood, S., MacGregor, S., Watson, P., Sanders, S., Ek, W., Harrison, RF., Moayyedi, P., de Caestecker, J., Barr, H., Stupka, E., Vaughan, TL., Peltonen, L., Spencer, CCA., Tomlinson, I., Donnelly, P., Jankowski, JAZ., Esophageal Adenocarcinoma Genetics Consortium, and Wellcome Trust Case Control Consortium 2, , 2012. Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet, v. 44
    Doi: http://doi.org/10.1038/ng.2408
  • Benjamin, P., Lawrence, AJ., Patel, P., Chung, AW., MacKinnon, A., Morris, R., Barrick, TR. and Markus, HS., 2012. Lacunar infarcts and cognition in cerebral small vessel disease: results from the SCANS study INTERNATIONAL JOURNAL OF STROKE, v. 7
  • Markus, H., 2012. Stroke: Causes and clinical features Medicine (United Kingdom), v. 40
    Doi: http://doi.org/10.1016/j.mpmed.2012.06.005
  • Keller, MF., Saad, M., Bras, J., Bettella, F., Nicolaou, N., Simón-Sánchez, J., Mittag, F., Büchel, F., Sharma, M., Gibbs, JR., Schulte, C., Moskvina, V., Durr, A., Holmans, P., Kilarski, LL., Guerreiro, R., Hernandez, DG., Brice, A., Ylikotila, P., Stefánsson, H., Majamaa, K., Morris, HR., Williams, N., Gasser, T., Heutink, P., Wood, NW., Hardy, J., Martinez, M., Singleton, AB., Nalls, MA., International Parkinson's Disease Genomics Consortium (IPDGC), and Wellcome Trust Case Control Consortium 2 (WTCCC2), , 2012. Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease. Hum Mol Genet, v. 21
    Doi: http://doi.org/10.1093/hmg/dds335
  • Markus, HS., 2012. Stroke genetics: prospects for personalized medicine. BMC Med, v. 10
    Doi: http://doi.org/10.1186/1741-7015-10-113
  • Traylor, M., Farrall, M., Holliday, EG., Sudlow, C., Hopewell, JC., Cheng, YC., Fornage, M., Ikram, MA., Malik, R., Bevan, S., Thorsteinsdottir, U., Nalls, MA., Longstreth, WT., Wiggins, KL., Yadav, S., Parati, EA., DeStefano, AL., Worrall, BB., Kittner, SJ., Khan, MS., Reiner, AP., Helgadottir, A., Achterberg, S., Fernandez-Cadenas, I., Abboud, S., Schmidt, R., Walters, M., Chen, WM., Ringelstein, EB., O'Donnell, M., Ho, WK., Pera, J., Lemmens, R., Norrving, B., Higgins, P., Benn, M., Sale, M., Kuhlenbäumer, G., Doney, ASF., Vicente, AM., Delavaran, H., Algra, A., Davies, G., Oliveira, SA., Palmer, CNA., Deary, I., Schmidt, H., Pandolfo, M., Montaner, J., Carty, C., de Bakker, PIW., Kostulas, K., Ferro, JM., van Zuydam, NR., Valdimarsson, E., Nordestgaard, BG., Lindgren, A., Thijs, V., Slowik, A., Saleheen, D., Paré, G., Berger, K., Thorleifsson, G., Hofman, A., Mosley, TH., Mitchell, BD., Furie, K., Clarke, R., Levi, C., Seshadri, S., Gschwendtner, A., Boncoraglio, GB., Sharma, P., Bis, JC., Gretarsdottir, S., Psaty, BM., Rothwell, PM., Rosand, J., Meschia, JF., Stefansson, K., Dichgans, M. and Markus, HS., 2012. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): A meta-analysis of genome-wide association studies The Lancet Neurology, v. 11
    Doi: http://doi.org/10.1016/S1474-4422(12)70234-X
  • Strange, A., Riley, BP., Spencer, CCA., Morris, DW., Pirinen, M., O'Dushlaine, CT., Su, Z., Maher, BS., Freeman, C., Cormican, P., Bellenguez, C., Kenny, EM., Band, G., Wormley, B., Donohoe, G., Dilthey, A., Moutsianas, L., Quinn, E., Edkins, S., Judge, R., Coleman, K., Hunt, S., Tropea, D., Roche, S., Cummings, L., Kelleher, E., McKeon, P., Dinan, T., McDonald, C., Murphy, KC., O'Callaghan, E., O'Neill, FA., Waddington, JL., Walsh, D., Giannoulatou, E., Langford, C., Deloukas, P., Gray, E., Dronov, S., Potter, S., Pearson, R., Vukcevic, D., Tashakkori-Ghanbaria, A., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Duncanson, A., Jankowski, J., Markus, HS., Mathew, CG., Palmer, CNA., Plomin, R., Rautanen, A., Sawcer, SJ., Trembath, RC., Viswanathan, AC., Wood, NW., Stone, J., Scolnick, E., Purcell, S., Sklar, P., Ripke, S., Walters, J., Owen, MJ., O'Donovan, MC., Peltonen, L., McVean, G., Kendler, KS., Gill, M., Donnelly, P. and Corvin, A., 2012. Genome-Wide Association Study Implicates HLA-C*01:02 as a Risk Factor at the Major Histocompatibility Complex Locus in Schizophrenia BIOLOGICAL PSYCHIATRY, v. 72
    Doi: http://doi.org/10.1016/j.biopsych.2012.05.035
  • Bevan, S., Traylor, M., Adib-Samii, P., Malik, R., Paul, NLM., Jackson, C., Farrall, M., Rothwell, PM., Sudlow, C., Dichgans, M. and Markus, HS., 2012. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations Stroke, v. 43
    Doi: http://doi.org/10.1161/STROKEAHA.112.665760
  • Helgadottir, A., Gretarsdottir, S., Thorleifsson, G., Holm, H., Patel, RS., Gudnason, T., Jones, GT., Van Rij, AM., Eapen, DJ., Baas, AF., Tregouet, DA., Morange, PE., Emmerich, J., Lindblad, B., Gottster, A., Kiemeny, LA., Lindholt, JS., Sakalihasan, N., Ferrell, RE., Carey, DJ., Elmore, JR., Tsao, PS., Grarup, N., Jørgensen, T., Witte, DR., Hansen, T., Pedersen, O., Pola, R., Gaetani, E., Magnadottir, HB., Wijmenga, C., Tromp, G., Ronkainen, A., Ruigrok, YM., Blankensteijn, JD., Mueller, T., Wells, PS., Corral, J., Soria, JM., Souto, JC., Peden, JF., Jalilzadeh, S., Mayosi, BM., Keavney, B., Strawbridge, RJ., Sabater-Lleal, M., Gertow, K., Baldassarre, D., Nyyssnen, K., Rauramaa, R., Smit, AJ., Mannarino, E., Giral, P., Tremoli, E., De Faire, U., Humphries, SE., Hamsten, A., Haraldsdottir, V., Olafsson, I., Magnusson, MK., Samani, NJ., Levey, AI., Markus, HS., Kostulas, K., Dichgans, M., Berger, K., Kuhlenbumer, G., Ringelstein, EB., Stoll, M., Seedorf, U., Rothwell, PM., Powell, JT., Kuivaniemi, H., Onundarson, PT., Valdimarsson, E., Matthiasson, SE., Gudbjartsson, DF., Thorgeirsson, G., Quyyumi, AA., Watkins, H., Farrall, M., Thorsteinsdottir, U. and Stefansson, K., 2012. Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism Journal of the American College of Cardiology, v. 60
    Doi: http://doi.org/10.1016/j.jacc.2012.01.078
  • Holliday, EG., Maguire, JM., Evans, TJ., Koblar, SA., Jannes, J., Sturm, JW., Hankey, GJ., Baker, R., Golledge, J., Parsons, MW., Malik, R., McEvoy, M., Biros, E., Lewis, MD., Lincz, LF., Peel, R., Oldmeadow, C., Smith, W., Moscato, P., Barlera, S., Bevan, S., Bis, JC., Boerwinkle, E., Boncoraglio, GB., Brott, TG., Brown, RD., Cheng, YC., Cole, JW., Cotlarciuc, I., Devan, WJ., Fornage, M., Furie, KL., Grétarsdóttir, S., Gschwendtner, A., Ikram, MA., Longstreth, WT., Meschia, JF., Mitchell, BD., Mosley, TH., Nalls, MA., Parati, EA., Psaty, BM., Sharma, P., Stefansson, K., Thorleifsson, G., Thorsteinsdottir, U., Traylor, M., Verhaaren, BFJ., Wiggins, KL., Worrall, BB., Sudlow, C., Rothwell, PM., Farrall, M., Dichgans, M., Rosand, J., Markus, HS., Scott, RJ., Levi, C. and Attia, J., 2012. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke Nature Genetics, v. 44
    Doi: http://doi.org/10.1038/ng.2397
  • Tsoi, LC., Spain, SL., Knight, J., Ellinghaus, E., Stuart, PE., Capon, F., Ding, J., Li, Y., Tejasvi, T., Gudjonsson, JE., Kang, HM., Allen, MH., McManus, R., Novelli, G., Samuelsson, L., Schalkwijk, J., Ståhle, M., Burden, AD., Smith, CH., Cork, MJ., Estivill, X., Bowcock, AM., Krueger, GG., Weger, W., Worthington, J., Tazi-Ahnini, R., Nestle, FO., Hayday, A., Hoffmann, P., Winkelmann, J., Wijmenga, C., Langford, C., Edkins, S., Andrews, R., Blackburn, H., Strange, A., Band, G., Pearson, RD., Vukcevic, D., Spencer, CCA., Deloukas, P., Mrowietz, U., Schreiber, S., Weidinger, S., Koks, S., Kingo, K., Esko, T., Metspalu, A., Lim, HW., Voorhees, JJ., Weichenthal, M., Wichmann, HE., Chandran, V., Rosen, CF., Rahman, P., Gladman, DD., Griffiths, CEM., Reis, A., Kere, J., Collaborative Association Study of Psoriasis (CASP), , Genetic Analysis of Psoriasis Consortium, , Psoriasis Association Genetics Extension, , Wellcome Trust Case Control Consortium 2, , Nair, RP., Franke, A., Barker, JNWN., Abecasis, GR., Elder, JT. and Trembath, RC., 2012. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet, v. 44
    Doi: http://doi.org/10.1038/ng.2467
  • Kennedy, F., Lanfranconi, S., Hicks, C., Reid, J., Gompertz, P., Price, C., Kerry, S., Norris, J. and Markus, HS., 2012. Antiplatelets vs anticoagulation for dissection: CADISS nonrandomized arm and meta-analysis Neurology, v. 79
    Doi: http://doi.org/10.1212/WNL.0b013e318264e36b
  • Lanfranconi, S. and Markus, HS., 2012. Stroke subtyping for genetic association studies? A comparison of the CCS and TOAST classifications. Int J Stroke,
    Doi: http://doi.org/10.1111/j.1747-4949.2012.00780.x
  • Brookes, RL., Willis, TA., Patel, B., Morris, RG. and Markus, HS., 2012. Depressive symptoms as a predictor of quality of life in cerebral small vessel disease, acting independently of disability; a study in both sporadic small vessel disease and CADASIL. Int J Stroke,
    Doi: http://doi.org/10.1111/j.1747-4949.2011.00763.x
  • 2011

  • Conde, L., Bevan, S., Sitzer, M., Klopp, N., Illig, T., Thiery, J., Seissler, J., Baumert, J., Raitakari, O., Kähönen, M., Lyytikäinen, LP., Laaksonen, R., Viikari, J., Lehtimäki, T., Koernig, W., Halperin, E. and Markus, HS., 2011. Novel associations for coronary artery disease derived from genome wide association studies are not associated with increased carotid intima-media thickness, suggesting they do not act via early atherosclerosis or vessel remodeling Atherosclerosis, v. 219
    Doi: http://doi.org/10.1016/j.atherosclerosis.2011.08.031
  • International Multiple Sclerosis Genetics Consortium, , Wellcome Trust Case Control Consortium 2, , Sawcer, S., Hellenthal, G., Pirinen, M., Spencer, CCA., Patsopoulos, NA., Moutsianas, L., Dilthey, A., Su, Z., Freeman, C., Hunt, SE., Edkins, S., Gray, E., Booth, DR., Potter, SC., Goris, A., Band, G., Oturai, AB., Strange, A., Saarela, J., Bellenguez, C., Fontaine, B., Gillman, M., Hemmer, B., Gwilliam, R., Zipp, F., Jayakumar, A., Martin, R., Leslie, S., Hawkins, S., Giannoulatou, E., D'alfonso, S., Blackburn, H., Martinelli Boneschi, F., Liddle, J., Harbo, HF., Perez, ML., Spurkland, A., Waller, MJ., Mycko, MP., Ricketts, M., Comabella, M., Hammond, N., Kockum, I., McCann, OT., Ban, M., Whittaker, P., Kemppinen, A., Weston, P., Hawkins, C., Widaa, S., Zajicek, J., Dronov, S., Robertson, N., Bumpstead, SJ., Barcellos, LF., Ravindrarajah, R., Abraham, R., Alfredsson, L., Ardlie, K., Aubin, C., Baker, A., Baker, K., Baranzini, SE., Bergamaschi, L., Bergamaschi, R., Bernstein, A., Berthele, A., Boggild, M., Bradfield, JP., Brassat, D., Broadley, SA., Buck, D., Butzkueven, H., Capra, R., Carroll, WM., Cavalla, P., Celius, EG., Cepok, S., Chiavacci, R., Clerget-Darpoux, F., Clysters, K., Comi, G., Cossburn, M., Cournu-Rebeix, I., Cox, MB., Cozen, W., Cree, BAC., Cross, AH., Cusi, D., Daly, MJ., Davis, E., de Bakker, PIW., Debouverie, M., D'hooghe, MB., Dixon, K., Dobosi, R., Dubois, B., Ellinghaus, D., Elovaara, I., Esposito, F., Fontenille, C., Foote, S., Franke, A., Galimberti, D., Ghezzi, A., Glessner, J., Gomez, R., Gout, O., Graham, C., Grant, SFA., Guerini, FR., Hakonarson, H., Hall, P., Hamsten, A., Hartung, H-P., Heard, RN., Heath, S., Hobart, J., Hoshi, M., Infante-Duarte, C., Ingram, G., Ingram, W., Islam, T., Jagodic, M., Kabesch, M., Kermode, AG., Kilpatrick, TJ., Kim, C., Klopp, N., Koivisto, K., Larsson, M., Lathrop, M., Lechner-Scott, JS., Leone, MA., Leppä, V., Liljedahl, U., Bomfim, IL., Lincoln, RR., Link, J., Liu, J., Lorentzen, AR., Lupoli, S., Macciardi, F., Mack, T., Marriott, M., Martinelli, V., Mason, D., McCauley, JL., Mentch, F., Mero, I-L., Mihalova, T., Montalban, X., Mottershead, J., Myhr, K-M., Naldi, P., Ollier, W., Page, A., Palotie, A., Pelletier, J., Piccio, L., Pickersgill, T., Piehl, F., Pobywajlo, S., Quach, HL., Ramsay, PP., Reunanen, M., Reynolds, R., Rioux, JD., Rodegher, M., Roesner, S., Rubio, JP., Rückert, I-M., Salvetti, M., Salvi, E., Santaniello, A., Schaefer, CA., Schreiber, S., Schulze, C., Scott, RJ., Sellebjerg, F., Selmaj, KW., Sexton, D., Shen, L., Simms-Acuna, B., Skidmore, S., Sleiman, PMA., Smestad, C., Sørensen, PS., Søndergaard, HB., Stankovich, J., Strange, RC., Sulonen, A-M., Sundqvist, E., Syvänen, A-C., Taddeo, F., Taylor, B., Blackwell, JM., Tienari, P., Bramon, E., Tourbah, A., Brown, MA., Tronczynska, E., Casas, JP., Tubridy, N., Corvin, A., Vickery, J., Jankowski, J., Villoslada, P., Markus, HS., Wang, K., Mathew, CG., Wason, J., Palmer, CNA., Wichmann, H-E., Plomin, R., Willoughby, E., Rautanen, A., Winkelmann, J., Wittig, M., Trembath, RC., Yaouanq, J., Viswanathan, AC., Zhang, H., Wood, NW., Zuvich, R., Deloukas, P., Langford, C., Duncanson, A., Oksenberg, JR., Pericak-Vance, MA., Haines, JL., Olsson, T., Hillert, J., Ivinson, AJ., De Jager, PL., Peltonen, L., Stewart, GJ., Hafler, DA., Hauser, SL., McVean, G., Donnelly, P. and Compston, A., 2011. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature, v. 476
    Doi: http://doi.org/10.1038/nature10251
  • Nitkunan, A., Lanfranconi, S., Charlton, RA., Barrick, TR. and Markus, HS., 2011. Brain atrophy and cerebral small vessel disease a prospective follow-up study Stroke, v. 42
    Doi: http://doi.org/10.1161/STROKEAHA.110.594267
  • Bis, JC., Kavousi, M., Franceschini, N., Isaacs, A., Abecasis, GR., Schminke, U., Post, WS., Smith, AV., Cupples, LA., Markus, HS., Schmidt, R., Huffman, JE., Lehtimäki, T., Baumert, J., Münzel, T., Heckbert, SR., Dehghan, A., North, K., Oostra, B., Bevan, S., Stoegerer, E-M., Hayward, C., Raitakari, O., Meisinger, C., Schillert, A., Sanna, S., Völzke, H., Cheng, Y-C., Thorsson, B., Fox, CS., Rice, K., Rivadeneira, F., Nambi, V., Halperin, E., Petrovic, KE., Peltonen, L., Wichmann, HE., Schnabel, RB., Dörr, M., Parsa, A., Aspelund, T., Demissie, S., Kathiresan, S., Reilly, MP., Taylor, K., Uitterlinden, A., Couper, DJ., Sitzer, M., Kähönen, M., Illig, T., Wild, PS., Orru, M., Lüdemann, J., Shuldiner, AR., Eiriksdottir, G., White, CC., Rotter, JI., Hofman, A., Seissler, J., Zeller, T., Usala, G., Ernst, F., Launer, LJ., D'Agostino, RB., O'Leary, DH., Ballantyne, C., Thiery, J., Ziegler, A., Lakatta, EG., Chilukoti, RK., Harris, TB., Wolf, PA., Psaty, BM., Polak, JF., Li, X., Rathmann, W., Uda, M., Boerwinkle, E., Klopp, N., Schmidt, H., Wilson, JF., Viikari, J., Koenig, W., Blankenberg, S., Newman, AB., Witteman, J., Heiss, G., van Duijn, C., Scuteri, A., Homuth, G., Mitchell, BD., Gudnason, V. and O'Donnell, CJ., 2011. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque Nature Genetics, v. 43
    Doi: 10.1038/ng.920
  • Bevan, S. and Markus, HS., 2011. Genetics of common polygenic ischaemic stroke: Current understanding and future challenges Stroke Research and Treatment,
    Doi: http://doi.org/10.4061/2011/179061
  • Topakian, R., King, A., Kwon, SU., Schaafsma, A., Shipley, M. and Markus, HS., 2011. Ultrasonic plaque echolucency and emboli signals predict stroke in asymptomatic carotid stenosis NEUROLOGY, v. 77
  • King, A., Shipley, M., Markus, H. and Investigators, ACES., 2011. Optimizing protocols for risk prediction in asymptomatic carotid stenosis using embolic signal detection: the Asymptomatic Carotid Emboli Study. Stroke, v. 42
    Doi: http://doi.org/10.1161/STROKEAHA.111.622514
  • Markus, HS., 2011. Stroke genetics. Hum Mol Genet, v. 20
    Doi: http://doi.org/10.1093/hmg/ddr345
  • Markus, HS., McCollum, C., Imray, C., Goulder, MA., Gilbert, J. and King, A., 2011. The von willebrand inhibitor ARC1779 reduces cerebral embolization after carotid endarterectomy: A randomized trial Stroke, v. 42
    Doi: http://doi.org/10.1161/STROKEAHA.111.616649
  • GoDARTS and UKPDS Diabetes Pharmacogenetics Study Group, , Wellcome Trust Case Control Consortium 2, , Zhou, K., Bellenguez, C., Spencer, CCA., Bennett, AJ., Coleman, RL., Tavendale, R., Hawley, SA., Donnelly, LA., Schofield, C., Groves, CJ., Burch, L., Carr, F., Strange, A., Freeman, C., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Gray, E., Hunt, S., Jankowski, J., Langford, C., Markus, HS., Mathew, CG., Plomin, R., Rautanen, A., Sawcer, SJ., Samani, NJ., Trembath, R., Viswanathan, AC., Wood, NW., MAGIC investigators, , Harries, LW., Hattersley, AT., Doney, ASF., Colhoun, H., Morris, AD., Sutherland, C., Hardie, DG., Peltonen, L., McCarthy, MI., Holman, RR., Palmer, CNA., Donnelly, P. and Pearson, ER., 2011. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet, v. 43
    Doi: http://doi.org/10.1038/ng.735
  • King, A., Serena, J., Bornstein, NM. and Markus, HS., 2011. Does impaired cerebrovascular reactivity predict stroke risk in asymptomatic carotid stenosis?: A prospective substudy of the asymptomatic carotid emboli study Stroke, v. 42
    Doi: http://doi.org/10.1161/STROKEAHA.110.609057
  • UK Parkinson's Disease Consortium, , Wellcome Trust Case Control Consortium 2, , Spencer, CCA., Plagnol, V., Strange, A., Gardner, M., Paisan-Ruiz, C., Band, G., Barker, RA., Bellenguez, C., Bhatia, K., Blackburn, H., Blackwell, JM., Bramon, E., Brown, MA., Brown, MA., Burn, D., Casas, J-P., Chinnery, PF., Clarke, CE., Corvin, A., Craddock, N., Deloukas, P., Edkins, S., Evans, J., Freeman, C., Gray, E., Hardy, J., Hudson, G., Hunt, S., Jankowski, J., Langford, C., Lees, AJ., Markus, HS., Mathew, CG., McCarthy, MI., Morrison, KE., Palmer, CNA., Pearson, JP., Peltonen, L., Pirinen, M., Plomin, R., Potter, S., Rautanen, A., Sawcer, SJ., Su, Z., Trembath, RC., Viswanathan, AC., Williams, NW., Morris, HR., Donnelly, P. and Wood, NW., 2011. Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet, v. 20
    Doi: http://doi.org/10.1093/hmg/ddq469
  • Bevan, S., Meidtner, K., Lorenz, M., Sitzer, M., Grant, PJ. and Markus, HS., 2011. Adiponectin level as a consequence of genetic variation, but not leptin level or leptin: adiponectin ratio, is a risk factor for carotid intima-media thickness. Stroke, v. 42
    Doi: http://doi.org/10.1161/STROKEAHA.110.602375
  • Markus, H., 2011. Revascularization of asymptomatic high-grade carotid stenosis is still indicated in some cases Stroke, v. 42
    Doi: http://doi.org/10.1161/STROKEAHA.110.612473
  • Patel, B. and Markus, HS., 2011. Magnetic resonance imaging in cerebral small vessel disease and its use as a surrogate disease marker International Journal of Stroke, v. 6
    Doi: http://doi.org/10.1111/j.1747-4949.2010.00552.x
  • King, A., Bath, PMW. and Markus, HS., 2011. Clopidogrel versus dipyridamole in addition to aspirin in reducing embolization detected with ambulatory transcranial Doppler: A randomized trial Stroke, v. 42
    Doi: http://doi.org/10.1161/STROKEAHA.110.601807
  • Evans, DM., Spencer, CCA., Pointon, JJ., Su, Z., Harvey, D., Kochan, G., Oppermann, U., Dilthey, A., Pirinen, M., Stone, MA., Appleton, L., Moutsianas, L., Leslie, S., Wordsworth, T., Kenna, TJ., Karaderi, T., Thomas, GP., Ward, MM., Weisman, MH., Farrar, C., Bradbury, LA., Danoy, P., Inman, RD., Maksymowych, W., Gladman, D., Rahman, P., Spondyloarthritis Research Consortium of Canada (SPARCC), , Morgan, A., Marzo-Ortega, H., Bowness, P., Gaffney, K., Gaston, JSH., Smith, M., Bruges-Armas, J., Couto, A-R., Sorrentino, R., Paladini, F., Ferreira, MA., Xu, H., Liu, Y., Jiang, L., Lopez-Larrea, C., Díaz-Peña, R., López-Vázquez, A., Zayats, T., Band, G., Bellenguez, C., Blackburn, H., Blackwell, JM., Bramon, E., Bumpstead, SJ., Casas, JP., Corvin, A., Craddock, N., Deloukas, P., Dronov, S., Duncanson, A., Edkins, S., Freeman, C., Gillman, M., Gray, E., Gwilliam, R., Hammond, N., Hunt, SE., Jankowski, J., Jayakumar, A., Langford, C., Liddle, J., Markus, HS., Mathew, CG., McCann, OT., McCarthy, MI., Palmer, CNA., Peltonen, L., Plomin, R., Potter, SC., Rautanen, A., Ravindrarajah, R., Ricketts, M., Samani, N., Sawcer, SJ., Strange, A., Trembath, RC., Viswanathan, AC., Waller, M., Weston, P., Whittaker, P., Widaa, S., Wood, NW., McVean, G., Reveille, JD., Wordsworth, BP., Brown, MA., Donnelly, P., Australo-Anglo-American Spondyloarthritis Consortium (TASC), and Wellcome Trust Case Control Consortium 2 (WTCCC2), , 2011. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet, v. 43
    Doi: http://doi.org/10.1038/ng.873
  • Wong, KS., Chen, C., Fu, J., Chang, HM., Suwanwela, NC., Huang, YN., Han, Z., Tan, KS., Ratanakorn, D., Chollate, P., Zhao, Y., Koh, A., Hao, Q. and Markus, HS., 2011. Clopidogrel plus aspirin versus aspirin alone for reducing embolisation in patients with acute symptomatic cerebral or carotid artery stenosis (CLAIR study): a randomised, open-label, blinded-endpoint trial. Lancet Neurology, v. 9
    Doi: http://doi.org/10.1016/S1474-4422(10)70060-0
  • 2010

  • Charlton, RA., Schiavone, F., Barrick, TR., Morris, RG. and Markus, HS., 2010. Diffusion tensor imaging detects age related white matter change over a 2 year follow-up which is associated with working memory decline Journal of Neurology, Neurosurgery and Psychiatry, v. 81
    Doi: http://doi.org/10.1136/jnnp.2008.167288
  • Markus, HS., 2010. Unravelling the genetics of ischaemic stroke. PLoS medicine, v. 7
    Doi: http://doi.org/10.1371/journal.pmed.1000225
  • Markus, HS., 2010. Emboli detection in asymptomatic carotid stenosis - Author's reply The Lancet Neurology, v. 9
    Doi: http://doi.org/10.1016/S1474-4422(10)70229-5
  • Ederle, J., Dobson, J., Featherstone, RL., Bonati, LH., van der Worp, HB., de Borst, GJ., Lo, TH., Gaines, P., Dorman, PJ., Macdonald, S., Lyrer, PA., Hendriks, JM., McCollum, C., Nederkoorn, PJ., Brown, MM., Algra, A., Bamford, J., Beard, J., Bland, M., Bradbury, AW., Brown, MM., Clifton, A., Gaines, P., Hacke, W., Halliday, A., Malik, I., Mas, JL., McGuire, AJ., Sidhu, P., Venables, G., Bradbury, A., Brown, MM., Clifton, A., Gaines, P., Collins, R., Molynewc, A., Naylor, R., Warlow, C., Ferro, JM., Thomas, D., Bonati, LH., Coward, L., Dobson, J., Ederle, J., Featherstone, RF., Tindall, H., McCabe, DJH., Wallis, A., Brooks, M., Chambers, B., Chan, A., Chu, P., Clark, D., Dewey, H., Donnan, G., Fell, G., Hoare, M., Molan, M., Roberts, A., Roberts, N., Beiles, B., Bladin, C., Clifford, C., Fell, G., Grigg, M., New, G., Bell, R., Bower, S., Chong, W., Holt, M., Saunder, A., Than, PG., Gett, S., Leggett, D., McGahan, T., Quinn, J., Ray, M., Wong, A., Woodruff, P., Foreman, R., Schultz, D., Scroop, R., Stanley, B., Allard, B., Atkinson, N., Cambell, W., Davies, S., Field, P., Milne, P., Mitchell, P., Tress, B., Yan, B., Beasley, A., Dunbabin, D., Stary, D., Walker, S., Cras, P., d'Archambeau, O., Hendriks, JMH., Van Schil, P., Bosiers, M., Deloose, K., van Buggenhout, E., De Letter, J., Devos, V., Ghekiere, J., Vanhooren, G., Astarci, P., Hammer, F., Lacroix, V., Peeters, A., Verhelst, R., DeJaegher, L., Peeters, A., Verbist, J., Blair, JF., Caron, JL., Daneault, N., Giroux, MF., Guilbert, F., Lanthier, S., Lebrun, LH., Oliva, V., Raymond, J., Roy, D., Soulez, G., Weill, A., Hill, M., Hu, W., Hudion, M., Morrish, W., Sutherland, G., Wong, J., Alback, A., Harno, H., Ijas, P., Kaste, M., Lepantalo, M., Mustanoja, S., Paananen, T., Porras, M., Putaala, J., Railo, M., Sairanen, T., Soinne, L., Vehmas, A., Vikatmaa, P., Goertler, M., Halloul, Z., Skalej, M., Brennan, P., Kelly, C., Leahy, A., Moroney, J., Thornton, J., Koelemay, MJW., Nederkoorn, PJ., Reekers, JAA., Roos, YBWEM., Hendriks, JM., Koudstaal, PJ., Pattynama, PMT., van der Lugt, A., van Dijk, LC., van Sambeek, MRHM., van Urk, H., Verhagen, HJM., Bruininckx, CMA., de Bruijn, SF., Keunen, R., Knippenberg, B., Mosch, A., Treurniet, F., van Dijk, L., van Overhagen, H., Wever, J., de Beer, FC., van den Berg, JSP., van Hasselt, BAAM., Zeilstra, DJ., Boiten, J., van Otterloo, JCAD., de Vries, AC., Nieholt, GJLA., van der Kallen, BFW., Blankensteijn, JD., De Leeuw, FE., Kool, LJS., van der Vliet, JA., de Borst, GJ., de Kort, GAP., Kapelle, LJ., Lo, TH., Mali, WPTM., Moll, F., van der Worp, HB., Verhagen, H., Barber, PA., Bourchier, R., Hill, A., Holden, A., Stewart, J., Bakke, SJ., Krohg-Sorensen, K., Skjelland, M., Tennoe, B., Bialek, P., Biejat, Z., Czepiel, W., Czlonkowska, A., Dowzenko, A., Jedrzejewska, J., Kobayashi, A., Lelek, M., Polanski, J., Kirbis, J., Milosevic, Z., Zvan, B., Blasco, J., Chamorro, A., Macho, J., Obach, V., Riambau, V., San Roman, L., Branera, J., Canovas, D., Estela, J., Gaibar, AG., Perendreu, J., Bjorses, K., Gottsater, A., Ivancev, K., Maetzsch, T., Sonesson, B., Berg, B., Delle, M., Formgren, J., Gillgren, P., Kall, TB., Konrad, P., Nyman, N., Takolander, R., Andersson, T., Malmstedt, J., Soderman, M., Wahlgren, C., Wahlgren, N., Binaghi, S., Hirt, L., Michel, P., Ruchat, P., Bonati, LH., Engelter, ST., Fluri, F., Guerke, L., Jacob, AL., Kirsch, E., Lyrer, PA., Radue, EW., Stierli, P., Wasner, M., Wetzel, S., Bonvin, C., Kalangos, A., Lovblad, K., Murith, N., Ruefenacht, D., Sztajzel, R., Higgins, N., Kirkpatrick, PJ., Martin, P., Adam, D., Bell, J., Bradbury, AW., Crowe, P., Gannon, M., Henderson, MJ., Sandler, D., Shinton, RA., Scriven, JM., Wilmink, T., D'Souza, S., Egun, A., Guta, R., Punekar, S., Seriki, DM., Thomson, G., Brennan, A., Enevoldson, TP., Gilling-Smith, G., Gould, DA., Harris, PL., McWilliams, RG., Nasser, HC., White, R., Prakash, KG., Serracino-Inglott, F., Subramanian, G., Symth, JV., Walker, MG., Clarke, M., Davis, M., Dixit, SA., Dolman, P., Dyker, A., Ford, G., Golkar, A., Jackson, R., Jayakrishnan, V., Lambert, D., Lees, T., Louw, S., Macdonald, S., Mendelow, AD., Rodgers, H., Rose, J., Stansby, G., Wyatt, M., Baker, T., Baldwin, N., Jones, L., Mitchell, D., Munro, E., Thornton, M., Baker, D., Davis, N., Hamilton, G., McCabe, D., Platts, A., Tibballs, J., Beard, J., Cleveland, T., Dodd, D., Gaines, P., Lonsdale, R., Nair, R., Nassef, A., Nawaz, S., Venables, G., Belli, A., Clifton, A., Cloud, G., Halliday, A., Markus, H., McFarland, R., Morgan, R., Pereira, A., Thompson, A., Chataway, J., Cheshire, N., Gibbs, R., Hammady, M., Jenkins, M., Malik, I., Wolfe, J., Adiseshiah, M., Bishop, C., Brew, S., Brookes, J., Brown, MM., Jager, R., Kitchen, N., Ashleigh, R., Butterfield, S., Gamble, GE., McCollum, C., Nasim, A., O'Neill, P., Wong, J., Edwards, RD., Lees, KR., MacKay, AJ., Moss, J., Rogers, P. and Int Carotid Stenting Study, , 2010. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial LANCET, v. 375
    Doi: http://doi.org/10.1016/S0140-6736(10)60239-5
  • Debette, S. and Markus, HS., 2010. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ, v. 341
  • Mackinnon, AD., Jerrard-Dunne, P., Porteous, L. and Markus, HS., 2010. Carotid intima-media thickness is greater but carotid plaque prevalence is lower in black compared with white subjects American Journal of Neuroradiology, v. 31
    Doi: http://doi.org/10.3174/ajnr.A2214
  • Moynihan, B., Davis, D., Pereira, A., Cloud, G. and Markus, HS., 2010. Delivering regional thrombolysis via a hub-and-spoke model Journal of the Royal Society of Medicine, v. 103
    Doi: http://doi.org/10.1258/jrsm.2010.090434
  • Robinson, TG., Potter, JF., Ford, GA., Bulpitt, CJ., Chernova, J., Jagger, C., James, MA., Knight, J., Markus, HS., Mistri, AK. and Poulter, NR., 2010. Effects of antihypertensive treatment after acute stroke in the Continue Or Stop post-Stroke Antihypertensives Collaborative Study (COSSACS): A prospective, randomised, open, blinded-endpoint trial The Lancet Neurology, v. 9
    Doi: http://doi.org/10.1016/S1474-4422(10)70163-0
  • Lanfranconi, S. and Markus, HS., 2010. COL4A1 mutations as a monogenic cause of cerebral small vessel disease: A systematic review Stroke, v. 41
    Doi: http://doi.org/10.1161/STROKEAHA.110.581918
  • Barrick, TR., Charlton, RA., Clark, CA. and Markus, HS., 2010. White matter structural decline in normal ageing: A prospective longitudinal study using tract-based spatial statistics NeuroImage, v. 51
    Doi: http://doi.org/10.1016/j.neuroimage.2010.02.033
  • Groves, RW., Liu, L., Dopping-Hepenstal, PJ., Markus, HS., Lovell, PA., Ozoemena, L., Lai-Cheong, JE., Gawler, J., Owaribe, K., Hashimoto, T., Mellerio, JE., Mee, JB. and McGrath, JA., 2010. A homozygous nonsense mutation within the dystonin gene coding for the coiled-coil domain of the epithelial isoform of BPAG1 underlies a new subtype of autosomal recessive epidermolysis bullosa simplex Journal of Investigative Dermatology, v. 130
    Doi: http://doi.org/10.1038/jid.2010.19
  • Charlton, RA., Barrick, TR., Lawes, INC., Markus, HS. and Morris, RG., 2010. White matter pathways associated with working memory in normal aging Cortex, v. 46
    Doi: http://doi.org/10.1016/j.cortex.2009.07.005
  • Markus, HS., 2010. Genetics studies in ischaemic stroke Translational Stroke Research, v. 1
    Doi: http://doi.org/10.1007/s12975-010-0041-5
  • Adib-Samii, P., Brice, G., Martin, RJ. and Markus, HS., 2010. Clinical spectrum of CADASIL and the effect of cardiovascular risk factors on phenotype: Study in 200 consecutively recruited individuals Stroke, v. 41
    Doi: http://doi.org/10.1161/STROKEAHA.109.568402
  • Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2, , Strange, A., Capon, F., Spencer, CCA., Knight, J., Weale, ME., Allen, MH., Barton, A., Band, G., Bellenguez, C., Bergboer, JGM., Blackwell, JM., Bramon, E., Bumpstead, SJ., Casas, JP., Cork, MJ., Corvin, A., Deloukas, P., Dilthey, A., Duncanson, A., Edkins, S., Estivill, X., Fitzgerald, O., Freeman, C., Giardina, E., Gray, E., Hofer, A., Hüffmeier, U., Hunt, SE., Irvine, AD., Jankowski, J., Kirby, B., Langford, C., Lascorz, J., Leman, J., Leslie, S., Mallbris, L., Markus, HS., Mathew, CG., McLean, WHI., McManus, R., Mössner, R., Moutsianas, L., Naluai, AT., Nestle, FO., Novelli, G., Onoufriadis, A., Palmer, CNA., Perricone, C., Pirinen, M., Plomin, R., Potter, SC., Pujol, RM., Rautanen, A., Riveira-Munoz, E., Ryan, AW., Salmhofer, W., Samuelsson, L., Sawcer, SJ., Schalkwijk, J., Smith, CH., Ståhle, M., Su, Z., Tazi-Ahnini, R., Traupe, H., Viswanathan, AC., Warren, RB., Weger, W., Wolk, K., Wood, N., Worthington, J., Young, HS., Zeeuwen, PLJM., Hayday, A., Burden, AD., Griffiths, CEM., Kere, J., Reis, A., McVean, G., Evans, DM., Brown, MA., Barker, JN., Peltonen, L., Donnelly, P. and Trembath, RC., 2010. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet, v. 42
    Doi: http://doi.org/10.1038/ng.694
  • Lamar, M., Charlton, RA., Morris, RG. and Markus, HS., 2010. The Impact of Subcortical White Matter Disease on Mood in Euthymic Older Adults: A Diffusion Tensor Imaging Study AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, v. 18
    Doi: http://doi.org/10.1097/JGP.0b013e3181cabad1
  • Topakian, R., Barrick, TR., Howe, FA. and Markus, HS., 2010. Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis Journal of Neurology, Neurosurgery and Psychiatry, v. 81
    Doi: http://doi.org/10.1136/jnnp.2009.172072
  • Charlton, RA., Landau, S., Schiavone, F., Barrick, TR., Clark, CA., Markus, HS. and Morris, RG., 2010. Up the garden path: A critique of Penke and Deary and further exploration concerning the Charlton et al. path analysis relating loss of white matter integrity to cognition in normal aging Neurobiology of Aging, v. 31
    Doi: http://doi.org/10.1016/j.neurobiolaging.2009.12.011
  • Markus, HS., King, A., Shipley, M., Topakian, R., Cullinane, M., Reihill, S., Bornstein, NM. and Schaafsma, A., 2010. Asymptomatic embolisation for prediction of stroke in the Asymptomatic Carotid Emboli Study (ACES): a prospective observational study. Lancet Neurol, v. 9
    Doi: http://doi.org/10.1016/S1474-4422(10)70120-4
  • Charlton, RA., Barrick, TR., Markus, HS. and Morris, RG., 2010. The relationship between episodic long-term memory and white matter integrity in normal aging NEUROPSYCHOLOGIA, v. 48
    Doi: http://doi.org/10.1016/j.neuropsychologia.2009.08.018
  • 2009

  • Nitkunan, A., Charlton, RA., Barrick, TR., Mcintyre, DJO., Howe, FA. and Markus, HS., 2009. Reduced N-acetylaspartate is consistent with axonal dysfunction in cerebral small vessel disease NMR in Biomedicine, v. 22
    Doi: http://doi.org/10.1002/nbm.1322
  • Birns, J., Morris, R., Jarosz, J., Markus, HS. and Kalra, L., 2009. Hypertension-related cognitive decline: is the time right for intervention studies? Minerva Cardioangiol, v. 57
  • Hannesdottir, K., Nitkunan, A., Charlton, RA., Barrick, TR., MacGregor, GA. and Markus, HS., 2009. Cognitive impairment and white matter damage in hypertension: a pilot study. Acta Neurol Scand, v. 119
    Doi: http://doi.org/10.1111/j.1600-0404.2008.01098.x
  • Schiavone, F., Charlton, RA., Barrick, TR., Morris, RG. and Markus, HS., 2009. Imaging Age-Related Cognitive Decline: A Comparison of Diffusion Tensor and Magnetization Transfer MRI JOURNAL OF MAGNETIC RESONANCE IMAGING, v. 29
    Doi: http://doi.org/10.1002/jmri.21572
  • King, A. and Markus, HS., 2009. Doppler embolic signals in cerebrovascular disease and prediction of stroke risk: A systematic review and meta-analysis Stroke, v. 40
    Doi: http://doi.org/10.1161/STROKEAHA.109.563056
  • Khan, S., Rich, P., Clifton, A. and Markus, HS., 2009. Noninvasive detection of vertebral artery stenosis: A comparison of contrast-enhanced MR angiography, CT angiography, and ultrasound Stroke, v. 40
    Doi: http://doi.org/10.1161/STROKEAHA.109.556035
  • UK IBD Genetics Consortium, , Barrett, JC., Lee, JC., Lees, CW., Prescott, NJ., Anderson, CA., Phillips, A., Wesley, E., Parnell, K., Zhang, H., Drummond, H., Nimmo, ER., Massey, D., Blaszczyk, K., Elliott, T., Cotterill, L., Dallal, H., Lobo, AJ., Mowat, C., Sanderson, JD., Jewell, DP., Newman, WG., Edwards, C., Ahmad, T., Mansfield, JC., Satsangi, J., Parkes, M., Mathew, CG., Wellcome Trust Case Control Consortium 2, , Donnelly, P., Peltonen, L., Blackwell, JM., Bramon, E., Brown, MA., Casas, JP., Corvin, A., Craddock, N., Deloukas, P., Duncanson, A., Jankowski, J., Markus, HS., Mathew, CG., McCarthy, MI., Palmer, CNA., Plomin, R., Rautanen, A., Sawcer, SJ., Samani, N., Trembath, RC., Viswanathan, AC., Wood, N., Spencer, CCA., Barrett, JC., Bellenguez, C., Davison, D., Freeman, C., Strange, A., Donnelly, P., Langford, C., Hunt, SE., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, SJ., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, OT., Liddle, J., Perez, ML., Potter, SC., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S., Whittaker, P., Deloukas, P., Peltonen, L., Mathew, CG., Blackwell, JM., Brown, MA., Corvin, A., McCarthy, MI., Spencer, CCA., Attwood, AP., Stephens, J., Sambrook, J., Ouwehand, WH., McArdle, WL., Ring, SM. and Strachan, DP., 2009. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet, v. 41
    Doi: http://doi.org/10.1038/ng.483
  • Gudbjartsson, DF., Holm, H., Gretarsdottir, S., Thorleifsson, G., Walters, GB., Thorgeirsson, G., Gulcher, J., Mathiesen, EB., Njølstad, I., Nyrnes, A., Wilsgaard, T., Hald, EM., Hveem, K., Stoltenberg, C., Kucera, G., Stubblefield, T., Carter, S., Roden, D., Ng, MCY., Baum, L., So, WY., Wong, KS., Chan, JCN., Gieger, C., Wichmann, H-E., Gschwendtner, A., Dichgans, M., Kuhlenbäumer, G., Berger, K., Ringelstein, EB., Bevan, S., Markus, HS., Kostulas, K., Hillert, J., Sveinbjörnsdóttir, S., Valdimarsson, EM., Løchen, M-L., Ma, RCW., Darbar, D., Kong, A., Arnar, DO., Thorsteinsdottir, U. and Stefansson, K., 2009. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke Nature Genetics, v. 41
    Doi: 10.1038/ng.417
  • Gschwendtner, A., Bevan, S., Cole, JW., Plourde, A., Matarin, M., Ross-Adams, H., Meitinger, T., Wichmann, E., Mitchell, BD., Furie, K., Slowik, A., Rich, SS., Syme, PD., MacLeod, MJ., Meschia, JF., Rosand, J., Kittner, SJ., Markus, HS., Müller-Myhsok, B., Dichgans, M. and International Stroke Genetics Consortium, , 2009. Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke. Ann Neurol, v. 65
    Doi: http://doi.org/10.1002/ana.21590
  • Ederle, J., Bonati, LH., Dobson, J., Featherstone, RL., Gaines, PA., Beard, JD., Venables, GS., Markus, HS., Clifton, A., Sandercock, P. and Brown, MM., 2009. Endovascular treatment with angioplasty or stenting versus endarterectomy in patients with carotid artery stenosis in the Carotid And Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial The Lancet Neurology, v. 8
    Doi: http://doi.org/10.1016/S1474-4422(09)70228-5
  • Bevan, S., Lorenz, MW., Sitzer, M. and Markus, HS., 2009. Genetic Variation in the Leukotriene Pathway and Carotid Intima-Media Thickness Stroke, v. 40
    Doi: 10.1161/strokeaha.108.525733
  • Markus, H., 2009. The Asymptomatic carotid emboli study: Study design and baseline results International Journal of Stroke, v. 4
    Doi: http://doi.org/10.1111/j.1747-4949.2009.00339.x
  • Birns, J., Jarosz, J., Markus, HS. and Kalra, L., 2009. Cerebrovascular reactivity and dynamic autoregulation in ischaemic subcortical white matter disease Journal of Neurology, Neurosurgery and Psychiatry, v. 80
    Doi: http://doi.org/10.1136/jnnp.2009.174607
  • Bonati, LH., Ederle, J., McCabe, DJ., Dobson, J., Featherstone, RL., Gaines, PA., Beard, JD., Venables, GS., Markus, HS., Clifton, A., Sandercock, P. and Brown, MM., 2009. Long-term risk of carotid restenosis in patients randomly assigned to endovascular treatment or endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS): long-term follow-up of a randomised trial The Lancet Neurology, v. 8
    Doi: http://doi.org/10.1016/S1474-4422(09)70227-3
  • Freilinger, T., Bevan, S., Ripke, S., Gschwendtner, A., Lichtner, P., Müller-Myhsok, B., Wichmann, H-E., Markus, HS., Meitinger, T. and Dichgans, M., 2009. Genetic variation in the lymphotoxin-alpha pathway and the risk of ischemic stroke in European populations. Stroke, v. 40
    Doi: http://doi.org/10.1161/STROKEAHA.107.510800
  • Gulli, G., Khan, S. and Markus, HS., 2009. Vertebrobasilar stenosis predicts high early recurrent stroke risk in posterior circulation stroke and TIA Stroke, v. 40
    Doi: http://doi.org/10.1161/STROKEAHA.109.553859
  • Debette, S. and Markus, HS., 2009. The genetics of cervical artery dissection: A systematic review Stroke, v. 40
    Doi: http://doi.org/10.1161/STROKEAHA.108.534669
  • Debette, S., Metso, TM., Pezzini, A., Engelter, ST., Leys, D., Lyrer, P., Metso, AJ., Brandt, T., Kloss, M., Lichy, C., Hausser, I., Touzé, E., Markus, HS., Abboud, S., Caso, V., Bersano, A., Grau, A., Altintas, A., Amouyel, P., Tatlisumak, T., Dallongeville, J., Grond-Ginsbach, C., Pandolfo, M., Thijs, V., Metso, M., Tatlisumak, T., Bodenant, M., Leys, D., Ossou, P., Louillet, F., Mas, JL., Leder, S., Léger, A., Deltour, S., Crozier, S., Méresse, I., Samson, Y., Canaple, S., Godefroy, O., Lamy, C., Béjot, Y., Giroud, M., Decavel, P., Medeiros, E., Montiel, P., Moulin, T., Vuillier, F., Fievet, N., Bellengier, L., Deplanque, D., Libersa, C., Schilling, S., Montel, S., Rémy, C., Wiest, T., Werner, I., Arnold, ML., Dos Santos, M., Dichgans, M., Brandt, T., Thomas-Feles, C., Weber, R., Del Zotto, E., Giossi, A., Padovani, A., Ballabio, E., Beretta, S., Ferrarese, C., Sessa, M., Paolucci, S., Engelter, S., Fluri, F., Hatz, F., Gisler, D., Tiemessen, A. and Martin, JJ., 2009. CADISP-genetics: An International project searching for genetic risk factors of cervical artery dissections International Journal of Stroke, v. 4
    Doi: 10.1111/j.1747-4949.2009.00281.x
  • Charlton, RA., Barrick, TR., Markus, HS. and Morris, RG., 2009. Theory of Mind Associations With Other Cognitive Functions and Brain Imaging in Normal Aging PSYCHOLOGY AND AGING, v. 24
    Doi: http://doi.org/10.1037/a0015225
  • Debette, S., Bevan, S., Dartigues, JF., Sitzer, M., Lorenz, M., Ducimetière, P., Amouyel, P. and Markus, HS., 2009. Fractalkine receptor/ligand genetic variants and carotid intima-media thickness Stroke, v. 40
    Doi: http://doi.org/10.1161/STROKEAHA.108.537159
  • Birns, J., Morris, R., Jarosz, J., Markus, H. and Kalra, L., 2009. The structural and functional consequences of diurnal variations in blood pressure in treated patients with hypertensive cerebrovascular disease Journal of Hypertension, v. 27
    Doi: http://doi.org/10.1097/HJH.0b013e32832810d5
  • 2008

  • Markus, HS., 2008. Genes, endothelial function and cerebral small vessel disease in man Experimental Physiology, v. 93
    Doi: http://doi.org/10.1113/expphysiol.2007.038752
  • Kerry, S., Markus, H., Khong, T., Doshi, R., Conroy, R. and Oakeshott, P., 2008. Community based trial of home blood pressure monitoring with nurse-led telephone support in patients with stroke or transient ischaemic attack recently discharged from hospital Trials, v. 9
    Doi: http://doi.org/10.1186/1745-6215-9-15
  • Hainsworth, AH. and Markus, HS., 2008. Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review Journal of Cerebral Blood Flow and Metabolism, v. 28
    Doi: http://doi.org/10.1038/jcbfm.2008.91
  • Khan, U., Crossley, C., Kalra, L., Rudd, A., Wolfe, CDA., Collinson, P. and Markus, HS., 2008. Homocysteine and Its Relationship to Stroke Subtypes in a UK Black Population The South London Ethnicity and Stroke Study STROKE, v. 39
    Doi: http://doi.org/10.1161/STROKEAHA.107.513416
  • Markus, H., 2008. Small vessel versus large vessel vascular dementia: Risk factors and MRI findings Journal of Neurology, v. 255
    Doi: http://doi.org/10.1007/s00415-008-0946-z
  • Charlton, RA., Landau, S., Schiavone, F., Barrick, TR., Clark, CA., Markus, HS. and Morris, RG., 2008. A structural equation modeling investigation of age-related variance in executive function and DTI measured white matter damage Neurobiology of Aging, v. 29
    Doi: http://doi.org/10.1016/j.neurobiolaging.2007.03.017
  • Markus, H., 2008. Stroke: causes and clinical features Medicine, v. 36
    Doi: http://doi.org/10.1016/j.mpmed.2008.08.009
  • Menon, R., Kerry, S., Norris, JW. and Markus, HS., 2008. Treatment of cervical artery dissection: A systematic review and meta-analysis Journal of Neurology, Neurosurgery and Psychiatry, v. 79
    Doi: http://doi.org/10.1136/jnnp.2007.138800
  • Bevan, S., Dichgans, M., Gschwendtner, A., Kuhlenbäumer, G., Ringelstein, EB. and Markus, HS., 2008. Variation in the PDE4D Gene and Ischemic Stroke Risk Stroke, v. 39
    Doi: 10.1161/strokeaha.107.509992
  • Gretarsdottir, S., Thorleifsson, G., Manolescu, A., Styrkarsdottir, U., Helgadottir, A., Gschwendtner, A., Kostulas, K., Kuhlenbäumer, G., Bevan, S., Jonsdottir, T., Bjarnason, H., Saemundsdottir, J., Palsson, S., Arnar, DO., Holm, H., Thorgeirsson, G., Valdimarsson, EM., Sveinbjörnsdottir, S., Gieger, C., Berger, K., Wichmann, HE., Hillert, J., Markus, H., Gulcher, JR., Ringelstein, EB., Kong, A., Dichgans, M., Gudbjartsson, DF., Thorsteinsdottir, U. and Stefansson, K., 2008. Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke Annals of Neurology, v. 64
    Doi: http://doi.org/10.1002/ana.21480
  • Bevan, S., Dichgans, M., Wiechmann, HE., Gschwendtner, A., Meitinger, T. and Markus, HS., 2008. Genetic Variation in Members of the Leukotriene Biosynthesis Pathway Confer an Increased Risk of Ischemic Stroke Stroke, v. 39
    Doi: 10.1161/strokeaha.107.491969
  • Nitkunan, A., Barrick, TR., Charlton, RA., Clark, CA. and Markus, HS., 2008. Multimodal MRI in cerebral small vessel disease: Its relationship with cognition and sensitivity to change over time Stroke, v. 39
    Doi: http://doi.org/10.1161/STROKEAHA.107.507475
  • Menon, RK., Markus, HS. and Norris, JW., 2008. Results of a UK questionnaire of diagnosis and treatment in cervical artery dissection Journal of Neurology, Neurosurgery and Psychiatry, v. 79
    Doi: http://doi.org/10.1136/jnnp.2007.127639
  • Dichgans, M., Markus, HS., Salloway, S., Verkkoniemi, A., Moline, M., Wang, Q., Posner, H. and Chabriat, HS., 2008. Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL The Lancet Neurology, v. 7
    Doi: http://doi.org/10.1016/S1474-4422(08)70046-2
  • Nitkunan, A., Charlton, RA., McIntyre, DJO., Barrick, TR., Howe, FA. and Markus, HS., 2008. Diffusion tensor imaging and MR spectroscopy in hypertension and presumed cerebral small vessel disease Magnetic Resonance in Medicine, v. 59
    Doi: http://doi.org/10.1002/mrm.21461
  • Birns, J., Morris, R., Jarosz, J., Markus, H. and Kalra, L., 2008. Ethnic differences in the cerebrovascular impact of hypertension. Cerebrovasc Dis, v. 25
    Doi: http://doi.org/10.1159/000121341
  • 2007

  • Labrum, R., Bevan, S., Sitzer, M., Lorenz, M. and Markus, HS., 2007. Toll receptor polymorphisms and carotid artery intima-media thickness Stroke, v. 38
    Doi: http://doi.org/10.1161/01.STR.0000260184.85257.2b
  • Dikos, G., Marcus, HS. and Papadatos, MP., 2007. Old ideas may still be new: A system identification approach to tanker freight modelling Systems Research and Behavioral Science, v. 24
    Doi: http://doi.org/10.1002/sres.787
  • Nowell, J., Wilton, E., Markus, H. and Jahangiri, M., 2007. Antithrombotic therapy following bioprosthetic aortic valve replacement European Journal of Cardio-thoracic Surgery, v. 31
    Doi: http://doi.org/10.1016/j.ejcts.2006.12.017
  • Rangi, PS., Markus, HS., Punter, MNM. and Clifton, A., 2007. The use of intraoperative monitoring and treatment of symptomatic microemboli in carotid artery stenting: case report and discussion NEURORADIOLOGY, v. 49
    Doi: http://doi.org/10.1007/s00234-006-0172-2
  • Khan, U., Hassan, A., Vallance, P. and Markus, HS., 2007. Asymmetric dimethylarginine in cerebral small vessel disease Stroke, v. 38
    Doi: http://doi.org/10.1161/01.STR.0000254500.27412.ac
  • Motallebzadeh, R., Bland, JM., Markus, HS., Kaski, JC. and Jahangiri, M., 2007. Neurocognitive function and cerebral emboli: randomized study of on-pump versus off-pump coronary artery bypass surgery. Ann Thorac Surg, v. 83
    Doi: http://doi.org/10.1016/j.athoracsur.2006.09.024
  • Markus, HS., Khan, U., Birns, J., Evans, A., Kalra, L., Rudd, AG., Wolfe, CDA. and Jerrard-Dunne, P., 2007. Differences in stroke subtypes between black and white patients with stroke - The south London ethnicity and stroke study CIRCULATION, v. 116
    Doi: http://doi.org/10.1161/CIRCULATIONAHA.107.699785
  • Khan, S., Cloud, GC., Kerry, S. and Markus, HS., 2007. Imaging of vertebral artery stenosis: A systematic review Journal of Neurology, Neurosurgery and Psychiatry, v. 78
    Doi: http://doi.org/10.1136/jnnp.2006.111716
  • Armstrong, C., Abilleira, S., Sitzer, M., Markus, HS. and Bevan, S., 2007. Polymorphisms in MMP family and TIMP genes and carotid artery intima-media thickness Stroke, v. 38
    Doi: http://doi.org/10.1161/STROKEAHA.107.491696
  • Lorenz, MW., Markus, HS., Bots, ML., Rosvall, M. and Sitzer, M., 2007. Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and meta-analysis Circulation, v. 115
    Doi: http://doi.org/10.1161/CIRCULATIONAHA.106.628875
  • Markus, H., 2007. Antiplatelet therapy vs. anticoagulation in cervical artery dissection; Rationale and design of the Cervical Artery Dissection in Stroke Study (CADISS) International Journal of Stroke, v. 2
    Doi: http://doi.org/10.1111/j.1747-4949.2007.00165.x
  • Gormley, K., Bevan, S. and Markus, HS., 2007. Polymorphisms in genes of the renin-angiotensin system and cerebral small vessel disease Cerebrovascular Diseases, v. 23
    Doi: http://doi.org/10.1159/000097052
  • Markus, HS., 2007. Mild cognitive impairment after lacunar infarction: Voxel-based morphometry and neuropsychological assessment Cerebrovascular Diseases, v. 23
    Doi: http://doi.org/10.1159/000099129
  • Khan, U., Bevan, S. and Markus, HS., 2007. NADPH oxidase polymorphisms in cerebral small vessel disease Cerebrovascular Diseases, v. 24
    Doi: http://doi.org/10.1159/000103615
  • Lorenz, MW., Sitzer, M., Markus, HS., Bots, ML. and Rosvall, M., 2007. Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and meta-analysis - Response CIRCULATION, v. 116
    Doi: http://doi.org/10.1161/CIRCULATIONAHA.107.707067
  • Markus, H., 2007. Improving the outcome of stroke - UK needs to reorganise services to follow the example of other countries BRITISH MEDICAL JOURNAL, v. 335
    Doi: http://doi.org/10.1136/bmj.39296.711563.AD
  • McIntyre, DJO., Charlton, RA., Markus, HS. and Howe, FA., 2007. Long and short echo time proton magnetic resonance spectroscopic imaging of the healthy aging brain Journal of Magnetic Resonance Imaging, v. 26
    Doi: http://doi.org/10.1002/jmri.21198
  • Charlton, RA., McIntyre, DJO., Howe, FA., Morris, RG. and Markus, HS., 2007. The relationship between white matter brain metabolites and cognition in normal aging: The GENIE study BRAIN RESEARCH, v. 1164
    Doi: http://doi.org/10.1016/j.brainres.2007.06.027
  • Khan, U. and Markus, HS., 2007. Asymmetric dimethylarginine and hypertension in cerebral small vessel disease - Response to letter by Tsuda STROKE, v. 38
    Doi: http://doi.org/10.1161/STROKEAHA.107.487603
  • Khan, U., Porteous, L., Hassan, A. and Markus, HS., 2007. Risk factor profile of cerebral small vessel disease and its subtypes Journal of Neurology, Neurosurgery and Psychiatry, v. 78
    Doi: http://doi.org/10.1136/jnnp.2006.103549
  • Lorenz, MW., Karbstein, P., Markus, HS. and Sitzer, M., 2007. High-sensitivity C-reactive protein is not associated with carotid intima-media progression - The carotid atherosclerosis progression study STROKE, v. 38
    Doi: http://doi.org/10.1161/STROKEAHA.106.476135
  • Markus, HS., 2007. Genetics: What is relevant for the stroke physician? International Journal of Stroke, v. 2
    Doi: http://doi.org/10.1111/j.1747-4949.2007.00110.x
  • 2006

  • Charlton, RA., Morris, RG., Nitkunan, A. and Markus, HS., 2006. The cognitive profiles of CADASIL and sporadic small vessel disease NEUROLOGY, v. 66
    Doi: http://doi.org/10.1212/01.wnl.0000216270.02610.7e
  • Markus, HS., 2006. Can microemboli on transcranial Doppler identify patients at increased stroke risk? Commentary Nature Clinical Practice Cardiovascular Medicine, v. 3
    Doi: http://doi.org/10.1038/ncpcardio0533
  • Dikos, G., Marcus, HS., Papadatos, MP. and Papakonstantinou, V., 2006. Niver lines: A system-dynamics approach to tanker freight modeling Interfaces, v. 36
    Doi: http://doi.org/10.1287/inte.1060.0218
  • Dittrich, R., Ritter, MA., Kaps, M., Siebler, M., Lees, K., Larrue, V., Nabavi, DG., Ringelstein, EB., Markus, HS. and Droste, DW., 2006. The use of embolic signal detection in multicenter trials to evaluate antiplatelet efficacy: Signal analysis and quality control mechanisms in the CARESS (Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic carotid Stenosis) trial Stroke, v. 37
    Doi: http://doi.org/10.1161/01.STR.0000209331.39894.3d
  • Armstrong, CA., Bevan, SN., Gormley, KT., Markus, HS. and Koblar, SA., 2006. Tissue plasminogen activator -7351C/T polymorphism and lacunar stroke [1] Stroke, v. 37
    Doi: http://doi.org/10.1161/01.STR.0000199663.64894.4f
  • Motallebzadeh, R., Bland, JM., Markus, HS., Kaski, JC. and Jahangiri, M., 2006. Health-related quality of life outcome after on-pump versus off-pump coronary artery bypass graft surgery: a prospective randomized study. Ann Thorac Surg, v. 82
    Doi: http://doi.org/10.1016/j.athoracsur.2006.03.081
  • Markus, HS. and Alberts, MJ., 2006. Update on genetics of stroke and cerebrovascular disease 2005. Stroke, v. 37
    Doi: http://doi.org/10.1161/01.STR.0000200449.58684.8a
  • Markus, HS. and Punter, M., 2006. Embolus detection and differentiation using multifrequency transcranial Doppler - Response STROKE, v. 37
  • Charlton, RA., Barrick, TR., McIntyre, DJ., Shen, Y., O'Sullivan, M., Howe, FA., Clark, CA., Morris, RG. and Markus, HS., 2006. White matter damage on diffusion tensor imaging correlates with age-related cognitive decline Neurology, v. 66
    Doi: http://doi.org/10.1212/01.wnl.0000194256.15247.83
  • Lorenz, MW., von Kegler, S., Steinmetz, H., Markus, HS. and Sitzer, M., 2006. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke, v. 37
    Doi: http://doi.org/10.1161/01.STR.0000196964.24024.ea
  • Masdeu, JC., Irimia, P., Asenbaum, S., Bogousslavsky, J., Brainin, M., Chabriat, H., Herholz, K., Markus, HS., Martínez-Vila, E., Niederkorn, K., Schellinger, PD. and Seitz, RJ., 2006. EFNS guideline on neuroimaging in acute stroke. Report of an EFNS task force European Journal of Neurology, v. 13
    Doi: http://doi.org/10.1111/j.1468-1331.2006.01507.x
  • Abilleira, S., Bevan, S. and Markus, HS., 2006. The role of genetic variants of matrix metalloproteinases in coronary and carotid atherosclerosis Journal of Medical Genetics, v. 43
    Doi: http://doi.org/10.1136/jmg.2006.040808
  • Markus, HS., Labrum, R., Bevan, S., Reindl, M., Egger, G., Wiedermann, CJ., Xu, Q., Kiechl, S. and Willeit, J., 2006. Genetic and acquired inflammatory conditions are synergistically associated with early carotid atherosclerosis Stroke, v. 37
    Doi: http://doi.org/10.1161/01.STR.0000236637.72124.3f
  • Lee, J-M. and Markus, HS., 2006. Does the white matter matter in Alzheimer disease and cerebral amyloid angiopathy? Neurology, v. 66
    Doi: http://doi.org/10.1212/01.wnl.0000196863.43951.44
  • Nitkunan, A., McIntyre, DJO., Barrick, TR., O'Sullivan, M., Shen, Y., Clark, CA., Howe, FA. and Markus, HS., 2006. Correlations between MRS and DTI in cerebral small vessel disease NMR in Biomedicine, v. 19
    Doi: http://doi.org/10.1002/nbm.1052
  • 2005

  • Gormley, K., Bevan, S., Hassan, A. and Markus, HS., 2005. Polymorphisms in genes of the endothelin system and cerebral small-vessel disease Stroke, v. 36
    Doi: http://doi.org/10.1161/01.STR.0000173173.38289.69
  • Hassan, A. and Markus, HS., 2005. Practicalities of genetic studies in human stroke. Methods in molecular medicine, v. 104
  • Mackinnon, AD., Aaslid, R. and Markus, HS., 2005. Ambulatory transcranial Doppler cerebral embolic signal detection in symptomatic and asymptomatic carotid stenosis STROKE, v. 36
    Doi: http://doi.org/10.1161/01.STR.0000173402.88560.ae
  • O'Sullivan, M., Morris, RG. and Markus, HS., 2005. Brief cognitive assessment for patients with cerebral small vessel disease Journal of Neurology, Neurosurgery and Psychiatry, v. 76
    Doi: http://doi.org/10.1136/jnnp.2004.045963
  • Bess, HD., Marcus, HS. and Valdez, ME., 2005. Government transportation statistics: Use with caution: A research note TRANSPORTATION JOURNAL, v. 44
  • Markus, HS. and Punter, M., 2005. Can transcranial Doppler discriminate between solid and gaseous microemboli? Assessment of a dual-frequency transducer system Stroke, v. 36
    Doi: http://doi.org/10.1161/01.STR.0000173399.20127.b3
  • Markus, HS., Hunt, B., Palmer, K., Enzinger, C., Schmidt, H. and Schmidt, R., 2005. Markers of endothelial and hemostatic activation and progression of cerebral white matter hyperintensities: Longitudinal results of the Austrian Stroke Prevention Study Stroke, v. 36
    Doi: http://doi.org/10.1161/01.STR.0000169924.60783.d4
  • Markus, HS., Droste, DW., Ringelstein, EB., Kaps, M., Larrue, V., Lees, KR. and Siebler, M., 2005. Response [3] Circulation, v. 112
    Doi: http://doi.org/10.1161/CIRCULATION.AHA.105.560755
  • Birns, J., Markus, H. and Kalra, L., 2005. Blood pressure reduction for vascular risk: Is there a price to be paid? Stroke, v. 36
    Doi: http://doi.org/10.1161/01.STR.0000165901.38039.5f
  • Markus, HS., Droste, DW., Kaps, M., Larrue, V., Lees, KR., Siebler, M. and Ringelstein, EB., 2005. Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: The clopidogrel and aspirin for reduction of emboli in symptomatic carotid stenosis (CARESS) trial Circulation, v. 111
    Doi: http://doi.org/10.1161/01.CIR.0000163561.90680.1C
  • Bevan, S., Porteous, L., Sitzer, M. and Markus, HS., 2005. Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis Stroke, v. 36
    Doi: http://doi.org/10.1161/01.STR.0000162713.06519.41
  • Markus, HS. and MacKinnon, A., 2005. Asymptomatic embolization detected by Doppler ultrasound predicts stroke risk in symptomatic carotid artery stenosis Stroke, v. 36
    Doi: http://doi.org/10.1161/01.STR.0000162717.62684.40
  • O'Sullivan, M., Barrick, TR., Morris, RG., Clark, CA. and Markus, HS., 2005. Damage within a network of white matter regions underlies executive dysfunction in CADASIL Neurology, v. 65
    Doi: http://doi.org/10.1212/01.wnl.0000184480.07394.fb
  • Pomeroy, VM., Clark, CA., Miller, JSG., Baron, JC., Markus, HS. and Tallis, RC., 2005. The potential for utilizing the "mirror neurone system" to enhance recovery of the severely affected upper limb early after stroke: A review and hypothesis NEUROREHABILITATION AND NEURAL REPAIR, v. 19
    Doi: http://doi.org/10.1177/1545968304274351
  • Markus, HS., Droste, DW., Droste, DW., Ringelstein, EB., Kaps, M., Larrue, V., Lees, KR. and Siebler, M., 2005. id stenosis (CARESS) Trial" - To the editor - Response ... CIRCULATION, v. 112
  • Markus, HS., 2005. Current treatments in neurology: Stroke Journal of Neurology, v. 252
    Doi: http://doi.org/10.1007/s00415-005-0736-9
  • Singhal, S., Rich, P. and Markus, HS., 2005. The spatial distribution of MR imaging abnormalities in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy and their relationship to age and clinical features American Journal of Neuroradiology, v. 26
  • Singhal, S. and Markus, HS., 2005. Cerebrovascular reactivity and dynamic autoregulation in nondemented patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) Journal of Neurology, v. 252
    Doi: http://doi.org/10.1007/s00415-005-0624-3
  • Markus, HS. and MacKinnon, A., 2005. Transcranial doppler and carotid artery disease strokes: More than just risk stratification - Response STROKE, v. 36
  • Dichgans, M. and Markus, HS., 2005. Genetic association studies in stroke: Methodological issues and proposed standard criteria Stroke, v. 36
    Doi: http://doi.org/10.1161/01.STR.0000177498.21594.9e
  • 2004

  • Sidhu, JS., Kaposzta, Z., Markus, HS. and Kaski, JC., 2004. Effect of Rosiglitazone on Common Carotid Intima-Media Thickness Progression in Coronary Artery Disease Patients Without Diabetes Mellitus Arteriosclerosis, Thrombosis, and Vascular Biology, v. 24
    Doi: http://doi.org/10.1161/01.ATV.0000124890.40436.77
  • Marvasti, S., Gillies, D., Marvasti, F. and Markus, HS., 2004. Online automated detection of cerebral embolic signals using a wavelet-based system ULTRASOUND IN MEDICINE AND BIOLOGY, v. 30
    Doi: http://doi.org/10.1016/j.ultrasmedbio.2004.03.009
  • Hussain, MB., Singhal, S., Markus, HS. and Singer, DRJ., 2004. Abnormal Vasoconstrictor Responses to Angiotensin II and Noradrenaline in Isolated Small Arteries from Patients with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) Stroke, v. 35
    Doi: http://doi.org/10.1161/01.STR.0000120730.54282.A0
  • Markus, HS., 2004. Variations in care and outcome in the first year after stroke: A Western and Central European perspective Journal of Neurology, Neurosurgery and Psychiatry, v. 75
    Doi: http://doi.org/10.1136/jnnp.2004.048157
  • Cloud, GC. and Markus, HS., 2004. Vertebral artery stenosis Current Treatment Options in Cardiovascular Medicine, v. 6
    Doi: http://doi.org/10.1007/s11936-004-0040-5
  • O'Sullivan, M., Singhal, S., Charlton, R. and Markus, HS., 2004. Diffusion tensor imaging of thalamus correlates with cognition in CADASIL without dementia Neurology, v. 62
    Doi: http://doi.org/10.1212/01.WNL.0000113760.72706.D2
  • Jerrard-Dunne, P., Sitzer, M., Risley, P., Buehler, A., Von Kegler, S. and Markus, HS., 2004. Inflammatory gene load is associated with enhanced inflammation and early carotid atherosclerosis in smokers Stroke, v. 35
    Doi: http://doi.org/10.1161/01.STR.0000144681.46696.b3
  • O'Sullivan, M., Morris, RG., Huckstep, B., Jones, DK., Williams, SCR. and Markus, HS., 2004. Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis Journal of Neurology, Neurosurgery and Psychiatry, v. 75
    Doi: http://doi.org/10.1136/jnnp.2003.014910
  • Singhal, S., Bevan, S., Barrick, T., Rich, P. and Markus, HS., 2004. The influence of genetic and cardiovascular risk factors on the CADASIL phenotype Brain, v. 127
    Doi: http://doi.org/10.1093/brain/awh223
  • Markus, HS., 2004. Cerebral perfusion and stroke Journal of Neurology, Neurosurgery and Psychiatry, v. 75
    Doi: http://doi.org/10.1136/jnnp.2003.025825
  • Mackinnon, AD., Jerrard-Dunne, P., Sitzer, M., Buehler, A., Von Kegler, S. and Markus, HS., 2004. Rates and determinants of site-specific progression of carotid artery intima-media thickness: The carotid atherosclerosis progression study Stroke, v. 35
    Doi: http://doi.org/10.1161/01.STR.0000136720.21095.f3
  • Hassan, A., Gormley, K., O'Sullivan, M., Knight, J., Sham, P., Vallance, P., Bamford, J. and Markus, H., 2004. Endothelial Nitric Oxide Gene Haplotypes and Risk of Cerebral Small-Vessel Disease Stroke, v. 35
    Doi: http://doi.org/10.1161/01.STR.0000117238.75736.53
  • Markus, H., 2004. Genes for stroke Journal of Neurology, Neurosurgery and Psychiatry, v. 75
    Doi: http://doi.org/10.1136/jnnp.2004.036202
  • Mackinnon, AD., Aaslid, R. and Markus, HS., 2004. Long-Term Ambulatory Monitoring for Cerebral Emboli Using Transcranial Doppler Ultrasound Stroke, v. 35
    Doi: http://doi.org/10.1161/01.STR.0000106915.83041.0A
  • Schmidt, R., Scheltens, P., Erkinjuntti, T., Pantoni, L., Markus, HS., Wallin, A., Barkhof, F. and Fazekas, F., 2004. White matter lesion progression: A surrogate endpoint for trials in cerebral small-vessel disease Neurology, v. 63
    Doi: http://doi.org/10.1212/01.WNL.0000132635.75819.E5
  • Hassan, A., Hunt, BJ., O'Sullivan, M., Bell, R., D'Souza, R., Jeffery, S., Bamford, JM. and Markus, HS., 2004. Homocysteine is a risk factor for cerebral small vessel disease, acting via endothelial dysfunction Brain, v. 127
    Doi: http://doi.org/10.1093/brain/awh023
  • Aydin, N., Marvasti, F. and Markus, HS., 2004. Embolic Doppler ultrasound signal detection using discrete wavelet transform IEEE Transactions on Information Technology in Biomedicine, v. 8
    Doi: http://doi.org/10.1109/TITB.2004.828882
  • 2003

  • Jerrard-Dunne, P., Cloud, G., Hassan, A. and Markus, HS., 2003. Evaluating the genetic component of ischemic stroke subtypes: A family history study Stroke, v. 34
    Doi: http://doi.org/10.1161/01.STR.0000069723.17984.FD
  • Markus, H., 2003. Acute stroke International Psychogeriatrics, v. 15
    Doi: http://doi.org/10.1017/S104161020300913X
  • Cloud, GC., Crawley, F., Clifton, A., McCabe, DJH., Brown, MM. and Markus, HS., 2003. Vertebral artery origin angioplasty and primary stenting: Safety and restenosis rates in a prospective series Journal of Neurology Neurosurgery and Psychiatry, v. 74
    Doi: http://doi.org/10.1136/jnnp.74.5.586
  • Sitzer, M., Puac, D., Buehler, A., Steckel, DA., Von Kegler, S., Markus, HS. and Steinmetz, H., 2003. Internal carotid artery angle of origin: A novel risk factor for early carotid atherosclerosis Stroke, v. 34
    Doi: http://doi.org/10.1161/01.STR.0000060895.38298.C4
  • Risley, P., Jerrard-Dunne, P., Sitzer, M., Buehler, A., Von Kegler, S. and Markus, HS., 2003. Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: The Carotid Atherosclerosis Progression Study (CAPS) Stroke, v. 34
    Doi: http://doi.org/10.1161/01.STR.0000055941.61801.5A
  • Hassan, A., Hunt, BJ., O'Sullivan, M., Parmar, K., Bamford, JM., Briley, D., Brown, MM., Thomas, DJ. and Markus, HS., 2003. Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis Brain, v. 126
    Doi: http://doi.org/10.1093/brain/awg040
  • Jerrard-Dunne, P., Sitzer, M., Risley, P., Steckel, DA., Buehler, A., Von Kegler, S. and Markus, HS., 2003. Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: The carotid atherosclerosis progression study (CAPS) Stroke, v. 34
    Doi: http://doi.org/10.1161/01.STR.0000053849.09308.B2
  • Schon, F., Martin, RJ., Prevett, M., Clough, C., Enevoldson, TP. and Markus, HS., 2003. "CADASIL coma": an underdiagnosed acute encephalopathy JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 74
    Doi: http://doi.org/10.1136/jnnp.74.2.249
  • Jerrard-Dunne, P., Markus, HS., Steckel, DA., Buehler, A., von Kegler, S. and Sitzer, M., 2003. Early carotid atherosclerosis and family history of vascular disease: specific effects on arterial sites have implications for genetic studies. Arterioscler Thromb Vasc Biol, v. 23
  • Jerrard-Dunne, P., Evans, A., McGovern, R., Hajat, C., Kalra, L., Rudd, AG., Wolfe, CD. and Markus, HS., 2003. Ethnic differences in markers of thrombophilia implications for the investigation of ischemic stroke in multiethnic populations: The south London ethnicity and stroke study Stroke, v. 34
    Doi: http://doi.org/10.1161/01.STR.0000083049.65008.5F
  • Cloud, GC., Rich, PM. and Markus, HS., 2003. Serial MRI of a mycotic aneurysm of the cavernous carotid artery Neuroradiology, v. 45
    Doi: http://doi.org/10.1007/s00234-003-1021-1
  • Dong, Y., Hassan, A., Zhang, Z., Huber, D., Dalageorgou, C. and Markus, HS., 2003. Yield of screening for CADASIL mutations in lacunar stroke and leukoaraiosis Stroke, v. 34
    Doi: http://doi.org/10.1161/01.STR.0000048162.16852.88
  • O'Sullivan, M., Rich, PM., Barrick, TR., Clark, CA. and Markus, HS., 2003. Frequency of subclinical lacunar infarcts in ischemic leukoaraiosis and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy American Journal of Neuroradiology, v. 24
  • Cloud, GC. and Markus, HS., 2003. Diagnosis and management of vertebral artery stenosis QJM: An International Journal of Medicine, v. 96
    Doi: 10.1093/qjmed/hcg003
  • Cloud, GC. and Markus, HS., 2003. Diagnosis and management of vertebral artery stenosis. QJM, v. 96
  • 2002

  • Kaposzta, Z., Clifton, A., Molloy, J., Martin, JF. and Markus, HS., 2002. <i>S</i>-nitrosoglutathione reduces asymptomatic embolization after carotid angioplasty CIRCULATION, v. 106
    Doi: 10.1161/01.CIR.0000041251.07332.28
  • Markus, HS., Martin, RJ., Simpson, MA., Dong, YB., Ali, N., Crosby, AH. and Powell, JF., 2002. Diagnostic strategies in CADASIL NEUROLOGY, v. 59
    Doi: http://doi.org/10.1212/WNL.59.8.1134
  • Cullinane, M., Kaposzta, Z., Reihill, S. and Markus, HS., 2002. Online automated detection of cerebral embolic signals from a variety of embolic sources Ultrasound in Medicine and Biology, v. 28
    Doi: http://doi.org/10.1016/S0301-5629(02)00615-4
  • O'Sullivan, M., Lythgoe, DJ., Pereira, AC., Summers, PE., Jarosz, JM., Williams, SCR. and Markus, HS., 2002. Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis NEUROLOGY, v. 59
    Doi: http://doi.org/10.1212/WNL.59.3.321
  • O Sullivan, M., Rich, PM., Barrick, TR., Clark, CA. and Markus, HS., 2002. Detection of asymptomatic lacunar infarcts with diffusion weighted MRI: A potential surrogate marker of disease activity in ischaemic leukoaraiosis and CADASIL JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 73
  • Tinkler, K., Cullinane, M., Kaposzta, Z. and Markus, HS., 2002. Asymptomatic embolisation in non-valvular atrial fibrillation and its relationship to anticoagulation therapy European Journal of Ultrasound, v. 15
    Doi: http://doi.org/10.1016/S0929-8266(01)00169-0
  • Hassan, A., Sham, PC. and Markus, HS., 2002. Planning genetic studies in human stroke: Sample size estimates based on family history data Neurology, v. 58
    Doi: http://doi.org/10.1212/WNL.58.10.1483
  • Sitzer, M., Markus, HS., Mendall, MA., Liehr, R., Knorr, U. and Steinmetz, H., 2002. C-reactive protein and carotid intimal medial thickness in a community population. J Cardiovasc Risk, v. 9
  • Kaposzta, Z., Martin, JF. and Markus, HS., 2002. Switching off embolization from symptomatic carotid plaque using S-nitrosoglutathione Circulation, v. 105
    Doi: http://doi.org/10.1161/01.CIR.0000012347.47001.97
  • Markus, HS., Risley, P., Mendall, MA., Steinmetz, H. and Sitzer, M., 2002. Helicobacter pylori infection, the cytotoxin gene A strain, and carotid artery intima-media thickness European Journal of Cardiovascular Prevention &amp; Rehabilitation, v. 9
    Doi: http://doi.org/10.1177/174182670200900101
  • 2001

  • Hassan, A., Ali, N., Dong, Y., Carter, ND. and Markus, HS., 2001. Atrial natriuretic peptide gene G664A polymorphism and the risk of ischemic cerebrovascular disease Neurology, v. 57
    Doi: http://doi.org/10.1212/WNL.57.9.1726
  • Aydin, N., Markus, HS. and Marvasti, F., 2001. Detection and estimation of embolic Doppler signals using discrete wavelet transform ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, v. 2
    Doi: http://doi.org/10.1109/ICASSP.2001.941099
  • Risley, AFM., Stone, P., Markus, HS., Butland, BK., Strachan, DP., Elwood, PC. and Mendall, MA., 2001. Ischaemic heart disease and Cag a strains of Helicobacter pylori in the Caerphilly heart disease study Heart, v. 86
  • Hassan, A., Sham, P. and Markus, H., 2001. Modelling feasibility of genetic approaches to human stroke STROKE, v. 32
  • Markus, H., Kapozsta, Z., Ditrich, R., Wolfe, C., Ali, N., Powell, J., Mendell, M. and Cullinane, M., 2001. Increased common carotid intima-media thickness in UK African Caribbeans and its relation to chronic inflammation and vascular candidate gene polymorphisms STROKE, v. 32
    Doi: http://doi.org/10.1161/hs1101.098152
  • Simpson, M., Ali, N., Dong, YB., Powell, J., Martin, R., Crosby, A. and Markus, H., 2001. Screening of British CADASIL families for NOTCH 3 mutations JOURNAL OF MEDICAL GENETICS, v. 38
  • O'Sullivan, M., Jones, DK., Summers, PE., Morris, RG., Williams, SCR. and Markus, HS., 2001. Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline Neurology, v. 57
    Doi: http://doi.org/10.1212/WNL.57.4.632
  • Lythgoe, D., Simmons, A., Pereira, A., Cullinane, M., Williams, S. and Markus, HS., 2001. Magnetic resonance markers of ischaemia: Their correlation with vasodilatory reserve in patients with carotid artery stenosis and occlusion Journal of Neurology Neurosurgery and Psychiatry, v. 71
    Doi: http://doi.org/10.1136/jnnp.71.1.58
  • Cullinane, M. and Markus, HS., 2001. Evaluation of a 1 MHz transducer for transcranial doppler ultrasound including embolic signal detection Ultrasound in Medicine and Biology, v. 27
    Doi: http://doi.org/10.1016/S0301-5629(01)00369-6
  • Summers, PE., Jarosz, JM. and Markus, H., 2001. MR angiography in cerebrovascular disease CLINICAL RADIOLOGY, v. 56
    Doi: http://doi.org/10.1053/crad.2001.0618
  • Rose, SE., Chalk, JB., Griffin, MP., Janke, AL., Chen, F., McLachan, GJ., Peel, D., Zelaya, FO., Markus, HS., Jones, DK., Simmons, A., O'Sullivan, M., Jarosz, JM., Strugnell, W., Doddrell, DM. and Semple, J., 2001. MRI based diffusion and perfusion predictive model to estimate stroke evolution MAGN RESON IMAGING, v. 19
  • Kaposzta, Z., Baskerville, PA., Madge, D., Fraser, S., Martin, JF. and Markus, HS., 2001. L-arginine and <i>S</i>-nitrosoglutathione reduce embolization in humans CIRCULATION, v. 103
  • O'Sullivan, M., Jarosz, JM., Martin, RJ., Deasy, N., Powell, JF. and Markus, HS., 2001. MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL NEUROLOGY, v. 56
    Doi: http://doi.org/10.1212/WNL.56.5.628
  • Markus, H. and Cullinane, M., 2001. Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion. Brain, v. 124
  • Markus, H. and Cullinane, M., 2001. Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion Brain, v. 124
    Doi: http://doi.org/10.1093/brain/124.3.457
  • Kaposzta, Z., Baskerville, PA., Fraser, SCA., Madge, D., Martin, JF. and Markus, HS., 2001. S-nitrosoglutathione, a platelet specific nitric oxide donor, and L-arginine reduced embolisation post-carotid endarterectomy JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 70
  • Martin, RJ., Powell, JF. and Markus, HS., 2001. Phenotypic heterogeneity in a United Kingdom CADASIL prevalence study JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 70
  • Markus, H., 2001. The pathophysiology of stroke British Journal of Cardiology, v. 8
  • O Sullivan, M., Jones, DK., Summers, PE., Horsfield, MA., Williams, SCR., Jarosz, JM. and Markus, HS., 2001. Progressive frontal "disconnection": a mechanism for cognitive decline in normal aging JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 70
  • O Sullivan, M., Jarosz, JM., Deasy, N., Martin, RJ., Powell, J. and Markus, HS., 2001. Involvement of the temporal pole distinguishes CADASIL from ischaemic leukoaraiosis JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 70
  • O'Sullivan, M., Summers, PE., Jones, DK., Jarosz, JM., Williams, SCR. and Markus, HS., 2001. Normal-appearing white matter in ischemic leukoaraiosis: A diffusion tensor MRI study Neurology, v. 57
    Doi: http://doi.org/10.1212/WNL.57.12.2307
  • Aydin, N. and Markus, HS., 2001. Time-scale analysis of quadrature Doppler ultrasound signals IEE Proceedings: Science, Measurement and Technology, v. 148
    Doi: http://doi.org/10.1049/ip-smt:20010106
  • 2000

  • White, RP., Vallance, P. and Markus, HS., 2000. Effect of inhibition of nitric oxide synthase on dynamic cerebral autoregulation in humans CLINICAL SCIENCE, v. 99
    Doi: http://doi.org/10.1042/CS20000064
  • Aydin, N. and Markus, HS., 2000. Directional wavelet transform in the context of complex quadrature Doppler signals IEEE Signal Processing Letters, v. 7
    Doi: http://doi.org/10.1109/97.870680
  • Hassan, A. and Markus, HS., 2000. Genetics and ischaemic stroke Brain, v. 123
    Doi: http://doi.org/10.1093/brain/123.9.1784
  • White, RP., Deane, C., Hindley, C., Bloomfield, PM., Cunningham, VJ., Vallance, P., Brooks, DJ. and Markus, HS., 2000. The effect of the nitric oxide donor glyceryl trinitrate on global and regional cerebral blood flow in man JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 178
    Doi: http://doi.org/10.1016/S0022-510X(00)00357-9
  • Aydin, N. and Markus, HS., 2000. Optimization of processing parameters for the analysis and detection of embolic signals European Journal of Ultrasound, v. 12
    Doi: http://doi.org/10.1016/S0929-8266(00)00104-X
  • Markus, H., 2000. Monitoring embolism in real time Circulation, v. 102
    Doi: http://doi.org/10.1161/01.CIR.102.8.826
  • Markus, HS., Lythgoe, DJ., Ostegaard, L., O'Sullivan, M. and Williams, SCR., 2000. Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 69
    Doi: http://doi.org/10.1136/jnnp.69.1.48
  • Markus, H. and Kaposzta, Z., 2000. Clinical relevance of detecting asymptomatic embolic signals in acute stroke - Response STROKE, v. 31
  • Cullinane, M., Reid, G., Dittrich, R., Kaposzta, Z., Ackerstaff, R., Babikian, V., Droste, DW., Grossett, D., Siebler, M., Valton, L. and Markus, HS., 2000. Evaluation of new online automated embolic signal detection algorithm, including comparison with panel of international experts Stroke, v. 31
    Doi: http://doi.org/10.1161/01.STR.31.6.1335
  • Markus, HS., 2000. Transcranial Doppler sonography in acute stroke - Reply JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 68
  • Triantafyllou, C., Long, C., Suckling, J. and Markus, H., 2000. Multiscale registration of echo-planar with structural MR images using an automated 3D approach NeuroImage, v. 11
    Doi: http://doi.org/10.1016/s1053-8119(00)91609-4
  • Markus, HS., 2000. Developing models of embolism for evaluating anti-thromboembolic therapies using doppler ultrasound embolic signal detection Acta Neurologica Taiwanica, v. 9
  • Markus, H., 2000. Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis - Response STROKE, v. 31
  • Markus, HS., 2000. Transcranial Doppler ultrasound BRITISH MEDICAL BULLETIN, v. 56
    Doi: http://doi.org/10.1258/0007142001903021
  • Lythgoe, DJ., Ostergaard, L., William, SC., Cluckie, A., Buxton-Thomas, M., Simmons, A. and Markus, HS., 2000. Quantitative perfusion imaging in carotid artery stenosis using dynamic susceptibility contrast-enhanced magnetic resonance imaging. Magn Reson Imaging, v. 18
  • Aydin, N. and Markus, HS., 2000. Wavelet analysis of quadrature Doppler ultrasound signals IEE Conference Publication,
    Doi: http://doi.org/10.1049/cp:20000346
  • 1999

  • Kaposzta, Z., Young, E., Bath, PMW. and Markus, HS., 1999. Clinical application of asymptomatic embolic signal detection in acute stroke - A prospective study STROKE, v. 30
    Doi: http://doi.org/10.1161/01.STR.30.9.1814
  • Markus, HS., Sitzer, M., Carrington, D., Mendall, MA. and Steinmetz, H., 1999. <i>Chlamydia pneumoniae</i> infection and early asymptomatic carotid atherosclerosis CIRCULATION, v. 100
    Doi: 10.1161/01.CIR.100.8.832
  • Markus, HS., 1999. Transcranial Doppler ultrasound Journal of Neurology Neurosurgery and Psychiatry, v. 67
    Doi: http://doi.org/10.1136/jnnp.67.2.135
  • Markus, H., Cullinane, M. and Reid, G., 1999. Improved automated detection of embolic signals using a novel frequency filtering approach STROKE, v. 30
    Doi: http://doi.org/10.1161/01.STR.30.8.1610
  • Molloy, J. and Markus, HS., 1999. Asymptomatic embolization predicts stroke and TIA risk in patients with carotid artery stenosis STROKE, v. 30
    Doi: http://doi.org/10.1161/01.STR.30.7.1440
  • Aydin, N., Padayachee, S. and Markus, HS., 1999. The use of the wavelet transform to describe embolic signals ULTRASOUND IN MEDICINE AND BIOLOGY, v. 25
    Doi: http://doi.org/10.1016/S0301-5629(99)00052-6
  • White, RP., Hindley, C., Bloomfield, PM., Cunningham, VJ., Vallance, P., Brooks, DJ. and Markus, HS., 1999. The effect of the nitric oxide synthase inhibitor L-NMMA on basal CBF and vasoneuronal coupling in man: a PET study JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v. 19
    Doi: http://doi.org/10.1097/00004647-199906000-00011
  • Markus, HS. and Reid, G., 1999. Frequency filtering improves ultrasonic embolic signal detection ULTRASOUND IN MEDICINE AND BIOLOGY, v. 25
    Doi: http://doi.org/10.1016/S0301-5629(99)00029-0
  • Ruigrok, Y., Cox, TCS. and Markus, HS., 1999. Positional vertebrobasilar transient ischaemic attacks treated with vertebral angioplasty CEREBROVASCULAR DISEASES, v. 9
    Doi: http://doi.org/10.1159/000015949
  • Lythgoe, DJ., Williams, SCR., Cullinane, M. and Markus, HS., 1999. Mapping of cerebrovascular reactivity using bold magnetic resonance imaging MAGNETIC RESONANCE IMAGING, v. 17
    Doi: http://doi.org/10.1016/S0730-725X(98)00211-2
  • Jones, DK., Lythgoe, D., Horsfield, MA., Simmons, A., Williams, SCR. and Markus, HS., 1999. Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI STROKE, v. 30
    Doi: http://doi.org/10.1161/01.STR.30.2.393
  • Al-Hamali, S., Baskerville, P., Fraser, S., Walters, H. and Markus, HS., 1999. Detection of distal emboli in patients with peripheral arterial stenosis before and after iliac angioplasty: A prospective study JOURNAL OF VASCULAR SURGERY, v. 29
    Doi: http://doi.org/10.1016/S0741-5214(99)70387-3
  • Molloy, JE. and Markus, HS., 1999. Embolic signals predict risk of stroke and TIA in carotid artery stenosis STROKE, v. 30
  • 1998

  • Cullinane, M., Wainwright, R., Brown, A., Monaghan, M. and Markus, HS., 1998. Asymptomatic embolization in subjects with atrial fibrillation not taking anticoagulants - A prospective study STROKE, v. 29
    Doi: http://doi.org/10.1161/01.STR.29.9.1810
  • Markus, HS., Ruigrok, Y., Ali, N. and Powell, JF., 1998. Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma STROKE, v. 29
    Doi: http://doi.org/10.1161/01.STR.29.9.1908
  • Molloy, J., Khan, NH. and Markus, HS., 1998. Temporal variability of asymptomatic embolization in carotid artery stenosis and optimal recording protocols STROKE, v. 29
    Doi: http://doi.org/10.1161/01.STR.29.6.1129
  • White, RP., Barnes, P. and Markus, HS., 1998. Symptomatic haemodynamically significant carotid occlusion treated by posterior circulation revascularization CEREBROVASCULAR DISEASES, v. 8
    Doi: http://doi.org/10.1159/000015840
  • Markus, HS., 1998. Homozygous C677T mutation of the 5,10 methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in Italian patients with a history of early-onset ischemic stroke - Response STROKE, v. 29
  • Ringelstein, EB., Droste, DW., Babikian, VL., Evans, DH., Grosset, DG., Kaps, M., Markus, HS., Russell, D. and Siebler, M., 1998. Consensus on microembolus detection by TCD: International consensus group on microembolus detection Stroke, v. 29
    Doi: http://doi.org/10.1161/01.str.29.3.725
  • Ringelstein, EB., Droste, DW., Babikian, VL., Evans, DH., Grosset, DG., Kaps, M., Markus, HS., Russell, D. and Siebler, M., 1998. Consensus on microembolus detection by TCD STROKE, v. 29
  • Markus, HS., Kapadia, R. and Sherwood, RA., 1998. Lipoprotein (a) and ischaemic cerebrovascular disease - Authors' reply ANNALS OF CLINICAL BIOCHEMISTRY, v. 35
    Doi: http://doi.org/10.1177/000456329803500230
  • White, RP., Deane, C., Vallance, P. and Markus, HS., 1998. Nitric oxide synthase inhibition in humans reduces cerebral blood flow but not the hyperemic response to hypercapnia STROKE, v. 29
    Doi: http://doi.org/10.1161/01.STR.29.2.467
  • Markus, HS. and Hambley, H., 1998. Neurology and the blood: haematological abnormalities in ischaemic stroke JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 64
    Doi: http://doi.org/10.1136/jnnp.64.2.150
  • Markus, HS. and Mendall, MA., 1998. <i>Helicobacter pylori</i> infection:: a risk factor for ischaemic cerebrovascular disease and carotid atheroma JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 64
    Doi: 10.1136/jnnp.64.1.104
  • Molloy, J., Baskerville, PA., Fraser, SC., Martin, JF. and Markus, HS., 1998. S-nitrosoglutathione, a targeted NO donor, reduces cerebral embolisation in a new <i>in vivo</i> model STROKE, v. 29
  • Panerai, RB., White, RP., Markus, HS. and Evans, DH., 1998. Grading of cerebral dynamic autoregulation from spontaneous fluctuations in arterial blood pressure STROKE, v. 29
    Doi: http://doi.org/10.1161/01.STR.29.11.2341
  • Molloy, J., Martin, JF., Baskerville, PA., Fraser, SCA. and Markus, HS., 1998. S-nitrosoglutathione reduces the rate of embolization in humans Circulation, v. 98
    Doi: http://doi.org/10.1161/01.CIR.98.14.1372
  • 1997

  • White, RP. and Markus, HS., 1997. Impaired dynamic cerebral autoregulation in carotid artery stenosis STROKE, v. 28
    Doi: http://doi.org/10.1161/01.STR.28.7.1340
  • Markus, HS., Kapadia, R. and Sherwood, RA., 1997. Relationship between lipoprotein (a) and both stroke and carotid atheroma ANNALS OF CLINICAL BIOCHEMISTRY, v. 34
    Doi: http://doi.org/10.1177/000456329703400404
  • Markus, HS. and Molloy, J., 1997. Use of a decibel threshold in detecting Doppler embolic signals STROKE, v. 28
    Doi: http://doi.org/10.1161/01.STR.28.4.692
  • Crawley, F., Clifton, A., Markus, H. and Brown, MM., 1997. Delayed improvement in carotid artery diameter after carotid angioplasty STROKE, v. 28
    Doi: http://doi.org/10.1161/01.STR.28.3.574
  • Deane, CR. and Markus, HS., 1997. Colour velocity flow measurement: In vitro validation and application to human carotid arteries ULTRASOUND IN MEDICINE AND BIOLOGY, v. 23
    Doi: http://doi.org/10.1016/S0301-5629(96)00224-4
  • Saxena, V., Markus, H., Swaminathan, S. and Mendall, MA., 1997. Hyperhomocysteinaemia, Helicobacter pylori, and coronary heart disease HEART, v. 78
    Doi: http://doi.org/10.1136/hrt.78.5.524a
  • Ali, NS., Powell, J., Swaminathan, R. and Markus, HS., 1997. The relationship between MTHFR genotype, serum homocysteine and folate levels Biochemical Society Transactions, v. 25
    Doi: http://doi.org/10.1042/bst025386s
  • Markus, HS., Ackerstaff, R., Babikian, V., Bladin, C., Droste, D., Grosset, D., Levi, C., Russell, D., Siebler, M. and Tegeler, C., 1997. Intercenter agreement in reading Doppler embolic signals - A multicenter international study STROKE, v. 28
    Doi: http://doi.org/10.1161/01.STR.28.7.1307
  • 1996

  • Markus, H., Bland, JM., Rose, G., Sitzer, M. and Siebler, M., 1996. How good is intercenter agreement in the identification of embolic signals in carotid artery disease? STROKE, v. 27
    Doi: http://doi.org/10.1161/01.STR.27.7.1249
  • Markus, HS., Zhang, YF. and Jeffery, S., 1996. Screening for the factor-V Arg 506 Gln mutation in patients with TIA and stroke CEREBROVASCULAR DISEASES, v. 6
    Doi: http://doi.org/10.1159/000108053
  • Markus, HS., Clifton, A., Buckenham, T., Taylor, R. and Brown, MM., 1996. Improvement in cerebral hemodynamics after carotid angioplasty STROKE, v. 27
    Doi: http://doi.org/10.1161/01.STR.27.4.612
  • Molloy, J. and Markus, HS., 1996. Multigated Doppler ultrasound in the detection of emboli in a flow model and embolic signals in patients STROKE, v. 27
    Doi: http://doi.org/10.1161/01.STR.27.9.1548
  • Markus, HS., 1996. Angiotensin-converting enzyme gene and lacunar stroke - Response STROKE, v. 27
  • 1995

  • MARKUS, H., 1995. MICROEMBOLIC SIGNALS IN PATIENTS REFERRED FOR ECHOCARDIOGRAPHY STROKE, v. 26
  • Markus, HS. and Tegeler, CH., 1995. Experimental aspects of high-intensity transient signals in the detection of emboli Journal of Clinical Ultrasound, v. 23
    Doi: http://doi.org/10.1002/jcu.1870230204
  • MARKUS, H., BARLEY, J., LUNT, R., BLAND, M., JEFFERY, S., CARTER, N. and BROWN, M., 1995. ASSOCIATION OF DELETION POLYMORPHISM IN ANGIOTENSIN-CONVERTING ENZYME (ACE) GENE WITH SYMPTOMATIC CEREBROVASCULAR-DISEASE STROKE, v. 26
  • MARKUS, H., 1995. IMPORTANCE OF TIME-WINDOW OVERLAP IN THE DETECTION AND ANALYSIS OF EMBOLIC SIGNALS STROKE, v. 26
    Doi: http://doi.org/10.1161/01.STR.26.11.2044
  • DUARTE, J., MARKUS, H. and HARRISON, M., 1995. CHANGES IN CEREBRAL BLOOD-FLOW AS MONITORED BY TRANSCRANIAL DOPPLER DURING VOLUNTARY HYPERVENTILATION AND THEIR EFFECT ON THE ELECTROENCEPHALOGRAM JOURNAL OF NEUROIMAGING, v. 5
  • MARKUS, HS. and HARRISON, MJ., 1995. MICROEMBOLIC SIGNAL-DETECTION USING ULTRASOUND STROKE, v. 26
    Doi: http://doi.org/10.1161/01.STR.26.9.1517
  • Markus, HS., Thomson, ND. and Brown, MM., 1995. Asymptomatic cerebral embolic signals in symptomatic and asymptomatic carotid artery disease Brain, v. 118
    Doi: http://doi.org/10.1093/brain/118.4.1005
  • MARKUS, HS., BARLEY, J., LUNT, R., BLAND, JM., JEFFERY, S., CARTER, ND. and BROWN, MM., 1995. ANGIOTENSIN-CONVERTING ENZYME GENE DELETION POLYMORPHISM - A NEW RISK FACTOR FOR LACUNAR STROKE BUT NOT CAROTID ATHEROMA STROKE, v. 26
    Doi: http://doi.org/10.1161/01.STR.26.8.1329
  • Barley, J., Markus, H., Brown, M. and Carter, N., 1995. Lack of association between angiotensinogen polymorphism (M235T) and cerebrovascular disease and carotid atheroma Journal of Human Hypertension, v. 9
  • BUCKENHAM, T., CLIFTON, A., MARKUS, H., TAYLOR, R. and BROWN, M., 1995. CAROTID AND VERTEBRAL STENOSIS TREATED BY PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY BRITISH JOURNAL OF SURGERY, v. 82
  • MARKUS, H., 1995. RISK OF STROKE IN ASYMPTOMATIC CAROTID STENOSIS LANCET, v. 345
    Doi: http://doi.org/10.1016/S0140-6736(95)90892-7
  • MARKUS, HS., LEES, AJ., LENNOX, G., MARSDEN, CD. and COSTA, DC., 1995. PATTERNS OF REGIONAL CEREBRAL BLOOD-FLOW IN CORTICOBASAL DEGENERATION STUDIED USING HMPAO SPECT - COMPARISON WITH PARKINSONS-DISEASE AND NORMAL CONTROLS MOVEMENT DISORDERS, v. 10
    Doi: http://doi.org/10.1002/mds.870100208
  • 1994

  • Markus, HS., Clifton, A., Buckenham, T. and Brown, MM., 1994. Carotid angioplasty detection of embolic signals during and after the procedure Stroke, v. 25
    Doi: http://doi.org/10.1161/01.STR.25.12.2403
  • Markus, HS., Vallance, P. and Brown, MM., 1994. Differential effect of three cyclooxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity Stroke, v. 25
    Doi: http://doi.org/10.1161/01.STR.25.9.1760
  • Droste, DW., Markus, HS., Nassiri, D. and Brown, MM., 1994. The effect of velocity on the appearance of embolic signals studied in transcranial doppler models Stroke, v. 25
    Doi: http://doi.org/10.1161/01.STR.25.5.986
  • DROSTE, D., MARKUS, H. and BROWN, M., 1994. THE EFFECT OF DIFFERENT SETTINGS OF ULTRASOUND PULSE AMPLITUDE, GAIN AND SAMPLE VOLUME ON THE APPEARANCE OF EMBOLI STUDIED IN A TRANSCRANIAL DOPPLER MODEL CEREBROVASCULAR DISEASES, v. 4
    Doi: http://doi.org/10.1159/000108472
  • Markus, H., Droste, DW. and Brown, MM., 1994. Detection of asymptomatic cerebral embolic signals with doppler ultrasound The Lancet, v. 343
    Doi: http://doi.org/10.1016/S0140-6736(94)90129-5
  • DROSTE, D., MARKUS, H., NASSIRI, D. and BROWN, M., 1994. THE EFFECT OF VELOCITY ON THE APPEARANCE OF EMBOLI STUDIED IN TRANSCRANIAL DOPPLER MODELS STROKE, v. 25
  • Brown, MM. and Markus, HS., 1994. Transcranial Doppler detection of asymptomatic cerebral microemboli Journal of Heart Valve Disease, v. 3
  • Markus, H., Loh, A. and Brown, MM., 1994. Detection of circulating cerebral emboli using Doppler ultrasound in a sheep model Journal of the Neurological Sciences, v. 122
    Doi: http://doi.org/10.1016/0022-510X(94)90061-2
  • MARKUS, HS., COSTA, DC. and LEES, AJ., 1994. HMPAO SPECT IN PARKINSONS-DISEASE BEFORE AND AFTER LEVODOPA - CORRELATION WITH DOPAMINERGIC RESPONSIVENESS JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 57
    Doi: http://doi.org/10.1136/jnnp.57.2.180
  • 1993

  • Markus, HS., Droste, D. and Brown, MM., 1993. Ultrasonic detection of cerebral emboli in carotid stenosis. Lancet, v. 341
  • MARKUS, HS., MULLER, AF. and TOGHILL, PJ., 1993. SPLENIC FUNCTION, ASSESSED BY QUANTIFICATION OF ERYTHROCYTE-MEMBRANE PITS, IS NORMAL IN CHRONIC ACTIVE HEPATITIS AND PRIMARY BILIARY-CIRRHOSIS JOURNAL OF HEPATOLOGY, v. 18
    Doi: http://doi.org/10.1016/S0168-8278(05)80017-0
  • Markus, H., Israel, D., Brown, MM., Loh, A., Buckenham, T. and Clifton, A., 1993. Microscopic air embolism during cerebral angiography and strategies for its avoidance The Lancet, v. 341
    Doi: http://doi.org/10.1016/0140-6736(93)90561-T
  • MARKUS, H., VALLANCE, P. and BROWN, M., 1993. PROSTANGLANDINS DO NOT REGULATE CEREBRAL BLOOD-FLOW IN HUMANS - CLINICAL IMPORTANCE STROKE, v. 24
  • MARKUS, H., LOH, A. and BROWN, M., 1993. AIR-EMBOLISM DURING CEREBRAL-ANGIOGRAPHY AND STRATEGIES FOR ITS REMOVAL STROKE, v. 24
  • MARKUS, H., LOH, A., BROWN, M. and BRUCHER, R., 1993. INVIVO DETECTION OF CEREBRAL EMBOLI AND DISCRIMINATION FROM ARTIFACT STROKE, v. 24
  • MARKUS, HS., HARRISON, MJ. and ADISESHIAH, M., 1993. CAROTID ENDARTERECTOMY IMPROVES HEMODYNAMICS ON THE CONTRALATERAL SIDE - IMPLICATIONS FOR OPERATING CONTRALATERAL TO AN OCCLUDED CAROTID-ARTERY BRITISH JOURNAL OF SURGERY, v. 80
    Doi: http://doi.org/10.1002/bjs.1800800212
  • MARKUS, HS., TOMKINS, AM. and STERN, GM., 1993. INCREASED PREVALENCE OF UNDERNUTRITION IN PARKINSONS-DISEASE AND ITS RELATIONSHIP TO CLINICAL-DISEASE PARAMETERS JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION, v. 5
    Doi: http://doi.org/10.1007/BF02251202
  • Markus, HS. and Brown, MM., 1993. Differentiation between different pathological cerebral embolic materials using transcranial doppler in an in vitro model Stroke, v. 24
    Doi: http://doi.org/10.1161/01.STR.24.1.1
  • Markus, HS., 1993. Side effects of cerebral angiography Biomedicine and Pharmacotherapy, v. 47
    Doi: http://doi.org/10.1016/0753-3322(93)90089-4
  • MARKUS, H. and KENDALL, BE., 1993. MRI OF A DERMOID CYST CONTAINING HAIR NEURORADIOLOGY, v. 35
    Doi: http://doi.org/10.1007/BF00602606
  • Markus, H., Loh, A. and Brown, MM., 1993. Computerized detection of cerebral emboli and discrimination from artifact using doppler ultrasound Stroke, v. 24
    Doi: http://doi.org/10.1161/01.STR.24.11.1667
  • Markus, H., 1993. Transcranial doppler detection of circulating cerebral emboli: A review Stroke, v. 24
    Doi: http://doi.org/10.1161/01.STR.24.8.1246
  • Markus, HS., Ring, H., Kouris, K. and Costa, DC., 1993. Alterations in regional cerebral blood flow, with increased temporal interhemispheric asymmetries, in the normal elderly: an HMPAO SPECT study. Nucl Med Commun, v. 14
    Doi: http://doi.org/10.1097/00006231-199308000-00002
  • Markus, HS., Droste, D. and Brown, MM., 1993. Ultrasonic detection of cerebral emboli in carotid stenosis The Lancet, v. 341
    Doi: http://doi.org/10.1016/0140-6736(93)90752-3
  • 1992

  • Markus, HS., Kouris, K., Costa, DC. and Ell, PJ., 1992. SPECT in epilepsy. Neurology, v. 42
  • MARKUS, HS. and HARRISON, MJG., 1992. ESTIMATION OF CEREBROVASCULAR REACTIVITY USING TRANSCRANIAL DOPPLER, INCLUDING THE USE OF BREATH-HOLDING AS THE VASODILATORY STIMULUS STROKE, v. 23
    Doi: http://doi.org/10.1161/01.STR.23.5.668
  • MARKUS, HS. and HARRISON, MJH., 1992. CARBON-DIOXIDE REACTIVITY OF CEREBRAL BLOOD-FLOW MEASURED BY TRANSCRANIAL SONOGRAPHY AS A DIAGNOSTIC CLUE TO INTRACRANIAL CAROTID STENOSIS IN THE PRESENCE OF NORMAL EXTRACRANIAL CEREBRAL-ARTERIES CEREBROVASCULAR DISEASES, v. 2
    Doi: http://doi.org/10.1159/000109000
  • MARKUS, HS., DUCHEN, LW., PARKIN, EM., KURTZ, AB., JACOBS, HS., COSTA, DC. and HARRISON, MJ., 1992. CREUTZFELDT-JAKOB DISEASE IN RECIPIENTS OF HUMAN GROWTH-HORMONE IN THE UNITED-KINGDOM - A CLINICAL AND RADIOGRAPHIC STUDY QUARTERLY JOURNAL OF MEDICINE, v. 82
  • MARKUS, HS. and HOPKINSON, N., 1992. MIGRAINE AND HEADACHE IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND THEIR RELATIONSHIP WITH ANTIBODIES AGAINST PHOSPHOLIPIDS JOURNAL OF NEUROLOGY, v. 239
    Doi: http://doi.org/10.1007/BF00839210
  • MARKUS, HS., CHONG, EMF. and WILCOX, RG., 1992. GALLOPAMIL SLOW RELEASE - A DOUBLE-BLIND-STUDY OF TWICE DAILY VERSUS ONCE DAILY TREATMENT IN CHRONIC STABLE ANGINA EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, v. 42
  • HOWARD, LM. and MARKUS, H., 1992. PSEUDOOBSTRUCTION SECONDARY TO ANTICHOLINERGIC DRUGS IN PARKINSONS-DISEASE POSTGRADUATE MEDICAL JOURNAL, v. 68
    Doi: http://doi.org/10.1136/pgmj.68.795.70
  • Markus, HS. and Harrison, MJG., 1992. Response Stroke, v. 23
  • MARKUS, HS. and BOLAND, M., 1992. COGNITIVE ACTIVITY MONITORED BY NONINVASIVE MEASUREMENT OF CEREBRAL BLOOD-FLOW VELOCITY AND ITS APPLICATION TO THE INVESTIGATION OF CEREBRAL-DOMINANCE CORTEX, v. 28
    Doi: http://doi.org/10.1016/S0010-9452(13)80228-6
  • ABBOTT, RA., COX, M., MARKUS, H. and TOMKINS, A., 1992. DIET, BODY SIZE AND MICRONUTRIENT STATUS IN PARKINSONS-DISEASE EUROPEAN JOURNAL OF CLINICAL NUTRITION, v. 46
  • MARKUS, H. and HARRISON, M., 1992. USE OF BREATH HOLDING FOR EVALUATING CEREBROVASCULAR RESERVE CAPACITY - REPLY STROKE, v. 23
  • MARKUS, HS., COX, M. and TOMKINS, AM., 1992. RAISED RESTING ENERGY-EXPENDITURE IN PARKINSONS-DISEASE AND ITS RELATIONSHIP TO MUSCLE RIGIDITY CLINICAL SCIENCE, v. 83
    Doi: http://doi.org/10.1042/cs0830199
  • MARKUS, HS., BUNKER, CB., KOURIS, K., COSTA, DC. and HARRISON, MJ., 1992. RCBF ABNORMALITIES DETECTED, AND SEQUENTIALLY FOLLOWED, BY SPECT IN NEURO-BEHCETS SYNDROME WITH NORMAL CT AND MRI IMAGING JOURNAL OF NEUROLOGY, v. 239
  • MARKUS, H., POLKEY, M. and HARRISON, M., 1992. VISUAL-LOSS AND OPTIC ATROPHY ASSOCIATED WITH CYPROTERONE-ACETATE BRITISH MEDICAL JOURNAL, v. 305
    Doi: http://doi.org/10.1136/bmj.305.6846.159-a
  • 1991

  • MARKUS, HS., 1991. A PROSPECTIVE FOLLOW-UP OF THUNDERCLAP HEADACHE MIMICKING SUBARACHNOID HEMORRHAGE JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 54
    Doi: http://doi.org/10.1136/jnnp.54.12.1117
  • MARKUS, HS., HARRISON, MJH. and COSTA, DC., 1991. SINGLE PHOTON-EMISSION TOMOGRAPHY IN GROWTH-HORMONE RELATED CREUTZFELDT-JAKOB DISEASE LANCET, v. 338
    Doi: http://doi.org/10.1016/0140-6736(91)90637-5
  • MARKUS, HS. and TOGHILL, PJ., 1991. IMPAIRED SPLENIC FUNCTION IN ELDERLY PEOPLE AGE AND AGEING, v. 20
    Doi: http://doi.org/10.1093/ageing/20.4.287
  • MARKUS, H. and COWLEY, AJ., 1991. THE CENTRAL HEMODYNAMIC-EFFECTS OF A SINGLE INTRAVENOUS DOSE OF FLOSEQUINAN IN PATIENTS WITH SEVERE HEART-FAILURE EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, v. 40
  • 1990

  • MARKUS, H. and CLARK, J., 1990. PULMONARY HEMORRHAGE IN HENOCH-SCHONLEIN PURPURA - REPLIES THORAX, v. 45
    Doi: http://doi.org/10.1136/thx.45.6.496-b
  • MARKUS, HS., 1990. PARALYTIC ILEUS ASSOCIATED WITH IPRATROPIUM LANCET, v. 335
    Doi: http://doi.org/10.1016/0140-6736(90)92749-8
  • MARKUS, HS., 1990. EARLY EXERCISE TESTING AFTER MYOCARDIAL-INFARCTION BRITISH MEDICAL JOURNAL, v. 300
    Doi: http://doi.org/10.1136/bmj.300.6720.329-b
  • 1989

  • MARKUS, HS. and ALLISON, SP., 1989. STAPHYLOCOCCUS-AUREUS MENINGITIS FROM OSTEOMYELITIS OF THE SPINE POSTGRADUATE MEDICAL JOURNAL, v. 65
    Doi: http://doi.org/10.1136/pgmj.65.770.941
  • MARKUS, HS. and OBRIEN, JT., 1989. OBSTRUCTION OF THE VENA-CAVA SECONDARY TO AN ENLARGED BLADDER BRITISH JOURNAL OF UROLOGY, v. 64
    Doi: http://doi.org/10.1111/j.1464-410X.1989.tb05536.x
  • MARKUS, HS., 1989. HEMATOGENOUS OSTEOMYELITIS IN THE ADULT - A CLINICAL AND EPIDEMIOLOGICAL-STUDY QUARTERLY JOURNAL OF MEDICINE, v. 71
  • MARKUS, HS. and WOLVERSON, A., 1989. EYELID ABSCESS IN AN EGG NOG DRINKER BMJ-BRITISH MEDICAL JOURNAL, v. 299
    Doi: http://doi.org/10.1136/bmj.299.6715.1570
  • MARKUS, HS., 1989. DIAGNOSTIC INVESTIGATIONS IN THE ELDERLY - THE CLINICAL USEFULNESS OF SERUM IRON AND TRANSFERRIN MEASUREMENTS IN THE DIAGNOSIS OF IRON-DEFICIENCY ANEMIA - AN AUDIT BRITISH JOURNAL OF CLINICAL PRACTICE, v. 43
  • 1988

  • FOSS, A. and MARKUS, H., 1988. OSTEOLYTIC LESIONS IN AN ELDERLY DIABETIC WOMAN BRITISH MEDICAL JOURNAL, v. 296
    Doi: http://doi.org/10.1136/bmj.296.6617.280
  • 1986

  • MARKUS, H. and FORFAR, JC., 1986. SPLENIC IRRADIATION IN TREATING WARM AUTOIMMUNE HEMOLYTIC-ANEMIA BRITISH MEDICAL JOURNAL, v. 293
    Doi: http://doi.org/10.1136/bmj.293.6551.839
  • Book chapters

    2018

  • Tan, RYY. and Markus, HS., 2018. Genetics and genomics of stroke
    Doi: http://doi.org/10.1007/978-3-319-66114-8_24
  • 2014

  • Markus, HS., 2014. Dissection, Arterial
    Doi: http://doi.org/10.1016/B978-0-12-385157-4.00413-9
  • 2011

  • Hainsworth, AH. and S.Markus, H., 2011. Experimental animal models of cerebral small vessel disease
    Doi: http://doi.org/10.1017/CBO9781139382694.006
  • Markus, HS., Allan, CL. and Ebmeier, KP., 2011. Cerebral hemodynamics in cerebral small vessel disease
    Doi: http://doi.org/10.1017/CBO9781139382694.016
  • 2006

  • Markus, HS., 2006. The patent foramen ovale: Clinical significance in cerebrovascular disease
  • Markus, HS., 2006. Cerebral perfusion and stroke
    Doi: http://doi.org/10.1142/9781860948961_0012
  • 1997

  • Markus, HS., 1997. Methodological aspects of microembolic signal detection:
  • Conference proceedings

    2017

  • Walsh, J. and Markus, HS., 2017. Development and evaluation of a telemedicine clinic service for CADASIL INTERNATIONAL JOURNAL OF STROKE, v. 12
  • Lambert, C., Zeestraten, E., Williams, O., Benjamin, P., Lawrence, A., Morris, R., Mackinnon, A., Barrick, T. and Markus, H., 2017. Use of MRI to identify preclinical vascular dementia in symptomatic small vessel disease LANCET, v. 389
  • Markus, HS., Croall, ID., Barrick, TR., Moynihan, B., Khan, U., Cambridge, VC., O'Brien, JT., Dixit, AK., Tozer, DJ., Blamire, AM. and Ford, GA., 2017. The PRESERVE trial (perfusion substudy): intensive blood pressure lowering and cerebral blood flow in small vessel disease INTERNATIONAL JOURNAL OF STROKE, v. 12
  • 2016

  • Traylor, M., Curtis, C., Patel, H., Breen, G., Lee, SH., Xu, X., Newhouse, S., Dobson, R., Steer, S., Cope, A., Markus, HS., Lewis, C. and Scott, IC., 2016. RHEUMATOID ARTHRITIS RISK AND PROGNOSTIC FACTORS IDENTIFIED IN EUROPEAN AND ASIAN POPULATIONS ARE ALSO RELEVANT IN AFRICAN ANCESTRY INDIVIDUALS: THE GENRA STUDY RHEUMATOLOGY, v. 55
  • 2015

  • Tan, R. and Markus, H., 2015. THE SPECTRUM OF MIGRAINE IN 306 PATIENTS WITH CADASIL JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 86
    Doi: http://doi.org/10.1136/jnnp-2015-312379.7
  • Tan, R. and Markus, H., 2015. NEXT GENERATION SEQUENCING IN FAMILIAL CEREBRAL SMALL VESSEL DISEASE - AN ONGOING STUDY JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 86
    Doi: http://doi.org/10.1136/jnnp-2015-312379.194
  • Hollocks, MJ., Lawrence, AJ., Brookes, RL., Barrick, TR., Morris, RG., Husain, M. and Markus, HS., 2015. Differential Relationships between Apathy and Depression with White Matter Microstructural Changes and Functional Outcomes in Patients with Cerebral Small Vessel Disease BIOLOGICAL PSYCHIATRY, v. 77
  • 2014

  • Andoh, J., Bridges, LR., Lawrence, AJ., Esiri, MM., Markus, HS. and Hainsworth, A., 2014. Neuropathological markers of blood-brain barrier dysfunction in cerebral small vessel disease NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, v. 40
  • 2013

  • Dichgans, M., Malik, R., Koenig, IR., Rosand, J., Clarke, R., Gretarsdottir, S., Mitchell, BD., Erdmann, J., Kathiresan, S., McPherson, R., Sudlow, C., Reilly, MP., Thompson, JR., Sharma, P., Chambers, JC., Watkins, H., Rothwell, PM., Roberts, R., Markus, HS., Samani, NJ., Farrall, M. and Schunkert, H., 2013. Evidence for a shared genetic determination of Ischemic Stroke And Coronary Artery Disease - a genome-wide analysis CIRCULATION RESEARCH, v. 113
  • Willeit, P., Zampetaki, A., Kaudewitz, D., Lee, R., Dudek, K., King, A., Kirkby, NS., Markus, HS., Warner, TD., Kiechl, S., Morton, AC., Channon, K., Storey, RF. and Mayr, M., 2013. PLASMA MICRORNAS AS BIOMARKERS FOR PLATELET INHIBITION HEART, v. 99
    Doi: http://doi.org/10.1136/heartjnl-2013-304019.265
  • 2012

  • Schulz, U., Kennedy, F., Kueker, W., Clifton, A., Rothwell, P. and Markus, H., 2012. OUTCOME OF ENDOVASCULAR TREATMENT FOR SYMPTOMATIC VERTEBRAL ARTERY STENOSIS: EXPERIENCE IN TWO NEUROSCIENCES CENTRES JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 83
    Doi: http://doi.org/10.1136/jnnp-2011-301993.12
  • 2011

  • Gulli, G., Marquardt, L., Rothwell, PM. and Markus, HS., 2011. Relationship of Site of Vertebral Stenosis to Early Recurrent Stroke Risk in Posterior Circulation Stroke and TIA STROKE, v. 42
  • 2010

  • Robinson, T., Bulpitt, CJ., Ford, GA., Jagger, C., Knight, J., Markus, HS., Mistri, AK., Potter, JF. and Poulter, NR., 2010. CONTINUE OR STOP POST-STROKE ANTIHYPERTENSIVES COLLABORATIVE STUDY (COSSACS): MAIN RESULTS JOURNAL OF HYPERTENSION, v. 28
  • 2009

  • Adib-Samii, P., Brice, G., Khan, U., O Sullivan, M., Martin, RS. and Markus, HM., 2009. CLINICAL AND GENOTYPIC SPECTRUM OF CADASIL IN THE UK JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 80
  • Menon, RK., Markus, HS. and Norris, JW., 2009. IS THE OUTCOME OF CERVICAL ARTERY DISSECTION REALLY BENIGN? JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 80
    Doi: http://doi.org/10.1136/jnnp.2009.195180s
  • Markus, H., 2009. Genetics of cerebrovascular disease JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 283
    Doi: http://doi.org/10.1016/j.jns.2009.02.120
  • 2008

  • Birns, J., Jarosz, J., Morris, R., Markus, H. and Kalra, L., 2008. Heterogeneity in the relationships between blood pressure, white matter lesion volume and cognitive function in patients with small vessel disease. STROKE, v. 39
  • Debette, S., Bevan, S., Sitzer, M. and Markus, H., 2008. Association of carotid IMT with CX3CL1 and CX3CR1 genetic variants in a large population-based study STROKE, v. 39
  • Bims, J., Jarosz, J., Markus, H. and Kalra, L., 2008. Cerebral autoregulation and CO<sub>2</sub> reactivity in small vessel disease is affected by blood pressure and not by white matter disease load STROKE, v. 39
  • Birns, J., Jarosz, J., Markus, H. and Kalra, L., 2008. Vulnerability of infratentorial white matter to nocturnal decreases in blood pressure STROKE, v. 39
  • 2007

  • Khan, S., Cloud, GC., Kerry, S. and Markus, HS., 2007. A systematic review of the diagnostic accuracy of Doppler, MR angiography and CT angiography compared with intra-arterial angiography in vertebral artery stenosis JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 78
  • Norris, J., Menon, R. and Markus, H., 2007. A feasibility multicentre trial of cervical arterial dissection JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 78
  • Nitkunan, A., Barrick, TR., Charlton, RA., Clark, CA. and Markus, HS., 2007. Diffusion magnetic resonance histograms as a surrogate marker of cerebral small vessel disease progression JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 78
  • Menon, RK., Norris, JW. and Markus, HS., 2007. Secondary prevention following cervical artery dissection: A meta-analysis JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 78
  • Marvasti, S., Ghandi, M., Marvasti, F., Markus, HS. and Gillies, D., 2007. Multiple wavelet denoising for embolic signal enhancement ICT-MICC: 2007 IEEE INTERNATIONAL CONFERENCE ON TELECOMMUNICATIONS AND MALAYSIA INTERNATIONAL CONFERENCE ON COMMUNICATIONS, VOLS 1 AND 2, PROCEEDINGS,
    Doi: http://doi.org/10.1109/ICTMICC.2007.4448575
  • 2006

  • Nitkunan, A., Charlton, RA., Barrick, T., McIntyre, DJO., Howe, F. and Markus, HS., 2006. Magnetic resonance spectroscopy and cognitive function in cerebral small vessel disease JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 77
  • Lorenz, MW., von Kegler, S., Steinmetz, H., Markus, HS. and Sitzer, M., 2006. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: Prospective data from the carotid atherosclerosis progression STROKE, v. 37
  • Motallebzadeh, R., Bland, J., Markus, H., Kaski, J. and Jahangin, M., 2006. Neurocognitive function, cerebral emboli, and S100 beta after on-pump and off-pump coronary artery bypass surgery: A randomised study HEART, v. 92
  • Khan, U., Jerrard-Dunne, P., Birns, J., Burger, I., Evans, A., McGovern, R., Porteous, L., Rudd, A., Wolfe, C. and Markus, H., 2006. Ethnic differences in stroke risk factors and stroke subtype - First results from the South London ethnicity and stroke study JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 77
  • Birns, J., Markus, H. and Kalra, L., 2006. The role of blood pressure fluctuations and cerebral autoregulation in ischaemic small vessel cerebrovascular disease JOURNAL OF HYPERTENSION, v. 24
  • 2005

  • Charlton, RA., Barrick, TR., O Sullivan, M., Clark, CA., Markus, HS. and Morris, RG., 2005. Loss of white matter integrity, as measured using diffusion tensor imaging, is specifically associated with age related working memory decline JOURNAL OF COGNITIVE NEUROSCIENCE,
  • Singhal, S., Bevan, S., Barrick, T., Rich, P. and Markus, H., 2005. Factors modifying phenotype in CADASIL (cerebral autosomal dominant arteriopathy, subcortical infarcts and leukoencephalopathy) JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 76
  • Axford, JS., Peterson, P., Howe, F., Clark, C. and Markus, H., 2005. What are the pathophysiological mechanisms of neurocognitive dysfunction in Systemic Lupus Erythematosus? A study using quantitative imaging with magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) ANNALS OF THE RHEUMATIC DISEASES, v. 64
  • Labrum, R., Bevan, S., Egger, G., Wiedermann, C., Xu, QB., Kiechl, S., Willeit, J. and Markus, HS., 2005. Pro-inflammatory genes variants predispose to atherosclerosis in the presence of pro-inflammatory risk factors and chronic infection ATHEROSCLEROSIS, v. 181
  • Bims, JM., Markus, HS. and Kalra, L., 2005. The integrity of dynamic cerebral autoregulation in patients with small-vessel disease STROKE, v. 36
  • Markus, H. and Ringelstein, EB., 2005. Evaluating antiplatelet agents using asymptomatic microembolic signals as a surrogate end point: Lessons from the CARESS trial STROKE, v. 36
  • 2004

  • Marvasti, S., Gillies, D. and Markus, HS., 2004. Novel intelligent wavelet filtering of embolic signals from TCD ultrasound Conference Record - Asilomar Conference on Signals, Systems and Computers, v. 2
  • Birns, J., Markus, H. and Kalra, L., 2004. The role of blood pressure fluctuations and cerebral autoregulation in ischaemic small vessel cerebrovascular disease BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, v. 58
  • Hassan, A., Gormley, K., O Sullivan, M., Knight, J., Sham, P., Vallance, P., Bamford, J. and Markus, H., 2004. eNOS haplotypes and risk of cerebral small vessel disease JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 75
  • Norris, J. and Markus, H., 2004. Recurrent stroke risk and cervical arterial dissection: Implications for a therapeutic trial JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 75
  • McCall, S., Phillimore, H., Elanko, N., Fidanis, M., Williams, N., Cottrell, S., Markus, H. and Taylor, R., 2004. Detection of Notch3 mutations in CADASIL patients in the UK population JOURNAL OF MEDICAL GENETICS, v. 41
  • Singhal, S., Bevan, S., Barrick, T., Rich, R. and Markus, H., 2004. Factors modifying the CADASIL phenotype JOURNAL OF NEUROLOGY, v. 251
  • Nitkunan, A., McIntyre, D., Barrick, TR., O Sullivan, M., Clark, CA., Howe, FA. and Markus, HS., 2004. Diffusion tensor imaging and proton magnetic resonance spectroscopy in patients with cerebral small vessel disease JOURNAL OF NEUROLOGY, v. 251
  • O Sullivan, M., Barrick, T., Morris, R., Clark, C. and Markus, H., 2004. The anatomy of executive dysfunction: insights from CADASIL as a model of diffuse subcortical disease JOURNAL OF NEUROLOGY, v. 251
  • Singhal, S. and Markus, H., 2004. Cerebrovascular reactivity and dynamic autoregulation in non-demented patients with CADASIL JOURNAL OF NEUROLOGY, v. 251
  • 2003

  • Jerrard-Dunne, P., Sitzer, M., Risley, P., Steckel, D., Buehler, A., Von Kegler, S., Wolfgang, J. and Markus, H., 2003. Pro-inflammatory gene-load is associated with enhanced inflammation and early carotid atherosclerosis in smokers STROKE, v. 34
  • Sidhu, JS., Kaposzta, Z., Markus, HS. and Kaski, JC., 2003. Effect of rosiglitazone on common carotid intima-media thickness progression in coronary artery disease patients without diabetes mellitus HEART, v. 89
  • O Sullivan, M., Singhal, S., Chariton, R. and Markus, H., 2003. Diffusion tensor MRI measures in the subcortical grey matter correlate with executive dysfunction in non-demented patients with CADASIL STROKE, v. 34
  • O Sullivan, M., Morris, R. and Markus, H., 2003. Optimal tests for identifying executive dysfunction in patients with cerebral small vessel disease STROKE, v. 34
  • Hassan, A., O Sullivan, M., De Souza, R., Bamford, J., Briley, D., Brown, M., Thomas, D. and Markus, H., 2003. Homocysteine and cerebral small vessel disease: A potential disease mechanism through endothelial dysfunction STROKE, v. 34
  • Mackinnon, AD., Aaslid, R. and Markus, HS., 2003. Ambulatory transcranial doppler monitoring for circulating asymptomatic cerebral emboli JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 74
  • O Sullivan, M., Morris, RG., Huckstep, B., Jones, DK., Williams, SCR. and Markus, HS., 2003. Diffusion tensor MRI provides independent markers of cognitive dysfunction in ischaemic leukoaraiosis JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 74
  • Hassan, A., O Sullivan, M., de Souza, R., Bamford, J., Briley, D., Brown, M., Thomas, D. and Markus, H., 2003. Homocysteine and cerebral small vessel disease: A potential disease mechanism through endothelial dysfunction JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 74
  • Hassan, A., Hunt, B., O Sullivan, M., Parmar, K., Bamford, J., Briley, D., Brown, M., Thomas, D. and Markus, H., 2003. The role of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, v. 74
  • Gormley, K., Hassan, A., O Sullivan, M., Bamford, J. and Markus, H., 2003. Genetic variation in the angiotensin converting enzyme gene and lacunar stroke BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, v. 56
  • 2002

  • Aydin, N., Marvasti, F. and Markus, HS., 2002. Effect of wavelet denoizing on time-frequency and time-scale analysis of quadrature embolic Doppler signals Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, v. 1
  • 1999

  • Aydin, N. and Markus, HS., 1999. Detection of embolic signals using wavelet transform PROCEEDINGS OF THE IEEE-EURASIP WORKSHOP ON NONLINEAR SIGNAL AND IMAGE PROCESSING (NSIP'99),
  • 1997

  • Markus, HS., Ali, N., Swaminathan, R., Sankaralingam, A., Molloy, J. and Powell, J., 1997. A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischemic cerebrovascular disease STROKE, v. 28
    Doi: http://doi.org/10.1161/01.STR.28.9.1739
  • 1995

  • MARKUS, H., 1995. EXPERIMENTAL EMBOLIC EVENTS CEREBROVASCULAR DISEASES, v. 5
    Doi: http://doi.org/10.1159/000107834
  • Books

    2006

  • Brown, MM., Markus, HS. and Oppenheimer, S., 2006. Stroke Medicine