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Cambridge Public Health

 

In my retirement I remain a member of the scientific strategy committee for a major cort study of dementia (the MEMENTO study in France). I maintain an interest in statistical methods for longitudinal data.

Publications from Elements

Journal articles

2013

  • Fritsche, LG., Chen, W., Schu, M., Yaspan, BL., Yu, Y., Thorleifsson, G., Zack, DJ., Arakawa, S., Cipriani, V., Ripke, S., Igo, RP., Buitendijk, GHS., Sim, X., Weeks, DE., Guymer, RH., Merriam, JE., Francis, PJ., Hannum, G., Agarwal, A., Armbrecht, AM., Audo, I., Aung, T., Barile, GR., Benchaboune, M., Bird, AC., Bishop, PN., Branham, KE., Brooks, M., Brucker, AJ., Cade, WH., Cain, MS., Campochiaro, PA., Chan, CC., Cheng, CY., Chew, EY., Chin, KA., Chowers, I., Clayton, DG., Cojocaru, R., Conley, YP., Cornes, BK., Daly, MJ., Dhillon, B., Edwards, AO., Evangelou, E., Fagerness, J., Ferreyra, HA., Friedman, JS., Geirsdottir, A., George, RJ., Gieger, C., Gupta, N., Hagstrom, SA., Harding, SP., Haritoglou, C., Heckenlively, JR., Holz, FG., Hughes, G., Ioannidis, JPA., Ishibashi, T., Joseph, P., Jun, G., Kamatani, Y., Katsanis, N., N Keilhauer, C., Khan, JC., Kim, IK., Kiyohara, Y., Klein, BEK., Klein, R., Kovach, JL., Kozak, I., Lee, CJ., Lee, KE., Lichtner, P., Lotery, AJ., Meitinger, T., Mitchell, P., Mohand-Saïd, S., Moore, AT., Morgan, DJ., Morrison, MA., Myers, CE., Naj, AC., Nakamura, Y., Okada, Y., Orlin, A., Ortube, MC., Othman, MI., Pappas, C., Park, KH., Pauer, GJT., Peachey, NS., Poch, O., Priya, RR., Reynolds, R., Richardson, AJ., Ripp, R., Rudolph, G. and Ryu, E., 2013. Seven new loci associated with age-related macular degeneration Nature Genetics, v. 45
    Doi: http://doi.org/10.1038/ng.2578
  • 2012

  • Shahid, H., Khan, JC., Cipriani, V., Sepp, T., Matharu, BK., Bunce, C., Harding, SP., Clayton, DG., Moore, AT., Yates, JRW. and Genetic Factors in AMD Study Group, , 2012. Age-related macular degeneration: the importance of family history as a risk factor. Br J Ophthalmol, v. 96
    Doi: http://doi.org/10.1136/bjophthalmol-2011-300193
  • Cipriani, V., Matharu, BK., Khan, JC., Shahid, H., Hayward, C., Wright, AF., Armbrecht, AM., Dhillon, B., Harding, SP., Bishop, PN., Bunce, C., Clayton, DG., Moore, AT. and Yates, JRW., 2012. No evidence of association between complement factor i genetic variant rs10033900 and age-related macular degeneration European Journal of Human Genetics, v. 20
    Doi: http://doi.org/10.1038/ejhg.2011.118
  • Cipriani, V., Matharu, BK., Khan, JC., Shahid, H., Stanton, CM., Hayward, C., Wright, AF., Bunce, C., Clayton, DG., Moore, AT. and Yates, JRW., 2012. Genetic variation in complement regulators and susceptibility to age-related macular degeneration Immunobiology, v. 217
    Doi: http://doi.org/10.1016/j.imbio.2011.09.002
  • Shahid, H., Khan, JC., Cipriani, V., Sepp, T., Matharu, BK., Bunce, C., Harding, SP., Clayton, DG., Moore, AT. and Yates, JRW., 2012. Age-related macular degeneration: The importance of family history as a risk factor British Journal of Ophthalmology, v. 96
    Doi: http://doi.org/10.1136/bjophthalmol-2011-300193
  • Wallace, C., Rotival, M., Cooper, JD., Rice, CM., Yang, JHM., McNeill, M., Smyth, DJ., Niblett, D., Cambien, F., Cardiogenics Consortium, , Tiret, L., Todd, JA., Clayton, DG. and Blankenberg, S., 2012. Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes. Hum Mol Genet, v. 21
    Doi: http://doi.org/10.1093/hmg/dds098
  • Lyons, PA., Rayner, TF., Trivedi, S., Holle, JU., Watts, RA., Jayne, DRW., Baslund, B., Brenchley, P., Bruchfeld, A., Chaudhry, AN., Cohen Tervaert, JW., Deloukas, P., Feighery, C., Gross, WL., Guillevin, L., Gunnarsson, I., Harper, L., Hrušková, Z., Little, MA., Martorana, D., Neumann, T., Ohlsson, S., Padmanabhan, S., Pusey, CD., Salama, AD., Sanders, J-SF., Savage, CO., Segelmark, M., Stegeman, CA., Tesař, V., Vaglio, A., Wieczorek, S., Wilde, B., Zwerina, J., Rees, AJ., Clayton, DG. and Smith, KGC., 2012. Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med, v. 367
    Doi: http://doi.org/10.1056/NEJMoa1108735
  • Cipriani, V., Leung, HT., Plagnol, V., Bunce, C., Khan, JC., Shahid, H., Moore, AT., Harding, SP., Bishop, PN., Hayward, C., Campbell, S., Armbrecht, AM., Dhillon, B., Deary, IJ., Campbell, H., Dunlop, M., Dominiczak, AF., Mann, SS., Jenkins, SA., Webster, AR., Bird, AC., Lathrop, M., Zelenika, D., Souied, EH., Sahel, JA., Léveillard, T., Cree, AJ., Gibson, J., Ennis, S., Lotery, AJ., Wright, AF., Clayton, DG. and Yates, JRW., 2012. Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3 Human Molecular Genetics, v. 21
    Doi: http://doi.org/10.1093/hmg/dds225
  • Zanda, M., Onengut, S., Walker, N., Todd, JA., Clayton, DG., Rich, SS., Hurles, ME. and Plagnol, V., 2012. Validity of the Family-Based Association Test for Copy Number Variant Data in the Case of Non-Linear Intensity-Genotype Relationship Genetic Epidemiology,
  • Zanda, M., Onengut, S., Walker, N., Todd, JA., Clayton, DG., Rich, SS., Hurles, ME. and Plagnol, V., 2012. Validity of the Family-Based Association Test for Copy Number Variant Data in the Case of Non-Linear Intensity-Genotype Relationship Genetic Epidemiology, v. 36
    Doi: http://doi.org/10.1002/gepi.21674
  • 2011

  • Cipriani, V., Matharu, BK., Khan, JC., Shahid, H., Hayward, C., Wright, AF., Armbrecht, AM., Dhillon, B., Harding, SP., Bishop, PN., Bunce, C., Clayton, DG., Moore, AT. and Yates, JR., 2011. No evidence of association between complement factor I genetic variant rs10033900 and age-related macular degeneration European Journal of Human Genetics,
  • Cipriani, V., Matharu, BK., Khan, JC., Shahid, H., Stanton, CM., Hayward, C., Wright, AF., Bunce, C., Clayton, DG., Moore, AT. and Yates, JRW., 2011. Genetic variation in complement regulators and susceptibility to age-related macular degeneration Immunobiology,
  • 2010

  • Niederer, HA., Willcocks, LC., Rayner, TF., Yang, W., Lau, YL., Williams, TN., Scott, JAG., Urban, BC., Peshu, N., Dunstan, SJ., Hien, TT., Phu, NH., Padyukov, L., Gunnarsson, I., Svenungsson, E., Savage, CO., Watts, RA., Lyons, PA., Clayton, DG. and Smith, KGC., 2010. Copy number, linkage disequilibrium and disease association in the FCGR locus. Hum Mol Genet, v. 19
    Doi: http://doi.org/10.1093/hmg/ddq216
  • Heap, GA., Yang, JHM., Downes, K., Healy, BC., Hunt, KA., Bockett, N., Franke, L., Dubois, PC., Mein, CA., Dobson, RJ., Albert, TJ., Rodesch, MJ., Clayton, DG., Todd, JA., van Heel, DA. and Plagnol, V., 2010. Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet, v. 19
    Doi: http://doi.org/10.1093/hmg/ddp473
  • Wallace, C., Smyth, DJ., Maisuria-Armer, M., Walker, NM., Todd, JA. and Clayton, DG., 2010. The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet, v. 42
    Doi: http://doi.org/10.1038/ng.493
  • 2009

  • Field, SF., Howson, JMM., Maier, LM., Walker, S., Walker, NM., Smyth, DJ., Armour, JAL., Clayton, DG. and Todd, JA., 2009. Experimental aspects of copy number variant assays at CCL3L1 NAT MED, v. 15
    Doi: http://doi.org/10.1038/nm1009-1115
  • Newton-Cheh, C., Johnson, T., Gateva, V., Tobin, MD., Bochud, M., Coin, L., Najjar, SS., Zhao, JH., Heath, SC., Eyheramendy, S., Papadakis, K., Voight, BF., Scott, LJ., Zhang, F., Farrall, M., Tanaka, T., Wallace, C., Chambers, JC., Khaw, KT., Nilsson, P., Van Der Harst, P., Polidoro, S., Grobbee, DE., Onland-Moret, NC., Bots, ML., Wain, LV., Elliott, KS., Teumer, A., Luan, J., Lucas, G., Kuusisto, J., Burton, PR., Hadley, D., McArdle, WL., Brown, M., Dominiczak, A., Newhouse, SJ., Samani, NJ., Webster, J., Zeggini, E., Beckmann, JS., Bergmann, S., Lim, N., Song, K., Vollenweider, P., Waeber, G., Waterworth, DM., Yuan, X., Groop, L., Orho-Melander, M., Allione, A., Di Gregorio, A., Guarrera, S., Panico, S., Ricceri, F., Romanazzi, V., Sacerdote, C., Vineis, P., Barroso, I., Sandhu, MS., Luben, RN., Crawford, GJ., Jousilahti, P., Perola, M., Boehnke, M., Bonnycastle, LL., Collins, FS., Jackson, AU., Mohlke, KL., Stringham, HM., Valle, TT., Willer, CJ., Bergman, RN., Morken, MA., Döring, A., Gieger, C., Illig, T., Meitinger, T., Org, E., Pfeufer, A., Wichmann, HE., Kathiresan, S., Marrugat, J., O'Donnell, CJ., Schwartz, SM., Siscovick, DS., Subirana, I., Freimer, NB., Hartikainen, AL., McCarthy, MI., O'Reilly, PF., Peltonen, L., Pouta, A., De Jong, PE., Snieder, H., Van Gilst, WH., Clarke, R., Goel, A., Hamsten, A. and Altshuler, D., 2009. Genome-wide association study identifies eight loci associated with blood pressure Nature Genetics, v. 41
    Doi: http://doi.org/10.1038/ng.361
  • Heap, GA., Yang, JHM., Downes, K., Healy, BC., Hunt, KA., Bockett, N., Franke, L., Dubois, PC., Mein, CA., Dobson, RJ., Albert, TJ., Rodesch, MJ., Clayton, DG., Todd, JA., van Heel, DA. and Plagnol, V., 2009. Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing Human Molecular Genetics, v. 19
    Doi: http://doi.org/10.1093/hmg/ddp473
  • Plagnol, V., Smyth, DJ., Todd, JA. and Clayton, DG., 2009. Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. Biostatistics, v. 10
    Doi: http://doi.org/10.1093/biostatistics/kxn039
  • Barrett, JC., Clayton, DG., Concannon, P., Akolkar, B., Cooper, JD., Erlich, HA., Julier, C., Morahan, G., Nerup, J., Nierras, C., Plagnol, V., Pociot, F., Schuilenburg, H., Smyth, DJ., Stevens, H., Todd, JA., Walker, NM., Rich, SS. and Type 1 Diabetes Genetics Consortium, , 2009. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet, v. 41
    Doi: http://doi.org/10.1038/ng.381
  • Clayton, DG., 2009. Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet, v. 5
    Doi: http://doi.org/10.1371/journal.pgen.1000540
  • Clayton, DG., 2009. Sex chromosomes and genetic association studies. Genome Med, v. 1
    Doi: http://doi.org/10.1186/gm110
  • 2008

  • Smyth, DJ., Cooper, JD., Howson, JMM., Walker, NM., Plagnol, V., Stevens, H., Clayton, DG. and Todd, JA., 2008. PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes, v. 57
    Doi: http://doi.org/10.2337/db07-1131
  • Smyth, DJ., Plagnol, V., Walker, NM., Cooper, JD., Downes, K., Yang, JHM., Howson, JMM., Stevens, H., McManus, R., Wijmenga, C., Heap, GA., Dubois, PC., Clayton, DG., Hunt, KA., Van Heel, DA. and Todd, JA., 2008. Shared and distinct genetic variants in type 1 diabetes and celiac disease New England Journal of Medicine, v. 359
    Doi: http://doi.org/10.1056/NEJMoa0807917
  • Smyth, DJ., Plagnol, V., Walker, NM., Cooper, JD., Downes, K., Yang, JHM., Howson, JMM., Stevens, H., McManus, R., Wijmenga, C., Heap, GA., Dubois, PC., Clayton, DG., Hunt, KA., van Heel, DA. and Todd, JA., 2008. Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med, v. 359
    Doi: http://doi.org/10.1056/NEJMoa0807917
  • 2007

  • Burton, PR., Clayton, DG., Cardon, LR., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, DP., McCarthy, MI., Ouwehand, WH., Samani, NJ., Todd, JA., Donnelly, P., Barrett, JC., Davison, D., Easton, D., Evans, D., Leung, HT., Marchini, JL., Morris, AP., Spencer, CCA., Tobin, MD., Attwood, AP., Boorman, JP., Cant, B., Everson, U., Hussey, JM., Jolley, JD., Knight, AS., Koch, K., Meech, E., Nutland, S., Prowse, CV., Stevens, HE., Taylor, NC., Walters, GR., Walker, NM., Watkins, NA., Winzer, T., Jones, RW., McArdle, WL., Ring, SM., Strachan, DP., Pembrey, M., Breen, G., St Clair, D., Caesar, S., Gordon-Smith, K., Jones, L., Fraser, C., Green, EK., Grozeva, D., Hamshere, ML., Holmans, PA., Jones, IR., Kirov, G., Moskvina, V., Nikolov, I., O'Donovan, MC., Owen, MJ., Collier, DA., Elkin, A., Farmer, A., Williamson, R., McGuffin, P., Young, AH., Ferrier, IN., Ball, SG., Balmforth, AJ., Barrett, JH., Bishop, DT., Iles, MM., Maqbool, A., Yuldasheva, N., Hall, AS., Braund, PS., Dixon, RJ., Mangino, M., Stevens, S., Thompson, JR., Bredin, F., Tremelling, M., Parkes, M., Drummond, H., Lees, CW., Nimmo, ER., Satsangi, J., Fisher, SA., Forbes, A., Lewis, CM., Onnie, CM., Prescott, NJ., Sanderson, J., Mathew, CG., Barbour, J., Mohiuddin, MK., Todhunter, CE., Mansfield, JC., Ahmad, T., Cummings, FR., Jewell, DP., Webster, J., Brown, MJ., Lathrop, GM., Connell, J., Dominiczak, A., Marcano, CAB., Burke, B., Dobson, R., Gungadoo, J., Lee, KL., Munroe, PB., Newhouse, SJ., Onipinla, A., Wallace, C., Xue, MZ., Caulfield, M., Farrall, M., Barton, A., Bruce, IN., Donovan, H., Eyre, S., Gilbert, PD., Hider, SL., Hinks, AM., John, SL., Potter, C., Silman, AJ., Symmons, DPM., Thomson, W., Worthington, J., Dunger, DB., Widmer, B., Frayling, TM., Freathy, RM., Lango, H., Perry, JRB., Shields, BM., Weedon, MN., Hattersley, AT., Hitman, GA., Walker, M., Elliott, KS., Groves, CJ., Lindgren, CM., Rayner, NW., Timpson, NJ., Zeggini, E., Newport, M., Sirugo, G., Lyons, E., Vannberg, F., Brown, MA., Franklyn, JA., Heward, JM., Simmonds, MJ., Hill, AVS., Bradbury, LA., Farrar, C., Pointon, JJ., Wordsmith, P., Gough, SCL., Seal, S., Stratton, MR., Rahman, N., Ban, M., Goris, A., Sawcer, SJ., Compston, A., Conway, D., Jallow, M., Bumpstead, SJ., Chaney, A., Downes, K., Ghori, MJR., Gwilliam, R., Inouye, M., Keniry, A., King, E., McGinnis, R., Potter, S., Ravindrarajah, R., Whittaker, P., Withers, D., Easton, D., Pereira-Gale, J., Hallgrimsdottir, IB., Howie, BN., Su, Z., Teo, YY., Vukcevic, D., Bentley, D., Caulfield, M., Mathew, CG., Worthington, J., Wellcome Trust Case Control Consortium, , Biol RA Genet & Genom Study Syndicate, and Breast Canc Susceptib Collaborat, , 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls NATURE, v. 447
    Doi: http://doi.org/10.1038/nature05911
  • Plagnol, V., Cooper, JD., Todd, JA. and Clayton, DG., 2007. A method to address differential bias in genotyping in large-scale association studies PLOS GENET, v. 3
    Doi: http://doi.org/10.1371/journal.pgen
  • Plagnol, V., Cooper, JD., Todd, JA. and Clayton, DG., 2007. A method to address differential bias in genotyping in large-scale association studies. PLoS Genet, v. 3
    Doi: http://doi.org/10.1371/journal.pgen.0030074
  • Todd, JA., Walker, NM., Cooper, JD., Smyth, DJ., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., Field, SF., Payne, F., Lowe, CE., Szeszko, JS., Hafler, JP., Zeitels, L., Yang, JHM., Vella, A., Nutland, S., Stevens, HE., Schuilenburg, H., Coleman, G., Maisuria, M., Meadows, W., Smink, LJ., Healy, B., Burren, OS., Lam, AAC., Ovington, NR., Allen, J., Adlem, E., Leung, H-T., Wallace, C., Howson, JMM., Guja, C., Ionescu-Tîrgovişte, C., Genetics of Type 1 Diabetes in Finland, , Simmonds, MJ., Heward, JM., Gough, SCL., Wellcome Trust Case Control Consortium, , Dunger, DB., Wicker, LS. and Clayton, DG., 2007. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet, v. 39
    Doi: http://doi.org/10.1038/ng2068
  • Yates, JRW., Sepp, T., Matharu, BK., Khan, JC., Thurlby, DA., Shahid, H., Clayton, DG., Hayward, C., Morgan, J., Wright, AF., Armbrecht, AM., Dhillon, B., Deary, IJ., Redmond, E., Bird, AC., Moore, AT. and Genetic Factors in AMD Study Group, , 2007. Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med, v. 357
    Doi: http://doi.org/10.1056/NEJMoa072618
  • Burton, PR., Clayton, DG., Cardon, LR., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, DP., McCarthy, MI., Ouwehand, WH., Samani, NJ. and others, , 2007. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants Nature genetics, v. 39
  • Lowe, CE., Cooper, JD., Brusko, T., Walker, NM., Smyth, DJ., Bailey, R., Bourget, K., Plagnol, V., Field, S., Atkinson, M., Clayton, DG., Wicker, LS. and Todd, JA., 2007. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet, v. 39
    Doi: http://doi.org/10.1038/ng2102
  • Nejentsev, S., Howson, JMM., Walker, NM., Szeszko, J., Field, SF., Stevens, HE., Reynolds, P., Hardy, M., King, E., Masters, J., Hulme, J., Maier, LM., Smyth, D., Bailey, R., Cooper, JD., Ribas, G., Campbell, RD., Clayton, DG., Todd, JA. and Wellcome Trust Case Control Consortium, , 2007. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature, v. 450
    Doi: http://doi.org/10.1038/nature06406
  • Todd, JA., Walker, NM., Cooper, JD., Smyth, DJ., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., Field, SF., Payne, F., Lowe, CE., Szeszko, JS., Hafler, JP., Zeitels, L., Yang, JHM., Vella, A., Nutland, S., Stevens, HE., Schuilenburg, H., Coleman, G., Maisuria, M., Meadows, W., Smink, LJ., Healy, B., Burren, OS., Lam, AAC., Ovington, NR., Allen, J., Adlem, E., Leung, HT., Wallace, C., Howson, JMM., Guja, C., Ionescu-Tîrgovişte, C., Simmonds, MJ., Heward, JM., Gough, SCL., Dunger, DB., Wicker, LS. and Clayton, DG., 2007. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes Nature Genetics, v. 39
    Doi: http://doi.org/10.1038/ng2068
  • Nejentsev, S., Howson, JMM., Walker, NM., Szeszko, J., Field, SF., Stevens, HE., Reynolds, P., Hardy, M., King, E., Masters, J., Hulme, J., Maier, LM., Smyth, D., Bailey, R., Cooper, JD., Ribas, G., Campbell, RD., Clayton, DG., Todd, JA., Burton, PR., Cardon, LR., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, DP., McCarthy, MI., Ouwehand, WH., Samani, NJ., Donnelly, P., Barrett, JC., Davison, D., Easton, D., Evans, D., Leung, HT., Marchini, JL., Morris, AP., Spencer, CCA., Tobin, MD., Attwood, AP., Boorman, JP., Cant, B., Everson, U., Hussey, JM., Jolley, JD., Knight, AS., Koch, K., Meech, E., Nutland, S., Prowse, CV., Taylor, NC., Walters, GR., Watkins, NA., Winzer, T., Jones, RW., McArdle, WL., Ring, SM., Strachan, DP., Pembrey, M., Breen, G., St Clair, D., Caesar, S., Gordon-Smith, K., Jones, L., Fraser, C., Green, EK., Grozeva, D., Hamshere, ML., Holmans, PA., Jones, IR., Kirov, G., Moskvina, V., Nikolov, I., O'Donovan, MC., Owen, MJ., Collier, DA., Elkin, A., Farmer, A., Williamson, R., McGuffin, P., Young, AH., Ferrier, IN., Ball, SG., Balmforth, AJ., Barrett, JH., Bishop, DT., Iles, MM., Maqbool, A., Yuldasheva, N., Hall, AS., Braund, PS., Dixon, RJ., Mangino, M., Stevens, S., Thompson, JR., Bredin, F., Tremelling, M., Parkes, M., Drummond, H., Lees, CW. and Nimmo, ER., 2007. Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A Nature, v. 450
    Doi: http://doi.org/10.1038/nature06406
  • Lowe, CE., Cooper, JD., Brusko, T., Walker, NM., Smyth, DJ., Bailey, R., Bourget, K., Plagnol, V., Field, S., Atkinson, M., Clayton, DG., Wicker, LS. and Todd, JA., 2007. Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes Nature Genetics, v. 39
    Doi: http://doi.org/10.1038/ng2102
  • 2006

  • Wallace, C. and Clayton, DG., 2006. Appropriate use of information on family history of disease in recruitment for linkage analysis studies ANN HUM GENET, v. 70
    Doi: http://doi.org/10.1111/j.1469-1809.2005.00233.x
  • Smyth, DJ., Cooper, JD., Lowe, CE., Nutland, S., Walker, NM., Clayton, DG. and Todd, JA., 2006. No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases Diabetes, v. 55
    Doi: http://doi.org/10.2337/db05-1452
  • Khan, JC., Thurlby, DA., Shahid, H., Clayton, DG., Yates, JRW., Bradley, M., Moore, AT., Bird, AC. and Genetic Factors in AMD Study, , 2006. Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation. Br J Ophthalmol, v. 90
    Doi: http://doi.org/10.1136/bjo.2005.073643
  • Wallace, C., Chapman, JM. and Clayton, DG., 2006. Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping AM J HUM GENET, v. 78
  • Sepp, T., Khan, JC., Thurlby, DA., Shahid, H., Clayton, DG., Moore, AT., Bird, AC. and Yates, JRW., 2006. Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest Ophthalmol Vis Sci, v. 47
    Doi: http://doi.org/10.1167/iovs.05-1143
  • Wallace, C., Xue, MZ., Newhouse, SJ., Marcano, ACB., Onipinla, AK., Burke, B., Gungadoo, J., Dobson, RJ., Brown, M., Connell, JM., Dominiczak, A., Lathrop, GM., Webster, J., Farrall, M., Mein, C., Samani, NJ., Caulfield, MJ., Clayton, DG. and Munroe, PB., 2006. Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension AM J HUM GENET, v. 79
  • Smyth, DJ., Cooper, JD., Lowe, CE., Nutland, S., Walker, NM., Clayton, DG. and Todd, JA., 2006. No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases. Diabetes, v. 55
    Doi: http://doi.org/10.2337/db05-1452
  • Smyth, DJ., Cooper, JD., Bailey, R., Field, S., Burren, O., Smink, LJ., Guja, C., Ionescu-Tirgoviste, C., Widmer, B., Dunger, DB., Savage, DA., Walker, NM., Clayton, DG. and Todd, JA., 2006. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet, v. 38
    Doi: http://doi.org/10.1038/ng1800
  • Khan, JC., Shahid, H., Thurlby, DA., Bradley, M., Clayton, DG., Moore, AT., Bird, AC., Yates, JRW. and Genetic Factors in AMD Study, , 2006. Age related macular degeneration and sun exposure, iris colour, and skin sensitivity to sunlight. Br J Ophthalmol, v. 90
    Doi: http://doi.org/10.1136/bjo.2005.073825
  • 2005

  • Vella, A., Cooper, JD., Lowe, CE., Walker, N., Nutland, S., Widmer, B., Jones, R., Ring, SM., McArdle, W., Pembrey, ME., Strachan, DP., Dunger, DB., Twells, RCJ., Clayton, DG. and Todd, JA., 2005. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms American Journal of Human Genetics, v. 76
    Doi: http://doi.org/10.1086/429843
  • Maier, LM., Chapman, J., Howson, JMM., Clayton, DG., Pask, R., Strachan, DP., McArdle, WL., Twells, RCJ. and Todd, JA., 2005. No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. Am J Hum Genet, v. 76
    Doi: http://doi.org/10.1086/428387
  • Wang, WYS., Barratt, BJ., Clayton, DG. and Todd, JA., 2005. Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet, v. 6
    Doi: http://doi.org/10.1038/nrg1522
  • Vella, A., Cooper, JD., Lowe, CE., Walker, N., Nutland, S., Widmer, B., Jones, R., Ring, SM., McArdle, W., Pembrey, ME., Strachan, DP., Dunger, DB., Twells, RCJ., Clayton, DG. and Todd, JA., 2005. Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet, v. 76
    Doi: http://doi.org/10.1086/429843
  • Cordell, HJ. and Clayton, DG., 2005. Genetic association studies. Lancet, v. 366
    Doi: http://doi.org/10.1016/S0140-6736(05)67424-7
  • Clayton, DG., Walker, NM., Smyth, DJ., Pask, R., Cooper, JD., Maier, LM., Smink, LJ., Lam, AC., Ovington, NR., Stevens, HE., Nutland, S., Howson, JMM., Faham, M., Moorhead, M., Jones, HB., Falkowski, M., Hardenbol, P., Willis, TD. and Todd, JA., 2005. Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet, v. 37
    Doi: http://doi.org/10.1038/ng1653
  • Cordell, HJ. and Clayton, DG., 2005. Genetic epidemiology 3 - Genetic association studies LANCET, v. 366
  • 2004

  • Barratt, BJ., Payne, F., Lowe, CE., Hermann, R., Healy, BC., Harold, D., Concannon, P., Gharani, N., McCarthy, MI., Olavesen, MG., McCormack, R., Guja, C., Ionescu-Tîrgovişte, C., Undlien, DE., Rønningen, KS., Gillespie, KM., Tuomilehto-Wolf, E., Tuomilehto, J., Bennett, ST., Clayton, DG., Cordell, HJ. and Todd, JA., 2004. Remapping the insulin gene/IDDM2 locus in type 1 diabetes Diabetes, v. 53
    Doi: http://doi.org/10.2337/diabetes.53.7.1884
  • Lowe, CE., Cooper, JD., Chapman, JM., Barratt, BJ., Twells, RCJ., Green, EA., Savage, DA., Guja, C., Ionescu-Tîrgovişte, C., Tuomilehto-Wolf, E., Tuomilehto, J., Todd, JA. and Clayton, DG., 2004. Cost-effective analysis of candidate genes using htSNPs: A staged approach Genes and Immunity, v. 5
    Doi: http://doi.org/10.1038/sj.gene.6364064
  • Cordell, HJ., Barratt, BJ. and Clayton, DG., 2004. Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol, v. 26
    Doi: http://doi.org/10.1002/gepi.10307
  • Lowe, CE., Cooper, JD., Chapman, JM., Barratt, BJ., Twells, RCJ., Green, EA., Savage, DA., Guja, C., Ionescu-Tîrgovişte, C., Tuomilehto-Wolf, E., Tuomilehto, J., Todd, JA. and Clayton, DG., 2004. Cost-effective analysis of candidate genes using htSNPs: a staged approach. Genes Immun, v. 5
    Doi: http://doi.org/10.1038/sj.gene.6364064
  • Downes, K., Barratt, BJ., Akan, P., Bumpstead, SJ., Taylor, SD., Clayton, DG. and Deloukas, P., 2004. SNP allele frequency estimation in DNA pools and variance components analysis. Biotechniques, v. 36
    Doi: http://doi.org/10.2144/04365RR01
  • Nejentsev, S., Godfrey, L., Snook, H., Rance, H., Nutland, S., Walker, NM., Lam, AC., Guja, C., Ionescu-Tirgoviste, C., Undlien, DE., Rønningen, KS., Tuomilehto-Wolf, E., Tuomilehto, J., Newport, MJ., Clayton, DG. and Todd, JA., 2004. Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet, v. 13
    Doi: http://doi.org/10.1093/hmg/ddh169
  • Barratt, BJ., Payne, F., Lowe, CE., Hermann, R., Healy, BC., Harold, D., Concannon, P., Gharani, N., McCarthy, MI., Olavesen, MG., McCormack, R., Guja, C., Ionescu-Tîrgovişte, C., Undlien, DE., Rønningen, KS., Gillespie, KM., Tuomilehto-Wolf, E., Tuomilehto, J., Bennett, ST., Clayton, DG., Cordell, HJ. and Todd, JA., 2004. Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes, v. 53
    Doi: http://doi.org/10.2337/diabetes.53.7.1884
  • Smyth, D., Cooper, JD., Collins, JE., Heward, JM., Franklyn, JA., Howson, JMM., Vella, A., Nutland, S., Rance, HE., Maier, L., Barratt, BJ., Guja, C., Ionescu-Tîrgoviste, C., Savage, DA., Dunger, DB., Widmer, B., Strachan, DP., Ring, SM., Walker, N., Clayton, DG., Twells, RCJ., Gough, SCL. and Todd, JA., 2004. Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes, v. 53
    Doi: http://doi.org/10.2337/diabetes.53.11.3020
  • Thomas, DC. and Clayton, DG., 2004. Betting odds and genetic associations J NATL CANCER I, v. 96
    Doi: http://doi.org/10.1093/jnci/djh094
  • Hoggart, CJ., Shriver, MD., Kittles, RA., Clayton, DG. and McKeigue, PM., 2004. Design and analysis of admixture mapping studies AM J HUM GENET, v. 74
  • 2003

  • Ueda, H., Howson, JMM., Esposito, L., Heward, J., Snook, H., Chamberlain, G., Rainbow, DB., Hunter, KMD., Smith, AN., Di Genova, G., Herr, MH., Dahlman, I., Payne, F., Smyth, D., Lowe, C., Twells, RCJ., Howlett, S., Healy, B., Nutland, S., Rance, HE., Everett, V., Smink, LJ., Lam, AC., Cordell, HJ., Walker, NM., Bordin, C., Hulme, J., Motzo, C., Cucca, F., Hess, JF., Metzker, ML., Rogers, J., Gregory, S., Allahabadia, A., Nithiyananthan, R., Tuomilehto-Wolf, E., Tuomilehto, J., Bingley, P., Gillespie, KM., Undlien, DE., Rønningen, KS., Guja, C., Ionescu-Tîrgovişte, C., Savage, DA., Maxwell, AP., Carson, DJ., Patterson, CC., Franklyn, JA., Clayton, DG., Peterson, LB., Wicker, LS., Todd, JA. and Gough, SCL., 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature, v. 423
    Doi: http://doi.org/10.1038/nature01621
  • Maier, LM., Twells, RCJ., Howson, JMM., Lam, AC., Clayton, DG., Smyth, DJ., Savage, D., Carson, D., Patterson, CC., Smink, LJ., Walker, NM., Burren, OS., Nutland, S., Rance, H., Tuomilehto-Wolf, E., Tuomilehto, J., Guja, C., Ionescu-Tirgoviste, C., Undlien, DE., Rønningen, KS., Cucca, F. and Todd, JA., 2003. Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene. Genes Immun, v. 4
    Doi: http://doi.org/10.1038/sj.gene.6364007
  • Chapman, JM., Cooper, JD., Todd, JA. and Clayton, DG., 2003. Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered, v. 56
    Doi: http://doi.org/10.1159/000073729
  • Cordell, HJ., Howson, JMM. and Clayton, DG., 2003. Linkage analysis of a derived glucose phenotype in the Genetic Analysis Workshop 13 simulated data using a variety of Haseman-Elston based regression methods. BMC Genet, v. 4 Suppl 1
    Doi: http://doi.org/10.1186/1471-2156-4-S1-S6
  • Hoggart, CJ., Parra, EJ., Shriver, MD., Bonilla, C., Kittles, RA., Clayton, DG. and McKeigue, PM., 2003. Control of confounding of genetic associations in stratified populations AM J HUM GENET, v. 72
  • Ueda, H., Howson, JMM., Esposito, L., Heward, J., Snook, H., Chamberlain, G., Rainbow, DB., Hunter, KMD., Smith, AN., Di Genova, G., Herr, MH., Dahlman, I., Payne, F., Smyth, D., Lowe, C., Twells, RCJ., Howlett, S., Healy, B., Nutland, S., Rance, HE., Everett, V., Smink, LJ., Lam, AC., Cordell, HJ., Walker, NM., Bordin, C., Hulme, J., Motzo, C., Cucca, F., Hess, JF., Metzker, ML., Rogers, J., Gregory, S., Allahabadia, A., Nithiyananthan, R., Tuomilehto-Wolf, E., Tuomilehto, J., Bingley, P., Gillespie, KM., Undlien, DE., Rønningen, KS., Guja, C., Ionescu-Tirgovişte, C., Savage, DA., Maxwell, AP., Carson, DJ., Patterson, CC., Franklyn, JA., Clayton, DG., Peterson, LB., Wicker, LS., Todd, JA. and Gough, SCL., 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease Nature, v. 423
    Doi: http://doi.org/10.1038/nature01621
  • 2002

  • Cordell, HJ. and Clayton, DG., 2002. A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet, v. 70
    Doi: http://doi.org/10.1086/338007
  • Barratt, BJ., Payne, F., Rance, HE., Nutland, S., Todd, JA. and Clayton, DG., 2002. Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design. Ann Hum Genet, v. 66
    Doi: http://doi.org/10.1017/S0003480002001252
  • 2001

  • Bitti, PP., Murgia, BS., Ticca, A., Ferrai, R., Musu, L., Piras, ML., Puledda, E., Campo, S., Durando, S., Montomoli, C., Clayton, DG., Mander, AP. and Bernardinelli, L., 2001. Association between the ancestral haplotype HLA A30B18DR3 and multiple sclerosis in Central Sardinia GENET EPIDEMIOL, v. 20
  • Cordell, HJ., Todd, JA., Hill, NJ., Lord, CJ., Lyons, PA., Peterson, LB., Wicker, LS. and Clayton, DG., 2001. Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes. Genetics, v. 158
    Doi: http://doi.org/10.1093/genetics/158.1.357
  • Johnson, GC., Esposito, L., Barratt, BJ., Smith, AN., Heward, J., Di Genova, G., Ueda, H., Cordell, HJ., Eaves, IA., Dudbridge, F., Twells, RC., Payne, F., Hughes, W., Nutland, S., Stevens, H., Carr, P., Tuomilehto-Wolf, E., Tuomilehto, J., Gough, SC., Clayton, DG. and Todd, JA., 2001. Haplotype tagging for the identification of common disease genes. Nat Genet, v. 29
    Doi: http://doi.org/10.1038/ng1001-233
  • Johnson, GCL., Esposito, L., Barratt, BJ., Smith, AN., Heward, J., Di Genova, G., Ueda, H., Cordell, HJ., Eaves, IA., Dudbridge, F., Twells, RCJ., Payne, F., Hughes, W., Nutland, S., Stevens, H., Carr, P., Tuomilehto-Wolf, E., Tuomilehto, J., Gough, SCL., Clayton, DG. and Todd, JA., 2001. Haplotype tagging for the identification of common disease genes Nature Genetics, v. 29
    Doi: http://doi.org/10.1038/ng1001-233
  • 2000

  • Ecochard, R. and Clayton, DG., 2000. Multivariate parametric random effect regression models for fecundability studies BIOMETRICS, v. 56
  • Clarke, JR., Jenkins, MA., Hopper, JL., Carlin, JB., Mayne, C., Clayton, DG., Dalton, MF., Holst, DP. and Robertson, CF., 2000. Evidence for genetic associations between asthma, atopy, and bronchial hyperresponsiveness - A study of 8-to 18-yr-old twins AM J RESP CRIT CARE, v. 162
  • Dudbridge, F., Koeleman, BP., Todd, JA. and Clayton, DG., 2000. Unbiased application of the transmission/disequilibrium test to multilocus haplotypes. Am J Hum Genet, v. 66
    Doi: http://doi.org/10.1086/302915
  • 1999

  • Donaldson, MMK., McGrother, CW., Clayton, DG., Clarke, M. and Osborne, D., 1999. Calcaneal ultrasound attenuation in an elderly population: Measurement position and relationships with body size and past fractures OSTEOPOROSIS INT, v. 10
  • 1998

  • Chiano, MN. and Clayton, DG., 1998. Genotypic relative risks under ordered restriction. Genet Epidemiol, v. 15
    Doi: http://doi.org/10.1002/(SICI)1098-2272(1998)15:2<135::AID-GEPI3>3.0.CO;2-5
  • Chiano, MN. and Clayton, DG., 1998. Fine genetic mapping using haplotype analysis and the missing data problem. Ann Hum Genet, v. 62
    Doi: http://doi.org/10.1046/j.1469-1809.1998.6210055.x
  • Ecochard, R. and Clayton, DG., 1998. Multi-level modelling of conception in artificial insemination by donor STAT MED, v. 17
  • 1994

  • VANDUIJN, CM., CLAYTON, DG., CHANDRA, V., FRATIGLIONI, L., GRAVES, AB., HEYMAN, A., JORM, AF., KOKMEN, E., KONDO, K., MORTIMER, JA., ROCCA, WA., SHALAT, SL., SOININEN, H. and HOFMAN, A., 1994. INTERACTION BETWEEN GENETIC AND ENVIRONMENTAL RISK-FACTORS FOR ALZHEIMERS-DISEASE - A REANALYSIS OF CASE-CONTROL STUDIES GENET EPIDEMIOL, v. 11
  • 1993

  • Clayton, DG., Bernardinelli, L. and Montomoli, C., 1993. Spatial correlation in ecological analysis. Int J Epidemiol, v. 22
    Doi: http://doi.org/10.1093/ije/22.6.1193
  • BRESLOW, NE. and CLAYTON, DG., 1993. APPROXIMATE INFERENCE IN GENERALIZED LINEAR MIXED MODELS J AM STAT ASSOC, v. 88
  • GILKS, WR., CLAYTON, DG., SPIEGELHALTER, DJ., BEST, NG., MCNEIL, AJ., SHARPLES, LD. and KIRBY, AJ., 1993. MODELING COMPLEXITY - APPLICATIONS OF GIBBS SAMPLING IN MEDICINE J ROY STAT SOC B MET, v. 55
  • CLIFFORD, P., JENNISON, C., WAKEFIELD, J., PHILLIPS, D., FRIGESSI, A., GRAY, AJ., LAWSON, A., FORSTER, J., RAMGOPAL, P., ARSLAN, O., CONSTABLE, PDL., KENT, JT., WOLFF, RCL., HARDING, EF., MIDDLETON, R., DIGGLE, PJ., AYKROYD, RG., BERZUINI, C., BREWER, M., AITKEN, C., CELEUX, G., DIEBOLT, J., CRITCHLEY, F., DIACONIS, P., ROSENTHAL, JS., DIEBOLT, J., ROBERT, CP., GELFAND, AE., LEE, TM., GELMAN, A., RUBIN, DB., GEMAN, D., GEWEKE, J., GEYER, CJ., GIGLI, A., GIVENS, GH., GOODALL, C., JONALASINIO, GD., GRIEVE, AP., HAN, XL., KOLASSA, JE., TANNER, MA., KOOPERBERG, C., LEWIS, SM., LIN, S., THOMPSON, EA., LITTON, CD., BUCK, CE., LIU, CH., LIU, J., MARDIA, KV., MARRIOTT, JM., MOLLER, J., RAFTERY, AE., SHEPHARD, N., SINHA, D., SOKAL, AD., TITTERINGTON, DM., WILSON, JD., YORK, J., MADIGAN, D., SMITH, AFM., ROBERTS, GO., BESAG, J., GREEN, PJ., GILKS, WR., CLAYTON, DG. and SPIEGELHALTER, DJ., 1993. DISCUSSION ON THE MEETING ON THE GIBBS SAMPLER AND OTHER MARKOV CHAIN-MONTE CARLO METHODS J ROY STAT SOC B MET, v. 55
  • 1991

  • Clayton, DG., 1991. A Monte Carlo method for bayesian inference in frailty models Biometrics, v. 47
    Doi: http://doi.org/10.2307/2532139
  • Conference proceedings

    2007

  • Yates, J., Sepp, T., Matharu, BK., Khan, JC., Thurlby, DA., Shahid, H., Clayton, DG., Hayward, C., Morgan, J., Wright, AF., Armbrecht, AM., Dhillon, B., Deary, IJ., Redmond, E., Bird, AC. and Moore, AT., 2007. Complement C3 variant increases risk of age-related macular degeneration JOURNAL OF MEDICAL GENETICS, v. 44
  • 2003

  • Cooper, JD., Chapman, JM., Todd, JA. and Clayton, DG., 2003. Detecting disease associations using htSNPs. AMERICAN JOURNAL OF HUMAN GENETICS, v. 73
  • 2001

  • Thomas, DC., Morrison, JL. and Clayton, DG., 2001. Bayes estimates of haplotype effects GENETIC EPIDEMIOLOGY, v. 21